Gene Page: CHD7

Summary ?
GeneID55636
SymbolCHD7
SynonymsCRG|HH5|IS3|KAL5
Descriptionchromodomain helicase DNA binding protein 7
ReferenceMIM:608892|HGNC:HGNC:20626|Ensembl:ENSG00000171316|HPRD:10595|Vega:OTTHUMG00000165332
Gene typeprotein-coding
Map location8q12.2
Pascal p-value0.032
Fetal beta1.83
eGeneMyers' cis & trans
SupportAscano FMRP targets

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:GWASdbGenome-wide Association StudiesGWASdb records for schizophrenia
CV:PGCnpGenome-wide Association StudyGWAS

Section I. Genetics and epigenetics annotation

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs13447530chr191983798CHD7556360.19trans
rs7520276chr1205659490CHD7556360.11trans
rs16856160chr1205661366CHD7556360.11trans
rs17022378chr1206654057CHD7556360.06trans
rs17572651chr1218943612CHD7556360trans
rs6734526chr25616370CHD7556360.11trans
rs6753473chr226526418CHD7556360.01trans
rs2197597chr2129638077CHD7556360.15trans
rs2897468chr2129711721CHD7556360.14trans
rs16829545chr2151977407CHD7556361.914E-34trans
rs16841750chr2158288461CHD7556360.04trans
rs7584986chr2184111432CHD7556365.562E-5trans
rs6741060chr2217169088CHD7556369.897E-5trans
rs9810143chr35060209CHD7556360trans
rs6797307chr38601563CHD7556360trans
rs6773248chr3174790333CHD7556360.01trans
rs6797728chr3174790417CHD7556360.01trans
rs16882010chr411453741CHD7556360.16trans
rs17415971chr414272434CHD7556360.12trans
snp_a-18157710CHD7556360.02trans
rs17020035chr493873810CHD7556360.01trans
rs17020058chr493915972CHD7556360.02trans
rs17020066chr493921055CHD7556360.02trans
rs17008119chr4125321425CHD7556360.13trans
rs7692715chr4125335209CHD7556360.02trans
rs1480540chr4171103335CHD7556360.15trans
rs1396222chr4173279496CHD7556360.15trans
rs4488887chr4177695833CHD7556360.12trans
rs10474151chr584286402CHD7556360.03trans
rs133604960CHD7556360trans
rs13191953chr624151042CHD7556360.03trans
rs12196880chr624313746CHD7556360.08trans
rs16890367chr638078448CHD7556360.04trans
rs17149888chr724738371CHD7556360.15trans
rs10253181chr726563022CHD7556360.11trans
rs12706918chr780266147CHD7556360trans
rs4841493chr86521431CHD7556360.1trans
rs6996695chr877540580CHD7556360.07trans
rs11139334chr984209393CHD7556369.232E-4trans
rs2393316chr1059333070CHD7556365.988E-4trans
rs17124813chr10110347464CHD7556360.03trans
rs11061703chr121436977CHD7556360.04trans
rs9669370chr121466349CHD7556360.01trans
rs7337967chr1353519044CHD7556360.01trans
rs4112777chr1399281457CHD7556360trans
rs9989228chr1437809252CHD7556360trans
rs16955618chr1529937543CHD7556365.44E-29trans
rs2077735chr1558479024CHD7556360trans
rs4795850chr1732383815CHD7556360.07trans
rs4795851chr1732384050CHD7556360.06trans
rs1003837chr1732453154CHD7556360.19trans
rs11873184chr181584081CHD7556369.684E-4trans
rs12458173chr1831430166CHD7556360.05trans
rs17782355chr1955807585CHD7556360.12trans
rs7274477chr201676942CHD7556360.05trans
rs6046679chr2020146874CHD7556360.16trans
rs4813543chr2025004070CHD7556360.07trans
rs1041786chr2122617710CHD7556360trans
rs3829726chrX72666188CHD7556360.05trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
PSMA40.800.80
PSMA50.790.76
SRP190.780.77
UBE2T0.780.77
FKBP30.780.78
MEA10.770.77
ENY20.760.75
MED70.760.75
TCEAL80.760.75
MRPL320.760.75
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
AF347015.26-0.66-0.58
AF347015.2-0.64-0.54
AF347015.8-0.64-0.56
AF347015.15-0.64-0.57
AF347015.33-0.63-0.55
MT-CYB-0.63-0.56
MT-CO2-0.62-0.52
AF347015.27-0.60-0.55
AF347015.18-0.60-0.52
AF347015.31-0.57-0.51

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
PID WNT NONCANONICAL PATHWAY 3226All SZGR 2.0 genes in this pathway
ONKEN UVEAL MELANOMA UP 783507All SZGR 2.0 genes in this pathway
DAVICIONI MOLECULAR ARMS VS ERMS UP 332228All SZGR 2.0 genes in this pathway
KIM WT1 TARGETS UP 214155All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY DOXORUBICIN DN 17811082All SZGR 2.0 genes in this pathway
NUYTTEN NIPP1 TARGETS UP 769437All SZGR 2.0 genes in this pathway
LIAO METASTASIS 539324All SZGR 2.0 genes in this pathway
KOYAMA SEMA3B TARGETS DN 411249All SZGR 2.0 genes in this pathway
GEORGES TARGETS OF MIR192 AND MIR215 893528All SZGR 2.0 genes in this pathway
NIKOLSKY BREAST CANCER 8Q12 Q22 AMPLICON 13282All SZGR 2.0 genes in this pathway
NIKOLSKY MUTATED AND AMPLIFIED IN BREAST CANCER 9460All SZGR 2.0 genes in this pathway
DING LUNG CANCER EXPRESSION BY COPY NUMBER 10062All SZGR 2.0 genes in this pathway
ALCALAY AML BY NPM1 LOCALIZATION UP 14083All SZGR 2.0 genes in this pathway
HADDAD B LYMPHOCYTE PROGENITOR 293193All SZGR 2.0 genes in this pathway
REN ALVEOLAR RHABDOMYOSARCOMA UP 9864All SZGR 2.0 genes in this pathway
BILD E2F3 ONCOGENIC SIGNATURE 246153All SZGR 2.0 genes in this pathway
LEIN CEREBELLUM MARKERS 8547All SZGR 2.0 genes in this pathway
GAVIN FOXP3 TARGETS CLUSTER P4 10062All SZGR 2.0 genes in this pathway
ZHENG BOUND BY FOXP3 491310All SZGR 2.0 genes in this pathway
FOSTER TOLERANT MACROPHAGE DN 409268All SZGR 2.0 genes in this pathway
BOQUEST STEM CELL DN 216143All SZGR 2.0 genes in this pathway
LIN TUMOR ESCAPE FROM IMMUNE ATTACK 1812All SZGR 2.0 genes in this pathway
CAIRO HEPATOBLASTOMA CLASSES UP 605377All SZGR 2.0 genes in this pathway
ZHAN MULTIPLE MYELOMA MS DN 4624All SZGR 2.0 genes in this pathway
MARTENS BOUND BY PML RARA FUSION 456287All SZGR 2.0 genes in this pathway
VERHAAK GLIOBLASTOMA PRONEURAL 177132All SZGR 2.0 genes in this pathway
CHYLA CBFA2T3 TARGETS UP 387225All SZGR 2.0 genes in this pathway
PILON KLF1 TARGETS DN 19721213All SZGR 2.0 genes in this pathway
RAO BOUND BY SALL4 227149All SZGR 2.0 genes in this pathway
ZWANG TRANSIENTLY UP BY 2ND EGF PULSE ONLY 1725838All SZGR 2.0 genes in this pathway