Gene Page: VAC14

Summary ?
GeneID55697
SymbolVAC14
SynonymsArPIKfyve|TAX1BP2|TRX
DescriptionVac14 homolog (S. cerevisiae)
ReferenceMIM:604632|HGNC:HGNC:25507|Ensembl:ENSG00000103043|HPRD:07660|Vega:OTTHUMG00000137583
Gene typeprotein-coding
Map location16q22.1
Pascal p-value0.1
Sherlock p-value0.029
Fetal beta-0.426
DMG1 (# studies)
eGeneMyers' cis & trans

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
DMG:Jaffe_2016Genome-wide DNA methylation analysisThis dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05. 1

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

ProbeChromosomePositionNearest geneP (dis)Beta (dis)FDR (dis)Study
cg055479931670835035VAC142.72E-9-0.0131.95E-6DMG:Jaffe_2016

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs4526604chr142182143VAC14556970.02trans
rs710235chr142202713VAC14556970.02trans
rs4284254chr142213075VAC14556970.02trans
rs12495201chr3112896372VAC14556970.15trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
PML0.930.89
FSCN10.900.88
C17orf620.890.90
IRF2BP20.890.85
THAP110.890.91
C7orf130.890.88
ZNF5740.890.89
VARS0.890.86
FIZ10.880.88
RBM140.880.91
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
AF347015.27-0.61-0.78
C5orf53-0.61-0.70
AF347015.31-0.60-0.75
MT-CO2-0.60-0.77
AF347015.33-0.59-0.76
AF347015.8-0.59-0.78
MT-CYB-0.57-0.75
AF347015.21-0.57-0.82
COPZ2-0.56-0.67
S100B-0.56-0.71

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
REACTOME SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE 128All SZGR 2.0 genes in this pathway
REACTOME SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE 1710All SZGR 2.0 genes in this pathway
REACTOME PHOSPHOLIPID METABOLISM 198112All SZGR 2.0 genes in this pathway
REACTOME SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE 107All SZGR 2.0 genes in this pathway
REACTOME PI METABOLISM 4834All SZGR 2.0 genes in this pathway
REACTOME METABOLISM OF LIPIDS AND LIPOPROTEINS 478302All SZGR 2.0 genes in this pathway
FULCHER INFLAMMATORY RESPONSE LECTIN VS LPS UP 579346All SZGR 2.0 genes in this pathway
SENESE HDAC3 TARGETS DN 536332All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 16HR UP 225139All SZGR 2.0 genes in this pathway
KIM GASTRIC CANCER CHEMOSENSITIVITY 10364All SZGR 2.0 genes in this pathway
BONOME OVARIAN CANCER SURVIVAL SUBOPTIMAL DEBULKING 510309All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE LATE 1137655All SZGR 2.0 genes in this pathway
RATTENBACHER BOUND BY CELF1 467251All SZGR 2.0 genes in this pathway