Gene Page: ASF1B

Summary ?
GeneID55723
SymbolASF1B
SynonymsCIA-II
Descriptionanti-silencing function 1B histone chaperone
ReferenceMIM:609190|HGNC:HGNC:20996|Ensembl:ENSG00000105011|HPRD:16460|Vega:OTTHUMG00000150401
Gene typeprotein-coding
Map location19p13.12
Pascal p-value0.684
Fetal beta1.724
DMG1 (# studies)
eGeneMeta
SupportChromatin Remodeling Genes

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
DMG:Jaffe_2016Genome-wide DNA methylation analysisThis dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05. 1

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

ProbeChromosomePositionNearest geneP (dis)Beta (dis)FDR (dis)Study
cg063915481914247141ASF1B1.01E-9-0.0111.17E-6DMG:Jaffe_2016


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
TCEAL20.900.90
TCEAL50.840.84
CFDP10.840.84
SSB0.830.85
CXorf260.830.83
CIR10.820.80
POLR3GL0.810.81
EIF3J0.800.83
HTATSF10.800.81
DNAJB110.790.84
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
AF347015.31-0.59-0.59
MT-CO2-0.58-0.58
TM4SF1-0.57-0.60
AF347015.2-0.57-0.60
MT-CYB-0.56-0.57
IFI27-0.56-0.59
AF347015.9-0.56-0.61
AF347015.33-0.56-0.56
HIGD1B-0.55-0.56
ENHO-0.55-0.62

Section IV. Protein-protein interaction annotation

InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ASF1ACGI-98 | CIA | DKFZp547E2110 | HSPC146ASF1 anti-silencing function 1 homolog A (S. cerevisiae)-HPRD12842904 
C15orf41FLJ22851 | HH114 | MGC11326chromosome 15 open reading frame 41Affinity Capture-MSBioGRID17353931 
C6orf167DKFZp686C20164 | DKFZp781C2113 | FLJ46180 | KIAA1900 | dJ39B17.2chromosome 6 open reading frame 167Affinity Capture-MSBioGRID17353931 
CDAN1CDA-I | CDA1 | CDAI | DLT | PRO1295 | codanincongenital dyserythropoietic anemia, type IAffinity Capture-MSBioGRID17353931 
CHAF1ACAF-1 | CAF1 | CAF1B | CAF1P150 | MGC71229 | P150chromatin assembly factor 1, subunit A (p150)Affinity Capture-MS
Affinity Capture-Western
Reconstituted Complex		BioGRID11897662 |17353931 
CHAF1BCAF-1 | CAF-IP60 | CAF1 | CAF1A | CAF1P60 | MPHOSPH7 | MPP7chromatin assembly factor 1, subunit B (p60)Affinity Capture-MS
Affinity Capture-Western
Reconstituted Complex		BioGRID11897662 |17353931 
DOK2p56DOK | p56dok-2docking protein 2, 56kDaAffinity Capture-MSBioGRID17353931 
DYNLL1DLC1 | DLC8 | DNCL1 | DNCLC1 | LC8 | LC8a | MGC126137 | MGC126138 | PIN | hdlc1dynein, light chain, LC8-type 1Affinity Capture-MSBioGRID17353931 
H3F3AH3.3A | H3F3 | MGC87782 | MGC87783H3 histone, family 3AH3.3 interacts with Asf1b. This interaction was modeled on a demonstrated interaction between H3.3 from an unspecified species and human Asf1b.BIND15664198 
HIST1H3CH3.1 | H3/c | H3FChistone cluster 1, H3c-HPRD12842904 
HIST1H3EH3.1 | H3/d | H3FDhistone cluster 1, H3eH3.1 interacts with Asf1b. This interaction was modeled on a demonstrated interaction between H3.1 from an unspecified species and human Asf1b.BIND15664198 
HIST1H3FH3/i | H3FIhistone cluster 1, H3fAffinity Capture-MSBioGRID17353931 
HIST1H4FH4 | H4/c | H4FChistone cluster 1, H4f-HPRD12842904 
IPO4FLJ23338 | Imp4 | MGC131665importin 4Affinity Capture-MSBioGRID17353931 
MRPS7MRP-S | MRP-S7 | RP-S7 | RPMS7 | S7mt | bMRP27amitochondrial ribosomal protein S7Affinity Capture-MSBioGRID17353931 
NFKBIL2FLJ40087 | IKBRnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 2Affinity Capture-MSBioGRID17353931 
PSPHPSPphosphoserine phosphataseAffinity Capture-MSBioGRID17353931 
RBBP4NURF55 | RBAP48retinoblastoma binding protein 4Affinity Capture-MSBioGRID17353931 
RPL31MGC88191ribosomal protein L31Affinity Capture-MSBioGRID17353931 
RPS3AFTE1 | MFTL | MGC23240ribosomal protein S3AAffinity Capture-MSBioGRID17353931 
TAF1BA2R | CCG1 | CCGS | DYT3 | KAT4 | N-TAF1 | NSCL2 | OF | P250 | TAF2A | TAFII250TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa-HPRD12842904 
TLK1KIAA0137 | PKU-betatousled-like kinase 1-HPRD,BioGRID11470414 
TLK2MGC44450 | PKU-ALPHAtousled-like kinase 2-HPRD,BioGRID11470414 
TTNCMD1G | CMH9 | CMPD4 | CONNECTIN | DKFZp451N061 | EOMFC | FLJ26020 | FLJ26409 | FLJ32040 | FLJ34413 | FLJ39564 | FLJ43066 | HMERF | LGMD2J | TMDtitinAffinity Capture-MSBioGRID17353931 
UBXN12B28 | UBXD10UBX domain protein 1Affinity Capture-MSBioGRID17353931 


Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
CHEMNITZ RESPONSE TO PROSTAGLANDIN E2 UP 14686All SZGR 2.0 genes in this pathway
GRABARCZYK BCL11B TARGETS DN 5735All SZGR 2.0 genes in this pathway
HORIUCHI WTAP TARGETS DN 310188All SZGR 2.0 genes in this pathway
GAL LEUKEMIC STEM CELL DN 244153All SZGR 2.0 genes in this pathway
BASAKI YBX1 TARGETS UP 290177All SZGR 2.0 genes in this pathway
SENESE HDAC3 TARGETS DN 536332All SZGR 2.0 genes in this pathway
KINSEY TARGETS OF EWSR1 FLII FUSION UP 1278748All SZGR 2.0 genes in this pathway
BIDUS METASTASIS UP 214134All SZGR 2.0 genes in this pathway
MARKEY RB1 ACUTE LOF DN 228137All SZGR 2.0 genes in this pathway
BERENJENO TRANSFORMED BY RHOA UP 536340All SZGR 2.0 genes in this pathway
KONG E2F3 TARGETS 9758All SZGR 2.0 genes in this pathway
ROSTY CERVICAL CANCER PROLIFERATION CLUSTER 14073All SZGR 2.0 genes in this pathway
PATIL LIVER CANCER 747453All SZGR 2.0 genes in this pathway
MOHANKUMAR TLX1 TARGETS UP 414287All SZGR 2.0 genes in this pathway
LOPEZ MBD TARGETS 957597All SZGR 2.0 genes in this pathway
BENPORATH CYCLING GENES 648385All SZGR 2.0 genes in this pathway
MORI LARGE PRE BII LYMPHOCYTE UP 8649All SZGR 2.0 genes in this pathway
MANALO HYPOXIA DN 289166All SZGR 2.0 genes in this pathway
VERNELL RETINOBLASTOMA PATHWAY UP 7047All SZGR 2.0 genes in this pathway
IVANOVA HEMATOPOIESIS LATE PROGENITOR 544307All SZGR 2.0 genes in this pathway
KANG DOXORUBICIN RESISTANCE UP 5433All SZGR 2.0 genes in this pathway
BURTON ADIPOGENESIS 3 10164All SZGR 2.0 genes in this pathway
BURTON ADIPOGENESIS PEAK AT 16HR 4024All SZGR 2.0 genes in this pathway
MARSON BOUND BY E2F4 UNSTIMULATED 728415All SZGR 2.0 genes in this pathway
SARRIO EPITHELIAL MESENCHYMAL TRANSITION UP 180114All SZGR 2.0 genes in this pathway
FUJII YBX1 TARGETS DN 202132All SZGR 2.0 genes in this pathway
TOYOTA TARGETS OF MIR34B AND MIR34C 463262All SZGR 2.0 genes in this pathway
WHITEFORD PEDIATRIC CANCER MARKERS 11663All SZGR 2.0 genes in this pathway
GRADE COLON VS RECTAL CANCER UP 3821All SZGR 2.0 genes in this pathway
FLOTHO PEDIATRIC ALL THERAPY RESPONSE DN 2917All SZGR 2.0 genes in this pathway
GOLDRATH ANTIGEN RESPONSE 346192All SZGR 2.0 genes in this pathway
YOSHIMURA MAPK8 TARGETS DN 366257All SZGR 2.0 genes in this pathway
RUIZ TNC TARGETS DN 14279All SZGR 2.0 genes in this pathway
CHANG CYCLING GENES 14883All SZGR 2.0 genes in this pathway
ZHANG TLX TARGETS 60HR DN 277166All SZGR 2.0 genes in this pathway
COLINA TARGETS OF 4EBP1 AND 4EBP2 356214All SZGR 2.0 genes in this pathway
CHEN METABOLIC SYNDROM NETWORK 1210725All SZGR 2.0 genes in this pathway
ISHIDA E2F TARGETS 5327All SZGR 2.0 genes in this pathway
KOBAYASHI EGFR SIGNALING 24HR DN 251151All SZGR 2.0 genes in this pathway
WHITFIELD CELL CYCLE S 16286All SZGR 2.0 genes in this pathway
WANG RESPONSE TO GSK3 INHIBITOR SB216763 DN 374217All SZGR 2.0 genes in this pathway
DUTERTRE ESTRADIOL RESPONSE 24HR UP 324193All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE LATE 1137655All SZGR 2.0 genes in this pathway
LEE BMP2 TARGETS DN 882538All SZGR 2.0 genes in this pathway
FEVR CTNNB1 TARGETS DN 553343All SZGR 2.0 genes in this pathway
GOBERT OLIGODENDROCYTE DIFFERENTIATION UP 570339All SZGR 2.0 genes in this pathway
KRIEG HYPOXIA NOT VIA KDM3A 770480All SZGR 2.0 genes in this pathway