SZGR2

Summary ?

GeneID	5576
Symbol	PRKAR2A
Synonyms	PKR2\|PRKAR2
Description	protein kinase cAMP-dependent type II regulatory subunit alpha
Reference	MIM:176910\|HGNC:HGNC:9391\|Ensembl:ENSG00000114302\|HPRD:01484\|Vega:OTTHUMG00000133540
Gene type	protein-coding
Map location	3p21.3-p21.2
Pascal p-value	0.021
Fetal beta	1.025
DMG	1 (# studies)
Support	CANABINOID DOPAMINE INTRACELLULAR SIGNAL TRANSDUCTION SEROTONIN G2Cdb.human_BAYES-COLLINS-HUMAN-PSD-CONSENSUS G2Cdb.human_BAYES-COLLINS-HUMAN-PSD-FULL G2Cdb.human_BAYES-COLLINS-MOUSE-PSD-CONSENSUS G2Cdb.humanPSD G2Cdb.humanPSP CompositeSet

Gene in Data Sources

Gene set name	Method of gene set	Description	Info
CV:PGCnp	Genome-wide Association Study	GWAS
DMG:Wockner_2014	Genome-wide DNA methylation analysis	This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24).	1
Network	Shortest path distance of core genes in the Human protein-protein interaction network	Contribution to shortest path in PPI network: 0.0096

Section I. Genetics and epigenetics annotation

Differentially methylated gene

Probe	Chromosome	Position	Nearest gene	P (dis)	Beta (dis)	FDR (dis)	Study
cg22934568	3	48884614	PRKAR2A	4.48E-4	-0.278	0.045	DMG:Wockner_2014

Section II. Transcriptome annotation

General gene expression (GTEx)

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
NCBP1	0.90	0.89
WDR3	0.89	0.90
ZMYM4	0.89	0.90
CTDSPL2	0.89	0.91
CAND1	0.89	0.89
SCYL2	0.89	0.90
KIAA1430	0.89	0.90
IPO5	0.89	0.89
NUDT21	0.89	0.89
VEZT	0.89	0.90

Top 10 negatively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
MT-CO2	-0.73	-0.83
AF347015.33	-0.72	-0.83
FXYD1	-0.72	-0.84
HLA-F	-0.71	-0.79
AF347015.31	-0.71	-0.81
MT-CYB	-0.70	-0.81
AIFM3	-0.70	-0.77
HEPN1	-0.70	-0.78
AF347015.8	-0.70	-0.82
AF347015.27	-0.69	-0.81

Section III. Gene Ontology annotation

Molecular function	GO term	Evidence	Neuro keywords	PubMed ID
GO:0000166	nucleotide binding	IEA		-
GO:0008603	cAMP-dependent protein kinase regulator activity	IEA		-
GO:0008603	cAMP-dependent protein kinase regulator activity	NAS		9003463
GO:0016301	kinase activity	IEA		-
GO:0030552	cAMP binding	IEA		-
Biological process	GO term	Evidence	Neuro keywords	PubMed ID
GO:0001932	regulation of protein amino acid phosphorylation	IEA		-
GO:0007165	signal transduction	IEA		-
GO:0009755	hormone-mediated signaling	EXP		12626323
Cellular component	GO term	Evidence	Neuro keywords	PubMed ID
GO:0005624	membrane fraction	TAS		10799517
GO:0005737	cytoplasm	TAS		10799517
GO:0005952	cAMP-dependent protein kinase complex	IEA		-
GO:0005886	plasma membrane	TAS		10799517

Section IV. Protein-protein interaction annotation

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
AKAP1	AKAP \| AKAP121 \| AKAP149 \| AKAP84 \| D-AKAP1 \| MGC1807 \| PRKA1 \| SAKAP84	A kinase (PRKA) anchor protein 1	-	HPRD	9065479 \|10764601
AKAP1	AKAP \| AKAP121 \| AKAP149 \| AKAP84 \| D-AKAP1 \| MGC1807 \| PRKA1 \| SAKAP84	A kinase (PRKA) anchor protein 1	Far Western Reconstituted Complex	BioGRID	10413680 \|10764601
AKAP10	D-AKAP2 \| MGC9414 \| PRKA10	A kinase (PRKA) anchor protein 10	-	HPRD	9326583
AKAP11	AKAP220 \| DKFZp781I12161 \| FLJ11304 \| KIAA0629 \| PRKA11	A kinase (PRKA) anchor protein 11	-	HPRD,BioGRID	8621616
AKAP12	AKAP250 \| DKFZp686M0430 \| DKFZp686O0331 \| FLJ20945 \| FLJ97621	A kinase (PRKA) anchor protein 12	-	HPRD,BioGRID	11316952
AKAP13	AKAP-Lbc \| BRX \| FLJ11952 \| FLJ43341 \| HA-3 \| Ht31 \| LBC \| PROTO-LB \| PROTO-LBC \| c-lbc	A kinase (PRKA) anchor protein 13	-	HPRD	1618839 \|7929081
AKAP13	AKAP-Lbc \| BRX \| FLJ11952 \| FLJ43341 \| HA-3 \| Ht31 \| LBC \| PROTO-LB \| PROTO-LBC \| c-lbc	A kinase (PRKA) anchor protein 13	-	HPRD,BioGRID	12672969
AKAP14	AKAP28	A kinase (PRKA) anchor protein 14	-	HPRD,BioGRID	12475942
AKAP2	AKAPKL \| FLJ53197 \| PALM2 \| PRKA2	A kinase (PRKA) anchor protein 2	Far Western Protein-peptide Reconstituted Complex	BioGRID	9497389 \|12672969
AKAP3	AKAP110 \| FSP95 \| PRKA3 \| SOB1	A kinase (PRKA) anchor protein 3	-	HPRD,BioGRID	10319321 \|11278869 \|11696326
AKAP4	AKAP82 \| FSC1 \| HI \| hAKAP82 \| p82	A kinase (PRKA) anchor protein 4	Reconstituted Complex	BioGRID	9852104
AKAP5	AKAP75 \| AKAP79 \| H21	A kinase (PRKA) anchor protein 5	-	HPRD,BioGRID	12672969
AKAP6	ADAP100 \| ADAP6 \| AKAP100 \| KIAA0311 \| MGC165020 \| PRKA6 \| mAKAP	A kinase (PRKA) anchor protein 6	-	HPRD	10413680
AKAP6	ADAP100 \| ADAP6 \| AKAP100 \| KIAA0311 \| MGC165020 \| PRKA6 \| mAKAP	A kinase (PRKA) anchor protein 6	Protein-peptide	BioGRID	12672969
AKAP7	AKAP18	A kinase (PRKA) anchor protein 7	-	HPRD,BioGRID	12672969
AKAP8	AKAP95 \| DKFZp586B1222	A kinase (PRKA) anchor protein 8	-	HPRD,BioGRID	9473338 \|10601332
AKAP9	AKAP350 \| AKAP450 \| CG-NAP \| HYPERION \| KIAA0803 \| MU-RMS-40.16A \| PRKA9 \| YOTIAO	A kinase (PRKA) anchor protein (yotiao) 9	-	HPRD,BioGRID	10358086
AKAP9	AKAP350 \| AKAP450 \| CG-NAP \| HYPERION \| KIAA0803 \| MU-RMS-40.16A \| PRKA9 \| YOTIAO	A kinase (PRKA) anchor protein (yotiao) 9	-	HPRD	10358086 \|11799244
ARFGEF2	BIG2 \| FLJ23723 \| dJ1164I10.1	ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited)	Reconstituted Complex Two-hybrid	BioGRID	12571360
CBFA2T3	ETO2 \| MTG16 \| MTGR2 \| ZMYND4	core-binding factor, runt domain, alpha subunit 2; translocated to, 3	-	HPRD,BioGRID	11823486
CFTR	ABC35 \| ABCC7 \| CF \| CFTR/MRP \| MRP7 \| TNR-CFTR \| dJ760C5.1	cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)	PKA II interacts with and phosphorylates CFTR.	BIND	10799517
EZR	CVIL \| CVL \| DKFZp762H157 \| FLJ26216 \| MGC1584 \| VIL2	ezrin	PKA II interacts with Ezrin.	BIND	9009265 \|10799517 \|12080047
GNA13	G13 \| MGC46138	guanine nucleotide binding protein (G protein), alpha 13	Affinity Capture-Western	BioGRID	11696326
GSK3B	-	glycogen synthase kinase 3 beta	Affinity Capture-Western	BioGRID	12147701
KCNQ1	ATFB1 \| FLJ26167 \| JLNS1 \| KCNA8 \| KCNA9 \| KVLQT1 \| Kv1.9 \| Kv7.1 \| LQT \| LQT1 \| RWS \| SQT2 \| WRS	potassium voltage-gated channel, KQT-like subfamily, member 1	Affinity Capture-Western	BioGRID	11799244
MYCBPAP	AMAP-1 \| AMAP1 \| DKFZp434N1415	MYCBP associated protein	-	HPRD	12151104
NBEA	BCL8B \| LYST2	neurobeachin	-	HPRD	11102458
PALM2-AKAP2	AKAP2 \| DKFZp686H1948	PALM2-AKAP2 readthrough transcript	-	HPRD	9497389 \|12672969
PDE4A	DPDE2 \| PDE4 \| PDE46	phosphodiesterase 4A, cAMP-specific (phosphodiesterase E2 dunce homolog, Drosophila)	Affinity Capture-Western	BioGRID	11296225
PRKAR2A	MGC3606 \| PKR2 \| PRKAR2	protein kinase, cAMP-dependent, regulatory, type II, alpha	PKA forms a dimer. This interaction was modeled on a demonstrated interaction between mouse PKA (PDB ID: 1L6E_B) and mouse PKA (PDB ID: 1L6E_A).	BIND	9295304 \|10074940 \|11985580
RAB32	-	RAB32, member RAS oncogene family	Far Western Protein-peptide Two-hybrid	BioGRID	12186851 \|12672969
RUNX1T1	AML1T1 \| CBFA2T1 \| CDR \| ETO \| MGC2796 \| MTG8 \| MTG8b \| ZMYND2	runt-related transcription factor 1; translocated to, 1 (cyclin D-related)	-	HPRD,BioGRID	11593431
RYR2	ARVC2 \| ARVD2 \| VTSIP	ryanodine receptor 2 (cardiac)	-	HPRD,BioGRID	10830164
WASF1	FLJ31482 \| KIAA0269 \| SCAR1 \| WAVE \| WAVE1	WAS protein family, member 1	WAVE-1 interacts with PKA.	BIND	10970852

Section V. Pathway annotation

Pathway name	Pathway size	# SZGR 2.0 genes in pathway	Info
KEGG APOPTOSIS	88	62	All SZGR 2.0 genes in this pathway
KEGG INSULIN SIGNALING PATHWAY	137	103	All SZGR 2.0 genes in this pathway
BIOCARTA NO1 PATHWAY	33	24	All SZGR 2.0 genes in this pathway
BIOCARTA CSK PATHWAY	24	20	All SZGR 2.0 genes in this pathway
BIOCARTA AKAP95 PATHWAY	12	9	All SZGR 2.0 genes in this pathway
BIOCARTA AGPCR PATHWAY	13	12	All SZGR 2.0 genes in this pathway
BIOCARTA CFTR PATHWAY	12	11	All SZGR 2.0 genes in this pathway
BIOCARTA GATA3 PATHWAY	16	15	All SZGR 2.0 genes in this pathway
BIOCARTA MPR PATHWAY	34	28	All SZGR 2.0 genes in this pathway
BIOCARTA MCALPAIN PATHWAY	25	16	All SZGR 2.0 genes in this pathway
BIOCARTA PPARA PATHWAY	58	43	All SZGR 2.0 genes in this pathway
BIOCARTA IGF1R PATHWAY	23	20	All SZGR 2.0 genes in this pathway
BIOCARTA VIP PATHWAY	29	26	All SZGR 2.0 genes in this pathway
BIOCARTA NFAT PATHWAY	56	45	All SZGR 2.0 genes in this pathway
BIOCARTA NOS1 PATHWAY	24	21	All SZGR 2.0 genes in this pathway
BIOCARTA PLCE PATHWAY	12	10	All SZGR 2.0 genes in this pathway
BIOCARTA AKAPCENTROSOME PATHWAY	15	14	All SZGR 2.0 genes in this pathway
BIOCARTA CHREBP2 PATHWAY	42	35	All SZGR 2.0 genes in this pathway
BIOCARTA BAD PATHWAY	26	23	All SZGR 2.0 genes in this pathway
BIOCARTA CK1 PATHWAY	17	17	All SZGR 2.0 genes in this pathway
BIOCARTA DREAM PATHWAY	14	13	All SZGR 2.0 genes in this pathway
BIOCARTA AKAP13 PATHWAY	12	11	All SZGR 2.0 genes in this pathway
BIOCARTA GPCR PATHWAY	37	31	All SZGR 2.0 genes in this pathway
BIOCARTA SHH PATHWAY	16	15	All SZGR 2.0 genes in this pathway
BIOCARTA STATHMIN PATHWAY	19	17	All SZGR 2.0 genes in this pathway
BIOCARTA CREB PATHWAY	27	25	All SZGR 2.0 genes in this pathway
BIOCARTA CARM1 PATHWAY	13	11	All SZGR 2.0 genes in this pathway
REACTOME SIGNALLING BY NGF	217	167	All SZGR 2.0 genes in this pathway
REACTOME DAG AND IP3 SIGNALING	32	25	All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY ERBB2	101	78	All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY EGFR IN CANCER	109	80	All SZGR 2.0 genes in this pathway
REACTOME NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE	137	105	All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY FGFR IN DISEASE	127	88	All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY GPCR	920	449	All SZGR 2.0 genes in this pathway
REACTOME INTEGRATION OF ENERGY METABOLISM	120	84	All SZGR 2.0 genes in this pathway
REACTOME OPIOID SIGNALLING	78	56	All SZGR 2.0 genes in this pathway
REACTOME CA DEPENDENT EVENTS	30	23	All SZGR 2.0 genes in this pathway
REACTOME DARPP 32 EVENTS	25	20	All SZGR 2.0 genes in this pathway
REACTOME PLC BETA MEDIATED EVENTS	43	32	All SZGR 2.0 genes in this pathway
REACTOME PKA MEDIATED PHOSPHORYLATION OF CREB	18	14	All SZGR 2.0 genes in this pathway
REACTOME TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES	413	270	All SZGR 2.0 genes in this pathway
REACTOME GLUCAGON SIGNALING IN METABOLIC REGULATION	34	23	All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY PDGF	122	93	All SZGR 2.0 genes in this pathway
REACTOME DOWNSTREAM SIGNAL TRANSDUCTION	95	76	All SZGR 2.0 genes in this pathway
REACTOME REGULATION OF INSULIN SECRETION BY GLUCAGON LIKE PEPTIDE1	43	28	All SZGR 2.0 genes in this pathway
REACTOME REGULATION OF INSULIN SECRETION	93	65	All SZGR 2.0 genes in this pathway
REACTOME DOWNSTREAM SIGNALING OF ACTIVATED FGFR	100	74	All SZGR 2.0 genes in this pathway
REACTOME PHOSPHOLIPASE C MEDIATED CASCADE	54	40	All SZGR 2.0 genes in this pathway
REACTOME AQUAPORIN MEDIATED TRANSPORT	51	34	All SZGR 2.0 genes in this pathway
REACTOME REGULATION OF WATER BALANCE BY RENAL AQUAPORINS	44	30	All SZGR 2.0 genes in this pathway
REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION	132	101	All SZGR 2.0 genes in this pathway
REACTOME HEMOSTASIS	466	331	All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY FGFR	112	80	All SZGR 2.0 genes in this pathway
PARENT MTOR SIGNALING UP	567	375	All SZGR 2.0 genes in this pathway
FULCHER INFLAMMATORY RESPONSE LECTIN VS LPS DN	463	290	All SZGR 2.0 genes in this pathway
DODD NASOPHARYNGEAL CARCINOMA UP	1821	933	All SZGR 2.0 genes in this pathway
LASTOWSKA NEUROBLASTOMA COPY NUMBER DN	800	473	All SZGR 2.0 genes in this pathway
RASHI RESPONSE TO IONIZING RADIATION 4	61	34	All SZGR 2.0 genes in this pathway
MARTORIATI MDM4 TARGETS FETAL LIVER DN	514	319	All SZGR 2.0 genes in this pathway
GROSS HYPOXIA VIA ELK3 UP	209	139	All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE INCIPIENT UP	390	242	All SZGR 2.0 genes in this pathway
JOSEPH RESPONSE TO SODIUM BUTYRATE DN	64	45	All SZGR 2.0 genes in this pathway
SU TESTIS	76	53	All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE UP	1691	1088	All SZGR 2.0 genes in this pathway
MITSIADES RESPONSE TO APLIDIN DN	249	165	All SZGR 2.0 genes in this pathway
BOCHKIS FOXA2 TARGETS	425	261	All SZGR 2.0 genes in this pathway
BONCI TARGETS OF MIR15A AND MIR16 1	91	75	All SZGR 2.0 genes in this pathway
FIRESTEIN PROLIFERATION	175	125	All SZGR 2.0 genes in this pathway
HOFMANN MYELODYSPLASTIC SYNDROM HIGH RISK UP	10	7	All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 4HR DN	254	158	All SZGR 2.0 genes in this pathway
PILON KLF1 TARGETS UP	504	321	All SZGR 2.0 genes in this pathway
JOHNSTONE PARVB TARGETS 3 DN	918	550	All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE LATE	1137	655	All SZGR 2.0 genes in this pathway
GOBERT OLIGODENDROCYTE DIFFERENTIATION DN	1080	713	All SZGR 2.0 genes in this pathway
PLASARI TGFB1 TARGETS 10HR UP	199	143	All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-149	842	848	m8	hsa-miR-149^brain	UCUGGCUCCGUGUCUUCACUCC
miR-15/16/195/424/497	341	348	1A,m8	hsa-miR-15a^brain	UAGCAGCACAUAAUGGUUUGUG
				hsa-miR-16^brain	UAGCAGCACGUAAAUAUUGGCG
				hsa-miR-15b^brain	UAGCAGCACAUCAUGGUUUACA
				hsa-miR-195^SZ	UAGCAGCACAGAAAUAUUGGC
				hsa-miR-424	CAGCAGCAAUUCAUGUUUUGAA
				hsa-miR-497	CAGCAGCACACUGUGGUUUGU
miR-185	278	285	1A,m8	hsa-miR-185^brain	UGGAGAGAAAGGCAGUUC
miR-378*	307	314	1A,m8	hsa-miR-422b	CUGGACUUGGAGUCAGAAGGCC
miR-378*	307	314	1A,m8	hsa-miR-422a	CUGGACUUAGGGUCAGAAGGCC
miR-503	342	348	1A	hsa-miR-503	UAGCAGCGGGAACAGUUCUGCAG
miR-504	846	852	m8	hsa-miR-504	AGACCCUGGUCUGCACUCUAU

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.

Gene Page: PRKAR2A