Gene Page: ZNF83
Summary ?
| GeneID | 55769 |
| Symbol | ZNF83 |
| Synonyms | HPF1|ZNF816B |
| Description | zinc finger protein 83 |
| Reference | MIM:194558|HGNC:HGNC:13158|Ensembl:ENSG00000167766|HPRD:01935|Vega:OTTHUMG00000182761 |
| Gene type | protein-coding |
| Map location | 19q13.3 |
| Pascal p-value | 0.774 |
| Sherlock p-value | 0.418 |
| DMG | 1 (# studies) |
| eGene | Anterior cingulate cortex BA24 Caudate basal ganglia Cerebellum Cortex Hippocampus Meta |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| DMG:Wockner_2014 | Genome-wide DNA methylation analysis | This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). | 1 |
Section I. Genetics and epigenetics annotation
Differentially methylated gene
| Probe | Chromosome | Position | Nearest gene | P (dis) | Beta (dis) | FDR (dis) | Study |
|---|---|---|---|---|---|---|---|
| cg04386405 | 19 | 53141394 | ZNF83 | 1.61E-5 | -0.319 | 0.015 | DMG:Wockner_2014 |
eQTL annotation
| SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
|---|---|---|---|---|---|---|---|---|
| rs11668015 | 19 | 53115233 | ZNF83 | ENSG00000167766.14 | 2.782E-9 | 0 | 78516 | gtex_brain_ba24 |
| rs1046679 | 19 | 53115842 | ZNF83 | ENSG00000167766.14 | 2.473E-9 | 0 | 77907 | gtex_brain_ba24 |
| rs1046648 | 19 | 53116060 | ZNF83 | ENSG00000167766.14 | 7.452E-8 | 0 | 77689 | gtex_brain_ba24 |
| rs7257138 | 19 | 53119029 | ZNF83 | ENSG00000167766.14 | 4.879E-7 | 0 | 74720 | gtex_brain_ba24 |
| rs7256557 | 19 | 53119166 | ZNF83 | ENSG00000167766.14 | 2.099E-7 | 0 | 74583 | gtex_brain_ba24 |
| rs10421152 | 19 | 53119808 | ZNF83 | ENSG00000167766.14 | 9.667E-7 | 0 | 73941 | gtex_brain_ba24 |
| rs62118479 | 19 | 53119965 | ZNF83 | ENSG00000167766.14 | 4.537E-7 | 0 | 73784 | gtex_brain_ba24 |
| rs67949199 | 19 | 53121502 | ZNF83 | ENSG00000167766.14 | 4.879E-7 | 0 | 72247 | gtex_brain_ba24 |
| rs62118480 | 19 | 53121569 | ZNF83 | ENSG00000167766.14 | 4.879E-7 | 0 | 72180 | gtex_brain_ba24 |
| rs73582288 | 19 | 53121736 | ZNF83 | ENSG00000167766.14 | 4.814E-7 | 0 | 72013 | gtex_brain_ba24 |
| rs113063121 | 19 | 53121757 | ZNF83 | ENSG00000167766.14 | 4.949E-7 | 0 | 71992 | gtex_brain_ba24 |
| rs112485438 | 19 | 53121838 | ZNF83 | ENSG00000167766.14 | 4.957E-7 | 0 | 71911 | gtex_brain_ba24 |
| rs67710655 | 19 | 53121851 | ZNF83 | ENSG00000167766.14 | 4.921E-7 | 0 | 71898 | gtex_brain_ba24 |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
No co-expressed genes in brain regions
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| TURASHVILI BREAST DUCTAL CARCINOMA VS DUCTAL NORMAL DN | 198 | 110 | All SZGR 2.0 genes in this pathway |
| HAMAI APOPTOSIS VIA TRAIL UP | 584 | 356 | All SZGR 2.0 genes in this pathway |
| PEREZ TP53 TARGETS | 1174 | 695 | All SZGR 2.0 genes in this pathway |
| KIM MYC AMPLIFICATION TARGETS DN | 97 | 51 | All SZGR 2.0 genes in this pathway |
| BUYTAERT PHOTODYNAMIC THERAPY STRESS UP | 811 | 508 | All SZGR 2.0 genes in this pathway |
| BLALOCK ALZHEIMERS DISEASE INCIPIENT UP | 390 | 242 | All SZGR 2.0 genes in this pathway |
| BLALOCK ALZHEIMERS DISEASE UP | 1691 | 1088 | All SZGR 2.0 genes in this pathway |
| ACEVEDO LIVER CANCER UP | 973 | 570 | All SZGR 2.0 genes in this pathway |
| CHANG CORE SERUM RESPONSE DN | 209 | 137 | All SZGR 2.0 genes in this pathway |
| BOYAULT LIVER CANCER SUBCLASS G1 UP | 113 | 70 | All SZGR 2.0 genes in this pathway |
| CHIANG LIVER CANCER SUBCLASS CTNNB1 DN | 170 | 105 | All SZGR 2.0 genes in this pathway |
| CHICAS RB1 TARGETS SENESCENT | 572 | 352 | All SZGR 2.0 genes in this pathway |
| JOHNSTONE PARVB TARGETS 2 DN | 336 | 211 | All SZGR 2.0 genes in this pathway |
| ZWANG TRANSIENTLY UP BY 1ST EGF PULSE ONLY | 1839 | 928 | All SZGR 2.0 genes in this pathway |