Gene Page: PRKCA
Summary ?
GeneID | 5578 |
Symbol | PRKCA |
Synonyms | AAG6|PKC-alpha|PKCA|PRKACA |
Description | protein kinase C alpha |
Reference | MIM:176960|HGNC:HGNC:9393|Ensembl:ENSG00000154229|HPRD:01498|Vega:OTTHUMG00000179533 |
Gene type | protein-coding |
Map location | 17q24.2 |
Pascal p-value | 0.463 |
Fetal beta | -1.308 |
DMG | 3 (# studies) |
Support | CANABINOID INTRACELLULAR SIGNAL TRANSDUCTION METABOTROPIC GLUTAMATE RECEPTOR SEROTONIN G2Cdb.human_BAYES-COLLINS-HUMAN-PSD-FULL G2Cdb.humanPSD G2Cdb.humanPSP Potential synaptic genes |
Gene in Data Sources
Gene set name | Method of gene set | Description | Info |
---|---|---|---|
CV:PGCnp | Genome-wide Association Study | GWAS | |
DMG:Jaffe_2016 | Genome-wide DNA methylation analysis | This dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05. | 3 |
DMG:Nishioka_2013 | Genome-wide DNA methylation analysis | The authors investigated the methylation profiles of DNA in peripheral blood cells from 18 patients with first-episode schizophrenia (FESZ) and from 15 normal controls. | 3 |
DMG:Wockner_2014 | Genome-wide DNA methylation analysis | This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). | 3 |
PMID:cooccur | High-throughput literature-search | Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included. | |
Literature | High-throughput literature-search | Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenic,schizophrenias | Click to show details |
Network | Shortest path distance of core genes in the Human protein-protein interaction network | Contribution to shortest path in PPI network: 2.2158 |
Section I. Genetics and epigenetics annotation
Differentially methylated gene
Probe | Chromosome | Position | Nearest gene | P (dis) | Beta (dis) | FDR (dis) | Study |
---|---|---|---|---|---|---|---|
cg09146232 | 17 | 64672129 | PRKCA | 5.325E-4 | 0.668 | 0.048 | DMG:Wockner_2014 |
cg00050312 | 17 | 64299065 | PRKCA | -0.027 | 0.29 | DMG:Nishioka_2013 | |
cg00050312 | 17 | 64299065 | PRKCA | 1.67E-9 | -0.032 | 1.48E-6 | DMG:Jaffe_2016 |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
Top 10 positively co-expressed genes | ||
Gene | Pearson's Correlation | Spearman's Correlation |
IFNAR1 | 0.87 | 0.89 |
HOOK3 | 0.86 | 0.87 |
XIAP | 0.85 | 0.87 |
TRIP11 | 0.84 | 0.84 |
KIAA0232 | 0.83 | 0.85 |
KIAA1704 | 0.82 | 0.83 |
FMR1 | 0.81 | 0.82 |
RANBP2 | 0.81 | 0.83 |
DNAJC13 | 0.81 | 0.83 |
ATP11B | 0.81 | 0.82 |
Top 10 negatively co-expressed genes | ||
Gene | Pearson's Correlation | Spearman's Correlation |
AF347015.31 | -0.55 | -0.58 |
AF347015.21 | -0.54 | -0.54 |
METRN | -0.54 | -0.58 |
ENHO | -0.53 | -0.65 |
HIGD1B | -0.53 | -0.58 |
MT-CO2 | -0.53 | -0.56 |
AC131097.1 | -0.51 | -0.56 |
IFI27 | -0.51 | -0.55 |
FXYD1 | -0.50 | -0.52 |
CST3 | -0.50 | -0.54 |
Section III. Gene Ontology annotation
Molecular function | GO term | Evidence | Neuro keywords | PubMed ID |
---|---|---|---|---|
GO:0000166 | nucleotide binding | IEA | - | |
GO:0004698 | calcium-dependent protein kinase C activity | IEA | - | |
GO:0005509 | calcium ion binding | IEA | - | |
GO:0005515 | protein binding | IPI | 12893243 | |
GO:0005524 | ATP binding | IEA | - | |
GO:0016740 | transferase activity | IEA | - | |
GO:0008270 | zinc ion binding | IEA | - | |
GO:0019992 | diacylglycerol binding | IEA | - | |
GO:0046872 | metal ion binding | IEA | - | |
Biological process | GO term | Evidence | Neuro keywords | PubMed ID |
GO:0000188 | inactivation of MAPK activity | IEA | - | |
GO:0002062 | chondrocyte differentiation | IEA | - | |
GO:0002026 | regulation of the force of heart contraction | IEA | - | |
GO:0001933 | negative regulation of protein amino acid phosphorylation | IEA | - | |
GO:0001934 | positive regulation of protein amino acid phosphorylation | IEA | - | |
GO:0006469 | negative regulation of protein kinase activity | IEA | - | |
GO:0007242 | intracellular signaling cascade | IEA | - | |
GO:0008629 | induction of apoptosis by intracellular signals | IEA | - | |
GO:0006937 | regulation of muscle contraction | IEA | - | |
GO:0008624 | induction of apoptosis by extracellular signals | TAS | 10825394 | |
GO:0006874 | cellular calcium ion homeostasis | IEA | - | |
GO:0050930 | induction of positive chemotaxis | IEA | - | |
GO:0030593 | neutrophil chemotaxis | IEA | - | |
GO:0050729 | positive regulation of inflammatory response | IEA | - | |
GO:0050730 | regulation of peptidyl-tyrosine phosphorylation | IEA | - | |
GO:0046325 | negative regulation of glucose import | IEA | - | |
GO:0046627 | negative regulation of insulin receptor signaling pathway | IEA | - | |
Cellular component | GO term | Evidence | Neuro keywords | PubMed ID |
GO:0005829 | cytosol | EXP | 9814702 | |
GO:0005829 | cytosol | IDA | 17983652 | |
GO:0005624 | membrane fraction | IDA | 17983652 | |
GO:0005634 | nucleus | IEA | - | |
GO:0005737 | cytoplasm | IEA | - | |
GO:0005739 | mitochondrion | IEA | - | |
GO:0005886 | plasma membrane | EXP | 9814702 |10194441 |10856305 |
Section IV. Protein-protein interaction annotation
Interactors | Aliases B | Official full name B | Experimental | Source | PubMed ID |
---|---|---|---|---|---|
ACTA1 | ACTA | ASMA | CFTD | CFTD1 | CFTDM | MPFD | NEM1 | NEM2 | NEM3 | actin, alpha 1, skeletal muscle | - | HPRD,BioGRID | 10628374 |
ADAP1 | CENTA1 | GCS1L | p42IP4 | ArfGAP with dual PH domains 1 | - | HPRD | 12893243 |
ADCY5 | AC5 | adenylate cyclase 5 | - | HPRD | 7759492 |8206971 |
AFAP1 | AFAP | AFAP-110 | FLJ56849 | actin filament associated protein 1 | - | HPRD,BioGRID | 12134071 |
AKAP12 | AKAP250 | DKFZp686M0430 | DKFZp686O0331 | FLJ20945 | FLJ97621 | A kinase (PRKA) anchor protein 12 | - | HPRD,BioGRID | 11316952 |
AKAP13 | AKAP-Lbc | BRX | FLJ11952 | FLJ43341 | HA-3 | Ht31 | LBC | PROTO-LB | PROTO-LBC | c-lbc | A kinase (PRKA) anchor protein 13 | AKAP-Lbc interacts with PKC-alpha. This interaction was modeled on a demonstrated interaction between human AKAP-Lbc and rat PKC-alpha. | BIND | 15383279 |
ARHGEF1 | GEF1 | LBCL2 | LSC | P115-RHOGEF | SUB1.5 | Rho guanine nucleotide exchange factor (GEF) 1 | - | HPRD | 12754211 |
ATP1A1 | MGC3285 | MGC51750 | ATPase, Na+/K+ transporting, alpha 1 polypeptide | Biochemical Activity | BioGRID | 15069082 |
AVPR1A | AVPR1 | arginine vasopressin receptor 1A | - | HPRD,BioGRID | 10858434 |
AVPR1B | AVPR3 | arginine vasopressin receptor 1B | Affinity Capture-Western | BioGRID | 10858434 |
AVPR2 | ADHR | DI1 | DIR | DIR3 | MGC126533 | MGC138386 | NDI | V2R | arginine vasopressin receptor 2 | Affinity Capture-Western | BioGRID | 10858434 |
C1QBP | GC1QBP | HABP1 | SF2p32 | gC1Q-R | gC1qR | p32 | complement component 1, q subcomponent binding protein | - | HPRD,BioGRID | 10831594 |
CD9 | 5H9 | BA2 | BTCC-1 | DRAP-27 | GIG2 | MIC3 | MRP-1 | P24 | TSPAN29 | CD9 molecule | - | HPRD,BioGRID | 11325968 |
CDC42 | CDC42Hs | G25K | cell division cycle 42 (GTP binding protein, 25kDa) | - | HPRD,BioGRID | 11284700 |
DGKZ | DAGK5 | DAGK6 | DGK-ZETA | hDGKzeta | diacylglycerol kinase, zeta 104kDa | - | HPRD | 12890670 |
DLG4 | FLJ97752 | FLJ98574 | PSD95 | SAP90 | discs, large homolog 4 (Drosophila) | - | HPRD,BioGRID | 11937501 |
EGFR | ERBB | ERBB1 | HER1 | PIG61 | mENA | epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian) | - | HPRD,BioGRID | 12878187 |
EZR | CVIL | CVL | DKFZp762H157 | FLJ26216 | MGC1584 | VIL2 | ezrin | - | HPRD,BioGRID | 11387207 |
FSCN1 | FLJ38511 | SNL | p55 | fascin homolog 1, actin-bundling protein (Strongylocentrotus purpuratus) | - | HPRD,BioGRID | 14532112 |
GABRB3 | ECA5 | MGC9051 | gamma-aminobutyric acid (GABA) A receptor, beta 3 | Reconstituted Complex | BioGRID | 12595241 |
GABRR2 | - | gamma-aminobutyric acid (GABA) receptor, rho 2 | - | HPRD | 9839716 |
GJA1 | CX43 | DFNB38 | GJAL | ODDD | gap junction protein, alpha 1, 43kDa | - | HPRD,BioGRID | 11273731 |
GNA12 | MGC104623 | MGC99644 | NNX3 | RMP | gep | guanine nucleotide binding protein (G protein) alpha 12 | - | HPRD | 8647866 |
GNB2L1 | Gnb2-rs1 | H12.3 | HLC-7 | PIG21 | RACK1 | guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1 | Affinity Capture-Western | BioGRID | 12435334 |
GRM7 | FLJ40498 | GLUR7 | GPRC1G | MGLUR7 | mGlu7 | glutamate receptor, metabotropic 7 | Affinity Capture-Western | BioGRID | 11007882 |
GSK3B | - | glycogen synthase kinase 3 beta | Biochemical Activity | BioGRID | 1324914 |
HABP4 | IHABP4 | Ki-1/57 | MGC825 | SERBP1L | hyaluronan binding protein 4 | - | HPRD,BioGRID | 14699138 |
HAND1 | Hxt | Thing1 | bHLHa27 | eHand | heart and neural crest derivatives expressed 1 | Biochemical Activity | BioGRID | 14636580 |
HAND2 | DHAND2 | FLJ16260 | Hed | MGC125303 | MGC125304 | Thing2 | bHLHa26 | dHand | heart and neural crest derivatives expressed 2 | - | HPRD,BioGRID | 14636580 |
ITGB1 | CD29 | FNRB | GPIIA | MDF2 | MSK12 | VLA-BETA | VLAB | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | - | HPRD,BioGRID | 12138200 |
ITPKB | IP3K | IP3K-B | IP3KB | PIG37 | inositol 1,4,5-trisphosphate 3-kinase B | in vitro | BioGRID | 9374536 |
KCNE4 | MGC20353 | MIRP3 | potassium voltage-gated channel, Isk-related family, member 4 | - | HPRD | 12670483 |
KLF5 | BTEB2 | CKLF | IKLF | Kruppel-like factor 5 (intestinal) | Biochemical Activity | BioGRID | 12682370 |
LMNA | CDCD1 | CDDC | CMD1A | CMT2B1 | EMD2 | FPL | FPLD | HGPS | IDC | LDP1 | LFP | LGMD1B | LMN1 | LMNC | PRO1 | lamin A/C | - | HPRD,BioGRID | 12112001 |
LMNB1 | ADLD | LMN | LMN2 | LMNB | MGC111419 | lamin B1 | - | HPRD,BioGRID | 11901153 |12135703 |
MBP | MGC99675 | myelin basic protein | PKC-alpha phosphorylates and interacts with MBP. This interaction was modeled on a demonstrated interaction between PKC-alpha and MBP, both from unspecified species. | BIND | 10383403 |
MGMT | - | O-6-methylguanine-DNA methyltransferase | Biochemical Activity | BioGRID | 10667577 |
MYLK | DKFZp686I10125 | FLJ12216 | KRP | MLCK | MLCK1 | MLCK108 | MLCK210 | MSTP083 | MYLK1 | smMLCK | myosin light chain kinase | - | HPRD | 3160694 |
OGG1 | HMMH | HOGG1 | MUTM | OGH1 | 8-oxoguanine DNA glycosylase | - | HPRD,BioGRID | 12034821 |
PDLIM7 | LMP1 | PDZ and LIM domain 7 (enigma) | - | HPRD | 8940095 |
PEBP1 | HCNP | PBP | PEBP | RKIP | phosphatidylethanolamine binding protein 1 | PKCalpha interacts with and phosphorylates RKIP. This interaction was modelled on a demonstrated interaction between RKIP from an unspecified species and human PKCalpha. | BIND | 14654844 |
PICK1 | MGC15204 | PICK | PRKCABP | protein interacting with PRKCA 1 | Affinity Capture-Western | BioGRID | 11007882 |
PLD1 | - | phospholipase D1, phosphatidylcholine-specific | - | HPRD,BioGRID | 12839565 |
PLD2 | - | phospholipase D2 | - | HPRD,BioGRID | 11042115 |
PPP1R14A | CPI-17 | CPI17 | PPP1INL | protein phosphatase 1, regulatory (inhibitor) subunit 14A | - | HPRD | 15003508 |
RAC1 | MGC111543 | MIG5 | TC-25 | p21-Rac1 | ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) | - | HPRD,BioGRID | 11284700 |
RGS2 | G0S8 | regulator of G-protein signaling 2, 24kDa | - | HPRD,BioGRID | 11063746 |
RHOA | ARH12 | ARHA | RHO12 | RHOH12 | ras homolog gene family, member A | in vivo | BioGRID | 11284700 |
SDPR | PS-p68 | SDR | serum deprivation response (phosphatidylserine binding protein) | - | HPRD | 9566962 |
SELL | CD62L | LAM-1 | LAM1 | LECAM1 | LNHR | LSEL | LYAM1 | Leu-8 | Lyam-1 | PLNHR | TQ1 | hLHRc | selectin L | L-selectin interacts with PKC-alpha. | BIND | 15192100 |
SEMG1 | MGC14719 | SEMG | SGI | semenogelin I | - | HPRD | 12399526 |
SLC1A1 | EAAC1 | EAAT3 | solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1 | - | HPRD,BioGRID | 12843260 |
STXBP3 | MUNC18-3 | MUNC18C | PSP | UNC-18C | syntaxin binding protein 3 | - | HPRD | 10194441 |
TEP1 | TLP1 | TP1 | TROVE1 | VAULT2 | p240 | telomerase-associated protein 1 | - | HPRD | 9837921 |
TERT | EST2 | TCS1 | TP2 | TRT | hEST2 | telomerase reverse transcriptase | - | HPRD | 9837921 |
TIAM1 | FLJ36302 | T-cell lymphoma invasion and metastasis 1 | - | HPRD,BioGRID | 10212259 |
TP53 | FLJ92943 | LFS1 | TRP53 | p53 | tumor protein p53 | - | HPRD | 9935181 |
TRIM29 | ATDC | FLJ36085 | tripartite motif-containing 29 | - | HPRD | 7644499 |
YWHAG | 14-3-3GAMMA | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide | - | HPRD,BioGRID | 10433554 |
YWHAZ | KCIP-1 | MGC111427 | MGC126532 | MGC138156 | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide | - | HPRD,BioGRID | 11950841 |
Section V. Pathway annotation
Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
---|---|---|---|
KEGG MAPK SIGNALING PATHWAY | 267 | 205 | All SZGR 2.0 genes in this pathway |
KEGG ERBB SIGNALING PATHWAY | 87 | 71 | All SZGR 2.0 genes in this pathway |
KEGG CALCIUM SIGNALING PATHWAY | 178 | 134 | All SZGR 2.0 genes in this pathway |
KEGG PHOSPHATIDYLINOSITOL SIGNALING SYSTEM | 76 | 56 | All SZGR 2.0 genes in this pathway |
KEGG VASCULAR SMOOTH MUSCLE CONTRACTION | 115 | 81 | All SZGR 2.0 genes in this pathway |
KEGG WNT SIGNALING PATHWAY | 151 | 112 | All SZGR 2.0 genes in this pathway |
KEGG VEGF SIGNALING PATHWAY | 76 | 53 | All SZGR 2.0 genes in this pathway |
KEGG FOCAL ADHESION | 201 | 138 | All SZGR 2.0 genes in this pathway |
KEGG TIGHT JUNCTION | 134 | 86 | All SZGR 2.0 genes in this pathway |
KEGG GAP JUNCTION | 90 | 68 | All SZGR 2.0 genes in this pathway |
KEGG NATURAL KILLER CELL MEDIATED CYTOTOXICITY | 137 | 92 | All SZGR 2.0 genes in this pathway |
KEGG FC EPSILON RI SIGNALING PATHWAY | 79 | 58 | All SZGR 2.0 genes in this pathway |
KEGG FC GAMMA R MEDIATED PHAGOCYTOSIS | 97 | 71 | All SZGR 2.0 genes in this pathway |
KEGG LEUKOCYTE TRANSENDOTHELIAL MIGRATION | 118 | 78 | All SZGR 2.0 genes in this pathway |
KEGG LONG TERM POTENTIATION | 70 | 57 | All SZGR 2.0 genes in this pathway |
KEGG LONG TERM DEPRESSION | 70 | 53 | All SZGR 2.0 genes in this pathway |
KEGG GNRH SIGNALING PATHWAY | 101 | 77 | All SZGR 2.0 genes in this pathway |
KEGG MELANOGENESIS | 102 | 80 | All SZGR 2.0 genes in this pathway |
KEGG ALDOSTERONE REGULATED SODIUM REABSORPTION | 42 | 29 | All SZGR 2.0 genes in this pathway |
KEGG VIBRIO CHOLERAE INFECTION | 56 | 32 | All SZGR 2.0 genes in this pathway |
KEGG PATHOGENIC ESCHERICHIA COLI INFECTION | 59 | 36 | All SZGR 2.0 genes in this pathway |
KEGG PATHWAYS IN CANCER | 328 | 259 | All SZGR 2.0 genes in this pathway |
KEGG GLIOMA | 65 | 56 | All SZGR 2.0 genes in this pathway |
KEGG NON SMALL CELL LUNG CANCER | 54 | 47 | All SZGR 2.0 genes in this pathway |
BIOCARTA SRCRPTP PATHWAY | 11 | 9 | All SZGR 2.0 genes in this pathway |
BIOCARTA AT1R PATHWAY | 36 | 28 | All SZGR 2.0 genes in this pathway |
BIOCARTA CHEMICAL PATHWAY | 22 | 15 | All SZGR 2.0 genes in this pathway |
BIOCARTA SPPA PATHWAY | 22 | 18 | All SZGR 2.0 genes in this pathway |
BIOCARTA AGPCR PATHWAY | 13 | 12 | All SZGR 2.0 genes in this pathway |
BIOCARTA BCR PATHWAY | 37 | 28 | All SZGR 2.0 genes in this pathway |
BIOCARTA BIOPEPTIDES PATHWAY | 45 | 35 | All SZGR 2.0 genes in this pathway |
BIOCARTA CDMAC PATHWAY | 16 | 15 | All SZGR 2.0 genes in this pathway |
BIOCARTA CBL PATHWAY | 13 | 10 | All SZGR 2.0 genes in this pathway |
BIOCARTA CCR3 PATHWAY | 23 | 21 | All SZGR 2.0 genes in this pathway |
BIOCARTA CXCR4 PATHWAY | 24 | 22 | All SZGR 2.0 genes in this pathway |
BIOCARTA CALCINEURIN PATHWAY | 21 | 17 | All SZGR 2.0 genes in this pathway |
BIOCARTA EGF PATHWAY | 31 | 25 | All SZGR 2.0 genes in this pathway |
BIOCARTA GH PATHWAY | 28 | 22 | All SZGR 2.0 genes in this pathway |
BIOCARTA KERATINOCYTE PATHWAY | 46 | 38 | All SZGR 2.0 genes in this pathway |
BIOCARTA PYK2 PATHWAY | 31 | 24 | All SZGR 2.0 genes in this pathway |
BIOCARTA PPARA PATHWAY | 58 | 43 | All SZGR 2.0 genes in this pathway |
BIOCARTA NOS1 PATHWAY | 24 | 21 | All SZGR 2.0 genes in this pathway |
BIOCARTA ARENRF2 PATHWAY | 13 | 9 | All SZGR 2.0 genes in this pathway |
BIOCARTA PDGF PATHWAY | 32 | 25 | All SZGR 2.0 genes in this pathway |
BIOCARTA CCR5 PATHWAY | 20 | 16 | All SZGR 2.0 genes in this pathway |
BIOCARTA EDG1 PATHWAY | 27 | 24 | All SZGR 2.0 genes in this pathway |
BIOCARTA MYOSIN PATHWAY | 31 | 22 | All SZGR 2.0 genes in this pathway |
BIOCARTA EIF4 PATHWAY | 24 | 19 | All SZGR 2.0 genes in this pathway |
BIOCARTA CARDIACEGF PATHWAY | 18 | 16 | All SZGR 2.0 genes in this pathway |
BIOCARTA MEF2D PATHWAY | 23 | 16 | All SZGR 2.0 genes in this pathway |
BIOCARTA GPCR PATHWAY | 37 | 31 | All SZGR 2.0 genes in this pathway |
BIOCARTA TCR PATHWAY | 49 | 37 | All SZGR 2.0 genes in this pathway |
BIOCARTA TEL PATHWAY | 18 | 15 | All SZGR 2.0 genes in this pathway |
BIOCARTA PAR1 PATHWAY | 37 | 28 | All SZGR 2.0 genes in this pathway |
BIOCARTA TPO PATHWAY | 24 | 17 | All SZGR 2.0 genes in this pathway |
BIOCARTA CREB PATHWAY | 27 | 25 | All SZGR 2.0 genes in this pathway |
BIOCARTA TRKA PATHWAY | 12 | 10 | All SZGR 2.0 genes in this pathway |
BIOCARTA VEGF PATHWAY | 29 | 18 | All SZGR 2.0 genes in this pathway |
PID ENDOTHELIN PATHWAY | 63 | 52 | All SZGR 2.0 genes in this pathway |
PID TCR PATHWAY | 66 | 51 | All SZGR 2.0 genes in this pathway |
PID NFKAPPAB CANONICAL PATHWAY | 23 | 20 | All SZGR 2.0 genes in this pathway |
PID RET PATHWAY | 39 | 29 | All SZGR 2.0 genes in this pathway |
PID CD8 TCR PATHWAY | 53 | 42 | All SZGR 2.0 genes in this pathway |
PID TXA2PATHWAY | 57 | 43 | All SZGR 2.0 genes in this pathway |
PID NFAT 3PATHWAY | 54 | 47 | All SZGR 2.0 genes in this pathway |
PID MTOR 4PATHWAY | 69 | 55 | All SZGR 2.0 genes in this pathway |
PID TCR RAS PATHWAY | 14 | 14 | All SZGR 2.0 genes in this pathway |
PID ERBB1 DOWNSTREAM PATHWAY | 105 | 78 | All SZGR 2.0 genes in this pathway |
PID SYNDECAN 4 PATHWAY | 32 | 25 | All SZGR 2.0 genes in this pathway |
PID ATF2 PATHWAY | 59 | 43 | All SZGR 2.0 genes in this pathway |
PID PDGFRB PATHWAY | 129 | 103 | All SZGR 2.0 genes in this pathway |
PID RETINOIC ACID PATHWAY | 30 | 23 | All SZGR 2.0 genes in this pathway |
PID IL8 CXCR2 PATHWAY | 34 | 26 | All SZGR 2.0 genes in this pathway |
PID VEGFR1 PATHWAY | 26 | 23 | All SZGR 2.0 genes in this pathway |
PID VEGFR1 2 PATHWAY | 69 | 57 | All SZGR 2.0 genes in this pathway |
PID THROMBIN PAR1 PATHWAY | 43 | 32 | All SZGR 2.0 genes in this pathway |
PID A6B1 A6B4 INTEGRIN PATHWAY | 46 | 35 | All SZGR 2.0 genes in this pathway |
PID IL8 CXCR1 PATHWAY | 28 | 19 | All SZGR 2.0 genes in this pathway |
PID RAS PATHWAY | 30 | 22 | All SZGR 2.0 genes in this pathway |
PID CD8 TCR DOWNSTREAM PATHWAY | 65 | 56 | All SZGR 2.0 genes in this pathway |
REACTOME SIGNALLING BY NGF | 217 | 167 | All SZGR 2.0 genes in this pathway |
REACTOME SIGNALING BY SCF KIT | 78 | 59 | All SZGR 2.0 genes in this pathway |
REACTOME DAG AND IP3 SIGNALING | 32 | 25 | All SZGR 2.0 genes in this pathway |
REACTOME REGULATION OF KIT SIGNALING | 17 | 10 | All SZGR 2.0 genes in this pathway |
REACTOME SIGNALING BY ERBB2 | 101 | 78 | All SZGR 2.0 genes in this pathway |
REACTOME SIGNALING BY EGFR IN CANCER | 109 | 80 | All SZGR 2.0 genes in this pathway |
REACTOME NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE | 137 | 105 | All SZGR 2.0 genes in this pathway |
REACTOME SIGNALING BY FGFR IN DISEASE | 127 | 88 | All SZGR 2.0 genes in this pathway |
REACTOME GASTRIN CREB SIGNALLING PATHWAY VIA PKC AND MAPK | 205 | 136 | All SZGR 2.0 genes in this pathway |
REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 | 89 | 56 | All SZGR 2.0 genes in this pathway |
REACTOME TRANSMISSION ACROSS CHEMICAL SYNAPSES | 186 | 155 | All SZGR 2.0 genes in this pathway |
REACTOME NEURONAL SYSTEM | 279 | 221 | All SZGR 2.0 genes in this pathway |
REACTOME SIGNALING BY GPCR | 920 | 449 | All SZGR 2.0 genes in this pathway |
REACTOME INTEGRATION OF ENERGY METABOLISM | 120 | 84 | All SZGR 2.0 genes in this pathway |
REACTOME OPIOID SIGNALLING | 78 | 56 | All SZGR 2.0 genes in this pathway |
REACTOME CA DEPENDENT EVENTS | 30 | 23 | All SZGR 2.0 genes in this pathway |
REACTOME NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL | 137 | 110 | All SZGR 2.0 genes in this pathway |
REACTOME PLC BETA MEDIATED EVENTS | 43 | 32 | All SZGR 2.0 genes in this pathway |
REACTOME SIGNALING BY PDGF | 122 | 93 | All SZGR 2.0 genes in this pathway |
REACTOME DOWNSTREAM SIGNAL TRANSDUCTION | 95 | 76 | All SZGR 2.0 genes in this pathway |
REACTOME TRAFFICKING OF AMPA RECEPTORS | 28 | 23 | All SZGR 2.0 genes in this pathway |
REACTOME REGULATION OF INSULIN SECRETION | 93 | 65 | All SZGR 2.0 genes in this pathway |
REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE | 11 | 9 | All SZGR 2.0 genes in this pathway |
REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS | 16 | 11 | All SZGR 2.0 genes in this pathway |
REACTOME GPCR DOWNSTREAM SIGNALING | 805 | 368 | All SZGR 2.0 genes in this pathway |
REACTOME G ALPHA Z SIGNALLING EVENTS | 44 | 29 | All SZGR 2.0 genes in this pathway |
REACTOME METABOLISM OF MRNA | 284 | 128 | All SZGR 2.0 genes in this pathway |
REACTOME METABOLISM OF RNA | 330 | 155 | All SZGR 2.0 genes in this pathway |
REACTOME DOWNSTREAM SIGNALING OF ACTIVATED FGFR | 100 | 74 | All SZGR 2.0 genes in this pathway |
REACTOME PHOSPHOLIPASE C MEDIATED CASCADE | 54 | 40 | All SZGR 2.0 genes in this pathway |
REACTOME REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU RICH ELEMENTS | 84 | 50 | All SZGR 2.0 genes in this pathway |
REACTOME HEMOSTASIS | 466 | 331 | All SZGR 2.0 genes in this pathway |
REACTOME PLATELET ACTIVATION SIGNALING AND AGGREGATION | 208 | 138 | All SZGR 2.0 genes in this pathway |
REACTOME SIGNALING BY FGFR | 112 | 80 | All SZGR 2.0 genes in this pathway |
HOLLMANN APOPTOSIS VIA CD40 UP | 201 | 125 | All SZGR 2.0 genes in this pathway |
ONKEN UVEAL MELANOMA UP | 783 | 507 | All SZGR 2.0 genes in this pathway |
DAVICIONI PAX FOXO1 SIGNATURE IN ARMS UP | 59 | 38 | All SZGR 2.0 genes in this pathway |
DAVICIONI TARGETS OF PAX FOXO1 FUSIONS UP | 255 | 177 | All SZGR 2.0 genes in this pathway |
FULCHER INFLAMMATORY RESPONSE LECTIN VS LPS UP | 579 | 346 | All SZGR 2.0 genes in this pathway |
PUIFFE INVASION INHIBITED BY ASCITES UP | 82 | 51 | All SZGR 2.0 genes in this pathway |
CASORELLI ACUTE PROMYELOCYTIC LEUKEMIA UP | 177 | 110 | All SZGR 2.0 genes in this pathway |
HUTTMANN B CLL POOR SURVIVAL UP | 276 | 187 | All SZGR 2.0 genes in this pathway |
CHARAFE BREAST CANCER LUMINAL VS MESENCHYMAL DN | 460 | 312 | All SZGR 2.0 genes in this pathway |
BORCZUK MALIGNANT MESOTHELIOMA UP | 305 | 185 | All SZGR 2.0 genes in this pathway |
SENESE HDAC1 TARGETS DN | 260 | 143 | All SZGR 2.0 genes in this pathway |
SENESE HDAC3 TARGETS DN | 536 | 332 | All SZGR 2.0 genes in this pathway |
ELVIDGE HYPOXIA UP | 171 | 112 | All SZGR 2.0 genes in this pathway |
ELVIDGE HYPOXIA BY DMOG UP | 130 | 85 | All SZGR 2.0 genes in this pathway |
JAATINEN HEMATOPOIETIC STEM CELL DN | 226 | 132 | All SZGR 2.0 genes in this pathway |
GOZGIT ESR1 TARGETS DN | 781 | 465 | All SZGR 2.0 genes in this pathway |
KOKKINAKIS METHIONINE DEPRIVATION 48HR DN | 64 | 39 | All SZGR 2.0 genes in this pathway |
KOKKINAKIS METHIONINE DEPRIVATION 96HR UP | 117 | 84 | All SZGR 2.0 genes in this pathway |
GRAESSMANN APOPTOSIS BY SERUM DEPRIVATION DN | 234 | 147 | All SZGR 2.0 genes in this pathway |
GRAESSMANN RESPONSE TO MC AND SERUM DEPRIVATION DN | 84 | 54 | All SZGR 2.0 genes in this pathway |
PATIL LIVER CANCER | 747 | 453 | All SZGR 2.0 genes in this pathway |
YORDY RECIPROCAL REGULATION BY ETS1 AND SP100 DN | 87 | 48 | All SZGR 2.0 genes in this pathway |
DACOSTA UV RESPONSE VIA ERCC3 DN | 855 | 609 | All SZGR 2.0 genes in this pathway |
DACOSTA UV RESPONSE VIA ERCC3 COMMON DN | 483 | 336 | All SZGR 2.0 genes in this pathway |
AMUNDSON RESPONSE TO ARSENITE | 217 | 143 | All SZGR 2.0 genes in this pathway |
SHETH LIVER CANCER VS TXNIP LOSS PAM1 | 229 | 137 | All SZGR 2.0 genes in this pathway |
PUJANA BRCA1 PCC NETWORK | 1652 | 1023 | All SZGR 2.0 genes in this pathway |
PUJANA BRCA2 PCC NETWORK | 423 | 265 | All SZGR 2.0 genes in this pathway |
GOUYER TATI TARGETS UP | 10 | 7 | All SZGR 2.0 genes in this pathway |
NIKOLSKY BREAST CANCER 17Q21 Q25 AMPLICON | 335 | 181 | All SZGR 2.0 genes in this pathway |
ONDER CDH1 TARGETS 2 UP | 256 | 159 | All SZGR 2.0 genes in this pathway |
ONDER CDH1 TARGETS 1 UP | 140 | 85 | All SZGR 2.0 genes in this pathway |
ONDER CDH1 TARGETS 3 UP | 17 | 11 | All SZGR 2.0 genes in this pathway |
GOLDRATH HOMEOSTATIC PROLIFERATION | 171 | 102 | All SZGR 2.0 genes in this pathway |
FLECHNER BIOPSY KIDNEY TRANSPLANT REJECTED VS OK DN | 546 | 351 | All SZGR 2.0 genes in this pathway |
ZHAN MULTIPLE MYELOMA CD1 VS CD2 DN | 52 | 35 | All SZGR 2.0 genes in this pathway |
KUMAR TARGETS OF MLL AF9 FUSION | 405 | 264 | All SZGR 2.0 genes in this pathway |
REN ALVEOLAR RHABDOMYOSARCOMA DN | 408 | 274 | All SZGR 2.0 genes in this pathway |
LEE CALORIE RESTRICTION NEOCORTEX UP | 83 | 66 | All SZGR 2.0 genes in this pathway |
CUI TCF21 TARGETS 2 DN | 830 | 547 | All SZGR 2.0 genes in this pathway |
BROWNE HCMV INFECTION 24HR DN | 148 | 102 | All SZGR 2.0 genes in this pathway |
BROWNE HCMV INFECTION 48HR UP | 180 | 125 | All SZGR 2.0 genes in this pathway |
BROWNE HCMV INFECTION 14HR UP | 156 | 101 | All SZGR 2.0 genes in this pathway |
IVANOVA HEMATOPOIESIS STEM CELL SHORT TERM | 32 | 15 | All SZGR 2.0 genes in this pathway |
YIH RESPONSE TO ARSENITE C3 | 36 | 24 | All SZGR 2.0 genes in this pathway |
KRIGE RESPONSE TO TOSEDOSTAT 6HR UP | 953 | 554 | All SZGR 2.0 genes in this pathway |
KRIGE RESPONSE TO TOSEDOSTAT 24HR UP | 783 | 442 | All SZGR 2.0 genes in this pathway |
MONNIER POSTRADIATION TUMOR ESCAPE UP | 393 | 244 | All SZGR 2.0 genes in this pathway |
CREIGHTON ENDOCRINE THERAPY RESISTANCE 3 | 720 | 440 | All SZGR 2.0 genes in this pathway |
MITSIADES RESPONSE TO APLIDIN DN | 249 | 165 | All SZGR 2.0 genes in this pathway |
SMID BREAST CANCER BASAL UP | 648 | 398 | All SZGR 2.0 genes in this pathway |
ALONSO METASTASIS EMT UP | 36 | 24 | All SZGR 2.0 genes in this pathway |
ALONSO METASTASIS UP | 198 | 128 | All SZGR 2.0 genes in this pathway |
YAUCH HEDGEHOG SIGNALING PARACRINE DN | 264 | 159 | All SZGR 2.0 genes in this pathway |
GU PDEF TARGETS UP | 71 | 49 | All SZGR 2.0 genes in this pathway |
PARK APL PATHOGENESIS DN | 50 | 35 | All SZGR 2.0 genes in this pathway |
YOSHIMURA MAPK8 TARGETS UP | 1305 | 895 | All SZGR 2.0 genes in this pathway |
HAN SATB1 TARGETS UP | 395 | 249 | All SZGR 2.0 genes in this pathway |
COLINA TARGETS OF 4EBP1 AND 4EBP2 | 356 | 214 | All SZGR 2.0 genes in this pathway |
CAIRO HEPATOBLASTOMA UP | 207 | 143 | All SZGR 2.0 genes in this pathway |
ZHAN MULTIPLE MYELOMA MF DN | 41 | 28 | All SZGR 2.0 genes in this pathway |
BAE BRCA1 TARGETS UP | 75 | 47 | All SZGR 2.0 genes in this pathway |
BROWNE HCMV INFECTION 1HR UP | 61 | 44 | All SZGR 2.0 genes in this pathway |
JOHNSTONE PARVB TARGETS 2 DN | 336 | 211 | All SZGR 2.0 genes in this pathway |
BRUINS UVC RESPONSE LATE | 1137 | 655 | All SZGR 2.0 genes in this pathway |
FEVR CTNNB1 TARGETS UP | 682 | 433 | All SZGR 2.0 genes in this pathway |
GOBERT OLIGODENDROCYTE DIFFERENTIATION DN | 1080 | 713 | All SZGR 2.0 genes in this pathway |
PEDERSEN METASTASIS BY ERBB2 ISOFORM 7 | 403 | 240 | All SZGR 2.0 genes in this pathway |
WAKABAYASHI ADIPOGENESIS PPARG BOUND 8D | 658 | 397 | All SZGR 2.0 genes in this pathway |
FORTSCHEGGER PHF8 TARGETS DN | 784 | 464 | All SZGR 2.0 genes in this pathway |
BOSCO TH1 CYTOTOXIC MODULE | 114 | 62 | All SZGR 2.0 genes in this pathway |
Section VI. microRNA annotation
miRNA family | Target position | miRNA ID | miRNA seq | ||
---|---|---|---|---|---|
UTR start | UTR end | Match method | |||
miR-150 | 802 | 808 | 1A | hsa-miR-150 | UCUCCCAACCCUUGUACCAGUG |
miR-183 | 826 | 832 | m8 | hsa-miR-183 | UAUGGCACUGGUAGAAUUCACUG |
miR-200bc/429 | 1319 | 1325 | 1A | hsa-miR-200b | UAAUACUGCCUGGUAAUGAUGAC |
hsa-miR-200c | UAAUACUGCCGGGUAAUGAUGG | ||||
hsa-miR-429 | UAAUACUGUCUGGUAAAACCGU | ||||
miR-203.1 | 752 | 758 | 1A | hsa-miR-203 | UGAAAUGUUUAGGACCACUAG |
miR-326 | 366 | 372 | 1A | hsa-miR-326 | CCUCUGGGCCCUUCCUCCAG |
miR-362 | 762 | 769 | 1A,m8 | hsa-miR-362 | AAUCCUUGGAACCUAGGUGUGAGU |
miR-369-3p | 1320 | 1327 | 1A,m8 | hsa-miR-369-3p | AAUAAUACAUGGUUGAUCUUU |
miR-539 | 4312 | 4318 | 1A | hsa-miR-539 | GGAGAAAUUAUCCUUGGUGUGU |
hsa-miR-539 | GGAGAAAUUAUCCUUGGUGUGU | ||||
miR-9 | 5337 | 5343 | 1A | hsa-miR-9SZ | UCUUUGGUUAUCUAGCUGUAUGA |
- SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
- Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.