Summary ?
GeneID55810
SymbolFOXJ2
SynonymsFHX
Descriptionforkhead box J2
ReferenceHGNC:HGNC:24818|Ensembl:ENSG00000065970|HPRD:17014|Vega:OTTHUMG00000168526
Gene typeprotein-coding
Map location12p13.31
Pascal p-value0.369
Sherlock p-value0.486
Fetal beta0.037
DMG2 (# studies)
eGeneMyers' cis & trans

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
DMG:Nishioka_2013Genome-wide DNA methylation analysisThe authors investigated the methylation profiles of DNA in peripheral blood cells from 18 patients with first-episode schizophrenia (FESZ) and from 15 normal controls. 2
DMG:Wockner_2014Genome-wide DNA methylation analysisThis dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 2

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

ProbeChromosomePositionNearest geneP (dis)Beta (dis)FDR (dis)Study
cg13863617128186708FOXJ24.41E-40.390.045DMG:Wockner_2014
cg12958836128185024FOXJ2-0.0220.26DMG:Nishioka_2013

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs16827037chr3117203284FOXJ2558100.08trans
rs1020772chr976532511FOXJ2558100.02trans
rs3025425chr9136523165FOXJ2558100.18trans
rs10834670chr1125404015FOXJ2558100.08trans
rs1230712chr1854992531FOXJ2558100.12trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
HSPA60.55-0.05
CARD160.530.50
CLEC2B0.520.46
CXCL10.490.30
HSPA1A0.480.02
SERTAD10.480.49
BAG30.460.31
PIGB0.460.43
DNAJB10.45-0.02
EAF20.450.52
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
WDR81-0.43-0.45
TNKS1BP1-0.42-0.50
ZBTB3-0.42-0.48
NDST2-0.42-0.44
MAP2K7-0.42-0.41
HIP1R-0.41-0.51
ARHGAP1-0.41-0.39
FAM129B-0.41-0.54
PTPN23-0.41-0.48
C4orf42-0.41-0.48

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
BERTUCCI MEDULLARY VS DUCTAL BREAST CANCER UP 206111All SZGR 2.0 genes in this pathway
PROVENZANI METASTASIS DN 13694All SZGR 2.0 genes in this pathway
BENPORATH NANOG TARGETS 988594All SZGR 2.0 genes in this pathway
BENPORATH SOX2 TARGETS 734436All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE UP 16911088All SZGR 2.0 genes in this pathway
KRIGE RESPONSE TO TOSEDOSTAT 6HR UP 953554All SZGR 2.0 genes in this pathway
KRIGE RESPONSE TO TOSEDOSTAT 24HR UP 783442All SZGR 2.0 genes in this pathway
ACEVEDO LIVER CANCER WITH H3K27ME3 DN 228114All SZGR 2.0 genes in this pathway
RUTELLA RESPONSE TO CSF2RB AND IL4 UP 338225All SZGR 2.0 genes in this pathway
RUTELLA RESPONSE TO HGF UP 418282All SZGR 2.0 genes in this pathway
RUTELLA RESPONSE TO HGF VS CSF2RB AND IL4 DN 245150All SZGR 2.0 genes in this pathway
CARD MIR302A TARGETS 7762All SZGR 2.0 genes in this pathway
JUBAN TARGETS OF SPI1 AND FLI1 UP 11573All SZGR 2.0 genes in this pathway
RAO BOUND BY SALL4 ISOFORM A 182108All SZGR 2.0 genes in this pathway