Summary ?
GeneID55815
SymbolTSNAXIP1
SynonymsTXI1
Descriptiontranslin-associated factor X interacting protein 1
ReferenceMIM:607720|HGNC:HGNC:18586|Ensembl:ENSG00000102904|HPRD:09656|Vega:OTTHUMG00000137545
Gene typeprotein-coding
Map location16q22.1
Pascal p-value0.002
Sherlock p-value0.083
Fetal beta-0.467
DMG1 (# studies)
eGeneAnterior cingulate cortex BA24
Cerebellar Hemisphere
Frontal Cortex BA9
Myers' cis & trans
Meta

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
DMG:Wockner_2014Genome-wide DNA methylation analysisThis dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 1

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

ProbeChromosomePositionNearest geneP (dis)Beta (dis)FDR (dis)Study
cg052533261667850616TSNAXIP13.77E-5-0.5260.02DMG:Wockner_2014

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs4380312chr202239006TSNAXIP1558150.17trans
rs99229341668258981TSNAXIP1ENSG00000102904.108.26203E-60.05418313gtex_brain_ba24

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
YWHAZ0.880.86
ANKRD460.880.87
PRKRA0.870.86
AASDHPPT0.870.88
FBXO30.870.85
ORC4L0.860.87
RAP1GDS10.860.87
B3GALNT10.860.86
DYNC1LI10.860.87
UBA30.860.88
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
MT-CO2-0.69-0.67
AF347015.2-0.68-0.70
AF347015.8-0.68-0.68
AF347015.31-0.67-0.66
MT-CYB-0.66-0.66
AF347015.33-0.66-0.65
AF347015.15-0.64-0.65
AF347015.26-0.64-0.66
AF347015.27-0.64-0.63
AF347015.21-0.63-0.60

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
DODD NASOPHARYNGEAL CARCINOMA UP 1821933All SZGR 2.0 genes in this pathway
GAUSSMANN MLL AF4 FUSION TARGETS C UP 170114All SZGR 2.0 genes in this pathway
MOREAUX MULTIPLE MYELOMA BY TACI UP 412249All SZGR 2.0 genes in this pathway
MARSON BOUND BY FOXP3 STIMULATED 1022619All SZGR 2.0 genes in this pathway
MIKKELSEN ES ICP WITH H3K4ME3 718401All SZGR 2.0 genes in this pathway
MIKKELSEN NPC ICP WITH H3K4ME3 445257All SZGR 2.0 genes in this pathway