Summary ?
GeneID5588
SymbolPRKCQ
SynonymsPRKCT|nPKC-theta
Descriptionprotein kinase C theta
ReferenceMIM:600448|HGNC:HGNC:9410|Ensembl:ENSG00000065675|HPRD:02710|Vega:OTTHUMG00000017623
Gene typeprotein-coding
Map location10p15
Pascal p-value0.369
eGeneMeta
SupportAscano FMRP targets

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:GWAScatGenome-wide Association StudiesThis data set includes 560 SNPs associated with schizophrenia. A total of 486 genes were mapped to these SNPs within 50kb.
CV:GWASdbGenome-wide Association StudiesGWASdb records for schizophrenia
CV:PGCnpGenome-wide Association StudyGWAS
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 1 

Section I. Genetics and epigenetics annotation


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0000166nucleotide bindingIEA-
GO:0000287magnesium ion bindingIEA-
GO:0004697protein kinase C activityIEA-
GO:0005515protein bindingIPI10383400 |10636891 |11788586 
|17588663 
GO:0005524ATP bindingIEA-
GO:0005524ATP bindingNAS-
GO:0004674protein serine/threonine kinase activityIEA-
GO:0016740transferase activityIEA-
GO:0008270zinc ion bindingIEA-
GO:0019992diacylglycerol bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0001558regulation of cell growthNAS8444877 
GO:0006468protein amino acid phosphorylationIEA-
GO:0006468protein amino acid phosphorylationNAS-
GO:0007242intracellular signaling cascadeIEA-
GO:0007242intracellular signaling cascadeNAS7686153 
GO:0051092positive regulation of NF-kappaB transcription factor activityIDA15790681 
GO:0042102positive regulation of T cell proliferationIEA-
GO:0045086positive regulation of interleukin-2 biosynthetic processIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0001772immunological synapseIEASynap (GO term level: 7)-
GO:0005622intracellularNAS-
GO:0005737cytoplasmIEA-
GO:0005886plasma membraneIEA-

Section IV. Protein-protein interaction annotation

InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
AKT1AKT | MGC99656 | PKB | PKB-ALPHA | PRKBA | RAC | RAC-ALPHAv-akt murine thymoma viral oncogene homolog 1-HPRD,BioGRID11410591 
CARD11BIMP3 | CARMA1 | MGC133069caspase recruitment domain family, member 11PRKCQ (PKC-theta) interacts with CARD11 (CARMA1).BIND14673152 
CHUKIKBKA | IKK-alpha | IKK1 | IKKA | NFKBIKA | TCF16conserved helix-loop-helix ubiquitous kinasePKC-theta interacts with IKK-alpha.BIND15802604 
FYNMGC45350 | SLK | SYNFYN oncogene related to SRC, FGR, YES-HPRD,BioGRID10383400 
GLRX3FLJ11864 | GLRX4 | GRX3 | GRX4 | PICOT | TXNL2 | TXNL3 | bA500G10.4glutaredoxin 3-HPRD,BioGRID10636891 
HABP4IHABP4 | Ki-1/57 | MGC825 | SERBP1Lhyaluronan binding protein 4-HPRD14699138 
IKBKBFLJ40509 | IKK-beta | IKK2 | IKKB | MGC131801 | NFKBIKBinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase betaPKC-theta interacts with IKK-beta.BIND15802604 
IKBKBFLJ40509 | IKK-beta | IKK2 | IKKB | MGC131801 | NFKBIKBinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta-HPRD,BioGRID11120819 
IKBKGAMCBX1 | FIP-3 | FIP3 | Fip3p | IKK-gamma | IP | IP1 | IP2 | IPD2 | NEMOinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gammaPKC-theta interacts with NEMO.BIND15802604 
LCKYT16 | p56lck | pp58lcklymphocyte-specific protein tyrosine kinaseTwo-hybridBioGRID10383400 
LYNFLJ26625 | JTK8v-yes-1 Yamaguchi sarcoma viral related oncogene homolog-HPRD11358993 
PDPK1MGC20087 | MGC35290 | PDK1 | PRO04613-phosphoinositide dependent protein kinase-1PDK1 interacts with PKC-theta.BIND15802604 
SELLCD62L | LAM-1 | LAM1 | LECAM1 | LNHR | LSEL | LYAM1 | Leu-8 | Lyam-1 | PLNHR | TQ1 | hLHRcselectin LL-selectin interacts with and is phosphorlyated by PKC-theta.BIND15192100 
TAL1SCL | TCL5 | bHLHa17 | tal-1T-cell acute lymphocytic leukemia 1Two-hybridBioGRID10383400 
VAV1VAVvav 1 guanine nucleotide exchange factorPRKCQ (PKC-theta) interacts with VAV1. This interaction was modelled on a demonstrated interaction between human PRKCQ and VAV1 from an unspecified species.BIND14673152 
VAV1VAVvav 1 guanine nucleotide exchange factor-HPRD,BioGRID10725744 
YWHAG14-3-3GAMMAtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide-HPRD,BioGRID10433554 


Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG VASCULAR SMOOTH MUSCLE CONTRACTION 11581All SZGR 2.0 genes in this pathway
KEGG TIGHT JUNCTION 13486All SZGR 2.0 genes in this pathway
KEGG T CELL RECEPTOR SIGNALING PATHWAY 10889All SZGR 2.0 genes in this pathway
KEGG ADIPOCYTOKINE SIGNALING PATHWAY 6757All SZGR 2.0 genes in this pathway
BIOCARTA KERATINOCYTE PATHWAY 4638All SZGR 2.0 genes in this pathway
PID ENDOTHELIN PATHWAY 6352All SZGR 2.0 genes in this pathway
PID TCR PATHWAY 6651All SZGR 2.0 genes in this pathway
PID NFAT TFPATHWAY 4739All SZGR 2.0 genes in this pathway
PID CD8 TCR PATHWAY 5342All SZGR 2.0 genes in this pathway
PID TXA2PATHWAY 5743All SZGR 2.0 genes in this pathway
PID NFAT 3PATHWAY 5447All SZGR 2.0 genes in this pathway
PID CD8 TCR DOWNSTREAM PATHWAY 6556All SZGR 2.0 genes in this pathway
REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS 4026All SZGR 2.0 genes in this pathway
REACTOME DEVELOPMENTAL BIOLOGY 396292All SZGR 2.0 genes in this pathway
REACTOME GASTRIN CREB SIGNALLING PATHWAY VIA PKC AND MAPK 205136All SZGR 2.0 genes in this pathway
REACTOME TCR SIGNALING 5446All SZGR 2.0 genes in this pathway
REACTOME DOWNSTREAM TCR SIGNALING 3732All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY GPCR 920449All SZGR 2.0 genes in this pathway
REACTOME AXON GUIDANCE 251188All SZGR 2.0 genes in this pathway
REACTOME G ALPHA Q SIGNALLING EVENTS 184116All SZGR 2.0 genes in this pathway
REACTOME GPCR DOWNSTREAM SIGNALING 805368All SZGR 2.0 genes in this pathway
REACTOME G ALPHA Z SIGNALLING EVENTS 4429All SZGR 2.0 genes in this pathway
REACTOME EFFECTS OF PIP2 HYDROLYSIS 2517All SZGR 2.0 genes in this pathway
REACTOME NETRIN1 SIGNALING 4130All SZGR 2.0 genes in this pathway
REACTOME APOPTOSIS 14894All SZGR 2.0 genes in this pathway
REACTOME HEMOSTASIS 466331All SZGR 2.0 genes in this pathway
REACTOME IMMUNE SYSTEM 933616All SZGR 2.0 genes in this pathway
REACTOME ADAPTIVE IMMUNE SYSTEM 539350All SZGR 2.0 genes in this pathway
REACTOME PLATELET ACTIVATION SIGNALING AND AGGREGATION 208138All SZGR 2.0 genes in this pathway
REACTOME APOPTOTIC EXECUTION PHASE 5437All SZGR 2.0 genes in this pathway
DIAZ CHRONIC MEYLOGENOUS LEUKEMIA UP 1382904All SZGR 2.0 genes in this pathway
MULLIGHAN MLL SIGNATURE 1 DN 242165All SZGR 2.0 genes in this pathway
MULLIGHAN MLL SIGNATURE 2 DN 281186All SZGR 2.0 genes in this pathway
DELYS THYROID CANCER DN 232154All SZGR 2.0 genes in this pathway
LINDGREN BLADDER CANCER CLUSTER 1 UP 12171All SZGR 2.0 genes in this pathway
LINDGREN BLADDER CANCER CLUSTER 2A DN 14184All SZGR 2.0 genes in this pathway
OZANNE AP1 TARGETS UP 1811All SZGR 2.0 genes in this pathway
EBAUER TARGETS OF PAX3 FOXO1 FUSION UP 207128All SZGR 2.0 genes in this pathway
LINDGREN BLADDER CANCER WITH LOH IN CHR9Q 11671All SZGR 2.0 genes in this pathway
PUJANA BRCA2 PCC NETWORK 423265All SZGR 2.0 genes in this pathway
ASTON MAJOR DEPRESSIVE DISORDER DN 160110All SZGR 2.0 genes in this pathway
RADAEVA RESPONSE TO IFNA1 UP 5240All SZGR 2.0 genes in this pathway
CHEOK RESPONSE TO MERCAPTOPURINE AND LD MTX DN 2111All SZGR 2.0 genes in this pathway
KUMAR TARGETS OF MLL AF9 FUSION 405264All SZGR 2.0 genes in this pathway
IVANOVA HEMATOPOIESIS STEM CELL LONG TERM 302191All SZGR 2.0 genes in this pathway
ZHENG BOUND BY FOXP3 491310All SZGR 2.0 genes in this pathway
FINETTI BREAST CANCER KINOME GREEN 1614All SZGR 2.0 genes in this pathway
ACEVEDO LIVER CANCER WITH H3K27ME3 UP 295149All SZGR 2.0 genes in this pathway
SMID BREAST CANCER NORMAL LIKE UP 476285All SZGR 2.0 genes in this pathway
BOYLAN MULTIPLE MYELOMA C D DN 252155All SZGR 2.0 genes in this pathway
LEE DIFFERENTIATING T LYMPHOCYTE 200115All SZGR 2.0 genes in this pathway
MEISSNER BRAIN HCP WITH H3K4ME3 AND H3K27ME3 1069729All SZGR 2.0 genes in this pathway
YAGI AML WITH 11Q23 REARRANGED 351238All SZGR 2.0 genes in this pathway
WONG ADULT TISSUE STEM MODULE 721492All SZGR 2.0 genes in this pathway
NIELSEN GIST VS SYNOVIAL SARCOMA DN 2017All SZGR 2.0 genes in this pathway
NIELSEN GIST 9866All SZGR 2.0 genes in this pathway
GREGORY SYNTHETIC LETHAL WITH IMATINIB 14583All SZGR 2.0 genes in this pathway
CHYLA CBFA2T3 TARGETS UP 387225All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE VIA TP53 GROUP A 898516All SZGR 2.0 genes in this pathway
TORCHIA TARGETS OF EWSR1 FLI1 FUSION UP 271165All SZGR 2.0 genes in this pathway
GOBERT OLIGODENDROCYTE DIFFERENTIATION DN 1080713All SZGR 2.0 genes in this pathway
BOSCO TH1 CYTOTOXIC MODULE 11462All SZGR 2.0 genes in this pathway