Gene Page: UNC45A

Summary ?
GeneID55898
SymbolUNC45A
SynonymsGC-UNC45|GCUNC-45|GCUNC45|IRO039700|SMAP-1|SMAP1|UNC-45A
Descriptionunc-45 myosin chaperone A
ReferenceMIM:611219|HGNC:HGNC:30594|Ensembl:ENSG00000140553|HPRD:18070|Vega:OTTHUMG00000141261
Gene typeprotein-coding
Map location15q26.1
Pascal p-value7.22E-5
Sherlock p-value0.908
Fetal beta0.611
DMG1 (# studies)
eGeneMyers' cis & trans
Meta
SupportAscano FMRP targets

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
DMG:Wockner_2014Genome-wide DNA methylation analysisThis dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 1
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 1 

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

ProbeChromosomePositionNearest geneP (dis)Beta (dis)FDR (dis)Study
cg089393711591473059UNC45A2.081E-40.580.035DMG:Wockner_2014

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs16829545chr2151977407UNC45A558980.03trans
rs7787830chr798797019UNC45A558980.03trans
rs16955618chr1529937543UNC45A558980.09trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
NOSIP0.900.88
FAM128A0.890.85
GADD45GIP10.890.88
AC174470.10.890.85
MRPS240.880.85
FAM96B0.870.85
SCAND10.860.86
AIP0.860.83
ANAPC110.850.85
TCEB20.850.81
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
FLT1-0.49-0.54
COBLL1-0.49-0.51
TJP1-0.47-0.49
PDE8A-0.46-0.57
ABCA9-0.46-0.53
EPB41L2-0.46-0.50
PTPRB-0.45-0.47
PK4P-0.44-0.48
DST-0.44-0.44
ABCB1-0.44-0.48

Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005515protein bindingIPI17353931 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007519skeletal muscle developmentIEAneuron (GO term level: 8)-
GO:0007275multicellular organismal developmentIEA-
GO:0030154cell differentiationIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005634nucleusIEA-
GO:0005737cytoplasmIEA-

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
PARENT MTOR SIGNALING UP 567375All SZGR 2.0 genes in this pathway
FULCHER INFLAMMATORY RESPONSE LECTIN VS LPS DN 463290All SZGR 2.0 genes in this pathway
RODRIGUES THYROID CARCINOMA POORLY DIFFERENTIATED DN 805505All SZGR 2.0 genes in this pathway
BARRIER CANCER RELAPSE TUMOR SAMPLE DN 136All SZGR 2.0 genes in this pathway
KUROKAWA LIVER CANCER CHEMOTHERAPY DN 4128All SZGR 2.0 genes in this pathway
BURTON ADIPOGENESIS 1 3324All SZGR 2.0 genes in this pathway
LU EZH2 TARGETS UP 295155All SZGR 2.0 genes in this pathway
WAKABAYASHI ADIPOGENESIS PPARG BOUND 8D 658397All SZGR 2.0 genes in this pathway
LIM MAMMARY STEM CELL UP 489314All SZGR 2.0 genes in this pathway