Summary ?
GeneID55915
SymbolLANCL2
SynonymsGPR69B|TASP
DescriptionLanC like 2
ReferenceMIM:612919|HGNC:HGNC:6509|Ensembl:ENSG00000132434|HPRD:13956|Vega:OTTHUMG00000023779
Gene typeprotein-coding
Map location7q31.1-q31.33
Pascal p-value0.276
Sherlock p-value0.413
Fetal beta-1.324
DMG1 (# studies)
SupportINTRACELLULAR SIGNAL TRANSDUCTION
G2Cdb.humanPSD
G2Cdb.humanPSP
CompositeSet

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
DMG:Jaffe_2016Genome-wide DNA methylation analysisThis dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05. 1

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

ProbeChromosomePositionNearest geneP (dis)Beta (dis)FDR (dis)Study
cg25750380755434429LANCL25.17E-9-0.0232.91E-6DMG:Jaffe_2016


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
TMEM132B0.690.75
BCL2L130.680.68
ARNT20.680.72
SENP20.670.70
RGL10.670.69
COL5A20.670.76
SCRN10.660.65
TBC1D50.660.68
IPO80.650.63
DPY19L10.650.71
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
AF347015.21-0.51-0.38
APOC1-0.45-0.31
C1orf54-0.42-0.37
MT-CO2-0.41-0.34
AF347015.18-0.40-0.30
AL050337.1-0.40-0.33
IL32-0.40-0.30
AF347015.8-0.39-0.30
FAM159B-0.38-0.40
AC098691.2-0.38-0.32

Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0003824catalytic activityIEA-
GO:0005524ATP bindingNAS11762191 
GO:0005525GTP bindingNAS11762191 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0016481negative regulation of transcriptionIDA12566319 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005829cytosolIDA12566319 
GO:0005634nucleusIDA12566319 
GO:0005737cytoplasmIEA-
GO:0005886plasma membraneIDA12566319 

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
GARY CD5 TARGETS DN 431263All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY DOXORUBICIN DN 17811082All SZGR 2.0 genes in this pathway
GRAESSMANN RESPONSE TO MC AND DOXORUBICIN DN 770415All SZGR 2.0 genes in this pathway
LOCKWOOD AMPLIFIED IN LUNG CANCER 214139All SZGR 2.0 genes in this pathway
DOUGLAS BMI1 TARGETS UP 566371All SZGR 2.0 genes in this pathway
SANSOM APC TARGETS REQUIRE MYC 210123All SZGR 2.0 genes in this pathway
FOSTER TOLERANT MACROPHAGE DN 409268All SZGR 2.0 genes in this pathway
MARTINEZ RB1 TARGETS UP 673430All SZGR 2.0 genes in this pathway
MARTINEZ TP53 TARGETS UP 602364All SZGR 2.0 genes in this pathway
MARTINEZ RB1 AND TP53 TARGETS UP 601369All SZGR 2.0 genes in this pathway
CAIRO HEPATOBLASTOMA CLASSES UP 605377All SZGR 2.0 genes in this pathway
GOBERT OLIGODENDROCYTE DIFFERENTIATION UP 570339All SZGR 2.0 genes in this pathway
ROESSLER LIVER CANCER METASTASIS DN 5329All SZGR 2.0 genes in this pathway
ZWANG EGF PERSISTENTLY UP 3224All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-494228234m8hsa-miR-494brainUGAAACAUACACGGGAAACCUCUU