Gene Page: PRKG1

Summary
GeneID  5592
Symbol  PRKG1
Synonyms  CGKI|DKFZp686K042|FLJ36117|MGC71944|PGK|PKG|PRKG1B|PRKGR1B|cGKI-BETA|cGKI-alpha
Description  protein kinase, cGMP-dependent, type I
See related  HGNC:9414|MIM:176894|Ensembl:ENSG00000185532|HPRD:08910|
Locus tag  RP11-346D6.1
Gene type  protein-coding
Map location  10q11.2
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 3 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
AQP30.680.33
RIN10.640.65
FBXL80.610.54
CLEC4G0.610.61
KCNG20.600.57
METTL7B0.580.41
P2RX20.580.47
CNGB10.550.48
TRADD0.550.51
PNCK0.540.55
Top 10 negatively co-expressed genes
MLLT3-0.28-0.24
CBLB-0.28-0.26
C1orf26-0.28-0.26
ZNF286-0.28-0.24
DACT1-0.28-0.22
NFIL3-0.28-0.24
KCNRG-0.28-0.24
CEP170-0.28-0.23
KLF11-0.28-0.24
LRCH1-0.28-0.28
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0000166nucleotide bindingIEA-
GO:0005515protein bindingIEA-
GO:0005524ATP bindingIEA-
GO:0004674protein serine/threonine kinase activityIEA-
GO:0004692cGMP-dependent protein kinase activityIEA-
GO:0016740transferase activityIEA-
GO:0008603cAMP-dependent protein kinase regulator activityIEA-
GO:0030553cGMP bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0001764neuron migrationIEAneuron (GO term level: 8)-
GO:0030900forebrain developmentIEABrain (GO term level: 8)-
GO:0016358dendrite developmentIEAneurite, dendrite (GO term level: 11)-
GO:0001932regulation of protein amino acid phosphorylationIEA-
GO:0006468protein amino acid phosphorylationIEA-
GO:0007165signal transductionIEA-
GO:0007165signal transductionTAS2792381 
GO:0030036actin cytoskeleton organizationTAS10851246 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005794Golgi apparatusIEA-
GO:0005634nucleusIDA18029348 
GO:0005730nucleolusIDA18029348 
GO:0005737cytoplasmIDA18029348 
GO:0005952cAMP-dependent protein kinase complexIEA-
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
GAPDHG3PD | GAPD | MGC88685glyceraldehyde-3-phosphate dehydrogenaseAffinity Capture-WesternBioGRID9308888 
GTF2IBAP-135 | BAP135 | BTKAP1 | DIWS | FLJ38776 | FLJ56355 | IB291 | SPIN | TFII-I | WBS | WBSCR6general transcription factor II, i-HPRD,BioGRID12082086 
ITPR1INSP3R1 | IP3R | IP3R1 | SCA15 | SCA16inositol 1,4,5-triphosphate receptor, type 1Affinity Capture-Western
Biochemical Activity		BioGRID10724174 
MRVI1IRAG | JAW1Lmurine retrovirus integration site 1 homologAffinity Capture-Western
Biochemical Activity
Two-hybrid		BioGRID10724174 |11309393 
NPR1ANPRA | ANPa | GUC2A | GUCY2A | NPRAnatriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A)-HPRD,BioGRID12855709 
PPP1R12AMBS | MGC133042 | MYPT1protein phosphatase 1, regulatory (inhibitor) subunit 12AReconstituted ComplexBioGRID10567269 
PPP1R12BMGC131980 | MGC87886 | MYPT2protein phosphatase 1, regulatory (inhibitor) subunit 12BTwo-hybridBioGRID10567269 
RAF1CRAF | NS5 | Raf-1 | c-Rafv-raf-1 murine leukemia viral oncogene homolog 1Affinity Capture-WesternBioGRID12237340 
RGS2G0S8regulator of G-protein signaling 2, 24kDaAffinity Capture-Western
Reconstituted Complex		BioGRID14608379 
TNNT1ANM | FLJ98147 | MGC104241 | STNT | TNT | TNTStroponin T type 1 (skeletal, slow)Affinity Capture-Western
Biochemical Activity
Reconstituted Complex
Two-hybrid		BioGRID10601315 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_VASCULAR_SMOOTH_MUSCLE_CONTRACTION 11581All SZGR genes in this pathway
KEGG_GAP_JUNCTION 9068All SZGR genes in this pathway
KEGG_LONG_TERM_DEPRESSION 7053All SZGR genes in this pathway
KEGG_OLFACTORY_TRANSDUCTION 38985All SZGR genes in this pathway
BIOCARTA_NO1_PATHWAY 3324All SZGR genes in this pathway
PID_P38_ALPHA_BETA_PATHWAY 3125All SZGR genes in this pathway
PID_TXA2PATHWAY 5743All SZGR genes in this pathway
REACTOME_CGMP_EFFECTS 1913All SZGR genes in this pathway
REACTOME_NITRIC_OXIDE_STIMULATES_GUANYLATE_CYCLASE 2519All SZGR genes in this pathway
REACTOME_PLATELET_HOMEOSTASIS 7849All SZGR genes in this pathway
REACTOME_RAP1_SIGNALLING 1712All SZGR genes in this pathway
REACTOME_HEMOSTASIS 466331All SZGR genes in this pathway
REACTOME_IMMUNE_SYSTEM 933616All SZGR genes in this pathway
REACTOME_ADAPTIVE_IMMUNE_SYSTEM 539350All SZGR genes in this pathway
RODRIGUES_THYROID_CARCINOMA_ANAPLASTIC_DN 537339All SZGR genes in this pathway
GAUSSMANN_MLL_AF4_FUSION_TARGETS_G_UP 238135All SZGR genes in this pathway
GALLUZZI_PREVENT_MITOCHONDIAL_PERMEABILIZATION 2216All SZGR genes in this pathway
SCHLESINGER_METHYLATED_DE_NOVO_IN_CANCER 8864All SZGR genes in this pathway
FALVELLA_SMOKERS_WITH_LUNG_CANCER 8052All SZGR genes in this pathway
BENPORATH_SUZ12_TARGETS 1038678All SZGR genes in this pathway
BENPORATH_EED_TARGETS 1062725All SZGR genes in this pathway
BENPORATH_ES_WITH_H3K27ME3 1118744All SZGR genes in this pathway
BENPORATH_PRC2_TARGETS 652441All SZGR genes in this pathway
HOFMANN_CELL_LYMPHOMA_DN 3929All SZGR genes in this pathway
CUI_TCF21_TARGETS_2_DN 830547All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_24HR_DN 148102All SZGR genes in this pathway
WANG_CISPLATIN_RESPONSE_AND_XPC_DN 228146All SZGR genes in this pathway
IVANOVA_HEMATOPOIESIS_STEM_CELL 254164All SZGR genes in this pathway
RIZKI_TUMOR_INVASIVENESS_3D_DN 270181All SZGR genes in this pathway
FIRESTEIN_PROLIFERATION 175125All SZGR genes in this pathway
VANTVEER_BREAST_CANCER_BRCA1_DN 4428All SZGR genes in this pathway
MCMURRAY_TP53_HRAS_COOPERATION_RESPONSE_DN 6746All SZGR genes in this pathway
MEISSNER_BRAIN_HCP_WITH_H3K4ME3_AND_H3K27ME3 1069729All SZGR genes in this pathway
FONTAINE_FOLLICULAR_THYROID_ADENOMA_UP 7543All SZGR genes in this pathway
FONTAINE_PAPILLARY_THYROID_CARCINOMA_UP 6638All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-103/107121127m8hsa-miR-103brainAGCAGCAUUGUACAGGGCUAUGA
hsa-miR-107brainAGCAGCAUUGUACAGGGCUAUCA
miR-149103910451Ahsa-miR-149brainUCUGGCUCCGUGUCUUCACUCC
miR-15/16/195/424/497122128m8hsa-miR-15abrainUAGCAGCACAUAAUGGUUUGUG
hsa-miR-16brainUAGCAGCACGUAAAUAUUGGCG
hsa-miR-15bbrainUAGCAGCACAUCAUGGUUUACA
hsa-miR-195SZUAGCAGCACAGAAAUAUUGGC
hsa-miR-424CAGCAGCAAUUCAUGUUUUGAA
hsa-miR-497CAGCAGCACACUGUGGUUUGU
miR-203.17757811Ahsa-miR-203UGAAAUGUUUAGGACCACUAG
miR-2186276341A,m8hsa-miR-218brainUUGUGCUUGAUCUAACCAUGU
miR-299659711Ahsa-miR-29aSZUAGCACCAUCUGAAAUCGGUU
hsa-miR-29bSZUAGCACCAUUUGAAAUCAGUGUU
hsa-miR-29cSZUAGCACCAUUUGAAAUCGGU
miR-3203642m8hsa-miR-320AAAAGCUGGGUUGAGAGGGCGAA
miR-330281287m8hsa-miR-330brainGCAAAGCACACGGCCUGCAGAGA
miR-3651431491Ahsa-miR-365UAAUGCCCCUAAAAAUCCUUAU
miR-539410m8hsa-miR-539GGAGAAAUUAUCCUUGGUGUGU
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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