Gene Page: NXF3
Summary ?
| GeneID | 56000 |
| Symbol | NXF3 |
| Synonyms | - |
| Description | nuclear RNA export factor 3 |
| Reference | MIM:300316|HGNC:HGNC:8073|Ensembl:ENSG00000147206|HPRD:02261|Vega:OTTHUMG00000022088 |
| Gene type | protein-coding |
| Map location | Xq22 |
| Fetal beta | 0.023 |
| Support | CompositeSet |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| DNM:Fromer_2014 | Whole Exome Sequencing analysis | This study reported a WES study of 623 schizophrenia trios, reporting DNMs using genomic DNA. |
Section I. Genetics and epigenetics annotation
DNM table
| Gene | Chromosome | Position | Ref | Alt | Transcript | AA change | Mutation type | Sift | CG46 | Trait | Study |
|---|---|---|---|---|---|---|---|---|---|---|---|
| NXF3 | chrX | 102337238 | A | G | NM_022052 | p.279C>R | missense | Schizophrenia | DNM:Fromer_2014 |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| BOLA1 | 0.81 | 0.77 |
| THAP7 | 0.80 | 0.81 |
| C19orf50 | 0.80 | 0.76 |
| COMMD4 | 0.80 | 0.79 |
| GALK1 | 0.79 | 0.78 |
| C17orf81 | 0.77 | 0.72 |
| PEX10 | 0.76 | 0.77 |
| C7orf47 | 0.76 | 0.70 |
| SIVA1 | 0.76 | 0.75 |
| FAM96B | 0.76 | 0.73 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| MT-ATP8 | -0.42 | -0.40 |
| AF347015.8 | -0.40 | -0.35 |
| AF347015.18 | -0.39 | -0.38 |
| AF347015.26 | -0.38 | -0.35 |
| AF347015.27 | -0.38 | -0.36 |
| AF347015.15 | -0.38 | -0.34 |
| MT-CYB | -0.38 | -0.34 |
| AF347015.2 | -0.36 | -0.31 |
| MT-CO2 | -0.36 | -0.31 |
| AF347015.31 | -0.35 | -0.31 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| CASORELLI ACUTE PROMYELOCYTIC LEUKEMIA DN | 663 | 425 | All SZGR 2.0 genes in this pathway |
| WAGSCHAL EHMT2 TARGETS UP | 13 | 7 | All SZGR 2.0 genes in this pathway |
| TORCHIA TARGETS OF EWSR1 FLI1 FUSION UP | 271 | 165 | All SZGR 2.0 genes in this pathway |
| DURAND STROMA S UP | 297 | 194 | All SZGR 2.0 genes in this pathway |