Gene Page: MAP2K6

Summary ?
GeneID5608
SymbolMAP2K6
SynonymsMAPKK6|MEK6|MKK6|PRKMK6|SAPKK-3|SAPKK3
Descriptionmitogen-activated protein kinase kinase 6
ReferenceMIM:601254|HGNC:HGNC:6846|HPRD:03155|
Gene typeprotein-coding
Map location17q24.3
Pascal p-value0.004

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS

Section I. Genetics and epigenetics annotation


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG MAPK SIGNALING PATHWAY 267205All SZGR 2.0 genes in this pathway
KEGG TOLL LIKE RECEPTOR SIGNALING PATHWAY 10288All SZGR 2.0 genes in this pathway
KEGG FC EPSILON RI SIGNALING PATHWAY 7958All SZGR 2.0 genes in this pathway
KEGG GNRH SIGNALING PATHWAY 10177All SZGR 2.0 genes in this pathway
KEGG AMYOTROPHIC LATERAL SCLEROSIS ALS 5343All SZGR 2.0 genes in this pathway
BIOCARTA HDAC PATHWAY 3225All SZGR 2.0 genes in this pathway
BIOCARTA FMLP PATHWAY 3929All SZGR 2.0 genes in this pathway
BIOCARTA HCMV PATHWAY 1716All SZGR 2.0 genes in this pathway
BIOCARTA IL12 PATHWAY 2317All SZGR 2.0 genes in this pathway
BIOCARTA KERATINOCYTE PATHWAY 4638All SZGR 2.0 genes in this pathway
BIOCARTA MAPK PATHWAY 8768All SZGR 2.0 genes in this pathway
BIOCARTA NTHI PATHWAY 2420All SZGR 2.0 genes in this pathway
BIOCARTA P38MAPK PATHWAY 4031All SZGR 2.0 genes in this pathway
BIOCARTA IL1R PATHWAY 3329All SZGR 2.0 genes in this pathway
BIOCARTA STRESS PATHWAY 2518All SZGR 2.0 genes in this pathway
BIOCARTA TOLL PATHWAY 3731All SZGR 2.0 genes in this pathway
ST P38 MAPK PATHWAY 3728All SZGR 2.0 genes in this pathway
PID RHOA PATHWAY 4533All SZGR 2.0 genes in this pathway
PID P38 MKK3 6PATHWAY 2621All SZGR 2.0 genes in this pathway
PID IL12 2PATHWAY 6354All SZGR 2.0 genes in this pathway
PID P38 ALPHA BETA PATHWAY 3125All SZGR 2.0 genes in this pathway
PID CDC42 PATHWAY 7051All SZGR 2.0 genes in this pathway
PID FAS PATHWAY 3829All SZGR 2.0 genes in this pathway
PID IL1 PATHWAY 3428All SZGR 2.0 genes in this pathway
PID AR TF PATHWAY 5338All SZGR 2.0 genes in this pathway
PID IL6 7 PATHWAY 4740All SZGR 2.0 genes in this pathway
PID P38 GAMMA DELTA PATHWAY 119All SZGR 2.0 genes in this pathway
PID CXCR3 PATHWAY 4334All SZGR 2.0 genes in this pathway
PID VEGFR1 2 PATHWAY 6957All SZGR 2.0 genes in this pathway
PID ANTHRAX PATHWAY 1715All SZGR 2.0 genes in this pathway
PID MAPK TRK PATHWAY 3431All SZGR 2.0 genes in this pathway
PID RAC1 PATHWAY 5437All SZGR 2.0 genes in this pathway
REACTOME DEVELOPMENTAL BIOLOGY 396292All SZGR 2.0 genes in this pathway
REACTOME TRIF MEDIATED TLR3 SIGNALING 7454All SZGR 2.0 genes in this pathway
REACTOME MYOGENESIS 2820All SZGR 2.0 genes in this pathway
REACTOME MAP KINASE ACTIVATION IN TLR CASCADE 5037All SZGR 2.0 genes in this pathway
REACTOME ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION 1812All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY ILS 10786All SZGR 2.0 genes in this pathway
REACTOME IL1 SIGNALING 3930All SZGR 2.0 genes in this pathway
REACTOME TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION 7757All SZGR 2.0 genes in this pathway
REACTOME NFKB AND MAP KINASES ACTIVATION MEDIATED BY TLR4 SIGNALING REPERTOIRE 7253All SZGR 2.0 genes in this pathway
REACTOME MYD88 MAL CASCADE INITIATED ON PLASMA MEMBRANE 8363All SZGR 2.0 genes in this pathway
REACTOME INNATE IMMUNE SYSTEM 279178All SZGR 2.0 genes in this pathway
REACTOME ACTIVATED TLR4 SIGNALLING 9369All SZGR 2.0 genes in this pathway
REACTOME IMMUNE SYSTEM 933616All SZGR 2.0 genes in this pathway
REACTOME TOLL RECEPTOR CASCADES 11884All SZGR 2.0 genes in this pathway
REACTOME NOD1 2 SIGNALING PATHWAY 3022All SZGR 2.0 genes in this pathway
REACTOME CYTOKINE SIGNALING IN IMMUNE SYSTEM 270204All SZGR 2.0 genes in this pathway
REACTOME NUCLEOTIDE BINDING DOMAIN LEUCINE RICH REPEAT CONTAINING RECEPTOR NLR SIGNALING PATHWAYS 4633All SZGR 2.0 genes in this pathway
PARENT MTOR SIGNALING UP 567375All SZGR 2.0 genes in this pathway
LIU PROSTATE CANCER UP 9657All SZGR 2.0 genes in this pathway
ZHONG RESPONSE TO AZACITIDINE AND TSA DN 7038All SZGR 2.0 genes in this pathway
FULCHER INFLAMMATORY RESPONSE LECTIN VS LPS UP 579346All SZGR 2.0 genes in this pathway
CONCANNON APOPTOSIS BY EPOXOMICIN DN 172112All SZGR 2.0 genes in this pathway
FARMER BREAST CANCER APOCRINE VS LUMINAL 326213All SZGR 2.0 genes in this pathway
WEINMANN ADAPTATION TO HYPOXIA UP 2924All SZGR 2.0 genes in this pathway
HUI MAPK14 TARGETS UP 2111All SZGR 2.0 genes in this pathway
PUJANA BRCA2 PCC NETWORK 423265All SZGR 2.0 genes in this pathway
NUYTTEN EZH2 TARGETS DN 1024594All SZGR 2.0 genes in this pathway
WEI MYCN TARGETS WITH E BOX 795478All SZGR 2.0 genes in this pathway
RICKMAN TUMOR DIFFERENTIATED WELL VS POORLY UP 236139All SZGR 2.0 genes in this pathway
RICKMAN TUMOR DIFFERENTIATED WELL VS MODERATELY UP 10969All SZGR 2.0 genes in this pathway
BENPORATH CYCLING GENES 648385All SZGR 2.0 genes in this pathway
LEE TARGETS OF PTCH1 AND SUFU UP 5337All SZGR 2.0 genes in this pathway
NIKOLSKY BREAST CANCER 17Q21 Q25 AMPLICON 335181All SZGR 2.0 genes in this pathway
BYSTRYKH HEMATOPOIESIS STEM CELL FGF3 87All SZGR 2.0 genes in this pathway
NATSUME RESPONSE TO INTERFERON BETA UP 7149All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 16HR DN 8662All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 48HR DN 504323All SZGR 2.0 genes in this pathway
JIANG HYPOXIA NORMAL 311205All SZGR 2.0 genes in this pathway
BACOLOD RESISTANCE TO ALKYLATING AGENTS DN 6045All SZGR 2.0 genes in this pathway
LEIN OLIGODENDROCYTE MARKERS 7453All SZGR 2.0 genes in this pathway
MARSON BOUND BY FOXP3 STIMULATED 1022619All SZGR 2.0 genes in this pathway
MARSON BOUND BY FOXP3 UNSTIMULATED 1229713All SZGR 2.0 genes in this pathway
MARZEC IL2 SIGNALING DN 3624All SZGR 2.0 genes in this pathway
FIRESTEIN PROLIFERATION 175125All SZGR 2.0 genes in this pathway
YOSHIMURA MAPK8 TARGETS DN 366257All SZGR 2.0 genes in this pathway
WHITFIELD CELL CYCLE G1 S 14776All SZGR 2.0 genes in this pathway
ZWANG TRANSIENTLY UP BY 1ST EGF PULSE ONLY 1839928All SZGR 2.0 genes in this pathway