Gene Page: DNAJC3

Summary ?
GeneID5611
SymbolDNAJC3
SynonymsACPHD|ERdj6|HP58|P58|P58IPK|PRKRI
DescriptionDnaJ heat shock protein family (Hsp40) member C3
ReferenceMIM:601184|HGNC:HGNC:9439|Ensembl:ENSG00000102580|HPRD:03114|Vega:OTTHUMG00000017227
Gene typeprotein-coding
Map location13q32.1
Pascal p-value0.002
eGenePutamen basal ganglia

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS

Section I. Genetics and epigenetics annotation

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs47739301396529725DNAJC3ENSG00000102580.101.129E-60200332gtex_brain_putamen_basal
rs73330451396539336DNAJC3ENSG00000102580.109.419E-70209943gtex_brain_putamen_basal
rs23895311396550875DNAJC3ENSG00000102580.109.419E-70221482gtex_brain_putamen_basal
rs95619791396563586DNAJC3ENSG00000102580.102.434E-60234193gtex_brain_putamen_basal
rs751996221396564521DNAJC3ENSG00000102580.109.43E-70235128gtex_brain_putamen_basal
rs95250811396570207DNAJC3ENSG00000102580.109.676E-70240814gtex_brain_putamen_basal
rs19809421396576524DNAJC3ENSG00000102580.109.419E-70247131gtex_brain_putamen_basal
rs95250851396578933DNAJC3ENSG00000102580.102.527E-60249540gtex_brain_putamen_basal
rs95250861396579462DNAJC3ENSG00000102580.109.419E-70250069gtex_brain_putamen_basal
rs79928241396580858DNAJC3ENSG00000102580.102.31E-60251465gtex_brain_putamen_basal
rs95166261396586106DNAJC3ENSG00000102580.109.38E-70256713gtex_brain_putamen_basal
rs95250931396589076DNAJC3ENSG00000102580.104.283E-60259683gtex_brain_putamen_basal
rs64928261396595887DNAJC3ENSG00000102580.104.283E-60266494gtex_brain_putamen_basal
rs2003231391396598008DNAJC3ENSG00000102580.104.326E-60268615gtex_brain_putamen_basal
rs347568631396598009DNAJC3ENSG00000102580.104.283E-60268616gtex_brain_putamen_basal
rs95250951396600508DNAJC3ENSG00000102580.109.981E-70271115gtex_brain_putamen_basal
rs95250981396605062DNAJC3ENSG00000102580.104.283E-60275669gtex_brain_putamen_basal
rs19960541396607542DNAJC3ENSG00000102580.109.519E-70278149gtex_brain_putamen_basal
rs8161391396622673DNAJC3ENSG00000102580.105.014E-70293280gtex_brain_putamen_basal
rs27741131396630320DNAJC3ENSG00000102580.101.936E-60300927gtex_brain_putamen_basal
rs5668941396630347DNAJC3ENSG00000102580.104.272E-60300954gtex_brain_putamen_basal
rs8161431396636784DNAJC3ENSG00000102580.109.086E-70307391gtex_brain_putamen_basal
rs5212351396647957DNAJC3ENSG00000102580.108.339E-70318564gtex_brain_putamen_basal
rs4727881396658855DNAJC3ENSG00000102580.108.021E-70329462gtex_brain_putamen_basal
rs5907581396668927DNAJC3ENSG00000102580.104.234E-70339534gtex_brain_putamen_basal
rs5418111396672110DNAJC3ENSG00000102580.108.36E-70342717gtex_brain_putamen_basal
rs5514571396674796DNAJC3ENSG00000102580.108.36E-70345403gtex_brain_putamen_basal
rs4739301396676124DNAJC3ENSG00000102580.108.36E-70346731gtex_brain_putamen_basal
rs5440801396676209DNAJC3ENSG00000102580.108.36E-70346816gtex_brain_putamen_basal
rs5525981396698990DNAJC3ENSG00000102580.108.225E-70369597gtex_brain_putamen_basal
rs677661341396705833DNAJC3ENSG00000102580.107.273E-80376440gtex_brain_putamen_basal
rs5619961396706931DNAJC3ENSG00000102580.108.36E-70377538gtex_brain_putamen_basal
rs5396041396708108DNAJC3ENSG00000102580.108.323E-70378715gtex_brain_putamen_basal
rs4931091396709060DNAJC3ENSG00000102580.105.775E-70379667gtex_brain_putamen_basal
rs5171731396717364DNAJC3ENSG00000102580.102.564E-60387971gtex_brain_putamen_basal
rs5922051396719114DNAJC3ENSG00000102580.102.564E-60389721gtex_brain_putamen_basal
rs5323991396720476DNAJC3ENSG00000102580.102.564E-60391083gtex_brain_putamen_basal
rs5064741396722785DNAJC3ENSG00000102580.102.564E-60393392gtex_brain_putamen_basal
rs5366061396723774DNAJC3ENSG00000102580.102.564E-60394381gtex_brain_putamen_basal
rs5310901396724006DNAJC3ENSG00000102580.102.564E-60394613gtex_brain_putamen_basal
rs5293061396724189DNAJC3ENSG00000102580.102.563E-60394796gtex_brain_putamen_basal
rs5276801396746789DNAJC3ENSG00000102580.102.564E-60417396gtex_brain_putamen_basal
rs28494381396768287DNAJC3ENSG00000102580.101.207E-60438894gtex_brain_putamen_basal
rs5428341396792150DNAJC3ENSG00000102580.102.684E-60462757gtex_brain_putamen_basal

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005488bindingIEA-
GO:0004860protein kinase inhibitor activityTAS7511204 
GO:0031072heat shock protein bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006986response to unfolded proteinIEA-
GO:0009615response to virusIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005737cytoplasmTAS8666242 
GO:0005783endoplasmic reticulumIEA-

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
BIOCARTA RNA PATHWAY 109All SZGR 2.0 genes in this pathway
REACTOME DIABETES PATHWAYS 13391All SZGR 2.0 genes in this pathway
REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S 4634All SZGR 2.0 genes in this pathway
REACTOME UNFOLDED PROTEIN RESPONSE 8051All SZGR 2.0 genes in this pathway
REACTOME INFLUENZA LIFE CYCLE 20372All SZGR 2.0 genes in this pathway
REACTOME INFLUENZA VIRAL RNA TRANSCRIPTION AND REPLICATION 16947All SZGR 2.0 genes in this pathway
PARENT MTOR SIGNALING UP 567375All SZGR 2.0 genes in this pathway
SENGUPTA NASOPHARYNGEAL CARCINOMA WITH LMP1 UP 408247All SZGR 2.0 genes in this pathway
BASAKI YBX1 TARGETS DN 384230All SZGR 2.0 genes in this pathway
TAKEDA TARGETS OF NUP98 HOXA9 FUSION 8D DN 205127All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY SERUM DEPRIVATION UP 552347All SZGR 2.0 genes in this pathway
GAUSSMANN MLL AF4 FUSION TARGETS C UP 170114All SZGR 2.0 genes in this pathway
HAMAI APOPTOSIS VIA TRAIL UP 584356All SZGR 2.0 genes in this pathway
LINDGREN BLADDER CANCER CLUSTER 2B 392251All SZGR 2.0 genes in this pathway
NUYTTEN EZH2 TARGETS DN 1024594All SZGR 2.0 genes in this pathway
BENPORATH CYCLING GENES 648385All SZGR 2.0 genes in this pathway
GEORGES TARGETS OF MIR192 AND MIR215 893528All SZGR 2.0 genes in this pathway
ZHANG RESPONSE TO IKK INHIBITOR AND TNF UP 223140All SZGR 2.0 genes in this pathway
KUMAR TARGETS OF MLL AF9 FUSION 405264All SZGR 2.0 genes in this pathway
BURTON ADIPOGENESIS 12 3618All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 10HR UP 10169All SZGR 2.0 genes in this pathway
MONNIER POSTRADIATION TUMOR ESCAPE DN 373196All SZGR 2.0 genes in this pathway
CREIGHTON ENDOCRINE THERAPY RESISTANCE 3 720440All SZGR 2.0 genes in this pathway
LEIN CEREBELLUM MARKERS 8547All SZGR 2.0 genes in this pathway
MARTINEZ RB1 TARGETS UP 673430All SZGR 2.0 genes in this pathway
MARTINEZ TP53 TARGETS DN 593372All SZGR 2.0 genes in this pathway
MARTINEZ RB1 AND TP53 TARGETS DN 591366All SZGR 2.0 genes in this pathway
FUJII YBX1 TARGETS DN 202132All SZGR 2.0 genes in this pathway
ACEVEDO METHYLATED IN LIVER CANCER DN 940425All SZGR 2.0 genes in this pathway
CUI GLUCOSE DEPRIVATION 6044All SZGR 2.0 genes in this pathway
CHANDRAN METASTASIS UP 221135All SZGR 2.0 genes in this pathway
YAO TEMPORAL RESPONSE TO PROGESTERONE CLUSTER 8 4936All SZGR 2.0 genes in this pathway
WHITFIELD CELL CYCLE G1 S 14776All SZGR 2.0 genes in this pathway
STAMBOLSKY TARGETS OF MUTATED TP53 UP 4935All SZGR 2.0 genes in this pathway
STAMBOLSKY RESPONSE TO VITAMIN D3 UP 8448All SZGR 2.0 genes in this pathway
PILON KLF1 TARGETS DN 19721213All SZGR 2.0 genes in this pathway
JOHNSTONE PARVB TARGETS 3 DN 918550All SZGR 2.0 genes in this pathway
LEE BMP2 TARGETS DN 882538All SZGR 2.0 genes in this pathway
PHONG TNF RESPONSE NOT VIA P38 337236All SZGR 2.0 genes in this pathway