Summary ?
DescriptionPROP paired-like homeobox 1
Gene typeprotein-coding
Map location5q35.3
Pascal p-value0.277
DMG1 (# studies)

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
DMG:Wockner_2014Genome-wide DNA methylation analysisThis dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 1
GSMA_IIAGenome scan meta-analysis (All samples)Psr: 0.0276 
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 1 

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

ProbeChromosomePositionNearest geneP (dis)Beta (dis)FDR (dis)Study

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression of temporal and spatial changes (BrainSpan)

SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions

Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0003682chromatin bindingIEA-
GO:0003700transcription factor activityIEA-
GO:0003702RNA polymerase II transcription factor activityTAS9462743 
GO:0008022protein C-terminus bindingIEA-
GO:0008013beta-catenin bindingIEA-
GO:0043565sequence-specific DNA bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007417central nervous system developmentTASBrain (GO term level: 6)9462743 
GO:0000122negative regulation of transcription from RNA polymerase II promoterIEA-
GO:0001568blood vessel developmentIEA-
GO:0006355regulation of transcription, DNA-dependentIEA-
GO:0009953dorsal/ventral pattern formationIEA-
GO:0009887organ morphogenesisIEA-
GO:0043066negative regulation of apoptosisIEA-
GO:0021979hypothalamus cell differentiationIEA-
GO:0048732gland developmentIEA-
GO:0045944positive regulation of transcription from RNA polymerase II promoterIEA-
GO:0048850hypophysis morphogenesisIEA-
GO:0060126somatotropin secreting cell differentiationIEA-
GO:0060070Wnt receptor signaling pathway through beta-cateninIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005667transcription factor complexIEA-

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
HATADA METHYLATED IN LUNG CANCER UP 390236All SZGR 2.0 genes in this pathway
PUJANA BRCA1 PCC NETWORK 16521023All SZGR 2.0 genes in this pathway
PUJANA ATM PCC NETWORK 1442892All SZGR 2.0 genes in this pathway
NUYTTEN EZH2 TARGETS UP 1037673All SZGR 2.0 genes in this pathway
SHEN SMARCA2 TARGETS DN 357212All SZGR 2.0 genes in this pathway
MATZUK CENTRAL FOR FEMALE FERTILITY 2925All SZGR 2.0 genes in this pathway