Gene Page: PROP1
Summary ?
| GeneID | 5626 |
| Symbol | PROP1 |
| Synonyms | CPHD2|PROP-1 |
| Description | PROP paired-like homeobox 1 |
| Reference | MIM:601538|HGNC:HGNC:9455|Ensembl:ENSG00000175325|HPRD:03325|Vega:OTTHUMG00000130887 |
| Gene type | protein-coding |
| Map location | 5q35.3 |
| Pascal p-value | 0.277 |
| DMG | 1 (# studies) |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| DMG:Wockner_2014 | Genome-wide DNA methylation analysis | This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). | 1 |
| GSMA_IIA | Genome scan meta-analysis (All samples) | Psr: 0.0276 | |
| GO_Annotation | Mapping neuro-related keywords to Gene Ontology annotations | Hits with neuro-related keywords: 1 |
Section I. Genetics and epigenetics annotation
Differentially methylated gene
| Probe | Chromosome | Position | Nearest gene | P (dis) | Beta (dis) | FDR (dis) | Study |
|---|---|---|---|---|---|---|---|
| cg26532621 | 5 | 177423340 | PROP1 | 4E-6 | -0.522 | 0.009 | DMG:Wockner_2014 |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
No co-expressed genes in brain regions
Section III. Gene Ontology annotation
| Molecular function | GO term | Evidence | Neuro keywords | PubMed ID |
|---|---|---|---|---|
| GO:0003682 | chromatin binding | IEA | - | |
| GO:0003700 | transcription factor activity | IEA | - | |
| GO:0003702 | RNA polymerase II transcription factor activity | TAS | 9462743 | |
| GO:0008022 | protein C-terminus binding | IEA | - | |
| GO:0008013 | beta-catenin binding | IEA | - | |
| GO:0043565 | sequence-specific DNA binding | IEA | - | |
| Biological process | GO term | Evidence | Neuro keywords | PubMed ID |
| GO:0007417 | central nervous system development | TAS | Brain (GO term level: 6) | 9462743 |
| GO:0000122 | negative regulation of transcription from RNA polymerase II promoter | IEA | - | |
| GO:0001568 | blood vessel development | IEA | - | |
| GO:0006355 | regulation of transcription, DNA-dependent | IEA | - | |
| GO:0009953 | dorsal/ventral pattern formation | IEA | - | |
| GO:0009887 | organ morphogenesis | IEA | - | |
| GO:0043066 | negative regulation of apoptosis | IEA | - | |
| GO:0021979 | hypothalamus cell differentiation | IEA | - | |
| GO:0048732 | gland development | IEA | - | |
| GO:0045944 | positive regulation of transcription from RNA polymerase II promoter | IEA | - | |
| GO:0048850 | hypophysis morphogenesis | IEA | - | |
| GO:0060126 | somatotropin secreting cell differentiation | IEA | - | |
| GO:0060070 | Wnt receptor signaling pathway through beta-catenin | IEA | - | |
| Cellular component | GO term | Evidence | Neuro keywords | PubMed ID |
| GO:0005634 | nucleus | IEA | - | |
| GO:0005667 | transcription factor complex | IEA | - |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| HATADA METHYLATED IN LUNG CANCER UP | 390 | 236 | All SZGR 2.0 genes in this pathway |
| PUJANA BRCA1 PCC NETWORK | 1652 | 1023 | All SZGR 2.0 genes in this pathway |
| PUJANA ATM PCC NETWORK | 1442 | 892 | All SZGR 2.0 genes in this pathway |
| NUYTTEN EZH2 TARGETS UP | 1037 | 673 | All SZGR 2.0 genes in this pathway |
| SHEN SMARCA2 TARGETS DN | 357 | 212 | All SZGR 2.0 genes in this pathway |
| MATZUK CENTRAL FOR FEMALE FERTILITY | 29 | 25 | All SZGR 2.0 genes in this pathway |