Gene Page: PARD3

Summary ?
GeneID56288
SymbolPARD3
SynonymsASIP|Baz|PAR3|PAR3alpha|PARD-3|PARD3A|PPP1R118|SE2-5L16|SE2-5LT1|SE2-5T2
Descriptionpar-3 family cell polarity regulator
ReferenceMIM:606745|HGNC:HGNC:16051|Ensembl:ENSG00000148498|HPRD:05994|Vega:OTTHUMG00000017948
Gene typeprotein-coding
Map location10p11.21
Pascal p-value0.376
Fetal beta0.167
SupportAscano FMRP targets

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:GWAScatGenome-wide Association StudiesThis data set includes 560 SNPs associated with schizophrenia. A total of 486 genes were mapped to these SNPs within 50kb.
CV:GWASdbGenome-wide Association StudiesGWASdb records for schizophrenia
CV:PGCnpGenome-wide Association StudyGWAS
PMID:cooccurHigh-throughput literature-searchSystematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
ExpressionMeta-analysis of gene expressionP value: 1.991 
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: schizophrenia,schizophrenic,schizophreniasClick to show details
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 3 

Section I. Genetics and epigenetics annotation


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005515protein bindingISS-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007409axonogenesisTASneuron, axon, neurite (GO term level: 12)14676191 
GO:0007205activation of protein kinase C activityTAS11260256 
GO:0006461protein complex assemblyTAS10934474 
GO:0007163establishment or maintenance of cell polarityTAS14676191 
GO:0008356asymmetric cell divisionTAS10934474 
GO:0007049cell cycleIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005923tight junctionIDABrain (GO term level: 10)14676191 
GO:0005923tight junctionISSBrain (GO term level: 10)-
GO:0012505endomembrane systemIEA-
GO:0005819spindleIEA-
GO:0005737cytoplasmIEA-
GO:0005938cell cortexIEA-
GO:0005913cell-cell adherens junctionIEA-
GO:0005886plasma membraneIEA-
GO:0030054cell junctionIEA-

Section IV. Protein-protein interaction annotation

InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
CDC42CDC42Hs | G25Kcell division cycle 42 (GTP binding protein, 25kDa)-HPRD10934474 
DYNLL1DLC1 | DLC8 | DNCL1 | DNCLC1 | LC8 | LC8a | MGC126137 | MGC126138 | PIN | hdlc1dynein, light chain, LC8-type 1-HPRD14760703 
ECT2FLJ10461 | MGC138291epithelial cell transforming sequence 2 oncogeneAffinity Capture-WesternBioGRID15254234 
F11RCD321 | JAM | JAM-1 | JAM-A | JAM1 | JAMA | JCAM | KAT | PAM-1F11 receptor-HPRD11447115 
F11RCD321 | JAM | JAM-1 | JAM-A | JAM1 | JAMA | JCAM | KAT | PAM-1F11 receptorReconstituted ComplexBioGRID12953056 
JAM2C21orf43 | CD322 | JAM-B | JAMB | PRO245 | VE-JAM | VEJAMjunctional adhesion molecule 2Affinity Capture-Western
Reconstituted Complex		BioGRID12953056 
JAM3FLJ14529 | JAM-C | JAMCjunctional adhesion molecule 3Affinity Capture-Western
Reconstituted Complex		BioGRID12953056 
PARD6APAR-6A | PAR6 | PAR6C | PAR6alpha | TAX40 | TIP-40par-6 partitioning defective 6 homolog alpha (C. elegans)Affinity Capture-WesternBioGRID12459187 
PARD6BPAR6Bpar-6 partitioning defective 6 homolog beta (C. elegans)Affinity Capture-WesternBioGRID12459187 
PARD6GFLJ45701 | PAR-6G | PAR6gammapar-6 partitioning defective 6 homolog gamma (C. elegans)Affinity Capture-WesternBioGRID12459187 
PLCB1FLJ45792 | PI-PLC | PLC-154 | PLC-I | PLC154phospholipase C, beta 1 (phosphoinositide-specific)PLCB1 (PLC-beta-1) interacts with PARD3 (Par3). This interaction was modeled on a demonstrated interaction between rat PLCB1 and human Par3.BIND15782111 
PLCB3FLJ37084phospholipase C, beta 3 (phosphatidylinositol-specific)PLCB3 (PLC-beta-3) interacts with PARD3 (Par3).BIND15782111 
PRKCIDXS1179E | MGC26534 | PKCI | nPKC-iotaprotein kinase C, iotaAffinity Capture-Western
Reconstituted Complex		BioGRID12459187 
PRKCZPKC-ZETA | PKC2protein kinase C, zetaAffinity Capture-WesternBioGRID12459187 
PVRL3CD113 | CDw113 | DKFZp566B0846 | FLJ90624 | PPR3 | PRR3 | PVRR3 | nectin-3poliovirus receptor-related 3Affinity Capture-Western
Reconstituted Complex		BioGRID12515806 
SFNYWHASstratifinAffinity Capture-MSBioGRID15778465 
SMAD2JV18 | JV18-1 | MADH2 | MADR2 | MGC22139 | MGC34440 | hMAD-2 | hSMAD2SMAD family member 2-HPRD12650946 
SMAD7CRCS3 | FLJ16482 | MADH7 | MADH8SMAD family member 7-HPRD12650946 
YWHABGW128 | HS1 | KCIP-1tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptideAffinity Capture-MSBioGRID17353931 
YWHAG14-3-3GAMMAtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptideAffinity Capture-MSBioGRID17353931 


Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG CHEMOKINE SIGNALING PATHWAY 190128All SZGR 2.0 genes in this pathway
KEGG NEUROACTIVE LIGAND RECEPTOR INTERACTION 272195All SZGR 2.0 genes in this pathway
KEGG ENDOCYTOSIS 183132All SZGR 2.0 genes in this pathway
KEGG ADHERENS JUNCTION 7553All SZGR 2.0 genes in this pathway
KEGG TIGHT JUNCTION 13486All SZGR 2.0 genes in this pathway
SIG PIP3 SIGNALING IN CARDIAC MYOCTES 6754All SZGR 2.0 genes in this pathway
SIG INSULIN RECEPTOR PATHWAY IN CARDIAC MYOCYTES 5141All SZGR 2.0 genes in this pathway
REACTOME CELL CELL COMMUNICATION 12077All SZGR 2.0 genes in this pathway
REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION 167All SZGR 2.0 genes in this pathway
REACTOME CELL CELL JUNCTION ORGANIZATION 5631All SZGR 2.0 genes in this pathway
REACTOME TIGHT JUNCTION INTERACTIONS 2911All SZGR 2.0 genes in this pathway
REACTOME CELL JUNCTION ORGANIZATION 7843All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY TGF BETA RECEPTOR COMPLEX 6342All SZGR 2.0 genes in this pathway
SENESE HDAC3 TARGETS DN 536332All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY DOXORUBICIN DN 17811082All SZGR 2.0 genes in this pathway
MIDORIKAWA AMPLIFIED IN LIVER CANCER 5538All SZGR 2.0 genes in this pathway
HERNANDEZ ABERRANT MITOSIS BY DOCETACEL 2NM DN 2518All SZGR 2.0 genes in this pathway
DACOSTA UV RESPONSE VIA ERCC3 DN 855609All SZGR 2.0 genes in this pathway
DACOSTA UV RESPONSE VIA ERCC3 COMMON DN 483336All SZGR 2.0 genes in this pathway
LOCKWOOD AMPLIFIED IN LUNG CANCER 214139All SZGR 2.0 genes in this pathway
BENPORATH OCT4 TARGETS 290172All SZGR 2.0 genes in this pathway
BENPORATH SUZ12 TARGETS 1038678All SZGR 2.0 genes in this pathway
BENPORATH EED TARGETS 1062725All SZGR 2.0 genes in this pathway
FLECHNER BIOPSY KIDNEY TRANSPLANT REJECTED VS OK DN 546351All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE UP 16911088All SZGR 2.0 genes in this pathway
HEDENFALK BREAST CANCER BRCA1 VS BRCA2 163113All SZGR 2.0 genes in this pathway
BAELDE DIABETIC NEPHROPATHY DN 434302All SZGR 2.0 genes in this pathway
MCCOLLUM GELDANAMYCIN RESISTANCE DN 76All SZGR 2.0 genes in this pathway
AMBROSINI FLAVOPIRIDOL TREATMENT TP53 10963All SZGR 2.0 genes in this pathway
WANG RECURRENT LIVER CANCER UP 2013All SZGR 2.0 genes in this pathway
RAO BOUND BY SALL4 ISOFORM B 517302All SZGR 2.0 genes in this pathway