Gene Page: KLK6

Summary ?
GeneID5653
SymbolKLK6
SynonymsBssp|Klk7|PRSS18|PRSS9|SP59|hK6
Descriptionkallikrein related peptidase 6
ReferenceMIM:602652|HGNC:HGNC:6367|Ensembl:ENSG00000167755|HPRD:04037|Vega:OTTHUMG00000183098
Gene typeprotein-coding
Map location19q13.3
Pascal p-value0.068
Fetal beta-2.177
eGeneMyers' cis & trans

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
PMID:cooccurHigh-throughput literature-searchSystematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: schizophrenia,schizophreniasClick to show details
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 4 

Section I. Genetics and epigenetics annotation

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs6829546chr412587664KLK656530.19trans
rs6448932chr412595798KLK656530.11trans
rs7830259chr814087643KLK656530.02trans
rs8099473chr1856200121KLK656530.05trans
rs8099488chr1856200149KLK656530.17trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
PSMA30.910.89
SARNP0.900.91
C4orf270.900.90
CWC150.890.89
SSBP10.880.89
SRP190.870.87
UTP11L0.870.86
SIP10.870.85
LSM30.860.87
EAPP0.860.88
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
AF347015.2-0.69-0.68
AF347015.15-0.68-0.66
AF347015.26-0.68-0.68
AF347015.33-0.66-0.64
MT-CYB-0.66-0.64
AF347015.8-0.66-0.62
MT-CO2-0.65-0.60
AF347015.27-0.64-0.62
FAM38A-0.64-0.67
AF347015.9-0.63-0.64

Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0004252serine-type endopeptidase activityIEAglutamate (GO term level: 7)-
GO:0004252serine-type endopeptidase activityNASglutamate (GO term level: 7)12878203 
GO:0003824catalytic activityIEA-
GO:0005515protein bindingIPI12709365 |12878203 
GO:0008233peptidase activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007417central nervous system developmentNASBrain (GO term level: 6)12589961 
GO:0042552myelinationNASneuron, axon, Brain, oligodendrocyte (GO term level: 13)11668196 
GO:0006508proteolysisIEA-
GO:0009611response to woundingNAS12016211 
GO:0042982amyloid precursor protein metabolic processNAS12709365 
GO:0042246tissue regenerationNAS12878203 
GO:0016540protein autoprocessingNAS12878203 
GO:0042445hormone metabolic processNAS11668196 
GO:0030574collagen catabolic processNAS12878203 
GO:0045595regulation of cell differentiationNAS11668196 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005792microsomeIEA-
GO:0005576extracellular regionIDA11668196 
GO:0005634nucleusIEA-
GO:0005737cytoplasmIDA11668196 
GO:0005739mitochondrionIEA-
GO:0005783endoplasmic reticulumIEA-

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
PID ALPHA SYNUCLEIN PATHWAY 3325All SZGR 2.0 genes in this pathway
CHARAFE BREAST CANCER BASAL VS MESENCHYMAL UP 12145All SZGR 2.0 genes in this pathway
GAL LEUKEMIC STEM CELL DN 244153All SZGR 2.0 genes in this pathway
RODRIGUES NTN1 TARGETS DN 158102All SZGR 2.0 genes in this pathway
VECCHI GASTRIC CANCER EARLY UP 430232All SZGR 2.0 genes in this pathway
PROVENZANI METASTASIS DN 13694All SZGR 2.0 genes in this pathway
COLDREN GEFITINIB RESISTANCE DN 230115All SZGR 2.0 genes in this pathway
DELYS THYROID CANCER UP 443294All SZGR 2.0 genes in this pathway
WANG BARRETTS ESOPHAGUS DN 2513All SZGR 2.0 genes in this pathway
HAMAI APOPTOSIS VIA TRAIL DN 186107All SZGR 2.0 genes in this pathway
DARWICHE SKIN TUMOR PROMOTER DN 185115All SZGR 2.0 genes in this pathway
DARWICHE PAPILLOMA RISK LOW UP 162104All SZGR 2.0 genes in this pathway
DARWICHE PAPILLOMA RISK HIGH UP 147101All SZGR 2.0 genes in this pathway
DARWICHE SQUAMOUS CELL CARCINOMA UP 146104All SZGR 2.0 genes in this pathway
RICKMAN HEAD AND NECK CANCER C 11347All SZGR 2.0 genes in this pathway
LIN SILENCED BY TUMOR MICROENVIRONMENT 10873All SZGR 2.0 genes in this pathway
ASTON MAJOR DEPRESSIVE DISORDER DN 160110All SZGR 2.0 genes in this pathway
CHANG IMMORTALIZED BY HPV31 DN 6545All SZGR 2.0 genes in this pathway
KAYO AGING MUSCLE DN 12376All SZGR 2.0 genes in this pathway
BAELDE DIABETIC NEPHROPATHY DN 434302All SZGR 2.0 genes in this pathway
YAMASHITA METHYLATED IN PROSTATE CANCER 5729All SZGR 2.0 genes in this pathway
ENGELMANN CANCER PROGENITORS DN 7044All SZGR 2.0 genes in this pathway
SMID BREAST CANCER RELAPSE IN BONE DN 315197All SZGR 2.0 genes in this pathway
SMID BREAST CANCER RELAPSE IN LUNG UP 2110All SZGR 2.0 genes in this pathway
SMID BREAST CANCER LUMINAL B DN 564326All SZGR 2.0 genes in this pathway
SMID BREAST CANCER BASAL UP 648398All SZGR 2.0 genes in this pathway
HUPER BREAST BASAL VS LUMINAL DN 5944All SZGR 2.0 genes in this pathway
HINATA NFKB TARGETS KERATINOCYTE DN 2315All SZGR 2.0 genes in this pathway
SHEDDEN LUNG CANCER GOOD SURVIVAL A12 317177All SZGR 2.0 genes in this pathway
MARTENS TRETINOIN RESPONSE UP 857456All SZGR 2.0 genes in this pathway
STAMBOLSKY RESPONSE TO VITAMIN D3 UP 8448All SZGR 2.0 genes in this pathway
KIM ALL DISORDERS OLIGODENDROCYTE NUMBER CORR UP 756494All SZGR 2.0 genes in this pathway
KIM ALL DISORDERS DURATION CORR DN 14690All SZGR 2.0 genes in this pathway
FEVR CTNNB1 TARGETS UP 682433All SZGR 2.0 genes in this pathway
ZWANG CLASS 3 TRANSIENTLY INDUCED BY EGF 222159All SZGR 2.0 genes in this pathway