SZGR2

Summary ?

GeneID	567
Symbol	B2M
Synonyms	IMD43
Description	beta-2-microglobulin
Reference	MIM:109700\|HGNC:HGNC:914\|Ensembl:ENSG00000166710\|HPRD:00189\|
Gene type	protein-coding
Map location	15q21.1
Pascal p-value	0.201
Sherlock p-value	0.748
Fetal beta	-2.352
eGene	Myers' cis & trans

Gene in Data Sources

Gene set name	Method of gene set	Description	Info
CV:PGCnp	Genome-wide Association Study	GWAS
PMID:cooccur	High-throughput literature-search	Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
Literature	High-throughput literature-search	Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenics,schizophrenias	Click to show details

Section I. Genetics and epigenetics annotation

eQTL annotation

SNP ID	Chromosome	Position	eGene	Gene Entrez ID	pvalue	qvalue	TSS distance	eQTL type
rs8104298	chr19	11867512	B2M	567		0.17		trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
EFR3A	0.75	0.71
STEAP2	0.75	0.64
ZNF365	0.75	0.73
NSF	0.75	0.74
B4GALT6	0.75	0.73
OXR1	0.75	0.71
SYNJ1	0.74	0.72
GLS	0.74	0.72
HLF	0.74	0.65
GLRB	0.74	0.74

Top 10 negatively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
BCL7C	-0.45	-0.53
SLC38A5	-0.41	-0.46
NME4	-0.39	-0.49
HYAL2	-0.39	-0.39
TBC1D10A	-0.39	-0.32
SIGIRR	-0.38	-0.44
FADS2	-0.38	-0.29
RPLP1	-0.37	-0.41
CDC42EP4	-0.37	-0.35
AC006276.2	-0.37	-0.38

Section IV. Protein-protein interaction annotation

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
A2M	CPAMD5 \| DKFZp779B086 \| FWP007 \| S863-7	alpha-2-macroglobulin	-	HPRD,BioGRID	10731476
BAT3	BAG-6 \| BAG6 \| D6S52E \| G3	HLA-B associated transcript 3	Two-hybrid	BioGRID	16169070
CALR	CRT \| FLJ26680 \| RO \| SSA \| cC1qR	calreticulin	-	HPRD	8769474
CD1A	CD1 \| FCB6 \| HTA1 \| R4 \| T6	CD1a molecule	-	HPRD	12833155
CD1B	CD1 \| CD1A \| MGC125990 \| MGC125991 \| R1	CD1b molecule	-	HPRD	12118248
CD1D	CD1A \| MGC34622 \| R3	CD1d molecule	-	HPRD,BioGRID	10221650 \|11257307
CD1E	CD1A \| R2	CD1e molecule	-	HPRD	10948205
FCGRT	FCRN \| alpha-chain	Fc fragment of IgG, receptor, transporter, alpha	-	HPRD	12006623\|12023961
HFE	HFE1 \| HH \| HLA-H \| MGC103790 \| dJ221C16.10.1	hemochromatosis	-	HPRD	10791995
HLA-A	HLAA	major histocompatibility complex, class I, A	-	HPRD	93026
HLA-B	AS \| HLA-B-7301 \| HLA-B73 \| HLAB \| HLAC \| SPDA1	major histocompatibility complex, class I, B	-	HPRD	2450918
HLA-C	D6S204 \| FLJ27082 \| HLA-Cw \| HLA-Cw12 \| HLA-JY3 \| HLC-C \| PSORS1	major histocompatibility complex, class I, C	-	HPRD	2450918
HLA-E	DKFZp686P19218 \| EA1.2 \| EA2.1 \| HLA-6.2 \| MHC \| QA1	major histocompatibility complex, class I, E	-	HPRD,BioGRID	9605335 \|10064069
HLA-F	CDA12 \| HLA-5.4 \| HLA-CDA12 \| HLAF	major histocompatibility complex, class I, F	-	HPRD	11169396
HLA-G	MHC-G	major histocompatibility complex, class I, G	-	HPRD	9228302
LILRB1	CD85 \| CD85J \| FLJ37515 \| ILT2 \| LIR-1 \| LIR1 \| MIR-7 \| MIR7	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1	-	HPRD	12897781
PRSS23	MGC5107 \| SIG13 \| SPUVE \| ZSIG13	protease, serine, 23	Two-hybrid	BioGRID	16169070

Section V. Pathway annotation

Pathway name	Pathway size	# SZGR 2.0 genes in pathway	Info
KEGG ANTIGEN PROCESSING AND PRESENTATION	89	65	All SZGR 2.0 genes in this pathway
BIOCARTA CTL PATHWAY	15	11	All SZGR 2.0 genes in this pathway
BIOCARTA NKCELLS PATHWAY	20	13	All SZGR 2.0 genes in this pathway
WNT SIGNALING	89	71	All SZGR 2.0 genes in this pathway
PID IL12 2PATHWAY	63	54	All SZGR 2.0 genes in this pathway
PID CD8 TCR PATHWAY	53	42	All SZGR 2.0 genes in this pathway
PID CD8 TCR DOWNSTREAM PATHWAY	65	56	All SZGR 2.0 genes in this pathway
REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION	10	5	All SZGR 2.0 genes in this pathway
REACTOME ANTIGEN PROCESSING CROSS PRESENTATION	76	48	All SZGR 2.0 genes in this pathway
REACTOME ENDOSOMAL VACUOLAR PATHWAY	9	7	All SZGR 2.0 genes in this pathway
REACTOME ER PHAGOSOME PATHWAY	61	40	All SZGR 2.0 genes in this pathway
REACTOME NEF MEDIATES DOWN MODULATION OF CELL SURFACE RECEPTORS BY RECRUITING THEM TO CLATHRIN ADAPTERS	21	12	All SZGR 2.0 genes in this pathway
REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL	70	37	All SZGR 2.0 genes in this pathway
REACTOME INTERFERON GAMMA SIGNALING	63	48	All SZGR 2.0 genes in this pathway
REACTOME INTERFERON SIGNALING	159	116	All SZGR 2.0 genes in this pathway
REACTOME HIV INFECTION	207	122	All SZGR 2.0 genes in this pathway
REACTOME HOST INTERACTIONS OF HIV FACTORS	132	81	All SZGR 2.0 genes in this pathway
REACTOME THE ROLE OF NEF IN HIV1 REPLICATION AND DISEASE PATHOGENESIS	28	19	All SZGR 2.0 genes in this pathway
REACTOME IMMUNE SYSTEM	933	616	All SZGR 2.0 genes in this pathway
REACTOME ADAPTIVE IMMUNE SYSTEM	539	350	All SZGR 2.0 genes in this pathway
REACTOME CYTOKINE SIGNALING IN IMMUNE SYSTEM	270	204	All SZGR 2.0 genes in this pathway
REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC	21	17	All SZGR 2.0 genes in this pathway
REACTOME CLASS I MHC MEDIATED ANTIGEN PROCESSING PRESENTATION	251	156	All SZGR 2.0 genes in this pathway
REACTOME AMYLOIDS	83	63	All SZGR 2.0 genes in this pathway
WATANABE RECTAL CANCER RADIOTHERAPY RESPONSIVE UP	108	67	All SZGR 2.0 genes in this pathway
ONKEN UVEAL MELANOMA UP	783	507	All SZGR 2.0 genes in this pathway
CHARAFE BREAST CANCER LUMINAL VS BASAL DN	455	304	All SZGR 2.0 genes in this pathway
LAIHO COLORECTAL CANCER SERRATED UP	112	71	All SZGR 2.0 genes in this pathway
WANG LMO4 TARGETS DN	352	225	All SZGR 2.0 genes in this pathway
TIEN INTESTINE PROBIOTICS 2HR UP	27	19	All SZGR 2.0 genes in this pathway
TIEN INTESTINE PROBIOTICS 6HR UP	55	34	All SZGR 2.0 genes in this pathway
ENK UV RESPONSE KERATINOCYTE UP	530	342	All SZGR 2.0 genes in this pathway
CASTELLANO NRAS TARGETS UP	68	41	All SZGR 2.0 genes in this pathway
OUELLET OVARIAN CANCER INVASIVE VS LMP UP	117	85	All SZGR 2.0 genes in this pathway
JOHANSSON GLIOMAGENESIS BY PDGFB UP	58	44	All SZGR 2.0 genes in this pathway
LUI THYROID CANCER PAX8 PPARG DN	45	29	All SZGR 2.0 genes in this pathway
IVANOV MUTATED IN COLON CANCER	13	9	All SZGR 2.0 genes in this pathway
HUMMERICH SKIN CANCER PROGRESSION DN	100	64	All SZGR 2.0 genes in this pathway
MATTIOLI MGUS VS PCL	116	62	All SZGR 2.0 genes in this pathway
LUI TARGETS OF PAX8 PPARG FUSION	34	23	All SZGR 2.0 genes in this pathway
SPIELMAN LYMPHOBLAST EUROPEAN VS ASIAN UP	479	299	All SZGR 2.0 genes in this pathway
PUJANA ATM PCC NETWORK	1442	892	All SZGR 2.0 genes in this pathway
NUYTTEN EZH2 TARGETS UP	1037	673	All SZGR 2.0 genes in this pathway
LIU COMMON CANCER GENES	79	47	All SZGR 2.0 genes in this pathway
SCHAEFFER PROSTATE DEVELOPMENT 6HR UP	176	115	All SZGR 2.0 genes in this pathway
SCHAEFFER PROSTATE DEVELOPMENT AND CANCER BOX1 DN	10	7	All SZGR 2.0 genes in this pathway
BENPORATH NANOG TARGETS	988	594	All SZGR 2.0 genes in this pathway
SHIN B CELL LYMPHOMA CLUSTER 5	18	11	All SZGR 2.0 genes in this pathway
LEE TARGETS OF PTCH1 AND SUFU UP	53	37	All SZGR 2.0 genes in this pathway
GNATENKO PLATELET SIGNATURE	48	28	All SZGR 2.0 genes in this pathway
JECHLINGER EPITHELIAL TO MESENCHYMAL TRANSITION UP	71	51	All SZGR 2.0 genes in this pathway
DER IFN ALPHA RESPONSE UP	74	48	All SZGR 2.0 genes in this pathway
TARTE PLASMA CELL VS PLASMABLAST UP	398	262	All SZGR 2.0 genes in this pathway
BECKER TAMOXIFEN RESISTANCE UP	50	36	All SZGR 2.0 genes in this pathway
WIELAND UP BY HBV INFECTION	101	66	All SZGR 2.0 genes in this pathway
SHEPARD BMYB MORPHOLINO UP	205	126	All SZGR 2.0 genes in this pathway
DER IFN BETA RESPONSE UP	102	67	All SZGR 2.0 genes in this pathway
NELSON RESPONSE TO ANDROGEN UP	86	61	All SZGR 2.0 genes in this pathway
FLECHNER PBL KIDNEY TRANSPLANT REJECTED VS OK UP	63	48	All SZGR 2.0 genes in this pathway
DER IFN GAMMA RESPONSE UP	71	45	All SZGR 2.0 genes in this pathway
NADLER OBESITY DN	48	34	All SZGR 2.0 genes in this pathway
IGLESIAS E2F TARGETS UP	151	103	All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE DN	1237	837	All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 10HR DN	56	37	All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 24HR DN	148	102	All SZGR 2.0 genes in this pathway
YAMAZAKI TCEB3 TARGETS UP	175	116	All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 18HR DN	178	121	All SZGR 2.0 genes in this pathway
LEE AGING NEOCORTEX UP	89	59	All SZGR 2.0 genes in this pathway
LEE AGING CEREBELLUM UP	84	58	All SZGR 2.0 genes in this pathway
WELCSH BRCA1 TARGETS UP	198	132	All SZGR 2.0 genes in this pathway
DAZARD RESPONSE TO UV SCC UP	123	75	All SZGR 2.0 genes in this pathway
JIANG AGING HYPOTHALAMUS UP	47	31	All SZGR 2.0 genes in this pathway
KIM LRRC3B TARGETS	30	24	All SZGR 2.0 genes in this pathway
PELLICCIOTTA HDAC IN ANTIGEN PRESENTATION UP	64	40	All SZGR 2.0 genes in this pathway
HILLION HMGA1 TARGETS	90	71	All SZGR 2.0 genes in this pathway
LIN MELANOMA COPY NUMBER DN	41	34	All SZGR 2.0 genes in this pathway
MARTINEZ RB1 TARGETS DN	543	317	All SZGR 2.0 genes in this pathway
MARTINEZ TP53 TARGETS UP	602	364	All SZGR 2.0 genes in this pathway
MARTINEZ RB1 AND TP53 TARGETS UP	601	369	All SZGR 2.0 genes in this pathway
ACEVEDO LIVER CANCER UP	973	570	All SZGR 2.0 genes in this pathway
BASSO HAIRY CELL LEUKEMIA DN	80	66	All SZGR 2.0 genes in this pathway
GAURNIER PSMD4 TARGETS	73	55	All SZGR 2.0 genes in this pathway
WANG TUMOR INVASIVENESS DN	210	128	All SZGR 2.0 genes in this pathway
CHAUHAN RESPONSE TO METHOXYESTRADIOL DN	102	65	All SZGR 2.0 genes in this pathway
WUNDER INFLAMMATORY RESPONSE AND CHOLESTEROL UP	58	38	All SZGR 2.0 genes in this pathway
COLINA TARGETS OF 4EBP1 AND 4EBP2	356	214	All SZGR 2.0 genes in this pathway
HSIAO HOUSEKEEPING GENES	389	245	All SZGR 2.0 genes in this pathway
CHIANG LIVER CANCER SUBCLASS UNANNOTATED UP	85	50	All SZGR 2.0 genes in this pathway
YAGI AML WITH INV 16 TRANSLOCATION	422	277	All SZGR 2.0 genes in this pathway
CAIRO HEPATOBLASTOMA CLASSES DN	210	141	All SZGR 2.0 genes in this pathway
WONG ADULT TISSUE STEM MODULE	721	492	All SZGR 2.0 genes in this pathway
CHANDRAN METASTASIS DN	306	191	All SZGR 2.0 genes in this pathway
MARTENS TRETINOIN RESPONSE DN	841	431	All SZGR 2.0 genes in this pathway
WANG RESPONSE TO GSK3 INHIBITOR SB216763 UP	397	206	All SZGR 2.0 genes in this pathway
DEMAGALHAES AGING UP	55	39	All SZGR 2.0 genes in this pathway
JOHNSTONE PARVB TARGETS 2 UP	140	94	All SZGR 2.0 genes in this pathway
PASINI SUZ12 TARGETS DN	315	215	All SZGR 2.0 genes in this pathway
HUANG GATA2 TARGETS UP	149	96	All SZGR 2.0 genes in this pathway
KRIEG KDM3A TARGETS NOT HYPOXIA	208	107	All SZGR 2.0 genes in this pathway

Gene Page: B2M