SZGR2

Summary ?

GeneID	56915
Symbol	EXOSC5
Synonyms	RRP41B\|RRP46\|Rrp46p\|hRrp46p\|p12B
Description	exosome component 5
Reference	MIM:606492\|HGNC:HGNC:24662\|Ensembl:ENSG00000077348\|HPRD:16222\|Vega:OTTHUMG00000182759
Gene type	protein-coding
Map location	19q13.1
Pascal p-value	0.104
Sherlock p-value	0.047
Fetal beta	0.052
eGene	Cerebellum Meta

Gene in Data Sources

Gene set name	Method of gene set	Description	Info
CV:PGCnp	Genome-wide Association Study	GWAS

Section I. Genetics and epigenetics annotation

Section II. Transcriptome annotation

General gene expression (GTEx)

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions

Section IV. Protein-protein interaction annotation

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
EXOSC1	CGI-108 \| CSL4 \| Csl4p \| SKI4 \| Ski4p \| hCsl4p \| p13	exosome component 1	hCsl4p interacts with hRrp46p.	BIND	11812149
EXOSC1	CGI-108 \| CSL4 \| Csl4p \| SKI4 \| Ski4p \| hCsl4p \| p13	exosome component 1	-	HPRD,BioGRID	11110791 \|12419256\|11812149 \|12419256
EXOSC1	CGI-108 \| CSL4 \| Csl4p \| SKI4 \| Ski4p \| hCsl4p \| p13	exosome component 1	hRrp46p interacts with hCsl4p.	BIND	12419256
EXOSC10	PM-Scl \| PM/Scl-100 \| PMSCL \| PMSCL2 \| RRP6 \| Rrp6p \| p2 \| p3 \| p4	exosome component 10	-	HPRD	15231747
EXOSC3	CGI-102 \| MGC15120 \| MGC723 \| RP11-3J10.8 \| RRP40 \| Rrp40p \| bA3J10.7 \| hRrp40p \| p10	exosome component 3	-	HPRD	11110791 \|12419256\|12419256
EXOSC3	CGI-102 \| MGC15120 \| MGC723 \| RP11-3J10.8 \| RRP40 \| Rrp40p \| bA3J10.7 \| hRrp40p \| p10	exosome component 3	hRrp40p interacts with hRrp46p.	BIND	12419256
EXOSC8	CIP3 \| EAP2 \| OIP2 \| RP11-421P11.3 \| RRP43 \| Rrp43p \| bA421P11.3 \| p9	exosome component 8	hRrp46p interacts with OIP2.	BIND	12419256
EXOSC8	CIP3 \| EAP2 \| OIP2 \| RP11-421P11.3 \| RRP43 \| Rrp43p \| bA421P11.3 \| p9	exosome component 8	-	HPRD	12419256
KIAA1217	DKFZp761L0424 \| MGC31990 \| SKT	KIAA1217	Two-hybrid	BioGRID	16189514
LSM5	FLJ12710 \| YER146W	LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae)	-	HPRD,BioGRID	15231747
NUP210	FLJ22389 \| GP210 \| KIAA0906 \| POM210	nucleoporin 210kDa	-	HPRD,BioGRID	15231747
PA2G4	EBP1 \| HG4-1 \| p38-2G4	proliferation-associated 2G4, 38kDa	-	HPRD	15231747
PKM2	CTHBP \| MGC3932 \| OIP3 \| PK3 \| PKM \| TCB \| THBP1	pyruvate kinase, muscle	-	HPRD,BioGRID	15231747
POLR2L	RBP10 \| RPABC5 \| RPB10 \| RPB10beta \| RPB7.6 \| hRPB7.6 \| hsRPB10b	polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa	-	HPRD	15231747
SFPQ	POMP100 \| PSF	splicing factor proline/glutamine-rich (polypyrimidine tract binding protein associated)	-	HPRD,BioGRID	15231747
ZNF558	FLJ30932	zinc finger protein 558	-	HPRD	15231747

Section V. Pathway annotation

Pathway name	Pathway size	# SZGR 2.0 genes in pathway	Info
KEGG RNA DEGRADATION	59	37	All SZGR 2.0 genes in this pathway
REACTOME DIABETES PATHWAYS	133	91	All SZGR 2.0 genes in this pathway
REACTOME PERK REGULATED GENE EXPRESSION	29	14	All SZGR 2.0 genes in this pathway
REACTOME ACTIVATION OF GENES BY ATF4	26	12	All SZGR 2.0 genes in this pathway
REACTOME UNFOLDED PROTEIN RESPONSE	80	51	All SZGR 2.0 genes in this pathway
REACTOME METABOLISM OF MRNA	284	128	All SZGR 2.0 genes in this pathway
REACTOME MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE	11	5	All SZGR 2.0 genes in this pathway
REACTOME DEADENYLATION DEPENDENT MRNA DECAY	48	29	All SZGR 2.0 genes in this pathway
REACTOME METABOLISM OF RNA	330	155	All SZGR 2.0 genes in this pathway
REACTOME DESTABILIZATION OF MRNA BY BRF1	17	9	All SZGR 2.0 genes in this pathway
REACTOME REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU RICH ELEMENTS	84	50	All SZGR 2.0 genes in this pathway
REACTOME DESTABILIZATION OF MRNA BY KSRP	17	9	All SZGR 2.0 genes in this pathway
REACTOME DESTABILIZATION OF MRNA BY TRISTETRAPROLIN TTP	17	7	All SZGR 2.0 genes in this pathway
DODD NASOPHARYNGEAL CARCINOMA DN	1375	806	All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY DOXORUBICIN DN	1781	1082	All SZGR 2.0 genes in this pathway
GRAESSMANN RESPONSE TO MC AND DOXORUBICIN DN	770	415	All SZGR 2.0 genes in this pathway
SPIELMAN LYMPHOBLAST EUROPEAN VS ASIAN DN	584	395	All SZGR 2.0 genes in this pathway
BENPORATH ES 1	379	235	All SZGR 2.0 genes in this pathway
BENPORATH NANOG TARGETS	988	594	All SZGR 2.0 genes in this pathway
BENPORATH SOX2 TARGETS	734	436	All SZGR 2.0 genes in this pathway
BURTON ADIPOGENESIS PEAK AT 24HR	43	30	All SZGR 2.0 genes in this pathway
CUI TCF21 TARGETS 2 UP	428	266	All SZGR 2.0 genes in this pathway
BILD MYC ONCOGENIC SIGNATURE	206	117	All SZGR 2.0 genes in this pathway
KRIGE RESPONSE TO TOSEDOSTAT 6HR UP	953	554	All SZGR 2.0 genes in this pathway
KRIGE RESPONSE TO TOSEDOSTAT 24HR DN	1011	592	All SZGR 2.0 genes in this pathway
ACEVEDO LIVER TUMOR VS NORMAL ADJACENT TISSUE UP	863	514	All SZGR 2.0 genes in this pathway
WANG RESPONSE TO GSK3 INHIBITOR SB216763 DN	374	217	All SZGR 2.0 genes in this pathway
DUTERTRE ESTRADIOL RESPONSE 6HR UP	229	149	All SZGR 2.0 genes in this pathway
DUTERTRE ESTRADIOL RESPONSE 24HR UP	324	193	All SZGR 2.0 genes in this pathway
PILON KLF1 TARGETS DN	1972	1213	All SZGR 2.0 genes in this pathway

Gene Page: EXOSC5