Gene Page: PSMC3

Summary ?
GeneID5702
SymbolPSMC3
SynonymsTBP1
Descriptionproteasome 26S subunit, ATPase 3
ReferenceMIM:186852|HGNC:HGNC:9549|Ensembl:ENSG00000165916|HPRD:01733|Vega:OTTHUMG00000167692
Gene typeprotein-coding
Map location11p11.2
Pascal p-value0.023
Sherlock p-value0.595
Fetal beta-0.322
DMG1 (# studies)
eGeneAnterior cingulate cortex BA24
Caudate basal ganglia
Meta
SupportG2Cdb.humanPSD
G2Cdb.humanPSP

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
DMG:Jaffe_2016Genome-wide DNA methylation analysisThis dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05. 2
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.01 

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

ProbeChromosomePositionNearest geneP (dis)Beta (dis)FDR (dis)Study
cg087221041147448306PSMC33.73E-10-0.0197.47E-7DMG:Jaffe_2016
cg239204721147448172PSMC31.09E-8-0.0114.61E-6DMG:Jaffe_2016

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs47529181148253251PSMC3ENSG00000165916.43.201E-60.01-805258gtex_brain_ba24
rs45004481148253520PSMC3ENSG00000165916.42.606E-60.01-805527gtex_brain_ba24
rs108388381148253895PSMC3ENSG00000165916.42.576E-60.01-805902gtex_brain_ba24
rs110396001148254551PSMC3ENSG00000165916.44.048E-60.01-806558gtex_brain_ba24
rs73957261148256442PSMC3ENSG00000165916.43.323E-60.01-808449gtex_brain_ba24
rs110396371148306980PSMC3ENSG00000165916.44.127E-60.01-858987gtex_brain_ba24
rs122219981148308762PSMC3ENSG00000165916.43.827E-60.01-860769gtex_brain_ba24
rs122219991148308763PSMC3ENSG00000165916.43.827E-60.01-860770gtex_brain_ba24
rs115301901148309157PSMC3ENSG00000165916.43.017E-70.01-861164gtex_brain_ba24
rs115301931148309239PSMC3ENSG00000165916.46.288E-60.01-861246gtex_brain_ba24
rs110396441148314317PSMC3ENSG00000165916.44.669E-60.01-866324gtex_brain_ba24

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
TNFAIP8L30.610.52
WNT5A0.580.51
NR3C20.570.61
PKP20.560.51
NEUROD10.540.32
NRP10.540.46
BNC10.530.21
DUSP0.520.35
MATN20.520.60
C1QTNF30.520.24
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
AC098691.2-0.24-0.28
AF347015.21-0.23-0.20
MT-CO2-0.21-0.18
PLA2G5-0.21-0.15
AF347015.18-0.21-0.22
AF347015.8-0.21-0.17
CLEC2B-0.19-0.17
IL32-0.19-0.20
MT-CYB-0.19-0.15
AF347015.33-0.19-0.13

Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0000166nucleotide bindingIEA-
GO:0003713transcription coactivator activityTAS8419915 
GO:0003714transcription corepressor activityTAS2194290 
GO:0005515protein bindingIPI17220478 |17353931 
GO:0005524ATP bindingIEA-
GO:0016787hydrolase activityIEA-
GO:0017111nucleoside-triphosphatase activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0001824blastocyst developmentIEA-
GO:0031145anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic processEXP11285280 
GO:0030163protein catabolic processIEA-
GO:0044419interspecies interaction between organismsIEA-
GO:0051436negative regulation of ubiquitin-protein ligase activity during mitotic cell cycleEXP15029244 
GO:0051437positive regulation of ubiquitin-protein ligase activity during mitotic cell cycleEXP12791267 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0000502proteasome complexTAS8811196 
GO:0005829cytosolIEA-
GO:0005634nucleusTAS2194290 
GO:0005737cytoplasmIEA-

Section IV. Protein-protein interaction annotation

InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
CDKN2AARF | CDK4I | CDKN2 | CMM2 | INK4 | INK4a | MLM | MTS1 | TP16 | p14 | p14ARF | p16 | p16INK4 | p16INK4a | p19cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)p14ARF interacts with TBP-1.BIND14665636 
EPAS1ECYT4 | HIF2A | HLF | MOP2 | PASD2endothelial PAS domain protein 1Affinity Capture-WesternBioGRID14556007 
HIF1AHIF-1alpha | HIF1 | HIF1-ALPHA | MOP1 | PASD8hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)-HPRD,BioGRID14556007 
HTR1E5-HT1E5-hydroxytryptamine (serotonin) receptor 1EAffinity Capture-MSBioGRID17353931 
PAAF1FLJ11848 | PAAF | Rpn14 | WDR71proteasomal ATPase-associated factor 1Affinity Capture-MSBioGRID17353931 
PSMC3MGC8487 | TBP1proteasome (prosome, macropain) 26S subunit, ATPase, 3-HPRD11463857 
PSMC3IPGT198 | HOP2 | HUMGT198A | TBPIPPSMC3 interacting protein-HPRD9345291 
PSMC4MGC13687 | MGC23214 | MGC8570 | MIP224 | S6 | TBP7proteasome (prosome, macropain) 26S subunit, ATPase, 4Affinity Capture-MSBioGRID17353931 
PSMC4MGC13687 | MGC23214 | MGC8570 | MIP224 | S6 | TBP7proteasome (prosome, macropain) 26S subunit, ATPase, 4-HPRD11463857 
PSMC5S8 | SUG1 | TBP10 | TRIP1 | p45 | p45/SUGproteasome (prosome, macropain) 26S subunit, ATPase, 5-HPRD,BioGRID11463857 
PSMD10dJ889N15.2 | p28proteasome (prosome, macropain) 26S subunit, non-ATPase, 10Affinity Capture-MSBioGRID17353931 
PSMD13HSPC027 | Rpn9 | S11 | p40.5proteasome (prosome, macropain) 26S subunit, non-ATPase, 13Affinity Capture-MSBioGRID17353931 
PSMD6KIAA0107 | Rpn7 | S10 | SGA-113M | p44S10proteasome (prosome, macropain) 26S subunit, non-ATPase, 6Affinity Capture-MSBioGRID17353931 
STX11FHL4 | HLH4 | HPLH4syntaxin 11Two-hybridBioGRID16169070 
TRAF6MGC:3310 | RNF85TNF receptor-associated factor 6Affinity Capture-MSBioGRID14743216 
TXNRD2SELZ | TR | TR-BETA | TR3 | TRXR2thioredoxin reductase 2Affinity Capture-Western
Reconstituted Complex
Two-hybrid		BioGRID11463857 
VHLHRCA1 | RCA1 | VHL1von Hippel-Lindau tumor suppressor-HPRD,BioGRID14556007 


Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG PROTEASOME 4828All SZGR 2.0 genes in this pathway
BIOCARTA PROTEASOME PATHWAY 2819All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY WNT 6541All SZGR 2.0 genes in this pathway
REACTOME CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES 4829All SZGR 2.0 genes in this pathway
REACTOME ANTIGEN PROCESSING CROSS PRESENTATION 7648All SZGR 2.0 genes in this pathway
REACTOME ER PHAGOSOME PATHWAY 6140All SZGR 2.0 genes in this pathway
REACTOME CELL CYCLE 421253All SZGR 2.0 genes in this pathway
REACTOME ORC1 REMOVAL FROM CHROMATIN 6737All SZGR 2.0 genes in this pathway
REACTOME DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR BCR 9766All SZGR 2.0 genes in this pathway
REACTOME ACTIVATION OF NF KAPPAB IN B CELLS 6443All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY THE B CELL RECEPTOR BCR 12690All SZGR 2.0 genes in this pathway
REACTOME P53 INDEPENDENT G1 S DNA DAMAGE CHECKPOINT 5131All SZGR 2.0 genes in this pathway
REACTOME CDK MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6 4827All SZGR 2.0 genes in this pathway
REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES 200136All SZGR 2.0 genes in this pathway
REACTOME REGULATION OF ORNITHINE DECARBOXYLASE ODC 4933All SZGR 2.0 genes in this pathway
REACTOME REGULATION OF APOPTOSIS 5834All SZGR 2.0 genes in this pathway
REACTOME CELL CYCLE MITOTIC 325185All SZGR 2.0 genes in this pathway
REACTOME CELL CYCLE CHECKPOINTS 12470All SZGR 2.0 genes in this pathway
REACTOME CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION 6540All SZGR 2.0 genes in this pathway
REACTOME P53 DEPENDENT G1 DNA DAMAGE RESPONSE 5735All SZGR 2.0 genes in this pathway
REACTOME M G1 TRANSITION 8145All SZGR 2.0 genes in this pathway
REACTOME G1 S TRANSITION 11263All SZGR 2.0 genes in this pathway
REACTOME CDT1 ASSOCIATION WITH THE CDC6 ORC ORIGIN COMPLEX 5631All SZGR 2.0 genes in this pathway
REACTOME SYNTHESIS OF DNA 9253All SZGR 2.0 genes in this pathway
REACTOME AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1 5130All SZGR 2.0 genes in this pathway
REACTOME METABOLISM OF MRNA 284128All SZGR 2.0 genes in this pathway
REACTOME METABOLISM OF RNA 330155All SZGR 2.0 genes in this pathway
REACTOME MITOTIC G1 G1 S PHASES 13779All SZGR 2.0 genes in this pathway
REACTOME REGULATION OF MITOTIC CELL CYCLE 8546All SZGR 2.0 genes in this pathway
REACTOME MITOTIC M M G1 PHASES 17298All SZGR 2.0 genes in this pathway
REACTOME ASSEMBLY OF THE PRE REPLICATIVE COMPLEX 6536All SZGR 2.0 genes in this pathway
REACTOME REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU RICH ELEMENTS 8450All SZGR 2.0 genes in this pathway
REACTOME DESTABILIZATION OF MRNA BY AUF1 HNRNP D0 5331All SZGR 2.0 genes in this pathway
REACTOME DNA REPLICATION 192110All SZGR 2.0 genes in this pathway
REACTOME APOPTOSIS 14894All SZGR 2.0 genes in this pathway
REACTOME HIV INFECTION 207122All SZGR 2.0 genes in this pathway
REACTOME HOST INTERACTIONS OF HIV FACTORS 13281All SZGR 2.0 genes in this pathway
REACTOME APC C CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1 7238All SZGR 2.0 genes in this pathway
REACTOME APC C CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS 7340All SZGR 2.0 genes in this pathway
REACTOME AUTODEGRADATION OF CDH1 BY CDH1 APC C 6434All SZGR 2.0 genes in this pathway
REACTOME SCF BETA TRCP MEDIATED DEGRADATION OF EMI1 5132All SZGR 2.0 genes in this pathway
REACTOME IMMUNE SYSTEM 933616All SZGR 2.0 genes in this pathway
REACTOME ADAPTIVE IMMUNE SYSTEM 539350All SZGR 2.0 genes in this pathway
REACTOME CLASS I MHC MEDIATED ANTIGEN PROCESSING PRESENTATION 251156All SZGR 2.0 genes in this pathway
REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION 212129All SZGR 2.0 genes in this pathway
REACTOME S PHASE 10966All SZGR 2.0 genes in this pathway
REACTOME SCFSKP2 MEDIATED DEGRADATION OF P27 P21 5634All SZGR 2.0 genes in this pathway
REACTOME VIF MEDIATED DEGRADATION OF APOBEC3G 5230All SZGR 2.0 genes in this pathway
GARY CD5 TARGETS DN 431263All SZGR 2.0 genes in this pathway
CASORELLI ACUTE PROMYELOCYTIC LEUKEMIA DN 663425All SZGR 2.0 genes in this pathway
DIAZ CHRONIC MEYLOGENOUS LEUKEMIA UP 1382904All SZGR 2.0 genes in this pathway
KINSEY TARGETS OF EWSR1 FLII FUSION UP 1278748All SZGR 2.0 genes in this pathway
KIM WT1 TARGETS DN 459276All SZGR 2.0 genes in this pathway
ROVERSI GLIOMA COPY NUMBER UP 10075All SZGR 2.0 genes in this pathway
DACOSTA UV RESPONSE VIA ERCC3 UP 309199All SZGR 2.0 genes in this pathway
JAZAG TGFB1 SIGNALING DN 3524All SZGR 2.0 genes in this pathway
LOPEZ MBD TARGETS 957597All SZGR 2.0 genes in this pathway
STARK PREFRONTAL CORTEX 22Q11 DELETION DN 517309All SZGR 2.0 genes in this pathway
WHITEHURST PACLITAXEL SENSITIVITY 3919All SZGR 2.0 genes in this pathway
PAL PRMT5 TARGETS UP 203135All SZGR 2.0 genes in this pathway
DELASERNA MYOD TARGETS UP 8951All SZGR 2.0 genes in this pathway
LEE CALORIE RESTRICTION MUSCLE UP 4333All SZGR 2.0 genes in this pathway
LEE AGING MUSCLE DN 4629All SZGR 2.0 genes in this pathway
PELLICCIOTTA HDAC IN ANTIGEN PRESENTATION DN 4938All SZGR 2.0 genes in this pathway
MARSON BOUND BY FOXP3 UNSTIMULATED 1229713All SZGR 2.0 genes in this pathway
WONG PROTEASOME GENE MODULE 4935All SZGR 2.0 genes in this pathway
CHANG CORE SERUM RESPONSE UP 212128All SZGR 2.0 genes in this pathway
HOFFMANN LARGE TO SMALL PRE BII LYMPHOCYTE UP 163102All SZGR 2.0 genes in this pathway
CHIANG LIVER CANCER SUBCLASS UNANNOTATED DN 193112All SZGR 2.0 genes in this pathway
SASSON RESPONSE TO GONADOTROPHINS UP 9159All SZGR 2.0 genes in this pathway
SASSON RESPONSE TO FORSKOLIN UP 9058All SZGR 2.0 genes in this pathway
LU EZH2 TARGETS UP 295155All SZGR 2.0 genes in this pathway
LI DCP2 BOUND MRNA 8957All SZGR 2.0 genes in this pathway