Gene Page: SLC12A5
Summary ?
| GeneID | 57468 |
| Symbol | SLC12A5 |
| Synonyms | EIEE34|EIG14|KCC2|hKCC2 |
| Description | solute carrier family 12 member 5 |
| Reference | MIM:606726|HGNC:HGNC:13818|Ensembl:ENSG00000124140|HPRD:09469|Vega:OTTHUMG00000032638 |
| Gene type | protein-coding |
| Map location | 20q13.12 |
| Pascal p-value | 0.049 |
| Sherlock p-value | 0.924 |
| Fetal beta | -3.241 |
| eGene | Meta |
| Support | ION BALANCE G2Cdb.human_BAYES-COLLINS-HUMAN-PSD-FULL G2Cdb.human_BAYES-COLLINS-MOUSE-PSD-CONSENSUS G2Cdb.human_mGluR5 G2Cdb.humanPSD G2Cdb.humanPSP CompositeSet Darnell FMRP targets |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| PMID:cooccur | High-throughput literature-search | Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included. | |
| Literature | High-throughput literature-search | Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias | Click to show details |
Section I. Genetics and epigenetics annotation
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| AC132186.2 | 0.72 | 0.71 |
| SOSTDC1 | 0.70 | 0.57 |
| MYO16 | 0.70 | 0.50 |
| TMEM102 | 0.68 | 0.52 |
| NPNT | 0.67 | 0.55 |
| RTDR1 | 0.67 | 0.56 |
| TMEM145 | 0.67 | 0.61 |
| AC079061.1 | 0.67 | 0.59 |
| GDF10 | 0.66 | 0.70 |
| RASGEF1C | 0.65 | 0.50 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| AF347015.27 | -0.37 | -0.22 |
| AF347015.31 | -0.37 | -0.23 |
| MT-CO2 | -0.37 | -0.22 |
| AF347015.8 | -0.36 | -0.23 |
| MT-CYB | -0.36 | -0.22 |
| AF347015.33 | -0.35 | -0.20 |
| AF347015.2 | -0.35 | -0.24 |
| AF347015.15 | -0.34 | -0.21 |
| AF347015.21 | -0.33 | -0.21 |
| AIF1L | -0.33 | -0.26 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| REACTOME TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES | 413 | 270 | All SZGR 2.0 genes in this pathway |
| REACTOME SLC MEDIATED TRANSMEMBRANE TRANSPORT | 241 | 157 | All SZGR 2.0 genes in this pathway |
| REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES | 94 | 65 | All SZGR 2.0 genes in this pathway |
| KOYAMA SEMA3B TARGETS DN | 411 | 249 | All SZGR 2.0 genes in this pathway |
| BENPORATH SUZ12 TARGETS | 1038 | 678 | All SZGR 2.0 genes in this pathway |
| AFFAR YY1 TARGETS UP | 214 | 133 | All SZGR 2.0 genes in this pathway |
| BLALOCK ALZHEIMERS DISEASE DN | 1237 | 837 | All SZGR 2.0 genes in this pathway |
| MASSARWEH TAMOXIFEN RESISTANCE UP | 578 | 341 | All SZGR 2.0 genes in this pathway |
| YOSHIMURA MAPK8 TARGETS UP | 1305 | 895 | All SZGR 2.0 genes in this pathway |
| MEISSNER NPC HCP WITH H3K4ME2 AND H3K27ME3 | 349 | 234 | All SZGR 2.0 genes in this pathway |
| MIKKELSEN NPC HCP WITH H3K27ME3 | 341 | 243 | All SZGR 2.0 genes in this pathway |
| MIKKELSEN MEF HCP WITH H3K27ME3 | 590 | 403 | All SZGR 2.0 genes in this pathway |
| KIM ALL DISORDERS CALB1 CORR UP | 548 | 370 | All SZGR 2.0 genes in this pathway |