SZGR2

Summary ?

GeneID	5757
Symbol	PTMA
Synonyms	TMSA
Description	prothymosin, alpha
Reference	MIM:188390\|HGNC:HGNC:9623\|Ensembl:ENSG00000187514\|HPRD:01778\|Vega:OTTHUMG00000153810
Gene type	protein-coding
Map location	2q37.1
Pascal p-value	0.202
Sherlock p-value	0.471
Fetal beta	0.906
DMG	1 (# studies)

Gene in Data Sources

Gene set name	Method of gene set	Description	Info
CV:PGCnp	Genome-wide Association Study	GWAS
DMG:Jaffe_2016	Genome-wide DNA methylation analysis	This dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05.	1

Section I. Genetics and epigenetics annotation

Differentially methylated gene

Probe	Chromosome	Position	Nearest gene	P (dis)	Beta (dis)	FDR (dis)	Study
cg06155979	2	232575824	PTMA	5.25E-9	-0.014	2.93E-6	DMG:Jaffe_2016

Section II. Transcriptome annotation

General gene expression (GTEx)

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
NR2C2	0.92	0.93
KIAA0240	0.91	0.94
ABL2	0.91	0.93
HERC1	0.91	0.93
PCNX	0.91	0.94
JMY	0.91	0.94
NAV3	0.91	0.92
TANC2	0.91	0.94
MYO9A	0.90	0.94
C10orf18	0.90	0.93

Top 10 negatively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
FXYD1	-0.69	-0.78
AF347015.31	-0.69	-0.78
HSD17B14	-0.68	-0.74
MT-CO2	-0.67	-0.78
SERPINB6	-0.67	-0.70
HIGD1B	-0.67	-0.79
METRN	-0.66	-0.80
ENHO	-0.66	-0.81
IFI27	-0.65	-0.75
TLCD1	-0.65	-0.76

Section IV. Protein-protein interaction annotation

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
CCNA2	CCN1 \| CCNA	cyclin A2	-	HPRD	11310559
CCNB1	CCNB	cyclin B1	-	HPRD	11310559
CDC2	CDC28A \| CDK1 \| DKFZp686L20222 \| MGC111195	cell division cycle 2, G1 to S and G2 to M	-	HPRD	11310559
CDK2	p33(CDK2)	cyclin-dependent kinase 2	-	HPRD	11310559
CDK4	CMM3 \| MGC14458 \| PSK-J3	cyclin-dependent kinase 4	-	HPRD	11310559
CREBBP	CBP \| KAT3A \| RSTS	CREB binding protein	-	HPRD,BioGRID	11897665
ELAVL1	ELAV1 \| HUR \| Hua \| MelG	ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R)	ELAVL1 (HuR) interacts with PMTA (ProT-alpha) mRNA.	BIND	15861128
EP300	KAT3B \| p300	E1A binding protein p300	-	HPRD,BioGRID	11967287
ESR1	DKFZp686N23123 \| ER \| ESR \| ESRA \| Era \| NR3A1	estrogen receptor 1	Reconstituted Complex	BioGRID	12943695
HDAC1	DKFZp686H12203 \| GON-10 \| HD1 \| RPD3 \| RPD3L1	histone deacetylase 1	-	HPRD,BioGRID	12634383
HDAC2	RPD3 \| YAF1	histone deacetylase 2	-	HPRD,BioGRID	12634383
HIST1H2BG	H2B.1A \| H2B/a \| H2BFA \| HIST1H2BF \| HIST1H2BI \| dJ221C16.8	histone cluster 1, H2bg	-	HPRD	8814229
HIST1H4A	H4/a \| H4FA	histone cluster 1, H4a	-	HPRD	11310559
HIST2H2BE	GL105 \| H2B \| H2B.1 \| H2B/q \| H2BFQ \| MGC119802 \| MGC119804 \| MGC129733 \| MGC129734	histone cluster 2, H2be	-	HPRD	11310559
HIST2H3C	H3 \| H3.2 \| H3/M \| H3F2 \| H3FM \| MGC9629	histone cluster 2, H3c	-	HPRD	8814229
HIST2H4A	FO108 \| H4 \| H4/n \| H4F2 \| H4FN \| HIST2H4	histone cluster 2, H4a	-	HPRD	8814229
HIST3H3	H3.4 \| H3/g \| H3FT \| H3t \| MGC126886 \| MGC126888	histone cluster 3, H3	-	HPRD	11310559
HNRNPA1	HNRPA1 \| MGC102835	heterogeneous nuclear ribonucleoprotein A1	HNRPA1 (hnRNP A1) interacts with PTMA (ProT-alpha) mRNA.	BIND	15861128
HSPA1A	FLJ54303 \| FLJ54370 \| FLJ54392 \| FLJ54408 \| FLJ75127 \| HSP70-1 \| HSP70-1A \| HSP70I \| HSP72 \| HSPA1 \| HSPA1B	heat shock 70kDa protein 1A	-	HPRD	11310559
KPNA2	IPOA1 \| QIP2 \| RCH1 \| SRP1alpha	karyopherin alpha 2 (RAG cohort 1, importin alpha 1)	-	HPRD	11310559
KPNB1	IMB1 \| IPOB \| Impnb \| MGC2155 \| MGC2156 \| MGC2157 \| NTF97	karyopherin (importin) beta 1	-	HPRD	11310559
NCOR1	KIAA1047 \| MGC104216 \| N-CoR \| TRAC1 \| hCIT529I10 \| hN-CoR	nuclear receptor co-repressor 1	-	HPRD,BioGRID	12634383
NUP62	DKFZp547L134 \| FLJ20822 \| FLJ43869 \| IBSN \| MGC841 \| SNDI \| p62	nucleoporin 62kDa	-	HPRD	11310559
PCNA	MGC8367	proliferating cell nuclear antigen	-	HPRD	11310559
PHB2	BAP \| BCAP37 \| Bap37 \| MGC117268 \| PNAS-141 \| REA \| p22	prohibitin 2	Affinity Capture-Western Two-hybrid	BioGRID	12943695
PHB2	BAP \| BCAP37 \| Bap37 \| MGC117268 \| PNAS-141 \| REA \| p22	prohibitin 2	PT-alpha interacts with REA	BIND	10938099
RAN	ARA24 \| Gsp1 \| TC4	RAN, member RAS oncogene family	-	HPRD	11310559
RCC1	CHC1 \| RCC1-I	regulator of chromosome condensation 1	-	HPRD	11310559
SIN3A	DKFZp434K2235 \| FLJ90319 \| KIAA0700	SIN3 homolog A, transcription regulator (yeast)	Reconstituted Complex	BioGRID	12634383
VIPR1	FLJ41949 \| HVR1 \| II \| PACAP-R-2 \| RDC1 \| VAPC1 \| VIPR \| VIRG \| VPAC1 \| VPCAP1R	vasoactive intestinal peptide receptor 1	-	HPRD	8886855

Section V. Pathway annotation

Pathway name	Pathway size	# SZGR 2.0 genes in pathway	Info
PID MYC ACTIV PATHWAY	79	62	All SZGR 2.0 genes in this pathway
PRAMOONJAGO SOX4 TARGETS DN	51	35	All SZGR 2.0 genes in this pathway
VECCHI GASTRIC CANCER EARLY UP	430	232	All SZGR 2.0 genes in this pathway
UDAYAKUMAR MED1 TARGETS UP	135	82	All SZGR 2.0 genes in this pathway
KINSEY TARGETS OF EWSR1 FLII FUSION UP	1278	748	All SZGR 2.0 genes in this pathway
ENK UV RESPONSE KERATINOCYTE DN	485	334	All SZGR 2.0 genes in this pathway
MARKEY RB1 ACUTE LOF DN	228	137	All SZGR 2.0 genes in this pathway
CAIRO PML TARGETS BOUND BY MYC UP	23	17	All SZGR 2.0 genes in this pathway
OLSSON E2F3 TARGETS DN	49	33	All SZGR 2.0 genes in this pathway
APPIERTO RESPONSE TO FENRETINIDE DN	51	35	All SZGR 2.0 genes in this pathway
SCHLOSSER SERUM RESPONSE DN	712	443	All SZGR 2.0 genes in this pathway
JAZAG TGFB1 SIGNALING VIA SMAD4 UP	108	66	All SZGR 2.0 genes in this pathway
SPIELMAN LYMPHOBLAST EUROPEAN VS ASIAN UP	479	299	All SZGR 2.0 genes in this pathway
PUJANA BRCA1 PCC NETWORK	1652	1023	All SZGR 2.0 genes in this pathway
PUJANA ATM PCC NETWORK	1442	892	All SZGR 2.0 genes in this pathway
PUJANA CHEK2 PCC NETWORK	779	480	All SZGR 2.0 genes in this pathway
NUYTTEN EZH2 TARGETS DN	1024	594	All SZGR 2.0 genes in this pathway
LIU BREAST CANCER	30	19	All SZGR 2.0 genes in this pathway
LIAO METASTASIS	539	324	All SZGR 2.0 genes in this pathway
GARCIA TARGETS OF FLI1 AND DAX1 DN	176	104	All SZGR 2.0 genes in this pathway
SCHAEFFER PROSTATE DEVELOPMENT 6HR DN	514	330	All SZGR 2.0 genes in this pathway
BENPORATH MYC TARGETS WITH EBOX	230	156	All SZGR 2.0 genes in this pathway
SWEET KRAS TARGETS DN	66	39	All SZGR 2.0 genes in this pathway
GNATENKO PLATELET SIGNATURE	48	28	All SZGR 2.0 genes in this pathway
ZUCCHI METASTASIS UP	43	24	All SZGR 2.0 genes in this pathway
FERNANDEZ BOUND BY MYC	182	116	All SZGR 2.0 genes in this pathway
FLECHNER BIOPSY KIDNEY TRANSPLANT OK VS DONOR UP	555	346	All SZGR 2.0 genes in this pathway
PARK HSC AND MULTIPOTENT PROGENITORS	50	33	All SZGR 2.0 genes in this pathway
RHODES CANCER META SIGNATURE	64	47	All SZGR 2.0 genes in this pathway
HU GENOTOXIN ACTION DIRECT VS INDIRECT 24HR	55	38	All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE UP	1691	1088	All SZGR 2.0 genes in this pathway
ZHANG PROLIFERATING VS QUIESCENT	51	41	All SZGR 2.0 genes in this pathway
SESTO RESPONSE TO UV C7	68	44	All SZGR 2.0 genes in this pathway
KRIGE RESPONSE TO TOSEDOSTAT 6HR DN	911	527	All SZGR 2.0 genes in this pathway
KRIGE RESPONSE TO TOSEDOSTAT 24HR DN	1011	592	All SZGR 2.0 genes in this pathway
HILLION HMGA1B TARGETS	92	68	All SZGR 2.0 genes in this pathway
MARSON BOUND BY E2F4 UNSTIMULATED	728	415	All SZGR 2.0 genes in this pathway
ACEVEDO NORMAL TISSUE ADJACENT TO LIVER TUMOR UP	174	96	All SZGR 2.0 genes in this pathway
GRADE COLON CANCER UP	871	505	All SZGR 2.0 genes in this pathway
MALONEY RESPONSE TO 17AAG DN	79	45	All SZGR 2.0 genes in this pathway
BLUM RESPONSE TO SALIRASIB DN	342	220	All SZGR 2.0 genes in this pathway
MUELLER PLURINET	299	189	All SZGR 2.0 genes in this pathway
LEE LIVER CANCER SURVIVAL DN	175	103	All SZGR 2.0 genes in this pathway
HSIAO HOUSEKEEPING GENES	389	245	All SZGR 2.0 genes in this pathway
ROME INSULIN TARGETS IN MUSCLE UP	442	263	All SZGR 2.0 genes in this pathway
JISON SICKLE CELL DISEASE DN	181	97	All SZGR 2.0 genes in this pathway
WOO LIVER CANCER RECURRENCE UP	105	75	All SZGR 2.0 genes in this pathway
YAGI AML WITH INV 16 TRANSLOCATION	422	277	All SZGR 2.0 genes in this pathway
DANG MYC TARGETS UP	143	100	All SZGR 2.0 genes in this pathway
DANG BOUND BY MYC	1103	714	All SZGR 2.0 genes in this pathway
MARTENS TRETINOIN RESPONSE DN	841	431	All SZGR 2.0 genes in this pathway
CHICAS RB1 TARGETS SENESCENT	572	352	All SZGR 2.0 genes in this pathway
JOHNSTONE PARVB TARGETS 3 DN	918	550	All SZGR 2.0 genes in this pathway
LOPEZ TRANSLATION VIA FN1 SIGNALING	35	21	All SZGR 2.0 genes in this pathway
PECE MAMMARY STEM CELL UP	146	75	All SZGR 2.0 genes in this pathway
KUMAR PATHOGEN LOAD BY MACROPHAGES	275	155	All SZGR 2.0 genes in this pathway

Gene Page: PTMA