Gene Page: KIF17
Summary ?
| GeneID | 57576 |
| Symbol | KIF17 |
| Synonyms | KIF17B|KIF3X|KLP-2|OSM-3 |
| Description | kinesin family member 17 |
| Reference | MIM:605037|HGNC:HGNC:19167|Ensembl:ENSG00000117245|HPRD:10388|Vega:OTTHUMG00000002863 |
| Gene type | protein-coding |
| Map location | 1p36.12 |
| Pascal p-value | 0.153 |
| Sherlock p-value | 0.681 |
| Fetal beta | -0.38 |
| DMG | 1 (# studies) |
| eGene | Anterior cingulate cortex BA24 Caudate basal ganglia Frontal Cortex BA9 Nucleus accumbens basal ganglia Putamen basal ganglia Meta |
| Support | Potential synaptic genes |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| DMG:Wockner_2014 | Genome-wide DNA methylation analysis | This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). | 1 |
| DNM:Awadalla_2010 | Whole Exome Sequencing analysis | A survey of ~430 Mb of DNA from 401 synapse-expressed genes across all cases and 25 Mb of DNA in controls found 28 candidate DNMs. | |
| PMID:cooccur | High-throughput literature-search | Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included. | |
| Literature | High-throughput literature-search | Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenic,schizophrenias | Click to show details |
Section I. Genetics and epigenetics annotation
DNM table
| Gene | Chromosome | Position | Ref | Alt | Transcript | AA change | Mutation type | Sift | CG46 | Trait | Study |
|---|---|---|---|---|---|---|---|---|---|---|---|
| KIF17 | chr1 | 21014094 | C | A | KIF17:NM_001122819:exon8:c.C1725T:p.Y575Y KIF17:NM_001287212:exon8:c.C1425T:p.Y475Y KIF17:NM_020816:exon8:c.C1725T:p.Y575Y | Y575X | synonymous SNV | Schizophrenia | DNM:Awadalla_2010 |
Differentially methylated gene
| Probe | Chromosome | Position | Nearest gene | P (dis) | Beta (dis) | FDR (dis) | Study |
|---|---|---|---|---|---|---|---|
| cg07105891 | 1 | 21031312 | KIF17 | 8.98E-6 | 0.272 | 0.013 | DMG:Wockner_2014 |
eQTL annotation
| SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
|---|---|---|---|---|---|---|---|---|
| rs10799661 | 1 | 21040079 | KIF17 | ENSG00000117245.8 | 8.472E-7 | 0 | 4431 | gtex_brain_ba24 |
| rs666371 | 1 | 21041555 | KIF17 | ENSG00000117245.8 | 1.213E-8 | 0 | 2955 | gtex_brain_ba24 |
| rs554111 | 1 | 21042300 | KIF17 | ENSG00000117245.8 | 1.143E-8 | 0 | 2210 | gtex_brain_ba24 |
| rs710312 | 1 | 21042462 | KIF17 | ENSG00000117245.8 | 1.132E-8 | 0 | 2048 | gtex_brain_ba24 |
| rs586924 | 1 | 21043302 | KIF17 | ENSG00000117245.8 | 1.224E-6 | 0 | 1208 | gtex_brain_ba24 |
| rs519209 | 1 | 21043790 | KIF17 | ENSG00000117245.8 | 3.808E-7 | 0 | 720 | gtex_brain_ba24 |
| rs604659 | 1 | 21043913 | KIF17 | ENSG00000117245.8 | 3.793E-7 | 0 | 597 | gtex_brain_ba24 |
| rs604645 | 1 | 21043926 | KIF17 | ENSG00000117245.8 | 2.937E-8 | 0 | 584 | gtex_brain_ba24 |
| rs601329 | 1 | 21044161 | KIF17 | ENSG00000117245.8 | 1.824E-8 | 0 | 349 | gtex_brain_ba24 |
| rs78001072 | 1 | 21044632 | KIF17 | ENSG00000117245.8 | 1.196E-8 | 0 | -122 | gtex_brain_ba24 |
| rs10799661 | 1 | 21040079 | KIF17 | ENSG00000117245.8 | 5.591E-7 | 0 | 4431 | gtex_brain_putamen_basal |
| rs666371 | 1 | 21041555 | KIF17 | ENSG00000117245.8 | 5.86E-8 | 0 | 2955 | gtex_brain_putamen_basal |
| rs554111 | 1 | 21042300 | KIF17 | ENSG00000117245.8 | 5.948E-8 | 0 | 2210 | gtex_brain_putamen_basal |
| rs710312 | 1 | 21042462 | KIF17 | ENSG00000117245.8 | 5.956E-8 | 0 | 2048 | gtex_brain_putamen_basal |
| rs519209 | 1 | 21043790 | KIF17 | ENSG00000117245.8 | 3.544E-9 | 0 | 720 | gtex_brain_putamen_basal |
| rs604659 | 1 | 21043913 | KIF17 | ENSG00000117245.8 | 3.544E-9 | 0 | 597 | gtex_brain_putamen_basal |
| rs604645 | 1 | 21043926 | KIF17 | ENSG00000117245.8 | 8.693E-8 | 0 | 584 | gtex_brain_putamen_basal |
| rs601329 | 1 | 21044161 | KIF17 | ENSG00000117245.8 | 6.064E-8 | 0 | 349 | gtex_brain_putamen_basal |
| rs78001072 | 1 | 21044632 | KIF17 | ENSG00000117245.8 | 2.767E-8 | 0 | -122 | gtex_brain_putamen_basal |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
No co-expressed genes in brain regions
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| GRAESSMANN APOPTOSIS BY DOXORUBICIN UP | 1142 | 669 | All SZGR 2.0 genes in this pathway |
| PUJANA ATM PCC NETWORK | 1442 | 892 | All SZGR 2.0 genes in this pathway |
| SAKAI TUMOR INFILTRATING MONOCYTES UP | 27 | 19 | All SZGR 2.0 genes in this pathway |
| ROSS AML WITH CBFB MYH11 FUSION | 52 | 32 | All SZGR 2.0 genes in this pathway |
| AFFAR YY1 TARGETS UP | 214 | 133 | All SZGR 2.0 genes in this pathway |
| BREDEMEYER RAG SIGNALING VIA ATM NOT VIA NFKB UP | 49 | 32 | All SZGR 2.0 genes in this pathway |
| VALK AML CLUSTER 1 | 28 | 19 | All SZGR 2.0 genes in this pathway |
| RATTENBACHER BOUND BY CELF1 | 467 | 251 | All SZGR 2.0 genes in this pathway |
| VANOEVELEN MYOGENESIS SIN3A TARGETS | 220 | 133 | All SZGR 2.0 genes in this pathway |