Gene Page: USP36

Summary ?
GeneID57602
SymbolUSP36
SynonymsDUB1
Descriptionubiquitin specific peptidase 36
ReferenceMIM:612543|HGNC:HGNC:20062|Ensembl:ENSG00000055483|HPRD:07164|Vega:OTTHUMG00000177542
Gene typeprotein-coding
Map location17q25.3
Pascal p-value0.004
Sherlock p-value0.911
DMG1 (# studies)
eGeneCaudate basal ganglia
Cerebellar Hemisphere
Cerebellum
Cortex
Hippocampus
Nucleus accumbens basal ganglia
Putamen basal ganglia
Myers' cis & trans
Meta

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:GWASdbGenome-wide Association StudiesGWASdb records for schizophrenia
CV:PGCnpGenome-wide Association StudyGWAS
DMG:Wockner_2014Genome-wide DNA methylation analysisThis dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 1
ExpressionMeta-analysis of gene expressionP value: 2.033 

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

ProbeChromosomePositionNearest geneP (dis)Beta (dis)FDR (dis)Study
cg270210561776837047USP362.451E-4-0.2240.037DMG:Wockner_2014

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs10512617chr1776693550USP36576021.207E-7cis
rs17736494chr1776728667USP36576023.699E-8cis
rs1384367chr1776729756USP36576027.953E-8cis
rs8182269chr1776789990USP36576023.186E-6cis
rs10512617chr1776693550USP36576022.646E-5trans
rs17736494chr1776728667USP36576028.54E-6trans
rs1384367chr1776729756USP36576021.758E-5trans
rs8182269chr1776789990USP36576025.581E-4trans
rs37448021776793600USP36ENSG00000055483.159.501E-70.0243923gtex_brain_putamen_basal
rs38265521776793885USP36ENSG00000055483.159.134E-70.0243638gtex_brain_putamen_basal
rs23065261776798362USP36ENSG00000055483.154.587E-70.0239161gtex_brain_putamen_basal
rs30880401776799860USP36ENSG00000055483.151.811E-60.0237663gtex_brain_putamen_basal
rs93028851776799898USP36ENSG00000055483.151.584E-60.0237625gtex_brain_putamen_basal
rs116499641776800182USP36ENSG00000055483.157.396E-70.0237341gtex_brain_putamen_basal
rs65012501776808726USP36ENSG00000055483.154.688E-70.0228797gtex_brain_putamen_basal
rs72205321776808773USP36ENSG00000055483.154.682E-70.0228750gtex_brain_putamen_basal
rs2020897331776809351USP36ENSG00000055483.151.151E-60.0228172gtex_brain_putamen_basal
rs11102741776810284USP36ENSG00000055483.155.204E-70.0227239gtex_brain_putamen_basal
rs72186051776811803USP36ENSG00000055483.155.481E-70.0225720gtex_brain_putamen_basal
rs23768281776812840USP36ENSG00000055483.151.797E-60.0224683gtex_brain_putamen_basal
rs116500001776828154USP36ENSG00000055483.151.475E-60.029369gtex_brain_putamen_basal
rs43520961776833916USP36ENSG00000055483.151.024E-60.023607gtex_brain_putamen_basal

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
NDC800.990.76
SGOL10.980.75
TTK0.980.75
MELK0.980.75
HMGB20.980.59
EXO10.980.71
DLGAP50.970.79
KIF230.970.73
PBK0.970.75
CCNB20.970.77
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
SLC9A3R2-0.38-0.55
FBXO2-0.36-0.64
ASPHD1-0.36-0.61
PTH1R-0.36-0.63
HLA-F-0.36-0.65
TNFSF12-0.35-0.62
C5orf53-0.35-0.62
ADAP1-0.34-0.41
LHPP-0.34-0.58
CA4-0.34-0.67

Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0004221ubiquitin thiolesterase activityIEA-
GO:0008234cysteine-type peptidase activityIEA-
GO:0008233peptidase activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006511ubiquitin-dependent protein catabolic processIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005634nucleusIEA-

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
WANG LMO4 TARGETS UP 372227All SZGR 2.0 genes in this pathway
OSMAN BLADDER CANCER DN 406230All SZGR 2.0 genes in this pathway
RHEIN ALL GLUCOCORTICOID THERAPY UP 7841All SZGR 2.0 genes in this pathway
UDAYAKUMAR MED1 TARGETS DN 240171All SZGR 2.0 genes in this pathway
NAGASHIMA NRG1 SIGNALING UP 176123All SZGR 2.0 genes in this pathway
COLDREN GEFITINIB RESISTANCE UP 8557All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY DOXORUBICIN DN 17811082All SZGR 2.0 genes in this pathway
GRAESSMANN RESPONSE TO MC AND DOXORUBICIN DN 770415All SZGR 2.0 genes in this pathway
NUYTTEN NIPP1 TARGETS UP 769437All SZGR 2.0 genes in this pathway
NUYTTEN EZH2 TARGETS DN 1024594All SZGR 2.0 genes in this pathway
BUYTAERT PHOTODYNAMIC THERAPY STRESS UP 811508All SZGR 2.0 genes in this pathway
NIKOLSKY BREAST CANCER 17Q21 Q25 AMPLICON 335181All SZGR 2.0 genes in this pathway
SHEPARD BMYB MORPHOLINO UP 205126All SZGR 2.0 genes in this pathway
MITSIADES RESPONSE TO APLIDIN UP 439257All SZGR 2.0 genes in this pathway
BOQUEST STEM CELL DN 216143All SZGR 2.0 genes in this pathway
BEIER GLIOMA STEM CELL DN 6642All SZGR 2.0 genes in this pathway
KRIEG HYPOXIA NOT VIA KDM3A 770480All SZGR 2.0 genes in this pathway
ZWANG TRANSIENTLY UP BY 1ST EGF PULSE ONLY 1839928All SZGR 2.0 genes in this pathway