Gene Page: VPS18
Summary ?
| GeneID | 57617 |
| Symbol | VPS18 |
| Synonyms | PEP3 |
| Description | VPS18, CORVET/HOPS core subunit |
| Reference | MIM:608551|HGNC:HGNC:15972|Ensembl:ENSG00000104142|HPRD:09776|Vega:OTTHUMG00000130135 |
| Gene type | protein-coding |
| Map location | 15q15.1 |
| Pascal p-value | 0.333 |
| Sherlock p-value | 0.986 |
| Fetal beta | -0.492 |
| DMG | 1 (# studies) |
| Support | Ascano FMRP targets |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| DMG:Jaffe_2016 | Genome-wide DNA methylation analysis | This dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05. | 2 |
Section I. Genetics and epigenetics annotation
Differentially methylated gene
| Probe | Chromosome | Position | Nearest gene | P (dis) | Beta (dis) | FDR (dis) | Study |
|---|---|---|---|---|---|---|---|
| cg09976724 | 15 | 41186526 | VPS18 | 4.12E-9 | -0.02 | 2.5E-6 | DMG:Jaffe_2016 |
| cg03643709 | 15 | 41186784 | VPS18 | 4.4E-8 | -0.024 | 1.21E-5 | DMG:Jaffe_2016 |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
No co-expressed genes in brain regions
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| GRAESSMANN APOPTOSIS BY DOXORUBICIN UP | 1142 | 669 | All SZGR 2.0 genes in this pathway |
| KAMMINGA SENESCENCE | 41 | 26 | All SZGR 2.0 genes in this pathway |
| JOHNSTONE PARVB TARGETS 3 UP | 430 | 288 | All SZGR 2.0 genes in this pathway |