Summary ?
GeneID57717
SymbolPCDHB16
SynonymsME1|PCDH-BETA16|PCDH3X|PCDHB8a
Descriptionprotocadherin beta 16
ReferenceMIM:606345|HGNC:HGNC:14546|Ensembl:ENSG00000272674|HPRD:06961|Vega:OTTHUMG00000188325
Gene typeprotein-coding
Map location5q31
Pascal p-value0.041
Sherlock p-value0.212
eGeneCerebellar Hemisphere
Cerebellum

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
GSMA_IGenome scan meta-analysisPsr: 0.0032 
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 2 

Section I. Genetics and epigenetics annotation


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
A2ML10.710.67
EPHX20.700.67
KANK10.690.70
NFATC10.680.58
SLC12A40.680.65
ITPKB0.680.69
RYR10.670.76
PIPOX0.670.65
PBXIP10.670.72
ADHFE10.670.70
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
BZW2-0.52-0.53
CCNI-0.52-0.52
SSBP2-0.51-0.50
AC027307.2-0.51-0.47
VASH2-0.50-0.45
DACT1-0.50-0.46
SLA-0.50-0.43
FAM117B-0.50-0.44
PAK7-0.50-0.45
FANCE-0.50-0.45

Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005509calcium ion bindingIEA-
GO:0005515protein bindingNAS11322959 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007416synaptogenesisTASSynap (GO term level: 6)12231349 
GO:0007268synaptic transmissionTASneuron, Synap, Neurotransmitter (GO term level: 6)12231349 
GO:0007155cell adhesionIEA-
GO:0007156homophilic cell adhesionIEA-
GO:0016339calcium-dependent cell-cell adhesionNAS11322959 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0016020membraneIEA-
GO:0016021integral to membraneNAS11322959 

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
RODRIGUES DCC TARGETS DN 12184All SZGR 2.0 genes in this pathway
GOZGIT ESR1 TARGETS DN 781465All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY SERUM DEPRIVATION UP 552347All SZGR 2.0 genes in this pathway
GRAESSMANN RESPONSE TO MC AND SERUM DEPRIVATION UP 211136All SZGR 2.0 genes in this pathway
CHEN METABOLIC SYNDROM NETWORK 1210725All SZGR 2.0 genes in this pathway
MIKKELSEN IPS WITH HCP H3K27ME3 10276All SZGR 2.0 genes in this pathway
MIKKELSEN ES HCP WITH H3K27ME3 4130All SZGR 2.0 genes in this pathway
FIGUEROA AML METHYLATION CLUSTER 1 UP 12561All SZGR 2.0 genes in this pathway
FIGUEROA AML METHYLATION CLUSTER 3 UP 17097All SZGR 2.0 genes in this pathway
GOBERT OLIGODENDROCYTE DIFFERENTIATION DN 1080713All SZGR 2.0 genes in this pathway
PEDRIOLI MIR31 TARGETS DN 418245All SZGR 2.0 genes in this pathway