Gene Page: ANO8
Summary ?
| GeneID | 57719 |
| Symbol | ANO8 |
| Synonyms | KIAA1623|TMEM16H |
| Description | anoctamin 8 |
| Reference | MIM:610216|HGNC:HGNC:29329|Ensembl:ENSG00000074855|HPRD:17223|Vega:OTTHUMG00000182665 |
| Gene type | protein-coding |
| Map location | 19p13.11 |
| Pascal p-value | 0.885 |
| Sherlock p-value | 0.465 |
| Fetal beta | 0.4 |
| DMG | 1 (# studies) |
| eGene | Myers' cis & trans |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| DMG:Jaffe_2016 | Genome-wide DNA methylation analysis | This dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05. | 1 |
Section I. Genetics and epigenetics annotation
Differentially methylated gene
| Probe | Chromosome | Position | Nearest gene | P (dis) | Beta (dis) | FDR (dis) | Study |
|---|---|---|---|---|---|---|---|
| cg11446345 | 19 | 17445677 | ANO8 | 3.52E-9 | -0.012 | 2.29E-6 | DMG:Jaffe_2016 |
eQTL annotation
| SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
|---|---|---|---|---|---|---|---|---|
| rs3773648 | chr3 | 30716287 | ANO8 | 57719 | 0.2 | trans | ||
| rs2277184 | chr9 | 98239146 | ANO8 | 57719 | 0.18 | trans | ||
| rs2068673 | chr12 | 60333402 | ANO8 | 57719 | 0.02 | trans |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| BCAR1 | 0.84 | 0.86 |
| C9orf75 | 0.82 | 0.82 |
| FLYWCH1 | 0.81 | 0.83 |
| ZNF444 | 0.81 | 0.83 |
| MAP1S | 0.81 | 0.83 |
| POLRMT | 0.81 | 0.82 |
| EXOSC6 | 0.80 | 0.83 |
| RNH1 | 0.80 | 0.79 |
| KLHL26 | 0.79 | 0.81 |
| KIAA2013 | 0.79 | 0.80 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| AF347015.21 | -0.57 | -0.54 |
| SYCP3 | -0.55 | -0.58 |
| C1orf54 | -0.52 | -0.50 |
| GNG11 | -0.52 | -0.51 |
| AL050337.1 | -0.51 | -0.54 |
| NMI | -0.51 | -0.50 |
| AF347015.31 | -0.51 | -0.47 |
| SAT1 | -0.50 | -0.50 |
| CLEC2B | -0.49 | -0.48 |
| AP002478.3 | -0.49 | -0.49 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| BENPORATH NANOG TARGETS | 988 | 594 | All SZGR 2.0 genes in this pathway |
| BENPORATH OCT4 TARGETS | 290 | 172 | All SZGR 2.0 genes in this pathway |
| BENPORATH SOX2 TARGETS | 734 | 436 | All SZGR 2.0 genes in this pathway |
| BENPORATH NOS TARGETS | 179 | 105 | All SZGR 2.0 genes in this pathway |
| WANG RESPONSE TO GSK3 INHIBITOR SB216763 UP | 397 | 206 | All SZGR 2.0 genes in this pathway |