Summary ?
GeneID57721
SymbolMETTL14
Synonyms-
Descriptionmethyltransferase like 14
ReferenceMIM:616504|HGNC:HGNC:29330|HPRD:13879|
Gene typeprotein-coding
Map location4q26
Pascal p-value0.069
Sherlock p-value0.914
TADA p-value0.009
Fetal beta0.472
eGeneMyers' cis & trans
SupportCompositeSet

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
DNM:Fromer_2014Whole Exome Sequencing analysisThis study reported a WES study of 623 schizophrenia trios, reporting DNMs using genomic DNA.

Section I. Genetics and epigenetics annotation

@DNM table

GeneChromosomePositionRefAltTranscriptAA changeMutation typeSiftCG46TraitStudy
METTL14chr4119631282CTNM_020961p.399S>LmissenseSchizophreniaDNM:Fromer_2014

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs298980chr4119607375METTL14577210cis
rs10518324chr4119717712METTL14577210.02cis
rs10518323chr4119718084METTL14577210.02cis
rs6676309chr1234558965METTL14577210.19trans
rs16829545chr2151977407METTL14577210.11trans
rs298980chr4119607375METTL14577210.13trans
rs10035168chr55974295METTL14577210.13trans
rs4326721chr1094958885METTL14577210.1trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
MOHANKUMAR TLX1 TARGETS UP 414287All SZGR 2.0 genes in this pathway
LU IL4 SIGNALING 9456All SZGR 2.0 genes in this pathway
PILON KLF1 TARGETS DN 19721213All SZGR 2.0 genes in this pathway