Gene Page: METTL14
Summary ?
GeneID | 57721 |
Symbol | METTL14 |
Synonyms | - |
Description | methyltransferase like 14 |
Reference | MIM:616504|HGNC:HGNC:29330|HPRD:13879| |
Gene type | protein-coding |
Map location | 4q26 |
Pascal p-value | 0.069 |
Sherlock p-value | 0.914 |
TADA p-value | 0.009 |
Fetal beta | 0.472 |
eGene | Myers' cis & trans |
Support | CompositeSet |
Gene in Data Sources
Gene set name | Method of gene set | Description | Info |
---|---|---|---|
CV:PGCnp | Genome-wide Association Study | GWAS | |
DNM:Fromer_2014 | Whole Exome Sequencing analysis | This study reported a WES study of 623 schizophrenia trios, reporting DNMs using genomic DNA. |
Section I. Genetics and epigenetics annotation
DNM table
Gene | Chromosome | Position | Ref | Alt | Transcript | AA change | Mutation type | Sift | CG46 | Trait | Study |
---|---|---|---|---|---|---|---|---|---|---|---|
METTL14 | chr4 | 119631282 | C | T | NM_020961 | p.399S>L | missense | Schizophrenia | DNM:Fromer_2014 |
eQTL annotation
SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
---|---|---|---|---|---|---|---|---|
rs298980 | chr4 | 119607375 | METTL14 | 57721 | 0 | cis | ||
rs10518324 | chr4 | 119717712 | METTL14 | 57721 | 0.02 | cis | ||
rs10518323 | chr4 | 119718084 | METTL14 | 57721 | 0.02 | cis | ||
rs6676309 | chr1 | 234558965 | METTL14 | 57721 | 0.19 | trans | ||
rs16829545 | chr2 | 151977407 | METTL14 | 57721 | 0.11 | trans | ||
rs298980 | chr4 | 119607375 | METTL14 | 57721 | 0.13 | trans | ||
rs10035168 | chr5 | 5974295 | METTL14 | 57721 | 0.13 | trans | ||
rs4326721 | chr10 | 94958885 | METTL14 | 57721 | 0.1 | trans |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
No co-expressed genes in brain regions
Section V. Pathway annotation
Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
---|---|---|---|
MOHANKUMAR TLX1 TARGETS UP | 414 | 287 | All SZGR 2.0 genes in this pathway |
LU IL4 SIGNALING | 94 | 56 | All SZGR 2.0 genes in this pathway |
PILON KLF1 TARGETS DN | 1972 | 1213 | All SZGR 2.0 genes in this pathway |