Gene Page: RBAK
Summary ?
| GeneID | 57786 |
| Symbol | RBAK |
| Synonyms | ZNF769 |
| Description | RB associated KRAB zinc finger |
| Reference | MIM:608191|HGNC:HGNC:17680|Ensembl:ENSG00000146587|HPRD:16296| |
| Gene type | protein-coding |
| Map location | 7p22.1 |
| Pascal p-value | 0.019 |
| Fetal beta | 0.676 |
| DMG | 1 (# studies) |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| DMG:Wockner_2014 | Genome-wide DNA methylation analysis | This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). | 1 |
Section I. Genetics and epigenetics annotation
Differentially methylated gene
| Probe | Chromosome | Position | Nearest gene | P (dis) | Beta (dis) | FDR (dis) | Study |
|---|---|---|---|---|---|---|---|
| cg02646611 | 7 | 5084794 | RBAK | 3.295E-4 | 0.266 | 0.041 | DMG:Wockner_2014 |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| PLEKHB1 | 0.77 | 0.82 |
| MBP | 0.77 | 0.82 |
| KIF1C | 0.77 | 0.81 |
| DAAM2 | 0.77 | 0.79 |
| EFHD1 | 0.76 | 0.83 |
| HEPN1 | 0.75 | 0.79 |
| BCAS1 | 0.75 | 0.82 |
| PTRF | 0.75 | 0.68 |
| AL358113.1 | 0.75 | 0.80 |
| TFEB | 0.74 | 0.80 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| PPP3CC | -0.71 | -0.77 |
| PARP6 | -0.71 | -0.77 |
| STMN2 | -0.68 | -0.78 |
| TRO | -0.67 | -0.73 |
| TUBB2A | -0.67 | -0.73 |
| GPRIN1 | -0.67 | -0.75 |
| TMEM63B | -0.67 | -0.71 |
| SRD5A1 | -0.67 | -0.75 |
| RNF19B | -0.67 | -0.73 |
| PODXL2 | -0.67 | -0.73 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| CHARAFE BREAST CANCER LUMINAL VS BASAL UP | 380 | 215 | All SZGR 2.0 genes in this pathway |
| SENESE HDAC3 TARGETS UP | 501 | 327 | All SZGR 2.0 genes in this pathway |
| RODRIGUES THYROID CARCINOMA POORLY DIFFERENTIATED UP | 633 | 376 | All SZGR 2.0 genes in this pathway |
| RODRIGUES THYROID CARCINOMA ANAPLASTIC UP | 722 | 443 | All SZGR 2.0 genes in this pathway |
| MARIADASON REGULATED BY HISTONE ACETYLATION DN | 54 | 30 | All SZGR 2.0 genes in this pathway |
| MCCABE BOUND BY HOXC6 | 469 | 239 | All SZGR 2.0 genes in this pathway |
| ZHANG BREAST CANCER PROGENITORS UP | 425 | 253 | All SZGR 2.0 genes in this pathway |
| WAKABAYASHI ADIPOGENESIS PPARG BOUND 8D | 658 | 397 | All SZGR 2.0 genes in this pathway |
| ZWANG CLASS 1 TRANSIENTLY INDUCED BY EGF | 516 | 308 | All SZGR 2.0 genes in this pathway |