Summary ?
GeneID58
SymbolACTA1
SynonymsACTA|ASMA|CFTD|CFTD1|CFTDM|MPFD|NEM1|NEM2|NEM3|SHPM
Descriptionactin, alpha 1, skeletal muscle
ReferenceMIM:102610|HGNC:HGNC:129|Ensembl:ENSG00000143632|HPRD:00030|Vega:OTTHUMG00000038006
Gene typeprotein-coding
Map location1q42.13
Fetal beta-0.745
DMG1 (# studies)

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
DMG:Wockner_2014Genome-wide DNA methylation analysisThis dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 1
PMID:cooccurHigh-throughput literature-searchSystematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: schizophrenia,schizophreniasClick to show details
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.1982 

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

ProbeChromosomePositionNearest geneP (dis)Beta (dis)FDR (dis)Study
cg077777901229570188ACTA15.516E-4-0.3660.049DMG:Wockner_2014


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0000166nucleotide bindingIEA-
GO:0005515protein bindingIEA-
GO:0005515protein bindingIPI12849983 
GO:0005524ATP bindingIEA-
GO:0005524ATP bindingTAS10508519 
GO:0005198structural molecule activityIEA-
GO:0005200structural constituent of cytoskeletonTAS10508519 
GO:0017022myosin bindingTAS10508519 
GO:0043531ADP bindingTAS10508519 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0030240muscle thin filament assemblyIMP11333380 
GO:0006936muscle contractionTAS10508519 
GO:0048741skeletal muscle fiber developmentISS-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0001725stress fiberIDA15198992 
GO:0005856cytoskeletonIEA-
GO:0005865striated muscle thin filamentIDA15198992 
GO:0005737cytoplasmIEA-
GO:0005884actin filamentIDA12849983 

Section IV. Protein-protein interaction annotation

InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ACTR10ACTR11 | HARP11actin-related protein 10 homolog (S. cerevisiae)-HPRD12857853 
APC2APCLadenomatosis polyposis coli 2Co-localizationBioGRID11691822 
CCT4CCT-DELTA | Cctd | MGC126164 | MGC126165 | SRBchaperonin containing TCP1, subunit 4 (delta)-HPRD,BioGRID11580270 
CCT5CCT-epsilon | CCTE | KIAA0098 | TCP-1-epsilonchaperonin containing TCP1, subunit 5 (epsilon)-HPRD,BioGRID11580270 
CDH2CD325 | CDHN | CDw325 | NCADcadherin 2, type 1, N-cadherin (neuronal)Affinity Capture-WesternBioGRID12438242 
CFL1CFLcofilin 1 (non-muscle)Affinity Capture-MSBioGRID11950878 
CFL1CFLcofilin 1 (non-muscle)-HPRD11707283 
CNN1SMCC | Sm-Calpcalponin 1, basic, smooth muscleReconstituted ComplexBioGRID2161834 
CSNK1A1CK1 | HLCDGP1 | PRO2975casein kinase 1, alpha 1Affinity Capture-MSBioGRID12062430 
DMDBMD | CMD3B | DXS142 | DXS164 | DXS206 | DXS230 | DXS239 | DXS268 | DXS269 | DXS270 | DXS272dystrophin-HPRD,BioGRID1544421|11259305 
DMDBMD | CMD3B | DXS142 | DXS164 | DXS206 | DXS230 | DXS239 | DXS268 | DXS269 | DXS270 | DXS272dystrophin-HPRD1544421 
DNASE1DKFZp686H0155 | DNL1 | DRNI | FLJ38093 | FLJ44902deoxyribonuclease I-HPRD11707283 
DNMBPKIAA1010 | TUBAdynamin binding protein-HPRD,BioGRID14506234 
DVL1L1DSH | DVL | DVL-22 | DVL1 | DVL4dishevelled, dsh homolog 1 (Drosophila)-like 1Affinity Capture-WesternBioGRID12384700 
EPB414.1R | EL1 | HEerythrocyte membrane protein band 4.1 (elliptocytosis 1, RH-linked)-HPRD11071908 
ETV6TEL | TEL/ABLets variant 6Co-localizationBioGRID9695962 
FGD4CMT4H | DKFZp313E1818 | DKFZp434K1572 | FLJ34370 | FLJ42663 | FRABP | MGC57222 | ZFYVE6FYVE, RhoGEF and PH domain containing 4-HPRD9668039 |11429692 
FSCN1FLJ38511 | SNL | p55fascin homolog 1, actin-bundling protein (Strongylocentrotus purpuratus)-HPRD,BioGRID8999969 
GAS7KIAA0394 | MGC1348 | MLL/GAS7growth arrest-specific 7-HPRD11795944 
GCDBP | DBP/GC | VDBG | VDBPgroup-specific component (vitamin D binding protein)Co-crystal StructureBioGRID12554937 
GCDBP | DBP/GC | VDBG | VDBPgroup-specific component (vitamin D binding protein)-HPRD12119014 
GRB2ASH | EGFRBP-GRB2 | Grb3-3 | MST084 | MSTP084growth factor receptor-bound protein 2Affinity Capture-MSBioGRID12577067 
GSNDKFZp313L0718gelsolin (amyloidosis, Finnish type)-HPRD,BioGRID10583954 
HIP1RFLJ14000 | FLJ27022 | HIP12 | HIP3 | ILWEQ | KIAA0655 | MGC47513huntingtin interacting protein 1 related-HPRD11889126 
JUBAjuba | MGC15563jub, ajuba homolog (Xenopus laevis)-HPRD12417594 
KLHL20KHLHX | KLEIP | KLHLX | RP3-383J4.3kelch-like 20 (Drosophila)-HPRD,BioGRID14668487 
MARK4FLJ90097 | KIAA1860 | MARKL1 | Nbla00650MAP/microtubule affinity-regulating kinase 4Affinity Capture-MSBioGRID14594945 
MIB2FLJ20648 | FLJ39787 | ZZANK1 | ZZZ5mindbomb homolog 2 (Drosophila)Reconstituted Complex
Two-hybrid
BioGRID14507647 
MLPHMGC2771 | MGC59733 | SLAC2-AmelanophilinAffinity Capture-WesternBioGRID15059972 
MYL1MLC1F | MLC3Fmyosin, light chain 1, alkali; skeletal, fast-HPRD11707283 
NRAP-nebulin-related anchoring proteinReconstituted ComplexBioGRID10320340 
PARVAFLJ10793 | FLJ12254 | MXRA2parvin, alpha-HPRD11171322 
PCYT1BCCT-beta | CTBphosphate cytidylyltransferase 1, choline, beta-HPRD,BioGRID11580270 
PFDN1PDF | PFD1prefoldin subunit 1Reconstituted ComplexBioGRID14634002 
PFN1-profilin 1-HPRD8413665 
PHACTR1KIAA1733 | MGC126575 | MGC126577 | RPEL | RPEL1 | dJ257A7.2phosphatase and actin regulator 1-HPRD,BioGRID15107502 
PLDNPA | PALLIDpallidin homolog (mouse)-HPRD12019270 
PPP1CAMGC15877 | MGC1674 | PP-1A | PPP1Aprotein phosphatase 1, catalytic subunit, alpha isoformAffinity Capture-WesternBioGRID15107502 
PPP1R9BFLJ30345 | PPP1R6 | PPP1R9 | SPINO | Spnprotein phosphatase 1, regulatory (inhibitor) subunit 9BReconstituted ComplexBioGRID12417592 
PRKCAAAG6 | MGC129900 | MGC129901 | PKC-alpha | PKCA | PRKACAprotein kinase C, alpha-HPRD,BioGRID10628374 
PRKCEMGC125656 | MGC125657 | PKCE | nPKC-epsilonprotein kinase C, epsilonAffinity Capture-MS
Affinity Capture-Western
BioGRID11897493 
RAC1MGC111543 | MIG5 | TC-25 | p21-Rac1ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)-HPRD11027608 
RPS6KB1PS6K | S6K | S6K1 | STK14A | p70(S6K)-alpha | p70-S6K | p70-alpharibosomal protein S6 kinase, 70kDa, polypeptide 1Reconstituted ComplexBioGRID15149849 
S100A418A2 | 42A | CAPL | FSP1 | MTS1 | P9KA | PEL98S100 calcium binding protein A4-HPRD14640694 
SCINKIAA1905scinderinReconstituted ComplexBioGRID12438125 
TAGLNDKFZp686P11128 | SM22 | SMCC | TAGLN1 | WS3-10transgelin-HPRD,BioGRID11053353 
TESDKFZp586B2022 | MGC1146 | TESS | TESS-2testis derived transcript (3 LIM domains)Affinity Capture-WesternBioGRID12695497 
TLN1ILWEQ | KIAA1027 | TLNtalin 1-HPRD10581178 
TMSB4XFX | PTMB4 | TB4X | TMSB4thymosin beta 4, X-linked-HPRD,BioGRID11812134 
TMSB4YMGC26307 | TB4Ythymosin beta 4, Y-linkedReconstituted ComplexBioGRID8416954 
TNNI3CMD2A | CMH7 | MGC116817 | TNNC1 | cTnItroponin I type 3 (cardiac)-HPRD12383268 
TNNI3KCARK | MGC142099 | MGC33828TNNI3 interacting kinase-HPRD,BioGRID12721663 
TRAF3CAP-1 | CD40bp | CRAF1 | LAP1TNF receptor-associated factor 3-HPRD11950878 
TRIP6MGC10556 | MGC10558 | MGC29959 | MGC3837 | MGC4423 | OIP1 | ZRP-1thyroid hormone receptor interactor 6Co-localizationBioGRID14688263 
TSC1KIAA0243 | LAM | MGC86987 | TSCtuberous sclerosis 1Co-localizationBioGRID10806479 
VCLCMD1W | MVCLvinculin-HPRD7816144 
XIRP1CMYA1 | DKFZp451D042 | DKFZp779C1255 | DKFZp779C1947 | Xinxin actin-binding repeat containing 1-HPRD15454575 
XPO6EXP6 | FLJ22519 | KIAA0370 | RANBP20exportin 6Affinity Capture-MSBioGRID14592989 


Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
BIOCARTA NO1 PATHWAY 3324All SZGR 2.0 genes in this pathway
BIOCARTA AGR PATHWAY 3631All SZGR 2.0 genes in this pathway
BIOCARTA EPHA4 PATHWAY 108All SZGR 2.0 genes in this pathway
BIOCARTA SALMONELLA PATHWAY 1310All SZGR 2.0 genes in this pathway
BIOCARTA MPR PATHWAY 3428All SZGR 2.0 genes in this pathway
BIOCARTA INTEGRIN PATHWAY 3829All SZGR 2.0 genes in this pathway
BIOCARTA MCALPAIN PATHWAY 2516All SZGR 2.0 genes in this pathway
BIOCARTA NFAT PATHWAY 5645All SZGR 2.0 genes in this pathway
BIOCARTA RAB PATHWAY 128All SZGR 2.0 genes in this pathway
BIOCARTA MAL PATHWAY 1917All SZGR 2.0 genes in this pathway
BIOCARTA MET PATHWAY 3730All SZGR 2.0 genes in this pathway
BIOCARTA HSP27 PATHWAY 1511All SZGR 2.0 genes in this pathway
BIOCARTA UCALPAIN PATHWAY 1811All SZGR 2.0 genes in this pathway
BIOCARTA ACTINY PATHWAY 2014All SZGR 2.0 genes in this pathway
PID RHOA PATHWAY 4533All SZGR 2.0 genes in this pathway
PID AP1 PATHWAY 7060All SZGR 2.0 genes in this pathway
PID CASPASE PATHWAY 5239All SZGR 2.0 genes in this pathway
PID FAK PATHWAY 5945All SZGR 2.0 genes in this pathway
BERENJENO TRANSFORMED BY RHOA REVERSIBLY DN 2921All SZGR 2.0 genes in this pathway
MARKEY RB1 CHRONIC LOF DN 11878All SZGR 2.0 genes in this pathway
BERENJENO TRANSFORMED BY RHOA UP 536340All SZGR 2.0 genes in this pathway
DARWICHE SKIN TUMOR PROMOTER DN 185115All SZGR 2.0 genes in this pathway
DARWICHE PAPILLOMA RISK LOW DN 165107All SZGR 2.0 genes in this pathway
DARWICHE PAPILLOMA RISK HIGH DN 180110All SZGR 2.0 genes in this pathway
DARWICHE SQUAMOUS CELL CARCINOMA DN 181107All SZGR 2.0 genes in this pathway
LOPEZ MBD TARGETS 957597All SZGR 2.0 genes in this pathway
RICKMAN HEAD AND NECK CANCER F 5432All SZGR 2.0 genes in this pathway
BENPORATH ES 1 379235All SZGR 2.0 genes in this pathway
PENG GLUCOSE DEPRIVATION UP 4826All SZGR 2.0 genes in this pathway
BECKER TAMOXIFEN RESISTANCE UP 5036All SZGR 2.0 genes in this pathway
NING CHRONIC OBSTRUCTIVE PULMONARY DISEASE UP 157105All SZGR 2.0 genes in this pathway
YAO HOXA10 TARGETS VIA PROGESTERONE DN 1912All SZGR 2.0 genes in this pathway
CROMER METASTASIS DN 8158All SZGR 2.0 genes in this pathway
LU AGING BRAIN DN 153120All SZGR 2.0 genes in this pathway
LEE CALORIE RESTRICTION NEOCORTEX UP 8366All SZGR 2.0 genes in this pathway
LEE AGING CEREBELLUM DN 8666All SZGR 2.0 genes in this pathway
DELASERNA MYOD TARGETS UP 8951All SZGR 2.0 genes in this pathway
CHEN LVAD SUPPORT OF FAILING HEART UP 10369All SZGR 2.0 genes in this pathway
APRELIKOVA BRCA1 TARGETS 4933All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 18HR DN 178121All SZGR 2.0 genes in this pathway
KUNINGER IGF1 VS PDGFB TARGETS UP 8251All SZGR 2.0 genes in this pathway
MARTINEZ RB1 TARGETS UP 673430All SZGR 2.0 genes in this pathway
MARTINEZ TP53 TARGETS UP 602364All SZGR 2.0 genes in this pathway
MARTINEZ RB1 AND TP53 TARGETS UP 601369All SZGR 2.0 genes in this pathway
SARRIO EPITHELIAL MESENCHYMAL TRANSITION DN 154101All SZGR 2.0 genes in this pathway
SMID BREAST CANCER BASAL UP 648398All SZGR 2.0 genes in this pathway
MUELLER PLURINET 299189All SZGR 2.0 genes in this pathway
YAUCH HEDGEHOG SIGNALING PARACRINE DN 264159All SZGR 2.0 genes in this pathway
WUNDER INFLAMMATORY RESPONSE AND CHOLESTEROL DN 127All SZGR 2.0 genes in this pathway
SWEET LUNG CANCER KRAS DN 435289All SZGR 2.0 genes in this pathway
YAGI AML WITH 11Q23 REARRANGED 351238All SZGR 2.0 genes in this pathway
YAO TEMPORAL RESPONSE TO PROGESTERONE CLUSTER 14 14386All SZGR 2.0 genes in this pathway
SASSON RESPONSE TO GONADOTROPHINS DN 8766All SZGR 2.0 genes in this pathway
SASSON RESPONSE TO FORSKOLIN DN 8868All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE LATE 1137655All SZGR 2.0 genes in this pathway
PASINI SUZ12 TARGETS DN 315215All SZGR 2.0 genes in this pathway
FEVR CTNNB1 TARGETS UP 682433All SZGR 2.0 genes in this pathway
WAKABAYASHI ADIPOGENESIS PPARG BOUND 8D 658397All SZGR 2.0 genes in this pathway
PLASARI TGFB1 TARGETS 10HR UP 199143All SZGR 2.0 genes in this pathway
ACEVEDO FGFR1 TARGETS IN PROSTATE CANCER MODEL DN 308187All SZGR 2.0 genes in this pathway
CHEMELLO SOLEUS VS EDL MYOFIBERS UP 3516All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
let-7/981631691Ahsa-let-7abrainUGAGGUAGUAGGUUGUAUAGUU
hsa-let-7bbrainUGAGGUAGUAGGUUGUGUGGUU
hsa-let-7cbrainUGAGGUAGUAGGUUGUAUGGUU
hsa-let-7dbrainAGAGGUAGUAGGUUGCAUAGU
hsa-let-7ebrainUGAGGUAGGAGGUUGUAUAGU
hsa-let-7fbrainUGAGGUAGUAGAUUGUAUAGUU
hsa-miR-98brainUGAGGUAGUAAGUUGUAUUGUU
hsa-let-7gSZUGAGGUAGUAGUUUGUACAGU
hsa-let-7ibrainUGAGGUAGUAGUUUGUGCUGU
miR-1552232301A,m8hsa-miR-155UUAAUGCUAAUCGUGAUAGGGG
miR-262142201Ahsa-miR-26abrainUUCAAGUAAUCCAGGAUAGGC
hsa-miR-26bSZUUCAAGUAAUUCAGGAUAGGUU
miR-4951711771Ahsa-miR-495brainAAACAAACAUGGUGCACUUCUUU