Gene Page: ACTA1
Summary ?
GeneID | 58 |
Symbol | ACTA1 |
Synonyms | ACTA|ASMA|CFTD|CFTD1|CFTDM|MPFD|NEM1|NEM2|NEM3|SHPM |
Description | actin, alpha 1, skeletal muscle |
Reference | MIM:102610|HGNC:HGNC:129|Ensembl:ENSG00000143632|HPRD:00030|Vega:OTTHUMG00000038006 |
Gene type | protein-coding |
Map location | 1q42.13 |
Fetal beta | -0.745 |
DMG | 1 (# studies) |
Gene in Data Sources
Gene set name | Method of gene set | Description | Info |
---|---|---|---|
CV:PGCnp | Genome-wide Association Study | GWAS | |
DMG:Wockner_2014 | Genome-wide DNA methylation analysis | This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). | 1 |
PMID:cooccur | High-throughput literature-search | Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included. | |
Literature | High-throughput literature-search | Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias | Click to show details |
Network | Shortest path distance of core genes in the Human protein-protein interaction network | Contribution to shortest path in PPI network: 0.1982 |
Section I. Genetics and epigenetics annotation
Differentially methylated gene
Probe | Chromosome | Position | Nearest gene | P (dis) | Beta (dis) | FDR (dis) | Study |
---|---|---|---|---|---|---|---|
cg07777790 | 1 | 229570188 | ACTA1 | 5.516E-4 | -0.366 | 0.049 | DMG:Wockner_2014 |
Section II. Transcriptome annotation
General gene expression (GTEx)

Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
No co-expressed genes in brain regions
Section III. Gene Ontology annotation
Molecular function | GO term | Evidence | Neuro keywords | PubMed ID |
---|---|---|---|---|
GO:0000166 | nucleotide binding | IEA | - | |
GO:0005515 | protein binding | IEA | - | |
GO:0005515 | protein binding | IPI | 12849983 | |
GO:0005524 | ATP binding | IEA | - | |
GO:0005524 | ATP binding | TAS | 10508519 | |
GO:0005198 | structural molecule activity | IEA | - | |
GO:0005200 | structural constituent of cytoskeleton | TAS | 10508519 | |
GO:0017022 | myosin binding | TAS | 10508519 | |
GO:0043531 | ADP binding | TAS | 10508519 | |
Biological process | GO term | Evidence | Neuro keywords | PubMed ID |
GO:0030240 | muscle thin filament assembly | IMP | 11333380 | |
GO:0006936 | muscle contraction | TAS | 10508519 | |
GO:0048741 | skeletal muscle fiber development | ISS | - | |
Cellular component | GO term | Evidence | Neuro keywords | PubMed ID |
GO:0001725 | stress fiber | IDA | 15198992 | |
GO:0005856 | cytoskeleton | IEA | - | |
GO:0005865 | striated muscle thin filament | IDA | 15198992 | |
GO:0005737 | cytoplasm | IEA | - | |
GO:0005884 | actin filament | IDA | 12849983 |
Section IV. Protein-protein interaction annotation
Interactors | Aliases B | Official full name B | Experimental | Source | PubMed ID |
---|---|---|---|---|---|
ACTR10 | ACTR11 | HARP11 | actin-related protein 10 homolog (S. cerevisiae) | - | HPRD | 12857853 |
APC2 | APCL | adenomatosis polyposis coli 2 | Co-localization | BioGRID | 11691822 |
CCT4 | CCT-DELTA | Cctd | MGC126164 | MGC126165 | SRB | chaperonin containing TCP1, subunit 4 (delta) | - | HPRD,BioGRID | 11580270 |
CCT5 | CCT-epsilon | CCTE | KIAA0098 | TCP-1-epsilon | chaperonin containing TCP1, subunit 5 (epsilon) | - | HPRD,BioGRID | 11580270 |
CDH2 | CD325 | CDHN | CDw325 | NCAD | cadherin 2, type 1, N-cadherin (neuronal) | Affinity Capture-Western | BioGRID | 12438242 |
CFL1 | CFL | cofilin 1 (non-muscle) | Affinity Capture-MS | BioGRID | 11950878 |
CFL1 | CFL | cofilin 1 (non-muscle) | - | HPRD | 11707283 |
CNN1 | SMCC | Sm-Calp | calponin 1, basic, smooth muscle | Reconstituted Complex | BioGRID | 2161834 |
CSNK1A1 | CK1 | HLCDGP1 | PRO2975 | casein kinase 1, alpha 1 | Affinity Capture-MS | BioGRID | 12062430 |
DMD | BMD | CMD3B | DXS142 | DXS164 | DXS206 | DXS230 | DXS239 | DXS268 | DXS269 | DXS270 | DXS272 | dystrophin | - | HPRD,BioGRID | 1544421|11259305 |
DMD | BMD | CMD3B | DXS142 | DXS164 | DXS206 | DXS230 | DXS239 | DXS268 | DXS269 | DXS270 | DXS272 | dystrophin | - | HPRD | 1544421 |
DNASE1 | DKFZp686H0155 | DNL1 | DRNI | FLJ38093 | FLJ44902 | deoxyribonuclease I | - | HPRD | 11707283 |
DNMBP | KIAA1010 | TUBA | dynamin binding protein | - | HPRD,BioGRID | 14506234 |
DVL1L1 | DSH | DVL | DVL-22 | DVL1 | DVL4 | dishevelled, dsh homolog 1 (Drosophila)-like 1 | Affinity Capture-Western | BioGRID | 12384700 |
EPB41 | 4.1R | EL1 | HE | erythrocyte membrane protein band 4.1 (elliptocytosis 1, RH-linked) | - | HPRD | 11071908 |
ETV6 | TEL | TEL/ABL | ets variant 6 | Co-localization | BioGRID | 9695962 |
FGD4 | CMT4H | DKFZp313E1818 | DKFZp434K1572 | FLJ34370 | FLJ42663 | FRABP | MGC57222 | ZFYVE6 | FYVE, RhoGEF and PH domain containing 4 | - | HPRD | 9668039 |11429692 |
FSCN1 | FLJ38511 | SNL | p55 | fascin homolog 1, actin-bundling protein (Strongylocentrotus purpuratus) | - | HPRD,BioGRID | 8999969 |
GAS7 | KIAA0394 | MGC1348 | MLL/GAS7 | growth arrest-specific 7 | - | HPRD | 11795944 |
GC | DBP | DBP/GC | VDBG | VDBP | group-specific component (vitamin D binding protein) | Co-crystal Structure | BioGRID | 12554937 |
GC | DBP | DBP/GC | VDBG | VDBP | group-specific component (vitamin D binding protein) | - | HPRD | 12119014 |
GRB2 | ASH | EGFRBP-GRB2 | Grb3-3 | MST084 | MSTP084 | growth factor receptor-bound protein 2 | Affinity Capture-MS | BioGRID | 12577067 |
GSN | DKFZp313L0718 | gelsolin (amyloidosis, Finnish type) | - | HPRD,BioGRID | 10583954 |
HIP1R | FLJ14000 | FLJ27022 | HIP12 | HIP3 | ILWEQ | KIAA0655 | MGC47513 | huntingtin interacting protein 1 related | - | HPRD | 11889126 |
JUB | Ajuba | MGC15563 | jub, ajuba homolog (Xenopus laevis) | - | HPRD | 12417594 |
KLHL20 | KHLHX | KLEIP | KLHLX | RP3-383J4.3 | kelch-like 20 (Drosophila) | - | HPRD,BioGRID | 14668487 |
MARK4 | FLJ90097 | KIAA1860 | MARKL1 | Nbla00650 | MAP/microtubule affinity-regulating kinase 4 | Affinity Capture-MS | BioGRID | 14594945 |
MIB2 | FLJ20648 | FLJ39787 | ZZANK1 | ZZZ5 | mindbomb homolog 2 (Drosophila) | Reconstituted Complex Two-hybrid | BioGRID | 14507647 |
MLPH | MGC2771 | MGC59733 | SLAC2-A | melanophilin | Affinity Capture-Western | BioGRID | 15059972 |
MYL1 | MLC1F | MLC3F | myosin, light chain 1, alkali; skeletal, fast | - | HPRD | 11707283 |
NRAP | - | nebulin-related anchoring protein | Reconstituted Complex | BioGRID | 10320340 |
PARVA | FLJ10793 | FLJ12254 | MXRA2 | parvin, alpha | - | HPRD | 11171322 |
PCYT1B | CCT-beta | CTB | phosphate cytidylyltransferase 1, choline, beta | - | HPRD,BioGRID | 11580270 |
PFDN1 | PDF | PFD1 | prefoldin subunit 1 | Reconstituted Complex | BioGRID | 14634002 |
PFN1 | - | profilin 1 | - | HPRD | 8413665 |
PHACTR1 | KIAA1733 | MGC126575 | MGC126577 | RPEL | RPEL1 | dJ257A7.2 | phosphatase and actin regulator 1 | - | HPRD,BioGRID | 15107502 |
PLDN | PA | PALLID | pallidin homolog (mouse) | - | HPRD | 12019270 |
PPP1CA | MGC15877 | MGC1674 | PP-1A | PPP1A | protein phosphatase 1, catalytic subunit, alpha isoform | Affinity Capture-Western | BioGRID | 15107502 |
PPP1R9B | FLJ30345 | PPP1R6 | PPP1R9 | SPINO | Spn | protein phosphatase 1, regulatory (inhibitor) subunit 9B | Reconstituted Complex | BioGRID | 12417592 |
PRKCA | AAG6 | MGC129900 | MGC129901 | PKC-alpha | PKCA | PRKACA | protein kinase C, alpha | - | HPRD,BioGRID | 10628374 |
PRKCE | MGC125656 | MGC125657 | PKCE | nPKC-epsilon | protein kinase C, epsilon | Affinity Capture-MS Affinity Capture-Western | BioGRID | 11897493 |
RAC1 | MGC111543 | MIG5 | TC-25 | p21-Rac1 | ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) | - | HPRD | 11027608 |
RPS6KB1 | PS6K | S6K | S6K1 | STK14A | p70(S6K)-alpha | p70-S6K | p70-alpha | ribosomal protein S6 kinase, 70kDa, polypeptide 1 | Reconstituted Complex | BioGRID | 15149849 |
S100A4 | 18A2 | 42A | CAPL | FSP1 | MTS1 | P9KA | PEL98 | S100 calcium binding protein A4 | - | HPRD | 14640694 |
SCIN | KIAA1905 | scinderin | Reconstituted Complex | BioGRID | 12438125 |
TAGLN | DKFZp686P11128 | SM22 | SMCC | TAGLN1 | WS3-10 | transgelin | - | HPRD,BioGRID | 11053353 |
TES | DKFZp586B2022 | MGC1146 | TESS | TESS-2 | testis derived transcript (3 LIM domains) | Affinity Capture-Western | BioGRID | 12695497 |
TLN1 | ILWEQ | KIAA1027 | TLN | talin 1 | - | HPRD | 10581178 |
TMSB4X | FX | PTMB4 | TB4X | TMSB4 | thymosin beta 4, X-linked | - | HPRD,BioGRID | 11812134 |
TMSB4Y | MGC26307 | TB4Y | thymosin beta 4, Y-linked | Reconstituted Complex | BioGRID | 8416954 |
TNNI3 | CMD2A | CMH7 | MGC116817 | TNNC1 | cTnI | troponin I type 3 (cardiac) | - | HPRD | 12383268 |
TNNI3K | CARK | MGC142099 | MGC33828 | TNNI3 interacting kinase | - | HPRD,BioGRID | 12721663 |
TRAF3 | CAP-1 | CD40bp | CRAF1 | LAP1 | TNF receptor-associated factor 3 | - | HPRD | 11950878 |
TRIP6 | MGC10556 | MGC10558 | MGC29959 | MGC3837 | MGC4423 | OIP1 | ZRP-1 | thyroid hormone receptor interactor 6 | Co-localization | BioGRID | 14688263 |
TSC1 | KIAA0243 | LAM | MGC86987 | TSC | tuberous sclerosis 1 | Co-localization | BioGRID | 10806479 |
VCL | CMD1W | MVCL | vinculin | - | HPRD | 7816144 |
XIRP1 | CMYA1 | DKFZp451D042 | DKFZp779C1255 | DKFZp779C1947 | Xin | xin actin-binding repeat containing 1 | - | HPRD | 15454575 |
XPO6 | EXP6 | FLJ22519 | KIAA0370 | RANBP20 | exportin 6 | Affinity Capture-MS | BioGRID | 14592989 |
Section V. Pathway annotation
Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
---|---|---|---|
BIOCARTA NO1 PATHWAY | 33 | 24 | All SZGR 2.0 genes in this pathway |
BIOCARTA AGR PATHWAY | 36 | 31 | All SZGR 2.0 genes in this pathway |
BIOCARTA EPHA4 PATHWAY | 10 | 8 | All SZGR 2.0 genes in this pathway |
BIOCARTA SALMONELLA PATHWAY | 13 | 10 | All SZGR 2.0 genes in this pathway |
BIOCARTA MPR PATHWAY | 34 | 28 | All SZGR 2.0 genes in this pathway |
BIOCARTA INTEGRIN PATHWAY | 38 | 29 | All SZGR 2.0 genes in this pathway |
BIOCARTA MCALPAIN PATHWAY | 25 | 16 | All SZGR 2.0 genes in this pathway |
BIOCARTA NFAT PATHWAY | 56 | 45 | All SZGR 2.0 genes in this pathway |
BIOCARTA RAB PATHWAY | 12 | 8 | All SZGR 2.0 genes in this pathway |
BIOCARTA MAL PATHWAY | 19 | 17 | All SZGR 2.0 genes in this pathway |
BIOCARTA MET PATHWAY | 37 | 30 | All SZGR 2.0 genes in this pathway |
BIOCARTA HSP27 PATHWAY | 15 | 11 | All SZGR 2.0 genes in this pathway |
BIOCARTA UCALPAIN PATHWAY | 18 | 11 | All SZGR 2.0 genes in this pathway |
BIOCARTA ACTINY PATHWAY | 20 | 14 | All SZGR 2.0 genes in this pathway |
PID RHOA PATHWAY | 45 | 33 | All SZGR 2.0 genes in this pathway |
PID AP1 PATHWAY | 70 | 60 | All SZGR 2.0 genes in this pathway |
PID CASPASE PATHWAY | 52 | 39 | All SZGR 2.0 genes in this pathway |
PID FAK PATHWAY | 59 | 45 | All SZGR 2.0 genes in this pathway |
BERENJENO TRANSFORMED BY RHOA REVERSIBLY DN | 29 | 21 | All SZGR 2.0 genes in this pathway |
MARKEY RB1 CHRONIC LOF DN | 118 | 78 | All SZGR 2.0 genes in this pathway |
BERENJENO TRANSFORMED BY RHOA UP | 536 | 340 | All SZGR 2.0 genes in this pathway |
DARWICHE SKIN TUMOR PROMOTER DN | 185 | 115 | All SZGR 2.0 genes in this pathway |
DARWICHE PAPILLOMA RISK LOW DN | 165 | 107 | All SZGR 2.0 genes in this pathway |
DARWICHE PAPILLOMA RISK HIGH DN | 180 | 110 | All SZGR 2.0 genes in this pathway |
DARWICHE SQUAMOUS CELL CARCINOMA DN | 181 | 107 | All SZGR 2.0 genes in this pathway |
LOPEZ MBD TARGETS | 957 | 597 | All SZGR 2.0 genes in this pathway |
RICKMAN HEAD AND NECK CANCER F | 54 | 32 | All SZGR 2.0 genes in this pathway |
BENPORATH ES 1 | 379 | 235 | All SZGR 2.0 genes in this pathway |
PENG GLUCOSE DEPRIVATION UP | 48 | 26 | All SZGR 2.0 genes in this pathway |
BECKER TAMOXIFEN RESISTANCE UP | 50 | 36 | All SZGR 2.0 genes in this pathway |
NING CHRONIC OBSTRUCTIVE PULMONARY DISEASE UP | 157 | 105 | All SZGR 2.0 genes in this pathway |
YAO HOXA10 TARGETS VIA PROGESTERONE DN | 19 | 12 | All SZGR 2.0 genes in this pathway |
CROMER METASTASIS DN | 81 | 58 | All SZGR 2.0 genes in this pathway |
LU AGING BRAIN DN | 153 | 120 | All SZGR 2.0 genes in this pathway |
LEE CALORIE RESTRICTION NEOCORTEX UP | 83 | 66 | All SZGR 2.0 genes in this pathway |
LEE AGING CEREBELLUM DN | 86 | 66 | All SZGR 2.0 genes in this pathway |
DELASERNA MYOD TARGETS UP | 89 | 51 | All SZGR 2.0 genes in this pathway |
CHEN LVAD SUPPORT OF FAILING HEART UP | 103 | 69 | All SZGR 2.0 genes in this pathway |
APRELIKOVA BRCA1 TARGETS | 49 | 33 | All SZGR 2.0 genes in this pathway |
BROWNE HCMV INFECTION 18HR DN | 178 | 121 | All SZGR 2.0 genes in this pathway |
KUNINGER IGF1 VS PDGFB TARGETS UP | 82 | 51 | All SZGR 2.0 genes in this pathway |
MARTINEZ RB1 TARGETS UP | 673 | 430 | All SZGR 2.0 genes in this pathway |
MARTINEZ TP53 TARGETS UP | 602 | 364 | All SZGR 2.0 genes in this pathway |
MARTINEZ RB1 AND TP53 TARGETS UP | 601 | 369 | All SZGR 2.0 genes in this pathway |
SARRIO EPITHELIAL MESENCHYMAL TRANSITION DN | 154 | 101 | All SZGR 2.0 genes in this pathway |
SMID BREAST CANCER BASAL UP | 648 | 398 | All SZGR 2.0 genes in this pathway |
MUELLER PLURINET | 299 | 189 | All SZGR 2.0 genes in this pathway |
YAUCH HEDGEHOG SIGNALING PARACRINE DN | 264 | 159 | All SZGR 2.0 genes in this pathway |
WUNDER INFLAMMATORY RESPONSE AND CHOLESTEROL DN | 12 | 7 | All SZGR 2.0 genes in this pathway |
SWEET LUNG CANCER KRAS DN | 435 | 289 | All SZGR 2.0 genes in this pathway |
YAGI AML WITH 11Q23 REARRANGED | 351 | 238 | All SZGR 2.0 genes in this pathway |
YAO TEMPORAL RESPONSE TO PROGESTERONE CLUSTER 14 | 143 | 86 | All SZGR 2.0 genes in this pathway |
SASSON RESPONSE TO GONADOTROPHINS DN | 87 | 66 | All SZGR 2.0 genes in this pathway |
SASSON RESPONSE TO FORSKOLIN DN | 88 | 68 | All SZGR 2.0 genes in this pathway |
BRUINS UVC RESPONSE LATE | 1137 | 655 | All SZGR 2.0 genes in this pathway |
PASINI SUZ12 TARGETS DN | 315 | 215 | All SZGR 2.0 genes in this pathway |
FEVR CTNNB1 TARGETS UP | 682 | 433 | All SZGR 2.0 genes in this pathway |
WAKABAYASHI ADIPOGENESIS PPARG BOUND 8D | 658 | 397 | All SZGR 2.0 genes in this pathway |
PLASARI TGFB1 TARGETS 10HR UP | 199 | 143 | All SZGR 2.0 genes in this pathway |
ACEVEDO FGFR1 TARGETS IN PROSTATE CANCER MODEL DN | 308 | 187 | All SZGR 2.0 genes in this pathway |
CHEMELLO SOLEUS VS EDL MYOFIBERS UP | 35 | 16 | All SZGR 2.0 genes in this pathway |
Section VI. microRNA annotation
miRNA family | Target position | miRNA ID | miRNA seq | ||
---|---|---|---|---|---|
UTR start | UTR end | Match method | |||
let-7/98 | 163 | 169 | 1A | hsa-let-7abrain | UGAGGUAGUAGGUUGUAUAGUU |
hsa-let-7bbrain | UGAGGUAGUAGGUUGUGUGGUU | ||||
hsa-let-7cbrain | UGAGGUAGUAGGUUGUAUGGUU | ||||
hsa-let-7dbrain | AGAGGUAGUAGGUUGCAUAGU | ||||
hsa-let-7ebrain | UGAGGUAGGAGGUUGUAUAGU | ||||
hsa-let-7fbrain | UGAGGUAGUAGAUUGUAUAGUU | ||||
hsa-miR-98brain | UGAGGUAGUAAGUUGUAUUGUU | ||||
hsa-let-7gSZ | UGAGGUAGUAGUUUGUACAGU | ||||
hsa-let-7ibrain | UGAGGUAGUAGUUUGUGCUGU | ||||
miR-155 | 223 | 230 | 1A,m8 | hsa-miR-155 | UUAAUGCUAAUCGUGAUAGGGG |
miR-26 | 214 | 220 | 1A | hsa-miR-26abrain | UUCAAGUAAUCCAGGAUAGGC |
hsa-miR-26bSZ | UUCAAGUAAUUCAGGAUAGGUU | ||||
miR-495 | 171 | 177 | 1A | hsa-miR-495brain | AAACAAACAUGGUGCACUUCUUU |
- SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
- Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.