Gene Page: BAX
Summary ?
| GeneID | 581 |
| Symbol | BAX |
| Synonyms | BCL2L4 |
| Description | BCL2-associated X protein |
| Reference | MIM:600040|HGNC:HGNC:959|Ensembl:ENSG00000087088|HPRD:02498|Vega:OTTHUMG00000160476 |
| Gene type | protein-coding |
| Map location | 19q13.3-q13.4 |
| Pascal p-value | 0.226 |
| Fetal beta | 0.484 |
| eGene | Cerebellum Hypothalamus |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| PMID:cooccur | High-throughput literature-search | Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included. | |
| Literature | High-throughput literature-search | Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenic,schizophrenias | Click to show details |
| GO_Annotation | Mapping neuro-related keywords to Gene Ontology annotations | Hits with neuro-related keywords: 1 |
Section I. Genetics and epigenetics annotation
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
No co-expressed genes in brain regions
Section III. Gene Ontology annotation
| Molecular function | GO term | Evidence | Neuro keywords | PubMed ID |
|---|---|---|---|---|
| GO:0042803 | protein homodimerization activity | IDA | 16608847 | |
| GO:0042803 | protein homodimerization activity | IPI | 9111042 | |
| GO:0046982 | protein heterodimerization activity | IPI | 9111042 | |
| Biological process | GO term | Evidence | Neuro keywords | PubMed ID |
| GO:0043525 | positive regulation of neuron apoptosis | IDA | neuron (GO term level: 9) | 15637643 |
| GO:0006917 | induction of apoptosis | IDA | 11912183 | |
| GO:0006919 | caspase activation | IDA | 11912183 | |
| GO:0042981 | regulation of apoptosis | IEA | - | |
| GO:0043496 | regulation of protein homodimerization activity | IDA | 9111042 | |
| GO:0043497 | regulation of protein heterodimerization activity | IPI | 9111042 | |
| GO:0045786 | negative regulation of cell cycle | IEA | - | |
| Cellular component | GO term | Evidence | Neuro keywords | PubMed ID |
| GO:0005829 | cytosol | EXP | 10629050 | |
| GO:0005829 | cytosol | IDA | 11912183 | |
| GO:0005737 | cytoplasm | IEA | - | |
| GO:0005739 | mitochondrion | IDA | 11912183 | |
| GO:0005741 | mitochondrial outer membrane | EXP | 11136736 | |
| GO:0016020 | membrane | IEA | - | |
| GO:0016021 | integral to membrane | IEA | - |
Section IV. Protein-protein interaction annotation
| Interactors | Aliases B | Official full name B | Experimental | Source | PubMed ID |
|---|---|---|---|---|---|
| BAK1 | BAK | BAK-LIKE | BCL2L7 | CDN1 | MGC117255 | MGC3887 | BCL2-antagonist/killer 1 | - | HPRD,BioGRID | 11571294 |
| BAX | BCL2L4 | BCL2-associated X protein | Two-hybrid | BioGRID | 11161816 |
| BBC3 | JFY1 | PUMA | BCL2 binding component 3 | Bax interacts with PUMA. | BIND | 15574335 |
| BCL2 | Bcl-2 | B-cell CLL/lymphoma 2 | - | HPRD,BioGRID | 8358790 |
| BCL2 | Bcl-2 | B-cell CLL/lymphoma 2 | Bax interacts with Bcl-2. | BIND | 15574335 |
| BCL2 | Bcl-2 | B-cell CLL/lymphoma 2 | - | HPRD | 8358790|9111042 |
| BCL2 | Bcl-2 | B-cell CLL/lymphoma 2 | Bcl-2 interacts with Bax. | BIND | 9130713 |
| BCL2A1 | ACC-1 | ACC-2 | BCL2L5 | BFL1 | GRS | HBPA1 | BCL2-related protein A1 | - | HPRD,BioGRID | 10753914 |
| BCL2L1 | BCL-XL/S | BCL2L | BCLX | Bcl-X | DKFZp781P2092 | bcl-xL | bcl-xS | BCL2-like 1 | Bax interacts with Bcl-XL via its BH3 domain. This interaction was modeled on a demonstrated interaction between mouse Bax and human Bcl-XL. | BIND | 11060313 |
| BCL2L1 | BCL-XL/S | BCL2L | BCLX | Bcl-X | DKFZp781P2092 | bcl-xL | bcl-xS | BCL2-like 1 | Bax interacts with Bcl-XL. | BIND | 9372935 |
| BCL2L1 | BCL-XL/S | BCL2L | BCLX | Bcl-X | DKFZp781P2092 | bcl-xL | bcl-xS | BCL2-like 1 | Bax interacts with Bcl-xL. | BIND | 15574335 |
| BCL2L1 | BCL-XL/S | BCL2L | BCLX | Bcl-X | DKFZp781P2092 | bcl-xL | bcl-xS | BCL2-like 1 | Affinity Capture-Western Protein-peptide | BioGRID | 9824152 |12137781 |12853473 |
| BCL2L10 | BCL-B | Boo | Diva | MGC129810 | MGC129811 | BCL2-like 10 (apoptosis facilitator) | - | HPRD,BioGRID | 11278245 |
| BCL2L2 | BCL-W | BCLW | KIAA0271 | BCL2-like 2 | Affinity Capture-Western | BioGRID | 10381646 |
| BCLAF1 | BTF | KIAA0164 | bK211L9.1 | BCL2-associated transcription factor 1 | - | HPRD | 10330179 |
| BID | FP497 | MGC15319 | MGC42355 | BH3 interacting domain death agonist | Bax interacts with Bid. | BIND | 15574335 |
| BNIPL | BNIP-S | BNIPL-1 | BNIPL-2 | BNIPL1 | BNIPL2 | PP753 | BCL2/adenovirus E1B 19kD interacting protein like | Two-hybrid | BioGRID | 12901880 |
| CRYAA | CRYA1 | HSPB4 | crystallin, alpha A | HalphaA-crystallin interacts with Bax. | BIND | 14752512 |
| CRYAB | CRYA2 | CTPP2 | HSPB5 | crystallin, alpha B | HalphaB-crystallin interacts with Bax. | BIND | 14752512 |
| GTF2B | TF2B | TFIIB | general transcription factor IIB | GTF2B (TFIIB) interacts with the Bax promoter. | BIND | 15710329 |
| HSPD1 | CPN60 | GROEL | HSP60 | HSP65 | HuCHA60 | SPG13 | heat shock 60kDa protein 1 (chaperonin) | Affinity Capture-Western | BioGRID | 12070120 |
| MCL1 | BCL2L3 | EAT | MCL1L | MCL1S | MGC104264 | MGC1839 | TM | myeloid cell leukemia sequence 1 (BCL2-related) | - | HPRD,BioGRID | 10837489 |
| MOAP1 | MAP-1 | PNMA4 | modulator of apoptosis 1 | MAP-1 interacts with an unspecified isoform of Bax. | BIND | 15949439 |
| MOAP1 | MAP-1 | PNMA4 | modulator of apoptosis 1 | Bax interacts with MAP-1 via its BH1, BH2, and BH3 domains. This interaction was modeled on a demonstrated interaction between mouse Bax and human MAP-1. | BIND | 11060313 |
| MOAP1 | MAP-1 | PNMA4 | modulator of apoptosis 1 | - | HPRD,BioGRID | 11060313 |
| MUC1 | CD227 | EMA | H23AG | MAM6 | PEM | PEMT | PUM | mucin 1, cell surface associated | MUC1 C-ter interacts with the Bax promoter. | BIND | 15710329 |
| NOL3 | ARC | CARD2 | MYC | MYP | NOP | NOP30 | nucleolar protein 3 (apoptosis repressor with CARD domain) | ARC interacts with Bax. | BIND | 15383280 |
| PMAIP1 | APR | NOXA | phorbol-12-myristate-13-acetate-induced protein 1 | - | HPRD,BioGRID | 15705586 |
| SFN | YWHAS | stratifin | - | HPRD | 11574543 |
| SH3GLB1 | Bif-1 | CGI-61 | KIAA0491 | dJ612B15.2 | SH3-domain GRB2-like endophilin B1 | An unspecified isoform of Bax interacts with SH3GLB1. | BIND | 11161816 |
| SH3GLB1 | Bif-1 | CGI-61 | KIAA0491 | dJ612B15.2 | SH3-domain GRB2-like endophilin B1 | - | HPRD,BioGRID | 11161816 |11259440 |
| SLC25A4 | AAC1 | ANT | ANT1 | PEO2 | PEO3 | T1 | solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4 | - | HPRD,BioGRID | 9748162 |
| SNCA | MGC110988 | NACP | PARK1 | PARK4 | PD1 | synuclein, alpha (non A4 component of amyloid precursor) | Reconstituted Complex | BioGRID | 11742726 |
| TAF1 | BA2R | CCG1 | CCGS | DYT3 | KAT4 | N-TAF1 | NSCL2 | OF | P250 | TAF2A | TAFII250 | TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa | TAF1 (TAFII250) interacts with the Bax promoter. | BIND | 15710329 |
| TBP | GTF2D | GTF2D1 | MGC117320 | MGC126054 | MGC126055 | SCA17 | TFIID | TATA box binding protein | TBP interacts with the Bax promoter. | BIND | 15710329 |
| TP53 | FLJ92943 | LFS1 | TRP53 | p53 | tumor protein p53 | p53 interacts with Bax. | BIND | 15607964 |
| TP53 | FLJ92943 | LFS1 | TRP53 | p53 | tumor protein p53 | p53 interacts with bax promoter. | BIND | 16009130 |
| TP53 | FLJ92943 | LFS1 | TRP53 | p53 | tumor protein p53 | p53 interacts with the Bax promoter. | BIND | 15710329 |
| TP73 | P73 | tumor protein p73 | p73-alpha interacts with BAX promoter. | BIND | 15893728 |
| VDAC1 | MGC111064 | PORIN | PORIN-31-HL | voltage-dependent anion channel 1 | - | HPRD | 9843949 |12767928|12767928 |
| VDAC1 | MGC111064 | PORIN | PORIN-31-HL | voltage-dependent anion channel 1 | - | HPRD,BioGRID | 12767928 |
| YWHAQ | 14-3-3 | 1C5 | HS1 | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide | - | HPRD,BioGRID | 12426317 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| KEGG P53 SIGNALING PATHWAY | 69 | 45 | All SZGR 2.0 genes in this pathway |
| KEGG APOPTOSIS | 88 | 62 | All SZGR 2.0 genes in this pathway |
| KEGG NEUROTROPHIN SIGNALING PATHWAY | 126 | 103 | All SZGR 2.0 genes in this pathway |
| KEGG AMYOTROPHIC LATERAL SCLEROSIS ALS | 53 | 43 | All SZGR 2.0 genes in this pathway |
| KEGG HUNTINGTONS DISEASE | 185 | 109 | All SZGR 2.0 genes in this pathway |
| KEGG PRION DISEASES | 35 | 28 | All SZGR 2.0 genes in this pathway |
| KEGG PATHWAYS IN CANCER | 328 | 259 | All SZGR 2.0 genes in this pathway |
| KEGG COLORECTAL CANCER | 62 | 47 | All SZGR 2.0 genes in this pathway |
| BIOCARTA CHEMICAL PATHWAY | 22 | 15 | All SZGR 2.0 genes in this pathway |
| BIOCARTA CERAMIDE PATHWAY | 22 | 16 | All SZGR 2.0 genes in this pathway |
| BIOCARTA P53HYPOXIA PATHWAY | 23 | 21 | All SZGR 2.0 genes in this pathway |
| BIOCARTA P53 PATHWAY | 16 | 13 | All SZGR 2.0 genes in this pathway |
| BIOCARTA BAD PATHWAY | 26 | 23 | All SZGR 2.0 genes in this pathway |
| BIOCARTA MITOCHONDRIA PATHWAY | 21 | 15 | All SZGR 2.0 genes in this pathway |
| SA PROGRAMMED CELL DEATH | 12 | 9 | All SZGR 2.0 genes in this pathway |
| ST FAS SIGNALING PATHWAY | 65 | 54 | All SZGR 2.0 genes in this pathway |
| PID P73PATHWAY | 79 | 59 | All SZGR 2.0 genes in this pathway |
| PID HDAC CLASSIII PATHWAY | 25 | 20 | All SZGR 2.0 genes in this pathway |
| PID MYC ACTIV PATHWAY | 79 | 62 | All SZGR 2.0 genes in this pathway |
| PID NFAT 3PATHWAY | 54 | 47 | All SZGR 2.0 genes in this pathway |
| PID REG GR PATHWAY | 82 | 60 | All SZGR 2.0 genes in this pathway |
| PID CERAMIDE PATHWAY | 48 | 37 | All SZGR 2.0 genes in this pathway |
| PID P53 DOWNSTREAM PATHWAY | 137 | 94 | All SZGR 2.0 genes in this pathway |
| PID CASPASE PATHWAY | 52 | 39 | All SZGR 2.0 genes in this pathway |
| PID SYNDECAN 2 PATHWAY | 33 | 27 | All SZGR 2.0 genes in this pathway |
| PID TAP63 PATHWAY | 54 | 40 | All SZGR 2.0 genes in this pathway |
| REACTOME APOPTOSIS | 148 | 94 | All SZGR 2.0 genes in this pathway |
| REACTOME INTRINSIC PATHWAY FOR APOPTOSIS | 30 | 21 | All SZGR 2.0 genes in this pathway |
| GAZDA DIAMOND BLACKFAN ANEMIA ERYTHROID DN | 493 | 298 | All SZGR 2.0 genes in this pathway |
| GAZDA DIAMOND BLACKFAN ANEMIA MYELOID UP | 30 | 19 | All SZGR 2.0 genes in this pathway |
| GAZDA DIAMOND BLACKFAN ANEMIA PROGENITOR UP | 39 | 25 | All SZGR 2.0 genes in this pathway |
| CASORELLI ACUTE PROMYELOCYTIC LEUKEMIA DN | 663 | 425 | All SZGR 2.0 genes in this pathway |
| OSMAN BLADDER CANCER UP | 404 | 246 | All SZGR 2.0 genes in this pathway |
| OSWALD HEMATOPOIETIC STEM CELL IN COLLAGEN GEL DN | 275 | 168 | All SZGR 2.0 genes in this pathway |
| MULLIGHAN NPM1 SIGNATURE 3 UP | 341 | 197 | All SZGR 2.0 genes in this pathway |
| UDAYAKUMAR MED1 TARGETS DN | 240 | 171 | All SZGR 2.0 genes in this pathway |
| KOKKINAKIS METHIONINE DEPRIVATION 48HR UP | 128 | 95 | All SZGR 2.0 genes in this pathway |
| KOKKINAKIS METHIONINE DEPRIVATION 96HR UP | 117 | 84 | All SZGR 2.0 genes in this pathway |
| CASTELLANO NRAS TARGETS UP | 68 | 41 | All SZGR 2.0 genes in this pathway |
| CAIRO PML TARGETS BOUND BY MYC UP | 23 | 17 | All SZGR 2.0 genes in this pathway |
| BERENJENO TRANSFORMED BY RHOA UP | 536 | 340 | All SZGR 2.0 genes in this pathway |
| NUNODA RESPONSE TO DASATINIB IMATINIB DN | 13 | 10 | All SZGR 2.0 genes in this pathway |
| GALLUZZI PERMEABILIZE MITOCHONDRIA | 43 | 31 | All SZGR 2.0 genes in this pathway |
| DUTTA APOPTOSIS VIA NFKB | 33 | 25 | All SZGR 2.0 genes in this pathway |
| RASHI RESPONSE TO IONIZING RADIATION 2 | 127 | 92 | All SZGR 2.0 genes in this pathway |
| GALLUZZI PREVENT MITOCHONDIAL PERMEABILIZATION | 22 | 16 | All SZGR 2.0 genes in this pathway |
| SCHAVOLT TARGETS OF TP53 AND TP63 | 16 | 12 | All SZGR 2.0 genes in this pathway |
| SCHRAMM INHBA TARGETS UP | 7 | 7 | All SZGR 2.0 genes in this pathway |
| MARTORIATI MDM4 TARGETS NEUROEPITHELIUM UP | 176 | 111 | All SZGR 2.0 genes in this pathway |
| DAIRKEE TERT TARGETS UP | 380 | 213 | All SZGR 2.0 genes in this pathway |
| SPIELMAN LYMPHOBLAST EUROPEAN VS ASIAN UP | 479 | 299 | All SZGR 2.0 genes in this pathway |
| PUJANA BRCA1 PCC NETWORK | 1652 | 1023 | All SZGR 2.0 genes in this pathway |
| PUJANA BRCA2 PCC NETWORK | 423 | 265 | All SZGR 2.0 genes in this pathway |
| PUJANA ATM PCC NETWORK | 1442 | 892 | All SZGR 2.0 genes in this pathway |
| ALCALA APOPTOSIS | 88 | 60 | All SZGR 2.0 genes in this pathway |
| FUJIWARA PARK2 IN LIVER CANCER UP | 8 | 7 | All SZGR 2.0 genes in this pathway |
| GOTZMANN EPITHELIAL TO MESENCHYMAL TRANSITION DN | 206 | 136 | All SZGR 2.0 genes in this pathway |
| BENPORATH MYC TARGETS WITH EBOX | 230 | 156 | All SZGR 2.0 genes in this pathway |
| AMIT EGF RESPONSE 120 MCF10A | 43 | 28 | All SZGR 2.0 genes in this pathway |
| SHEPARD CRUSH AND BURN MUTANT UP | 197 | 110 | All SZGR 2.0 genes in this pathway |
| RADAEVA RESPONSE TO IFNA1 UP | 52 | 40 | All SZGR 2.0 genes in this pathway |
| SHEPARD BMYB MORPHOLINO UP | 205 | 126 | All SZGR 2.0 genes in this pathway |
| FERNANDEZ BOUND BY MYC | 182 | 116 | All SZGR 2.0 genes in this pathway |
| CHEOK RESPONSE TO HD MTX UP | 23 | 13 | All SZGR 2.0 genes in this pathway |
| FLECHNER BIOPSY KIDNEY TRANSPLANT OK VS DONOR DN | 25 | 15 | All SZGR 2.0 genes in this pathway |
| IGLESIAS E2F TARGETS UP | 151 | 103 | All SZGR 2.0 genes in this pathway |
| WEIGEL OXIDATIVE STRESS RESPONSE | 35 | 28 | All SZGR 2.0 genes in this pathway |
| BROWNE HCMV INFECTION 14HR DN | 298 | 200 | All SZGR 2.0 genes in this pathway |
| MACLACHLAN BRCA1 TARGETS DN | 16 | 12 | All SZGR 2.0 genes in this pathway |
| BAELDE DIABETIC NEPHROPATHY UP | 86 | 48 | All SZGR 2.0 genes in this pathway |
| INGA TP53 TARGETS | 17 | 13 | All SZGR 2.0 genes in this pathway |
| ZHANG PROLIFERATING VS QUIESCENT | 51 | 41 | All SZGR 2.0 genes in this pathway |
| GERHOLD ADIPOGENESIS DN | 64 | 44 | All SZGR 2.0 genes in this pathway |
| BURTON ADIPOGENESIS 8 | 86 | 57 | All SZGR 2.0 genes in this pathway |
| SANSOM WNT PATHWAY REQUIRE MYC | 58 | 43 | All SZGR 2.0 genes in this pathway |
| GALI TP53 TARGETS APOPTOTIC UP | 8 | 7 | All SZGR 2.0 genes in this pathway |
| MATZUK SPERMATOGONIA | 24 | 17 | All SZGR 2.0 genes in this pathway |
| BOQUEST STEM CELL CULTURED VS FRESH UP | 425 | 298 | All SZGR 2.0 genes in this pathway |
| MOOTHA HUMAN MITODB 6 2002 | 429 | 260 | All SZGR 2.0 genes in this pathway |
| MOOTHA MITOCHONDRIA | 447 | 277 | All SZGR 2.0 genes in this pathway |
| YOSHIMURA MAPK8 TARGETS UP | 1305 | 895 | All SZGR 2.0 genes in this pathway |
| AGUIRRE PANCREATIC CANCER COPY NUMBER UP | 298 | 174 | All SZGR 2.0 genes in this pathway |
| ZHANG TLX TARGETS 36HR UP | 221 | 150 | All SZGR 2.0 genes in this pathway |
| ZHANG TLX TARGETS 60HR UP | 293 | 203 | All SZGR 2.0 genes in this pathway |
| ZHANG TLX TARGETS UP | 108 | 78 | All SZGR 2.0 genes in this pathway |
| CHIANG LIVER CANCER SUBCLASS UNANNOTATED DN | 193 | 112 | All SZGR 2.0 genes in this pathway |
| DANG MYC TARGETS UP | 143 | 100 | All SZGR 2.0 genes in this pathway |
| DANG BOUND BY MYC | 1103 | 714 | All SZGR 2.0 genes in this pathway |
| WONG EMBRYONIC STEM CELL CORE | 335 | 193 | All SZGR 2.0 genes in this pathway |
| YAO TEMPORAL RESPONSE TO PROGESTERONE CLUSTER 14 | 143 | 86 | All SZGR 2.0 genes in this pathway |
| RAMPON ENRICHED LEARNING ENVIRONMENT EARLY DN | 10 | 10 | All SZGR 2.0 genes in this pathway |
| MARTENS TRETINOIN RESPONSE DN | 841 | 431 | All SZGR 2.0 genes in this pathway |
| PURBEY TARGETS OF CTBP1 NOT SATB1 UP | 344 | 215 | All SZGR 2.0 genes in this pathway |