Gene Page: NGB
Summary ?
GeneID | 58157 |
Symbol | NGB |
Synonyms | - |
Description | neuroglobin |
Reference | MIM:605304|HGNC:HGNC:14077|Ensembl:ENSG00000165553|HPRD:05602|Vega:OTTHUMG00000171558 |
Gene type | protein-coding |
Map location | 14q24.3 |
Pascal p-value | 0.282 |
Sherlock p-value | 0.799 |
Fetal beta | -2.443 |
eGene | Myers' cis & trans |
Gene in Data Sources
Gene set name | Method of gene set | Description | Info |
---|---|---|---|
CV:PGCnp | Genome-wide Association Study | GWAS | |
PMID:cooccur | High-throughput literature-search | Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included. | |
Literature | High-throughput literature-search | Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias | Click to show details |
Network | Shortest path distance of core genes in the Human protein-protein interaction network | Contribution to shortest path in PPI network: 0.0036 |
Section I. Genetics and epigenetics annotation
eQTL annotation
SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
---|---|---|---|---|---|---|---|---|
rs2151616 | chr9 | 101729102 | NGB | 58157 | 0.17 | trans | ||
rs6132977 | chr20 | 2825971 | NGB | 58157 | 0.16 | trans |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
Top 10 positively co-expressed genes | ||
Gene | Pearson's Correlation | Spearman's Correlation |
C4orf27 | 0.86 | 0.85 |
RG9MTD1 | 0.85 | 0.86 |
PSMA4 | 0.84 | 0.87 |
TIMM9 | 0.84 | 0.85 |
RBM34 | 0.84 | 0.85 |
DPM1 | 0.84 | 0.87 |
BXDC2 | 0.84 | 0.83 |
C7orf36 | 0.84 | 0.84 |
CWC15 | 0.83 | 0.87 |
FRG1 | 0.83 | 0.80 |
Top 10 negatively co-expressed genes | ||
Gene | Pearson's Correlation | Spearman's Correlation |
AF347015.15 | -0.59 | -0.61 |
MT-CYB | -0.59 | -0.59 |
AF347015.2 | -0.59 | -0.61 |
AF347015.26 | -0.58 | -0.63 |
AF347015.8 | -0.57 | -0.58 |
AF347015.27 | -0.56 | -0.56 |
SEMA3G | -0.56 | -0.62 |
AF347015.33 | -0.56 | -0.57 |
MT-CO2 | -0.56 | -0.54 |
ENG | -0.55 | -0.59 |
Section III. Gene Ontology annotation
Molecular function | GO term | Evidence | Neuro keywords | PubMed ID |
---|---|---|---|---|
GO:0005506 | iron ion binding | IEA | - | |
GO:0005344 | oxygen transporter activity | TAS | 11029004 | |
GO:0019825 | oxygen binding | IEA | - | |
GO:0020037 | heme binding | IEA | - | |
GO:0046872 | metal ion binding | IEA | - | |
Biological process | GO term | Evidence | Neuro keywords | PubMed ID |
GO:0006810 | transport | IEA | - | |
GO:0015671 | oxygen transport | NAS | 11029004 | |
Cellular component | GO term | Evidence | Neuro keywords | PubMed ID |
GO:0005833 | hemoglobin complex | NAS | - |
Section V. Pathway annotation
Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
---|---|---|---|
BENPORATH SUZ12 TARGETS | 1038 | 678 | All SZGR 2.0 genes in this pathway |
BENPORATH EED TARGETS | 1062 | 725 | All SZGR 2.0 genes in this pathway |
BENPORATH MYC MAX TARGETS | 775 | 494 | All SZGR 2.0 genes in this pathway |
MEISSNER NPC HCP WITH H3 UNMETHYLATED | 536 | 296 | All SZGR 2.0 genes in this pathway |
DANG BOUND BY MYC | 1103 | 714 | All SZGR 2.0 genes in this pathway |
MIKKELSEN MEF HCP WITH H3K27ME3 | 590 | 403 | All SZGR 2.0 genes in this pathway |
MARTENS TRETINOIN RESPONSE UP | 857 | 456 | All SZGR 2.0 genes in this pathway |