Gene Page: NGB

Summary ?
GeneID58157
SymbolNGB
Synonyms-
Descriptionneuroglobin
ReferenceMIM:605304|HGNC:HGNC:14077|Ensembl:ENSG00000165553|HPRD:05602|Vega:OTTHUMG00000171558
Gene typeprotein-coding
Map location14q24.3
Pascal p-value0.282
Sherlock p-value0.799
Fetal beta-2.443
eGeneMyers' cis & trans

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
PMID:cooccurHigh-throughput literature-searchSystematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: schizophrenia,schizophreniasClick to show details
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.0036 

Section I. Genetics and epigenetics annotation

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs2151616chr9101729102NGB581570.17trans
rs6132977chr202825971NGB581570.16trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
C4orf270.860.85
RG9MTD10.850.86
PSMA40.840.87
TIMM90.840.85
RBM340.840.85
DPM10.840.87
BXDC20.840.83
C7orf360.840.84
CWC150.830.87
FRG10.830.80
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
AF347015.15-0.59-0.61
MT-CYB-0.59-0.59
AF347015.2-0.59-0.61
AF347015.26-0.58-0.63
AF347015.8-0.57-0.58
AF347015.27-0.56-0.56
SEMA3G-0.56-0.62
AF347015.33-0.56-0.57
MT-CO2-0.56-0.54
ENG-0.55-0.59

Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005506iron ion bindingIEA-
GO:0005344oxygen transporter activityTAS11029004 
GO:0019825oxygen bindingIEA-
GO:0020037heme bindingIEA-
GO:0046872metal ion bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006810transportIEA-
GO:0015671oxygen transportNAS11029004 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005833hemoglobin complexNAS-

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
BENPORATH SUZ12 TARGETS 1038678All SZGR 2.0 genes in this pathway
BENPORATH EED TARGETS 1062725All SZGR 2.0 genes in this pathway
BENPORATH MYC MAX TARGETS 775494All SZGR 2.0 genes in this pathway
MEISSNER NPC HCP WITH H3 UNMETHYLATED 536296All SZGR 2.0 genes in this pathway
DANG BOUND BY MYC 1103714All SZGR 2.0 genes in this pathway
MIKKELSEN MEF HCP WITH H3K27ME3 590403All SZGR 2.0 genes in this pathway
MARTENS TRETINOIN RESPONSE UP 857456All SZGR 2.0 genes in this pathway