Gene Page: ABCD4
Summary ?
| GeneID | 5826 |
| Symbol | ABCD4 |
| Synonyms | ABC41|EST352188|MAHCJ|P70R|P79R|PMP69|PXMP1L |
| Description | ATP binding cassette subfamily D member 4 |
| Reference | MIM:603214|HGNC:HGNC:68|Ensembl:ENSG00000119688|HPRD:04446|Vega:OTTHUMG00000171207 |
| Gene type | protein-coding |
| Map location | 14q24.3 |
| Pascal p-value | 0.309 |
| Fetal beta | 0.349 |
| DMG | 1 (# studies) |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| DMG:Wockner_2014 | Genome-wide DNA methylation analysis | This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). | 1 |
Section I. Genetics and epigenetics annotation
Differentially methylated gene
| Probe | Chromosome | Position | Nearest gene | P (dis) | Beta (dis) | FDR (dis) | Study |
|---|---|---|---|---|---|---|---|
| cg10504545 | 14 | 74769802 | ABCD4 | 1.9E-5 | -0.413 | 0.016 | DMG:Wockner_2014 |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| AC026726.1 | 0.50 | 0.20 |
| AL031587.1 | 0.46 | 0.36 |
| AC055839.1 | 0.44 | 0.49 |
| SPDYE2 | 0.43 | 0.22 |
| AC110285.2 | 0.42 | 0.43 |
| PGAM1 | 0.42 | 0.12 |
| RP11-108K14.1 | 0.42 | 0.43 |
| PCDH15 | 0.42 | 0.48 |
| AC007546.1 | 0.42 | 0.44 |
| AC093616.2 | 0.41 | 0.40 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| RPSA | -0.38 | -0.52 |
| RPL15 | -0.37 | -0.50 |
| PPIA | -0.36 | -0.45 |
| RPL7A | -0.35 | -0.48 |
| XRCC6 | -0.35 | -0.48 |
| RPL5 | -0.35 | -0.48 |
| RPS10 | -0.34 | -0.46 |
| ST13 | -0.34 | -0.44 |
| RPS6 | -0.34 | -0.48 |
| RPL39L | -0.34 | -0.44 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| KEGG ABC TRANSPORTERS | 44 | 29 | All SZGR 2.0 genes in this pathway |
| KEGG PEROXISOME | 78 | 47 | All SZGR 2.0 genes in this pathway |
| PARENT MTOR SIGNALING UP | 567 | 375 | All SZGR 2.0 genes in this pathway |
| LINDGREN BLADDER CANCER CLUSTER 3 DN | 229 | 142 | All SZGR 2.0 genes in this pathway |
| GRAESSMANN APOPTOSIS BY SERUM DEPRIVATION DN | 234 | 147 | All SZGR 2.0 genes in this pathway |
| GRAESSMANN RESPONSE TO MC AND SERUM DEPRIVATION DN | 84 | 54 | All SZGR 2.0 genes in this pathway |
| INGRAM SHH TARGETS UP | 127 | 79 | All SZGR 2.0 genes in this pathway |
| RICKMAN METASTASIS UP | 344 | 180 | All SZGR 2.0 genes in this pathway |
| GUO HEX TARGETS UP | 81 | 54 | All SZGR 2.0 genes in this pathway |
| AFFAR YY1 TARGETS UP | 214 | 133 | All SZGR 2.0 genes in this pathway |
| BLALOCK ALZHEIMERS DISEASE UP | 1691 | 1088 | All SZGR 2.0 genes in this pathway |
| RIZKI TUMOR INVASIVENESS 2D UP | 69 | 46 | All SZGR 2.0 genes in this pathway |
| WANG TUMOR INVASIVENESS DN | 210 | 128 | All SZGR 2.0 genes in this pathway |
| BRUINS UVC RESPONSE VIA TP53 GROUP B | 549 | 316 | All SZGR 2.0 genes in this pathway |
| GOBERT OLIGODENDROCYTE DIFFERENTIATION DN | 1080 | 713 | All SZGR 2.0 genes in this pathway |