SZGR2

Summary ?

GeneID	5879
Symbol	RAC1
Synonyms	MIG5\|Rac-1\|TC-25\|p21-Rac1
Description	ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
Reference	MIM:602048\|HGNC:HGNC:9801\|Ensembl:ENSG00000136238\|HPRD:03627\|Vega:OTTHUMG00000023540
Gene type	protein-coding
Map location	7p22
Pascal p-value	0.705
Sherlock p-value	0.56
Fetal beta	-0.426
DMG	1 (# studies)
eGene	Cerebellum
Support	INTRACELLULAR SIGNAL TRANSDUCTION G2Cdb.human_BAYES-COLLINS-HUMAN-PSD-CONSENSUS G2Cdb.human_BAYES-COLLINS-HUMAN-PSD-FULL G2Cdb.human_BAYES-COLLINS-MOUSE-PSD-CONSENSUS G2Cdb.human_TAP-PSD-95-CORE G2Cdb.humanNRC G2Cdb.humanPSD G2Cdb.humanPSP CompositeSet Potential synaptic genes

Gene in Data Sources

Gene set name	Method of gene set	Description	Info
CV:PGCnp	Genome-wide Association Study	GWAS
DMG:Wockner_2014	Genome-wide DNA methylation analysis	This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24).	1
PMID:cooccur	High-throughput literature-search	Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
Literature	High-throughput literature-search	Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias	Click to show details
Network	Shortest path distance of core genes in the Human protein-protein interaction network	Contribution to shortest path in PPI network: 0.2217

Section I. Genetics and epigenetics annotation

Differentially methylated gene

Probe	Chromosome	Position	Nearest gene	P (dis)	Beta (dis)	FDR (dis)	Study
cg15381475	7	6436101	RAC1	1.34E-4	0.506	0.031	DMG:Wockner_2014

Section II. Transcriptome annotation

General gene expression (GTEx)

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
SPIRE1	0.91	0.95
SLAIN2	0.90	0.91
NELL2	0.89	0.88
RLBP1L1	0.89	0.89
NCOA2	0.89	0.94
ACVR1B	0.89	0.93
LASS6	0.88	0.93
KBTBD7	0.88	0.93
HERC3	0.88	0.92
ZNF238	0.88	0.89

Top 10 negatively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
FXYD1	-0.67	-0.84
SERPINB6	-0.65	-0.72
HSD17B14	-0.64	-0.76
MT-CO2	-0.64	-0.82
AF347015.31	-0.64	-0.80
S100B	-0.62	-0.77
AF347015.33	-0.62	-0.77
TSC22D4	-0.62	-0.73
HEPN1	-0.62	-0.71
AIFM3	-0.62	-0.71

Section III. Gene Ontology annotation

Molecular function	GO term	Evidence	Neuro keywords	PubMed ID
GO:0000166	nucleotide binding	IEA		-
GO:0003924	GTPase activity	TAS		9312003
GO:0005525	GTP binding	IEA		-
GO:0019899	enzyme binding	IPI		16636067
GO:0030742	GTP-dependent protein binding	IPI		10954424
Biological process	GO term	Evidence	Neuro keywords	PubMed ID
GO:0007155	cell adhesion	TAS		9572733
GO:0009653	anatomical structure morphogenesis	TAS		9572733
GO:0010310	regulation of hydrogen peroxide metabolic process	TAS		16636067
GO:0006954	inflammatory response	TAS		9572733
GO:0006928	cell motion	TAS		9572733
GO:0007264	small GTPase mediated signal transduction	IEA		-
GO:0035025	positive regulation of Rho protein signal transduction	TAS		9312003
GO:0031529	ruffle organization	TAS		9312003
GO:0048261	negative regulation of receptor-mediated endocytosis	TAS		9312003
GO:0030041	actin filament polymerization	TAS		9312003
GO:0030032	lamellipodium biogenesis	IMP		9312003
GO:0051668	localization within membrane	IMP		16636067
GO:0060263	regulation of respiratory burst	IDA		16636067
Cellular component	GO term	Evidence	Neuro keywords	PubMed ID
GO:0005829	cytosol	EXP		7744773 \|10648409 \|14737186
GO:0005622	intracellular	IEA		-
GO:0005886	plasma membrane	IEA		-
GO:0042470	melanosome	IEA		-

Section IV. Protein-protein interaction annotation

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
ACTA1	ACTA \| ASMA \| CFTD \| CFTD1 \| CFTDM \| MPFD \| NEM1 \| NEM2 \| NEM3	actin, alpha 1, skeletal muscle	-	HPRD	11027608
ACTB	PS1TP5BP1	actin, beta	-	HPRD,BioGRID	11027608
ARFIP2	POR1	ADP-ribosylation factor interacting protein 2	Co-crystal Structure Reconstituted Complex Two-hybrid	BioGRID	8670882 \|11346801 \|11478794
ARFIP2	POR1	ADP-ribosylation factor interacting protein 2	-	HPRD	8670882 \|11478794
ARHGAP15	BM046	Rho GTPase activating protein 15	-	HPRD,BioGRID	12650940
ARHGAP17	DKFZp564A1363 \| FLJ37567 \| FLJ43368 \| MGC87805 \| MST066 \| MST110 \| MSTP038 \| MSTP066 \| MSTP110 \| NADRIN \| RICH1 \| WBP15	Rho GTPase activating protein 17	Biochemical Activity	BioGRID	11431473
ARHGAP27	CAMGAP1 \| FLJ43547 \| MGC120624	Rho GTPase activating protein 27	Biochemical Activity	BioGRID	15147912
ARHGAP8	BPGAP1 \| FLJ20185 \| PP610	Rho GTPase activating protein 8	BPGAP1 interacts with Rac1.	BIND	12944407
ARHGDIA	GDIA1 \| MGC117248 \| RHOGDI \| RHOGDI-1	Rho GDP dissociation inhibitor (GDI) alpha	-	HPRD	10346909 \|10673424\|11513579
ARHGDIA	GDIA1 \| MGC117248 \| RHOGDI \| RHOGDI-1	Rho GDP dissociation inhibitor (GDI) alpha	-	HPRD,BioGRID	10673424
ARHGDIB	D4 \| GDIA2 \| GDID4 \| LYGDI \| Ly-GDI \| RAP1GN1 \| RhoGDI2	Rho GDP dissociation inhibitor (GDI) beta	-	HPRD,BioGRID	9799233
ARHGDIG	RHOGDI-3	Rho GDP dissociation inhibitor (GDI) gamma	Rac1 interacts with RhoGDI.	BIND	14764880
ARHGEF2	DKFZp547L106 \| DKFZp547P1516 \| GEF \| GEF-H1 \| GEFH1 \| KIAA0651 \| LFP40 \| P40	rho/rac guanine nucleotide exchange factor (GEF) 2	-	HPRD,BioGRID	9857026 \|11595749
ARHGEF4	ASEF \| ASEF1 \| GEF4 \| STM6	Rho guanine nucleotide exchange factor (GEF) 4	Reconstituted Complex	BioGRID	10947987
ARHGEF6	COOL2 \| Cool-2 \| KIAA0006 \| MRX46 \| PIXA \| alpha-PIX \| alphaPIX	Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6	ARHGEF6 (Cool-2) interacts with Rac1.	BIND	15649357
BAIAP2	BAP2 \| IRSP53	BAI1-associated protein 2	-	HPRD,BioGRID	11130076 \|12054568
CDC42	CDC42Hs \| G25K	cell division cycle 42 (GTP binding protein, 25kDa)	Two-hybrid	BioGRID	9427749
CDC42BPG	DMPK2 \| HSMDPKIN \| KAPPA-200 \| MRCKgamma	CDC42 binding protein kinase gamma (DMPK-like)	-	HPRD,BioGRID	15194684
CDC42SE1	SCIP1 \| SPEC1	CDC42 small effector 1	-	HPRD,BioGRID	10816584
CDC42SE2	FLJ21967 \| SPEC2	CDC42 small effector 2	Two-hybrid	BioGRID	10816584
CDGAP	KIAA1204 \| MGC138368 \| MGC138370	Cdc42 GTPase-activating protein	-	HPRD	9786927
CHN1	ARHGAP2 \| CHN \| DURS2 \| RHOGAP2	chimerin (chimaerin) 1	-	HPRD	8496137
CIT	CRIK \| KIAA0949 \| STK21	citron (rho-interacting, serine/threonine kinase 21)	Far Western	BioGRID	8543060
CLIP1	CLIP \| CLIP-170 \| CLIP170 \| CYLN1 \| MGC131604 \| RSN	CAP-GLY domain containing linker protein 1	Affinity Capture-Western	BioGRID	12110184
CYBA	p22-PHOX	cytochrome b-245, alpha polypeptide	-	HPRD	10486263
CYFIP1	FLJ45151 \| P140SRA-1 \| SHYC \| SRA1	cytoplasmic FMR1 interacting protein 1	-	HPRD	9417078
DEF6	IBP \| SLAT	differentially expressed in FDCP 6 homolog (mouse)	-	HPRD,BioGRID	15023524
DEF6	IBP \| SLAT	differentially expressed in FDCP 6 homolog (mouse)	DEF6 interacts with Rac1. This interaction was modelled on a demonstrated interaction between human DEF6 and Rac1 from an unspecified species.	BIND	15023524
DIAPH1	DFNA1 \| DIA1 \| DRF1 \| FLJ25265 \| LFHL1 \| hDIA1	diaphanous homolog 1 (Drosophila)	-	HPRD	11590143
DMPK	DM \| DM1 \| DM1PK \| DMK \| MDPK \| MT-PK	dystrophia myotonica-protein kinase	Reconstituted Complex	BioGRID	10869570
DOCK1	DOCK180 \| ced5	dedicator of cytokinesis 1	Rac interacts with Dock180.	BIND	12134158
DOCK1	DOCK180 \| ced5	dedicator of cytokinesis 1	-	HPRD,BioGRID	9808620
DOCK2	FLJ46592 \| KIAA0209	dedicator of cytokinesis 2	-	HPRD,BioGRID	10559471
DOCK8	FLJ00026 \| FLJ00152 \| FLJ00346 \| MRD2 \| ZIR8	dedicator of cytokinesis 8	-	HPRD,BioGRID	15304341
EIF2AK2	EIF2AK1 \| MGC126524 \| PKR \| PRKR	eukaryotic translation initiation factor 2-alpha kinase 2	-	HPRD	7738010
FHOD1	FHOS	formin homology 2 domain containing 1	-	HPRD,BioGRID	11590143
FLNA	ABP-280 \| ABPX \| DKFZp434P031 \| FLN \| FLN1 \| FMD \| MNS \| NHBP \| OPD \| OPD1 \| OPD2	filamin A, alpha (actin binding protein 280)	-	HPRD	10051605
FMNL1	C17orf1 \| C17orf1B \| FHOD4 \| FMNL \| KW-13 \| MGC133052 \| MGC1894 \| MGC21878	formin-like 1	-	HPRD,BioGRID	10958683
GEFT	p63RhoGEF	RhoA/RAC/CDC42 exchange factor	-	HPRD,BioGRID	12547822
ICMT	HSTE14 \| MGC39955 \| MST098 \| MSTP098 \| PCCMT \| PCMT \| PPMT	isoprenylcysteine carboxyl methyltransferase	-	HPRD,BioGRID	12006387
IL1RAP	C3orf13 \| FLJ37788 \| IL-1RAcP \| IL1R3	interleukin 1 receptor accessory protein	-	HPRD,BioGRID	11416133
IQGAP1	HUMORFA01 \| KIAA0051 \| SAR1 \| p195	IQ motif containing GTPase activating protein 1	-	HPRD,BioGRID	8670801
IQGAP2	-	IQ motif containing GTPase activating protein 2	-	HPRD,BioGRID	8702968 \|8756646\|8756646
IQGAP2	-	IQ motif containing GTPase activating protein 2	-	HPRD	8756646
KTN1	CG1 \| KIAA0004 \| KNT \| MGC133337 \| MU-RMS-40.19	kinectin 1 (kinesin receptor)	-	HPRD,BioGRID	8769096
MAP3K10	MLK2 \| MST	mitogen-activated protein kinase kinase kinase 10	Reconstituted Complex	BioGRID	9427749
MAP3K11	MGC17114 \| MLK-3 \| MLK3 \| PTK1 \| SPRK	mitogen-activated protein kinase kinase kinase 11	-	HPRD	9427749
MAP3K4	FLJ42439 \| KIAA0213 \| MAPKKK4 \| MEKK4 \| MTK1 \| PRO0412	mitogen-activated protein kinase kinase kinase 4	Reconstituted Complex	BioGRID	9079650
MCF2L	ARHGEF14 \| DBS \| FLJ12122 \| KIAA0362 \| OST	MCF.2 cell line derived transforming sequence-like	-	HPRD,BioGRID	7957046 \|14701795
METAP2	MAP2 \| MNPEP \| p67 \| p67eIF2	methionyl aminopeptidase 2	-	HPRD	7738010
MYD88	MYD88D	myeloid differentiation primary response gene (88)	Affinity Capture-Western Reconstituted Complex	BioGRID	11416133
NCF1C	SH3PXD1C	neutrophil cytosolic factor 1C pseudogene	-	HPRD	9255350
NCF2	FLJ93058 \| NCF-2 \| NOXA2 \| P67-PHOX \| P67PHOX	neutrophil cytosolic factor 2	-	HPRD	9255350 \|9624165 \|11896062\|11090627
NCF2	FLJ93058 \| NCF-2 \| NOXA2 \| P67-PHOX \| P67PHOX	neutrophil cytosolic factor 2	-	HPRD	7738010 \|8036496 \|9255350 \|9624165 \|11090627 \|11896062\|11090627
NCF2	FLJ93058 \| NCF-2 \| NOXA2 \| P67-PHOX \| P67PHOX	neutrophil cytosolic factor 2	Co-crystal Structure Reconstituted Complex	BioGRID	9624165 \|9642115 \|11090627
NCK1	MGC12668 \| NCK \| NCKalpha	NCK adaptor protein 1	-	HPRD	10766742
NCKAP1	FLJ11291 \| HEM2 \| KIAA0587 \| MGC8981 \| NAP1 \| NAP125	NCK-associated protein 1	-	HPRD	9148763 \|9417078
NCKAP1	FLJ11291 \| HEM2 \| KIAA0587 \| MGC8981 \| NAP1 \| NAP125	NCK-associated protein 1	-	HPRD,BioGRID	9148763
NOS2	HEP-NOS \| INOS \| NOS \| NOS2A	nitric oxide synthase 2, inducible	-	HPRD	11422783 \|11457725
NOS2	HEP-NOS \| INOS \| NOS \| NOS2A	nitric oxide synthase 2, inducible	-	HPRD,BioGRID	11457725
NOXA1	FLJ25475 \| MGC131800 \| NY-CO-31 \| SDCCAG31 \| p51NOX	NADPH oxidase activator 1	-	HPRD	12716910
OPHN1	MRX60 \| OPN1	oligophrenin 1	-	HPRD,BioGRID	9582072 \|11998687
PAK1	MGC130000 \| MGC130001 \| PAKalpha	p21 protein (Cdc42/Rac)-activated kinase 1	PAK1 interacts with an unspecified isoform of Rac. This interaction was modeled on a demonstrated interaction between human PAK1 and Rac from Chinese hamster.	BIND	15975516
PAK1	MGC130000 \| MGC130001 \| PAKalpha	p21 protein (Cdc42/Rac)-activated kinase 1	PAK1 interacts with an unspecified isoform of Rac. This interaction was modeled on a demonstrated interaction between PAK1 from an unspecified species and human Rac.	BIND	15864311
PAK1	MGC130000 \| MGC130001 \| PAKalpha	p21 protein (Cdc42/Rac)-activated kinase 1	-	HPRD	7744004 \|8107774 \|11134022 \|11950930\|11134022
PAK1	MGC130000 \| MGC130001 \| PAKalpha	p21 protein (Cdc42/Rac)-activated kinase 1	Reconstituted Complex	BioGRID	12650940 \|12879077
PAK1	MGC130000 \| MGC130001 \| PAKalpha	p21 protein (Cdc42/Rac)-activated kinase 1	Active GTP-bound RAC1 interacts with PAK1B. This interaction was modelled on a demonstrated interaction between chicken RAC1 and human PAK1B.	BIND	15735674
PAK1	MGC130000 \| MGC130001 \| PAKalpha	p21 protein (Cdc42/Rac)-activated kinase 1	Rac1 interacts with Pak1. This interaction was modeled on a demonstrated interaction between Rac1 and Pak1 from an unspecified species.	BIND	15652748
PAK1	MGC130000 \| MGC130001 \| PAKalpha	p21 protein (Cdc42/Rac)-activated kinase 1	Rac1 interacts with Pak1. This interaction was modelled on a demonstrated interacton between Rac1 from an unspecified species and human Pak1.	BIND	12944407
PAK2	PAK65 \| PAKgamma	p21 protein (Cdc42/Rac)-activated kinase 2	-	HPRD,BioGRID	9535855
PAK3	CDKN1A \| MRX30 \| MRX47 \| OPHN3 \| PAK3beta \| bPAK \| hPAK3	p21 protein (Cdc42/Rac)-activated kinase 3	Reconstituted Complex Two-hybrid	BioGRID	11478794
PAK4	-	p21 protein (Cdc42/Rac)-activated kinase 4	Affinity Capture-Western	BioGRID	11756552
PAK7	KIAA1264 \| MGC26232 \| PAK5	p21 protein (Cdc42/Rac)-activated kinase 7	-	HPRD,BioGRID	11756552
PARD6A	PAR-6A \| PAR6 \| PAR6C \| PAR6alpha \| TAX40 \| TIP-40	par-6 partitioning defective 6 homolog alpha (C. elegans)	-	HPRD,BioGRID	11260256
PARD6G	FLJ45701 \| PAR-6G \| PAR6gamma	par-6 partitioning defective 6 homolog gamma (C. elegans)	-	HPRD,BioGRID	11260256
PARK2	AR-JP \| LPRS2 \| PDJ \| PRKN	Parkinson disease (autosomal recessive, juvenile) 2, parkin	Two-hybrid	BioGRID	16169070
PIK3R1	GRB1 \| p85 \| p85-ALPHA	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)	-	HPRD	7629060 \|8034624 \|12086876
PIK3R1	GRB1 \| p85 \| p85-ALPHA	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)	-	HPRD	12086876
PLD1	-	phospholipase D1, phosphatidylcholine-specific	-	HPRD	11950936
PLEKHG2	CLG \| DKFZp667J2325 \| FLJ00018 \| FLJ22458 \| FLJ38638	pleckstrin homology domain containing, family G (with RhoGef domain) member 2	-	HPRD,BioGRID	11839748
PLXNB1	KIAA0407 \| MGC149167 \| PLEXIN-B1 \| PLXN5 \| SEP	plexin B1	-	HPRD	12123608
PLXNB1	KIAA0407 \| MGC149167 \| PLEXIN-B1 \| PLXN5 \| SEP	plexin B1	Plexin-B1 interacts with Rac1. This interaction was modelled on a demonstrated interaction between human Plexin-B1 and Rac1 from an unspecified species.	BIND	15642257
PRKCA	AAG6 \| MGC129900 \| MGC129901 \| PKC-alpha \| PKCA \| PRKACA	protein kinase C, alpha	-	HPRD,BioGRID	11284700
PTPLAD1	B-IND1 \| FLJ90376 \| HSPC121	protein tyrosine phosphatase-like A domain containing 1	-	HPRD,BioGRID	10747961
RAC1	MGC111543 \| MIG5 \| TC-25 \| p21-Rac1	ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)	Reconstituted Complex	BioGRID	11134022
RALBP1	RIP1 \| RLIP1 \| RLIP76	ralA binding protein 1	Rac1 interacts with RLIP76.	BIND	7673236
RALBP1	RIP1 \| RLIP1 \| RLIP76	ralA binding protein 1	-	HPRD,BioGRID	7673236
RAP1GDS1	GDS1 \| MGC118859 \| MGC118861 \| SmgGDS	RAP1, GTP-GDP dissociation stimulator 1	-	HPRD,BioGRID	11948427
RCC2	DKFZp762N0610 \| KIAA1470 \| TD-60	regulator of chromosome condensation 2	-	HPRD	12919680
RGL2	HKE1.5 \| KE1.5 \| RAB2L	ral guanine nucleotide dissociation stimulator-like 2	Two-hybrid	BioGRID	8939933
RICH2	KIAA0672 \| NPC-A-10	Rho-type GTPase-activating protein RICH2	Biochemical Activity	BioGRID	11431473
RICS	GC-GAP \| GRIT \| KIAA0712 \| MGC1892 \| p200RhoGAP \| p250GAP	Rho GTPase-activating protein	Biochemical Activity	BioGRID	12454018 \|12819203
RPS6KB1	PS6K \| S6K \| S6K1 \| STK14A \| p70(S6K)-alpha \| p70-S6K \| p70-alpha	ribosomal protein S6 kinase, 70kDa, polypeptide 1	-	HPRD	11438723
SH3BP1	-	SH3-domain binding protein 1	-	HPRD	10508610
STAT3	APRF \| FLJ20882 \| HIES \| MGC16063	signal transducer and activator of transcription 3 (acute-phase response factor)	-	HPRD,BioGRID	11021801
SYNJ2	INPP5H \| KIAA0348 \| MGC44422	synaptojanin 2	-	HPRD,BioGRID	11084340
TBC1D3	TBC1D3A \| TRE17	TBC1 domain family, member 3	-	HPRD,BioGRID	12612085
TCF7L2	TCF-4 \| TCF4	transcription factor 7-like 2 (T-cell specific, HMG-box)	Rac1 interacts with TCF4.	BIND	15377999
TEC	MGC126760 \| MGC126762 \| PSCTK4	tec protein tyrosine kinase	Phenotypic Enhancement	BioGRID	11328862
TIAM1	FLJ36302	T-cell lymphoma invasion and metastasis 1	The GTPase Rac1 specifically interacts with Dbl-homology domain of the nucleotide exchange factor TIAM1. This interaction is modelled on a demonstrated interaction between mouse TIAM1 and human Rac1.	BIND	11130063
TIAM1	FLJ36302	T-cell lymphoma invasion and metastasis 1	-	HPRD,BioGRID	11130063 \|11595749
TNFRSF12A	CD266 \| FN14 \| TWEAKR	tumor necrosis factor receptor superfamily, member 12A	-	HPRD	14573547
TNFRSF12A	CD266 \| FN14 \| TWEAKR	tumor necrosis factor receptor superfamily, member 12A	Fn14 interacts with Rac1.	BIND	14573547
TRIO	FLJ42780 \| tgat	triple functional domain (PTPRF interacting)	-	HPRD,BioGRID	11595749
TUBA4A	FLJ30169 \| H2-ALPHA \| TUBA1	tubulin, alpha 4a	-	HPRD	8631991
VAV1	VAV	vav 1 guanine nucleotide exchange factor	Affinity Capture-Western	BioGRID	11287617
VAV3	FLJ40431	vav 3 guanine nucleotide exchange factor	-	HPRD,BioGRID	10523675
WAS	IMD2 \| THC \| WASP	Wiskott-Aldrich syndrome (eczema-thrombocytopenia)	-	HPRD,BioGRID	8643625
WASF1	FLJ31482 \| KIAA0269 \| SCAR1 \| WAVE \| WAVE1	WAS protein family, member 1	-	HPRD	9843499

Section V. Pathway annotation

Pathway name	Pathway size	# SZGR 2.0 genes in pathway	Info
KEGG MAPK SIGNALING PATHWAY	267	205	All SZGR 2.0 genes in this pathway
KEGG CHEMOKINE SIGNALING PATHWAY	190	128	All SZGR 2.0 genes in this pathway
KEGG WNT SIGNALING PATHWAY	151	112	All SZGR 2.0 genes in this pathway
KEGG AXON GUIDANCE	129	103	All SZGR 2.0 genes in this pathway
KEGG VEGF SIGNALING PATHWAY	76	53	All SZGR 2.0 genes in this pathway
KEGG FOCAL ADHESION	201	138	All SZGR 2.0 genes in this pathway
KEGG ADHERENS JUNCTION	75	53	All SZGR 2.0 genes in this pathway
KEGG TOLL LIKE RECEPTOR SIGNALING PATHWAY	102	88	All SZGR 2.0 genes in this pathway
KEGG NATURAL KILLER CELL MEDIATED CYTOTOXICITY	137	92	All SZGR 2.0 genes in this pathway
KEGG B CELL RECEPTOR SIGNALING PATHWAY	75	56	All SZGR 2.0 genes in this pathway
KEGG FC EPSILON RI SIGNALING PATHWAY	79	58	All SZGR 2.0 genes in this pathway
KEGG FC GAMMA R MEDIATED PHAGOCYTOSIS	97	71	All SZGR 2.0 genes in this pathway
KEGG LEUKOCYTE TRANSENDOTHELIAL MIGRATION	118	78	All SZGR 2.0 genes in this pathway
KEGG NEUROTROPHIN SIGNALING PATHWAY	126	103	All SZGR 2.0 genes in this pathway
KEGG REGULATION OF ACTIN CYTOSKELETON	216	144	All SZGR 2.0 genes in this pathway
KEGG AMYOTROPHIC LATERAL SCLEROSIS ALS	53	43	All SZGR 2.0 genes in this pathway
KEGG EPITHELIAL CELL SIGNALING IN HELICOBACTER PYLORI INFECTION	68	44	All SZGR 2.0 genes in this pathway
KEGG PATHWAYS IN CANCER	328	259	All SZGR 2.0 genes in this pathway
KEGG COLORECTAL CANCER	62	47	All SZGR 2.0 genes in this pathway
KEGG RENAL CELL CARCINOMA	70	60	All SZGR 2.0 genes in this pathway
KEGG PANCREATIC CANCER	70	56	All SZGR 2.0 genes in this pathway
KEGG VIRAL MYOCARDITIS	73	58	All SZGR 2.0 genes in this pathway
BIOCARTA AGR PATHWAY	36	31	All SZGR 2.0 genes in this pathway
BIOCARTA AT1R PATHWAY	36	28	All SZGR 2.0 genes in this pathway
BIOCARTA BCR PATHWAY	37	28	All SZGR 2.0 genes in this pathway
BIOCARTA FMLP PATHWAY	39	29	All SZGR 2.0 genes in this pathway
BIOCARTA SALMONELLA PATHWAY	13	10	All SZGR 2.0 genes in this pathway
BIOCARTA RACCYCD PATHWAY	26	23	All SZGR 2.0 genes in this pathway
BIOCARTA PYK2 PATHWAY	31	24	All SZGR 2.0 genes in this pathway
BIOCARTA MAPK PATHWAY	87	68	All SZGR 2.0 genes in this pathway
BIOCARTA P38MAPK PATHWAY	40	31	All SZGR 2.0 genes in this pathway
BIOCARTA PTDINS PATHWAY	23	16	All SZGR 2.0 genes in this pathway
BIOCARTA EDG1 PATHWAY	27	24	All SZGR 2.0 genes in this pathway
BIOCARTA RAC1 PATHWAY	23	16	All SZGR 2.0 genes in this pathway
BIOCARTA RAS PATHWAY	23	20	All SZGR 2.0 genes in this pathway
BIOCARTA NKCELLS PATHWAY	20	13	All SZGR 2.0 genes in this pathway
BIOCARTA MAL PATHWAY	19	17	All SZGR 2.0 genes in this pathway
BIOCARTA CDC42RAC PATHWAY	16	13	All SZGR 2.0 genes in this pathway
BIOCARTA TCR PATHWAY	49	37	All SZGR 2.0 genes in this pathway
BIOCARTA CREB PATHWAY	27	25	All SZGR 2.0 genes in this pathway
BIOCARTA ARF PATHWAY	17	13	All SZGR 2.0 genes in this pathway
BIOCARTA UCALPAIN PATHWAY	18	11	All SZGR 2.0 genes in this pathway
BIOCARTA ACTINY PATHWAY	20	14	All SZGR 2.0 genes in this pathway
SA B CELL RECEPTOR COMPLEXES	24	20	All SZGR 2.0 genes in this pathway
ST MYOCYTE AD PATHWAY	27	25	All SZGR 2.0 genes in this pathway
PID ENDOTHELIN PATHWAY	63	52	All SZGR 2.0 genes in this pathway
PID BCR 5PATHWAY	65	50	All SZGR 2.0 genes in this pathway
PID PRL SIGNALING EVENTS PATHWAY	23	17	All SZGR 2.0 genes in this pathway
PID LYSOPHOSPHOLIPID PATHWAY	66	53	All SZGR 2.0 genes in this pathway
PID P38 MKK3 6PATHWAY	26	21	All SZGR 2.0 genes in this pathway
PID WNT NONCANONICAL PATHWAY	32	26	All SZGR 2.0 genes in this pathway
PID MET PATHWAY	80	60	All SZGR 2.0 genes in this pathway
PID S1P S1P3 PATHWAY	29	24	All SZGR 2.0 genes in this pathway
PID EPHB FWD PATHWAY	40	38	All SZGR 2.0 genes in this pathway
PID AVB3 OPN PATHWAY	31	29	All SZGR 2.0 genes in this pathway
PID ILK PATHWAY	45	32	All SZGR 2.0 genes in this pathway
PID NECTIN PATHWAY	30	20	All SZGR 2.0 genes in this pathway
PID P38 ALPHA BETA PATHWAY	31	25	All SZGR 2.0 genes in this pathway
PID CDC42 PATHWAY	70	51	All SZGR 2.0 genes in this pathway
PID RET PATHWAY	39	29	All SZGR 2.0 genes in this pathway
PID ANGIOPOIETIN RECEPTOR PATHWAY	50	41	All SZGR 2.0 genes in this pathway
PID TXA2PATHWAY	57	43	All SZGR 2.0 genes in this pathway
PID S1P S1P1 PATHWAY	21	18	All SZGR 2.0 genes in this pathway
PID NETRIN PATHWAY	32	27	All SZGR 2.0 genes in this pathway
PID INTEGRIN A9B1 PATHWAY	25	18	All SZGR 2.0 genes in this pathway
PID ARF6 DOWNSTREAM PATHWAY	15	14	All SZGR 2.0 genes in this pathway
PID MTOR 4PATHWAY	69	55	All SZGR 2.0 genes in this pathway
PID CXCR4 PATHWAY	102	78	All SZGR 2.0 genes in this pathway
PID PI3KCI PATHWAY	49	40	All SZGR 2.0 genes in this pathway
PID AJDISS 2PATHWAY	48	38	All SZGR 2.0 genes in this pathway
PID IL2 PI3K PATHWAY	34	27	All SZGR 2.0 genes in this pathway
PID P75 NTR PATHWAY	69	51	All SZGR 2.0 genes in this pathway
PID ECADHERIN NASCENT AJ PATHWAY	39	33	All SZGR 2.0 genes in this pathway
PID AVB3 INTEGRIN PATHWAY	75	53	All SZGR 2.0 genes in this pathway
PID LIS1 PATHWAY	28	22	All SZGR 2.0 genes in this pathway
PID ERBB1 DOWNSTREAM PATHWAY	105	78	All SZGR 2.0 genes in this pathway
PID SYNDECAN 4 PATHWAY	32	25	All SZGR 2.0 genes in this pathway
PID UPA UPAR PATHWAY	42	30	All SZGR 2.0 genes in this pathway
PID ERBB2 ERBB3 PATHWAY	44	35	All SZGR 2.0 genes in this pathway
PID IL6 7 PATHWAY	47	40	All SZGR 2.0 genes in this pathway
PID ECADHERIN KERATINOCYTE PATHWAY	21	19	All SZGR 2.0 genes in this pathway
PID PDGFRB PATHWAY	129	103	All SZGR 2.0 genes in this pathway
PID TRKR PATHWAY	62	48	All SZGR 2.0 genes in this pathway
PID NEPHRIN NEPH1 PATHWAY	31	24	All SZGR 2.0 genes in this pathway
PID AR NONGENOMIC PATHWAY	31	27	All SZGR 2.0 genes in this pathway
PID A6B1 A6B4 INTEGRIN PATHWAY	46	35	All SZGR 2.0 genes in this pathway
PID RAC1 REG PATHWAY	38	25	All SZGR 2.0 genes in this pathway
PID ARF 3PATHWAY	19	13	All SZGR 2.0 genes in this pathway
PID EPHRINB REV PATHWAY	30	25	All SZGR 2.0 genes in this pathway
PID NCADHERIN PATHWAY	33	32	All SZGR 2.0 genes in this pathway
PID S1P S1P2 PATHWAY	24	19	All SZGR 2.0 genes in this pathway
PID EPHA2 FWD PATHWAY	19	16	All SZGR 2.0 genes in this pathway
PID INTEGRIN A4B1 PATHWAY	33	24	All SZGR 2.0 genes in this pathway
PID RAC1 PATHWAY	54	37	All SZGR 2.0 genes in this pathway
PID FAK PATHWAY	59	45	All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY RHO GTPASES	113	81	All SZGR 2.0 genes in this pathway
REACTOME SIGNALLING BY NGF	217	167	All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY SCF KIT	78	59	All SZGR 2.0 genes in this pathway
REACTOME DEVELOPMENTAL BIOLOGY	396	292	All SZGR 2.0 genes in this pathway
REACTOME CELL CELL COMMUNICATION	120	77	All SZGR 2.0 genes in this pathway
REACTOME NRAGE SIGNALS DEATH THROUGH JNK	43	33	All SZGR 2.0 genes in this pathway
REACTOME CELL DEATH SIGNALLING VIA NRAGE NRIF AND NADE	60	43	All SZGR 2.0 genes in this pathway
REACTOME P75 NTR RECEPTOR MEDIATED SIGNALLING	81	61	All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY GPCR	920	449	All SZGR 2.0 genes in this pathway
REACTOME GPVI MEDIATED ACTIVATION CASCADE	31	25	All SZGR 2.0 genes in this pathway
REACTOME AXON GUIDANCE	251	188	All SZGR 2.0 genes in this pathway
REACTOME G ALPHA1213 SIGNALLING EVENTS	74	56	All SZGR 2.0 genes in this pathway
REACTOME CD28 CO STIMULATION	32	26	All SZGR 2.0 genes in this pathway
REACTOME GPCR DOWNSTREAM SIGNALING	805	368	All SZGR 2.0 genes in this pathway
REACTOME ACTIVATION OF RAC	14	11	All SZGR 2.0 genes in this pathway
REACTOME SEMA3A PAK DEPENDENT AXON REPULSION	15	14	All SZGR 2.0 genes in this pathway
REACTOME CD28 DEPENDENT VAV1 PATHWAY	11	10	All SZGR 2.0 genes in this pathway
REACTOME SEMA4D IN SEMAPHORIN SIGNALING	32	22	All SZGR 2.0 genes in this pathway
REACTOME SEMAPHORIN INTERACTIONS	68	53	All SZGR 2.0 genes in this pathway
REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE	27	21	All SZGR 2.0 genes in this pathway
REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION	13	9	All SZGR 2.0 genes in this pathway
REACTOME COSTIMULATION BY THE CD28 FAMILY	63	48	All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY ROBO RECEPTOR	30	26	All SZGR 2.0 genes in this pathway
REACTOME L1CAM INTERACTIONS	86	62	All SZGR 2.0 genes in this pathway
REACTOME NETRIN1 SIGNALING	41	30	All SZGR 2.0 genes in this pathway
REACTOME SIGNAL TRANSDUCTION BY L1	34	25	All SZGR 2.0 genes in this pathway
REACTOME DCC MEDIATED ATTRACTIVE SIGNALING	13	11	All SZGR 2.0 genes in this pathway
REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION	132	101	All SZGR 2.0 genes in this pathway
REACTOME DSCAM INTERACTIONS	11	10	All SZGR 2.0 genes in this pathway
REACTOME HEMOSTASIS	466	331	All SZGR 2.0 genes in this pathway
REACTOME HIV INFECTION	207	122	All SZGR 2.0 genes in this pathway
REACTOME HOST INTERACTIONS OF HIV FACTORS	132	81	All SZGR 2.0 genes in this pathway
REACTOME THE ROLE OF NEF IN HIV1 REPLICATION AND DISEASE PATHOGENESIS	28	19	All SZGR 2.0 genes in this pathway
REACTOME IMMUNE SYSTEM	933	616	All SZGR 2.0 genes in this pathway
REACTOME ADAPTIVE IMMUNE SYSTEM	539	350	All SZGR 2.0 genes in this pathway
REACTOME PLATELET ACTIVATION SIGNALING AND AGGREGATION	208	138	All SZGR 2.0 genes in this pathway
TURASHVILI BREAST DUCTAL CARCINOMA VS LOBULAR NORMAL UP	73	50	All SZGR 2.0 genes in this pathway
DIAZ CHRONIC MEYLOGENOUS LEUKEMIA UP	1382	904	All SZGR 2.0 genes in this pathway
TIMOFEEVA GROWTH STRESS VIA STAT1 DN	16	12	All SZGR 2.0 genes in this pathway
BORCZUK MALIGNANT MESOTHELIOMA UP	305	185	All SZGR 2.0 genes in this pathway
SENESE HDAC1 TARGETS DN	260	143	All SZGR 2.0 genes in this pathway
KINSEY TARGETS OF EWSR1 FLII FUSION UP	1278	748	All SZGR 2.0 genes in this pathway
ENK UV RESPONSE KERATINOCYTE UP	530	342	All SZGR 2.0 genes in this pathway
WANG ESOPHAGUS CANCER VS NORMAL DN	101	66	All SZGR 2.0 genes in this pathway
LI LUNG CANCER	41	30	All SZGR 2.0 genes in this pathway
DAIRKEE TERT TARGETS UP	380	213	All SZGR 2.0 genes in this pathway
CALVET IRINOTECAN SENSITIVE VS REVERTED UP	5	5	All SZGR 2.0 genes in this pathway
NUYTTEN EZH2 TARGETS DN	1024	594	All SZGR 2.0 genes in this pathway
FRIDMAN SENESCENCE UP	77	60	All SZGR 2.0 genes in this pathway
FLECHNER BIOPSY KIDNEY TRANSPLANT OK VS DONOR UP	555	346	All SZGR 2.0 genes in this pathway
REN ALVEOLAR RHABDOMYOSARCOMA DN	408	274	All SZGR 2.0 genes in this pathway
ZAMORA NOS2 TARGETS UP	69	41	All SZGR 2.0 genes in this pathway
WHITESIDE CISPLATIN RESISTANCE UP	11	7	All SZGR 2.0 genes in this pathway
MURAKAMI UV RESPONSE 6HR UP	37	31	All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE UP	1691	1088	All SZGR 2.0 genes in this pathway
MACLACHLAN BRCA1 TARGETS UP	21	16	All SZGR 2.0 genes in this pathway
VERRECCHIA DELAYED RESPONSE TO TGFB1	39	26	All SZGR 2.0 genes in this pathway
LEE CALORIE RESTRICTION NEOCORTEX DN	88	58	All SZGR 2.0 genes in this pathway
VERRECCHIA RESPONSE TO TGFB1 C4	13	10	All SZGR 2.0 genes in this pathway
YOSHIMURA MAPK8 TARGETS DN	366	257	All SZGR 2.0 genes in this pathway
HINATA NFKB TARGETS KERATINOCYTE UP	91	63	All SZGR 2.0 genes in this pathway
HINATA NFKB TARGETS FIBROBLAST UP	84	60	All SZGR 2.0 genes in this pathway
HSIAO HOUSEKEEPING GENES	389	245	All SZGR 2.0 genes in this pathway
BYSTRYKH HEMATOPOIESIS STEM CELL IL3RA	9	6	All SZGR 2.0 genes in this pathway
JOHNSTONE PARVB TARGETS 3 DN	918	550	All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-101	537	544	1A,m8	hsa-miR-101	UACAGUACUGUGAUAACUGAAG
miR-137	987	993	1A	hsa-miR-137	UAUUGCUUAAGAAUACGCGUAG
miR-142-3p	747	754	1A,m8	hsa-miR-142-3p	UGUAGUGUUUCCUACUUUAUGGA
miR-144	538	544	1A	hsa-miR-144	UACAGUAUAGAUGAUGUACUAG
miR-182	308	315	1A,m8	hsa-miR-182	UUUGGCAAUGGUAGAACUCACA
miR-194	127	133	1A	hsa-miR-194	UGUAACAGCAACUCCAUGUGGA
miR-200bc/429	715	721	m8	hsa-miR-200b	UAAUACUGCCUGGUAAUGAUGAC
				hsa-miR-200c	UAAUACUGCCGGGUAAUGAUGG
				hsa-miR-429	UAAUACUGUCUGGUAAAACCGU
miR-361	1018	1025	1A,m8	hsa-miR-361^brain	UUAUCAGAAUCUCCAGGGGUAC
miR-485-3p	1493	1499	m8	hsa-miR-485-3p	GUCAUACACGGCUCUCCUCUCU
miR-485-5p	466	472	m8	hsa-miR-485-5p	AGAGGCUGGCCGUGAUGAAUUC
miR-495	125	131	1A	hsa-miR-495^brain	AAACAAACAUGGUGCACUUCUUU
miR-96	309	315	1A	hsa-miR-96^brain	UUUGGCACUAGCACAUUUUUGC
miR-99/100	777	783	1A	hsa-miR-99a^brain	AACCCGUAGAUCCGAUCUUGUG
				hsa-miR-100^brain	AACCCGUAGAUCCGAACUUGUG
				hsa-miR-99b^brain	CACCCGUAGAACCGACCUUGCG

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.

Gene Page: RAC1