Summary ?
GeneID5879
SymbolRAC1
SynonymsMIG5|Rac-1|TC-25|p21-Rac1
Descriptionras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
ReferenceMIM:602048|HGNC:HGNC:9801|Ensembl:ENSG00000136238|HPRD:03627|Vega:OTTHUMG00000023540
Gene typeprotein-coding
Map location7p22
Pascal p-value0.705
Sherlock p-value0.56
Fetal beta-0.426
DMG1 (# studies)
eGeneCerebellum
SupportINTRACELLULAR SIGNAL TRANSDUCTION
G2Cdb.human_BAYES-COLLINS-HUMAN-PSD-CONSENSUS
G2Cdb.human_BAYES-COLLINS-HUMAN-PSD-FULL
G2Cdb.human_BAYES-COLLINS-MOUSE-PSD-CONSENSUS
G2Cdb.human_TAP-PSD-95-CORE
G2Cdb.humanNRC
G2Cdb.humanPSD
G2Cdb.humanPSP
CompositeSet
Potential synaptic genes

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
DMG:Wockner_2014Genome-wide DNA methylation analysisThis dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 1
PMID:cooccurHigh-throughput literature-searchSystematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: schizophrenia,schizophreniasClick to show details
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.2217 

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

ProbeChromosomePositionNearest geneP (dis)Beta (dis)FDR (dis)Study
cg1538147576436101RAC11.34E-40.5060.031DMG:Wockner_2014


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
SPIRE10.910.95
SLAIN20.900.91
NELL20.890.88
RLBP1L10.890.89
NCOA20.890.94
ACVR1B0.890.93
LASS60.880.93
KBTBD70.880.93
HERC30.880.92
ZNF2380.880.89
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
FXYD1-0.67-0.84
SERPINB6-0.65-0.72
HSD17B14-0.64-0.76
MT-CO2-0.64-0.82
AF347015.31-0.64-0.80
S100B-0.62-0.77
AF347015.33-0.62-0.77
TSC22D4-0.62-0.73
HEPN1-0.62-0.71
AIFM3-0.62-0.71

Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0000166nucleotide bindingIEA-
GO:0003924GTPase activityTAS9312003 
GO:0005525GTP bindingIEA-
GO:0019899enzyme bindingIPI16636067 
GO:0030742GTP-dependent protein bindingIPI10954424 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007155cell adhesionTAS9572733 
GO:0009653anatomical structure morphogenesisTAS9572733 
GO:0010310regulation of hydrogen peroxide metabolic processTAS16636067 
GO:0006954inflammatory responseTAS9572733 
GO:0006928cell motionTAS9572733 
GO:0007264small GTPase mediated signal transductionIEA-
GO:0035025positive regulation of Rho protein signal transductionTAS9312003 
GO:0031529ruffle organizationTAS9312003 
GO:0048261negative regulation of receptor-mediated endocytosisTAS9312003 
GO:0030041actin filament polymerizationTAS9312003 
GO:0030032lamellipodium biogenesisIMP9312003 
GO:0051668localization within membraneIMP16636067 
GO:0060263regulation of respiratory burstIDA16636067 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005829cytosolEXP7744773 |10648409 |14737186 
GO:0005622intracellularIEA-
GO:0005886plasma membraneIEA-
GO:0042470melanosomeIEA-

Section IV. Protein-protein interaction annotation

InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ACTA1ACTA | ASMA | CFTD | CFTD1 | CFTDM | MPFD | NEM1 | NEM2 | NEM3actin, alpha 1, skeletal muscle-HPRD11027608 
ACTBPS1TP5BP1actin, beta-HPRD,BioGRID11027608 
ARFIP2POR1ADP-ribosylation factor interacting protein 2Co-crystal Structure
Reconstituted Complex
Two-hybrid
BioGRID8670882 |11346801 
|11478794 
ARFIP2POR1ADP-ribosylation factor interacting protein 2-HPRD8670882 |11478794 
ARHGAP15BM046Rho GTPase activating protein 15-HPRD,BioGRID12650940 
ARHGAP17DKFZp564A1363 | FLJ37567 | FLJ43368 | MGC87805 | MST066 | MST110 | MSTP038 | MSTP066 | MSTP110 | NADRIN | RICH1 | WBP15Rho GTPase activating protein 17Biochemical ActivityBioGRID11431473 
ARHGAP27CAMGAP1 | FLJ43547 | MGC120624Rho GTPase activating protein 27Biochemical ActivityBioGRID15147912 
ARHGAP8BPGAP1 | FLJ20185 | PP610Rho GTPase activating protein 8BPGAP1 interacts with Rac1.BIND12944407 
ARHGDIAGDIA1 | MGC117248 | RHOGDI | RHOGDI-1Rho GDP dissociation inhibitor (GDI) alpha-HPRD10346909 |10673424|11513579 
ARHGDIAGDIA1 | MGC117248 | RHOGDI | RHOGDI-1Rho GDP dissociation inhibitor (GDI) alpha-HPRD,BioGRID10673424 
ARHGDIBD4 | GDIA2 | GDID4 | LYGDI | Ly-GDI | RAP1GN1 | RhoGDI2Rho GDP dissociation inhibitor (GDI) beta-HPRD,BioGRID9799233 
ARHGDIGRHOGDI-3Rho GDP dissociation inhibitor (GDI) gammaRac1 interacts with RhoGDI.BIND14764880 
ARHGEF2DKFZp547L106 | DKFZp547P1516 | GEF | GEF-H1 | GEFH1 | KIAA0651 | LFP40 | P40rho/rac guanine nucleotide exchange factor (GEF) 2-HPRD,BioGRID9857026 |11595749 
ARHGEF4ASEF | ASEF1 | GEF4 | STM6Rho guanine nucleotide exchange factor (GEF) 4Reconstituted ComplexBioGRID10947987 
ARHGEF6COOL2 | Cool-2 | KIAA0006 | MRX46 | PIXA | alpha-PIX | alphaPIXRac/Cdc42 guanine nucleotide exchange factor (GEF) 6ARHGEF6 (Cool-2) interacts with Rac1.BIND15649357 
BAIAP2BAP2 | IRSP53BAI1-associated protein 2-HPRD,BioGRID11130076 |12054568 
CDC42CDC42Hs | G25Kcell division cycle 42 (GTP binding protein, 25kDa)Two-hybridBioGRID9427749 
CDC42BPGDMPK2 | HSMDPKIN | KAPPA-200 | MRCKgammaCDC42 binding protein kinase gamma (DMPK-like)-HPRD,BioGRID15194684 
CDC42SE1SCIP1 | SPEC1CDC42 small effector 1-HPRD,BioGRID10816584 
CDC42SE2FLJ21967 | SPEC2CDC42 small effector 2Two-hybridBioGRID10816584 
CDGAPKIAA1204 | MGC138368 | MGC138370Cdc42 GTPase-activating protein-HPRD9786927 
CHN1ARHGAP2 | CHN | DURS2 | RHOGAP2chimerin (chimaerin) 1-HPRD8496137 
CITCRIK | KIAA0949 | STK21citron (rho-interacting, serine/threonine kinase 21)Far WesternBioGRID8543060 
CLIP1CLIP | CLIP-170 | CLIP170 | CYLN1 | MGC131604 | RSNCAP-GLY domain containing linker protein 1Affinity Capture-WesternBioGRID12110184 
CYBAp22-PHOXcytochrome b-245, alpha polypeptide-HPRD10486263 
CYFIP1FLJ45151 | P140SRA-1 | SHYC | SRA1cytoplasmic FMR1 interacting protein 1-HPRD9417078 
DEF6IBP | SLATdifferentially expressed in FDCP 6 homolog (mouse)-HPRD,BioGRID15023524 
DEF6IBP | SLATdifferentially expressed in FDCP 6 homolog (mouse)DEF6 interacts with Rac1. This interaction was modelled on a demonstrated interaction between human DEF6 and Rac1 from an unspecified species.BIND15023524 
DIAPH1DFNA1 | DIA1 | DRF1 | FLJ25265 | LFHL1 | hDIA1diaphanous homolog 1 (Drosophila)-HPRD11590143 
DMPKDM | DM1 | DM1PK | DMK | MDPK | MT-PKdystrophia myotonica-protein kinaseReconstituted ComplexBioGRID10869570 
DOCK1DOCK180 | ced5dedicator of cytokinesis 1Rac interacts with Dock180.BIND12134158 
DOCK1DOCK180 | ced5dedicator of cytokinesis 1-HPRD,BioGRID9808620 
DOCK2FLJ46592 | KIAA0209dedicator of cytokinesis 2-HPRD,BioGRID10559471 
DOCK8FLJ00026 | FLJ00152 | FLJ00346 | MRD2 | ZIR8dedicator of cytokinesis 8-HPRD,BioGRID15304341 
EIF2AK2EIF2AK1 | MGC126524 | PKR | PRKReukaryotic translation initiation factor 2-alpha kinase 2-HPRD7738010 
FHOD1FHOSformin homology 2 domain containing 1-HPRD,BioGRID11590143 
FLNAABP-280 | ABPX | DKFZp434P031 | FLN | FLN1 | FMD | MNS | NHBP | OPD | OPD1 | OPD2filamin A, alpha (actin binding protein 280)-HPRD10051605 
FMNL1C17orf1 | C17orf1B | FHOD4 | FMNL | KW-13 | MGC133052 | MGC1894 | MGC21878formin-like 1-HPRD,BioGRID10958683 
GEFTp63RhoGEFRhoA/RAC/CDC42 exchange factor-HPRD,BioGRID12547822 
ICMTHSTE14 | MGC39955 | MST098 | MSTP098 | PCCMT | PCMT | PPMTisoprenylcysteine carboxyl methyltransferase-HPRD,BioGRID12006387 
IL1RAPC3orf13 | FLJ37788 | IL-1RAcP | IL1R3interleukin 1 receptor accessory protein-HPRD,BioGRID11416133 
IQGAP1HUMORFA01 | KIAA0051 | SAR1 | p195IQ motif containing GTPase activating protein 1-HPRD,BioGRID8670801 
IQGAP2-IQ motif containing GTPase activating protein 2-HPRD,BioGRID8702968 |8756646|8756646 
IQGAP2-IQ motif containing GTPase activating protein 2-HPRD8756646 
KTN1CG1 | KIAA0004 | KNT | MGC133337 | MU-RMS-40.19kinectin 1 (kinesin receptor)-HPRD,BioGRID8769096 
MAP3K10MLK2 | MSTmitogen-activated protein kinase kinase kinase 10Reconstituted ComplexBioGRID9427749 
MAP3K11MGC17114 | MLK-3 | MLK3 | PTK1 | SPRKmitogen-activated protein kinase kinase kinase 11-HPRD9427749 
MAP3K4FLJ42439 | KIAA0213 | MAPKKK4 | MEKK4 | MTK1 | PRO0412mitogen-activated protein kinase kinase kinase 4Reconstituted ComplexBioGRID9079650 
MCF2LARHGEF14 | DBS | FLJ12122 | KIAA0362 | OSTMCF.2 cell line derived transforming sequence-like-HPRD,BioGRID7957046 |14701795 
METAP2MAP2 | MNPEP | p67 | p67eIF2methionyl aminopeptidase 2-HPRD7738010 
MYD88MYD88Dmyeloid differentiation primary response gene (88)Affinity Capture-Western
Reconstituted Complex
BioGRID11416133 
NCF1CSH3PXD1Cneutrophil cytosolic factor 1C pseudogene-HPRD9255350 
NCF2FLJ93058 | NCF-2 | NOXA2 | P67-PHOX | P67PHOXneutrophil cytosolic factor 2-HPRD9255350 |9624165 
|11896062|11090627 
NCF2FLJ93058 | NCF-2 | NOXA2 | P67-PHOX | P67PHOXneutrophil cytosolic factor 2-HPRD7738010 |8036496 
|9255350 |9624165 
|11090627 |11896062|11090627 
NCF2FLJ93058 | NCF-2 | NOXA2 | P67-PHOX | P67PHOXneutrophil cytosolic factor 2Co-crystal Structure
Reconstituted Complex
BioGRID9624165 |9642115 
|11090627 
NCK1MGC12668 | NCK | NCKalphaNCK adaptor protein 1-HPRD10766742 
NCKAP1FLJ11291 | HEM2 | KIAA0587 | MGC8981 | NAP1 | NAP125NCK-associated protein 1-HPRD9148763 |9417078 
NCKAP1FLJ11291 | HEM2 | KIAA0587 | MGC8981 | NAP1 | NAP125NCK-associated protein 1-HPRD,BioGRID9148763 
NOS2HEP-NOS | INOS | NOS | NOS2Anitric oxide synthase 2, inducible-HPRD11422783 |11457725 
NOS2HEP-NOS | INOS | NOS | NOS2Anitric oxide synthase 2, inducible-HPRD,BioGRID11457725 
NOXA1FLJ25475 | MGC131800 | NY-CO-31 | SDCCAG31 | p51NOXNADPH oxidase activator 1-HPRD12716910 
OPHN1MRX60 | OPN1oligophrenin 1-HPRD,BioGRID9582072 |11998687 
PAK1MGC130000 | MGC130001 | PAKalphap21 protein (Cdc42/Rac)-activated kinase 1PAK1 interacts with an unspecified isoform of Rac. This interaction was modeled on a demonstrated interaction between human PAK1 and Rac from Chinese hamster.BIND15975516 
PAK1MGC130000 | MGC130001 | PAKalphap21 protein (Cdc42/Rac)-activated kinase 1PAK1 interacts with an unspecified isoform of Rac. This interaction was modeled on a demonstrated interaction between PAK1 from an unspecified species and human Rac.BIND15864311 
PAK1MGC130000 | MGC130001 | PAKalphap21 protein (Cdc42/Rac)-activated kinase 1-HPRD7744004 |8107774 
|11134022 |11950930|11134022 
PAK1MGC130000 | MGC130001 | PAKalphap21 protein (Cdc42/Rac)-activated kinase 1Reconstituted ComplexBioGRID12650940 |12879077 
PAK1MGC130000 | MGC130001 | PAKalphap21 protein (Cdc42/Rac)-activated kinase 1Active GTP-bound RAC1 interacts with PAK1B. This interaction was modelled on a demonstrated interaction between chicken RAC1 and human PAK1B.BIND15735674 
PAK1MGC130000 | MGC130001 | PAKalphap21 protein (Cdc42/Rac)-activated kinase 1Rac1 interacts with Pak1. This interaction was modeled on a demonstrated interaction between Rac1 and Pak1 from an unspecified species.BIND15652748 
PAK1MGC130000 | MGC130001 | PAKalphap21 protein (Cdc42/Rac)-activated kinase 1Rac1 interacts with Pak1. This interaction was modelled on a demonstrated interacton between Rac1 from an unspecified species and human Pak1.BIND12944407 
PAK2PAK65 | PAKgammap21 protein (Cdc42/Rac)-activated kinase 2-HPRD,BioGRID9535855 
PAK3CDKN1A | MRX30 | MRX47 | OPHN3 | PAK3beta | bPAK | hPAK3p21 protein (Cdc42/Rac)-activated kinase 3Reconstituted Complex
Two-hybrid
BioGRID11478794 
PAK4-p21 protein (Cdc42/Rac)-activated kinase 4Affinity Capture-WesternBioGRID11756552 
PAK7KIAA1264 | MGC26232 | PAK5p21 protein (Cdc42/Rac)-activated kinase 7-HPRD,BioGRID11756552 
PARD6APAR-6A | PAR6 | PAR6C | PAR6alpha | TAX40 | TIP-40par-6 partitioning defective 6 homolog alpha (C. elegans)-HPRD,BioGRID11260256 
PARD6GFLJ45701 | PAR-6G | PAR6gammapar-6 partitioning defective 6 homolog gamma (C. elegans)-HPRD,BioGRID11260256 
PARK2AR-JP | LPRS2 | PDJ | PRKNParkinson disease (autosomal recessive, juvenile) 2, parkinTwo-hybridBioGRID16169070 
PIK3R1GRB1 | p85 | p85-ALPHAphosphoinositide-3-kinase, regulatory subunit 1 (alpha)-HPRD7629060 |8034624 
|12086876 
PIK3R1GRB1 | p85 | p85-ALPHAphosphoinositide-3-kinase, regulatory subunit 1 (alpha)-HPRD12086876 
PLD1-phospholipase D1, phosphatidylcholine-specific-HPRD11950936 
PLEKHG2CLG | DKFZp667J2325 | FLJ00018 | FLJ22458 | FLJ38638pleckstrin homology domain containing, family G (with RhoGef domain) member 2-HPRD,BioGRID11839748 
PLXNB1KIAA0407 | MGC149167 | PLEXIN-B1 | PLXN5 | SEPplexin B1-HPRD12123608 
PLXNB1KIAA0407 | MGC149167 | PLEXIN-B1 | PLXN5 | SEPplexin B1Plexin-B1 interacts with Rac1. This interaction was modelled on a demonstrated interaction between human Plexin-B1 and Rac1 from an unspecified species.BIND15642257 
PRKCAAAG6 | MGC129900 | MGC129901 | PKC-alpha | PKCA | PRKACAprotein kinase C, alpha-HPRD,BioGRID11284700 
PTPLAD1B-IND1 | FLJ90376 | HSPC121protein tyrosine phosphatase-like A domain containing 1-HPRD,BioGRID10747961 
RAC1MGC111543 | MIG5 | TC-25 | p21-Rac1ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)Reconstituted ComplexBioGRID11134022 
RALBP1RIP1 | RLIP1 | RLIP76ralA binding protein 1Rac1 interacts with RLIP76.BIND7673236 
RALBP1RIP1 | RLIP1 | RLIP76ralA binding protein 1-HPRD,BioGRID7673236 
RAP1GDS1GDS1 | MGC118859 | MGC118861 | SmgGDSRAP1, GTP-GDP dissociation stimulator 1-HPRD,BioGRID11948427 
RCC2DKFZp762N0610 | KIAA1470 | TD-60regulator of chromosome condensation 2-HPRD12919680 
RGL2HKE1.5 | KE1.5 | RAB2Lral guanine nucleotide dissociation stimulator-like 2Two-hybridBioGRID8939933 
RICH2KIAA0672 | NPC-A-10Rho-type GTPase-activating protein RICH2Biochemical ActivityBioGRID11431473 
RICSGC-GAP | GRIT | KIAA0712 | MGC1892 | p200RhoGAP | p250GAPRho GTPase-activating proteinBiochemical ActivityBioGRID12454018 |12819203 
RPS6KB1PS6K | S6K | S6K1 | STK14A | p70(S6K)-alpha | p70-S6K | p70-alpharibosomal protein S6 kinase, 70kDa, polypeptide 1-HPRD11438723 
SH3BP1-SH3-domain binding protein 1-HPRD10508610 
STAT3APRF | FLJ20882 | HIES | MGC16063signal transducer and activator of transcription 3 (acute-phase response factor)-HPRD,BioGRID11021801 
SYNJ2INPP5H | KIAA0348 | MGC44422synaptojanin 2-HPRD,BioGRID11084340 
TBC1D3TBC1D3A | TRE17TBC1 domain family, member 3-HPRD,BioGRID12612085 
TCF7L2TCF-4 | TCF4transcription factor 7-like 2 (T-cell specific, HMG-box)Rac1 interacts with TCF4.BIND15377999 
TECMGC126760 | MGC126762 | PSCTK4tec protein tyrosine kinasePhenotypic EnhancementBioGRID11328862 
TIAM1FLJ36302T-cell lymphoma invasion and metastasis 1The GTPase Rac1 specifically interacts with Dbl-homology domain of the nucleotide exchange factor TIAM1. This interaction is modelled on a demonstrated interaction between mouse TIAM1 and human Rac1.BIND11130063 
TIAM1FLJ36302T-cell lymphoma invasion and metastasis 1-HPRD,BioGRID11130063 |11595749 
TNFRSF12ACD266 | FN14 | TWEAKRtumor necrosis factor receptor superfamily, member 12A-HPRD14573547 
TNFRSF12ACD266 | FN14 | TWEAKRtumor necrosis factor receptor superfamily, member 12AFn14 interacts with Rac1.BIND14573547 
TRIOFLJ42780 | tgattriple functional domain (PTPRF interacting)-HPRD,BioGRID11595749 
TUBA4AFLJ30169 | H2-ALPHA | TUBA1tubulin, alpha 4a-HPRD8631991 
VAV1VAVvav 1 guanine nucleotide exchange factorAffinity Capture-WesternBioGRID11287617 
VAV3FLJ40431vav 3 guanine nucleotide exchange factor-HPRD,BioGRID10523675 
WASIMD2 | THC | WASPWiskott-Aldrich syndrome (eczema-thrombocytopenia)-HPRD,BioGRID8643625 
WASF1FLJ31482 | KIAA0269 | SCAR1 | WAVE | WAVE1WAS protein family, member 1-HPRD9843499 


Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG MAPK SIGNALING PATHWAY 267205All SZGR 2.0 genes in this pathway
KEGG CHEMOKINE SIGNALING PATHWAY 190128All SZGR 2.0 genes in this pathway
KEGG WNT SIGNALING PATHWAY 151112All SZGR 2.0 genes in this pathway
KEGG AXON GUIDANCE 129103All SZGR 2.0 genes in this pathway
KEGG VEGF SIGNALING PATHWAY 7653All SZGR 2.0 genes in this pathway
KEGG FOCAL ADHESION 201138All SZGR 2.0 genes in this pathway
KEGG ADHERENS JUNCTION 7553All SZGR 2.0 genes in this pathway
KEGG TOLL LIKE RECEPTOR SIGNALING PATHWAY 10288All SZGR 2.0 genes in this pathway
KEGG NATURAL KILLER CELL MEDIATED CYTOTOXICITY 13792All SZGR 2.0 genes in this pathway
KEGG B CELL RECEPTOR SIGNALING PATHWAY 7556All SZGR 2.0 genes in this pathway
KEGG FC EPSILON RI SIGNALING PATHWAY 7958All SZGR 2.0 genes in this pathway
KEGG FC GAMMA R MEDIATED PHAGOCYTOSIS 9771All SZGR 2.0 genes in this pathway
KEGG LEUKOCYTE TRANSENDOTHELIAL MIGRATION 11878All SZGR 2.0 genes in this pathway
KEGG NEUROTROPHIN SIGNALING PATHWAY 126103All SZGR 2.0 genes in this pathway
KEGG REGULATION OF ACTIN CYTOSKELETON 216144All SZGR 2.0 genes in this pathway
KEGG AMYOTROPHIC LATERAL SCLEROSIS ALS 5343All SZGR 2.0 genes in this pathway
KEGG EPITHELIAL CELL SIGNALING IN HELICOBACTER PYLORI INFECTION 6844All SZGR 2.0 genes in this pathway
KEGG PATHWAYS IN CANCER 328259All SZGR 2.0 genes in this pathway
KEGG COLORECTAL CANCER 6247All SZGR 2.0 genes in this pathway
KEGG RENAL CELL CARCINOMA 7060All SZGR 2.0 genes in this pathway
KEGG PANCREATIC CANCER 7056All SZGR 2.0 genes in this pathway
KEGG VIRAL MYOCARDITIS 7358All SZGR 2.0 genes in this pathway
BIOCARTA AGR PATHWAY 3631All SZGR 2.0 genes in this pathway
BIOCARTA AT1R PATHWAY 3628All SZGR 2.0 genes in this pathway
BIOCARTA BCR PATHWAY 3728All SZGR 2.0 genes in this pathway
BIOCARTA FMLP PATHWAY 3929All SZGR 2.0 genes in this pathway
BIOCARTA SALMONELLA PATHWAY 1310All SZGR 2.0 genes in this pathway
BIOCARTA RACCYCD PATHWAY 2623All SZGR 2.0 genes in this pathway
BIOCARTA PYK2 PATHWAY 3124All SZGR 2.0 genes in this pathway
BIOCARTA MAPK PATHWAY 8768All SZGR 2.0 genes in this pathway
BIOCARTA P38MAPK PATHWAY 4031All SZGR 2.0 genes in this pathway
BIOCARTA PTDINS PATHWAY 2316All SZGR 2.0 genes in this pathway
BIOCARTA EDG1 PATHWAY 2724All SZGR 2.0 genes in this pathway
BIOCARTA RAC1 PATHWAY 2316All SZGR 2.0 genes in this pathway
BIOCARTA RAS PATHWAY 2320All SZGR 2.0 genes in this pathway
BIOCARTA NKCELLS PATHWAY 2013All SZGR 2.0 genes in this pathway
BIOCARTA MAL PATHWAY 1917All SZGR 2.0 genes in this pathway
BIOCARTA CDC42RAC PATHWAY 1613All SZGR 2.0 genes in this pathway
BIOCARTA TCR PATHWAY 4937All SZGR 2.0 genes in this pathway
BIOCARTA CREB PATHWAY 2725All SZGR 2.0 genes in this pathway
BIOCARTA ARF PATHWAY 1713All SZGR 2.0 genes in this pathway
BIOCARTA UCALPAIN PATHWAY 1811All SZGR 2.0 genes in this pathway
BIOCARTA ACTINY PATHWAY 2014All SZGR 2.0 genes in this pathway
SA B CELL RECEPTOR COMPLEXES 2420All SZGR 2.0 genes in this pathway
ST MYOCYTE AD PATHWAY 2725All SZGR 2.0 genes in this pathway
PID ENDOTHELIN PATHWAY 6352All SZGR 2.0 genes in this pathway
PID BCR 5PATHWAY 6550All SZGR 2.0 genes in this pathway
PID PRL SIGNALING EVENTS PATHWAY 2317All SZGR 2.0 genes in this pathway
PID LYSOPHOSPHOLIPID PATHWAY 6653All SZGR 2.0 genes in this pathway
PID P38 MKK3 6PATHWAY 2621All SZGR 2.0 genes in this pathway
PID WNT NONCANONICAL PATHWAY 3226All SZGR 2.0 genes in this pathway
PID MET PATHWAY 8060All SZGR 2.0 genes in this pathway
PID S1P S1P3 PATHWAY 2924All SZGR 2.0 genes in this pathway
PID EPHB FWD PATHWAY 4038All SZGR 2.0 genes in this pathway
PID AVB3 OPN PATHWAY 3129All SZGR 2.0 genes in this pathway
PID ILK PATHWAY 4532All SZGR 2.0 genes in this pathway
PID NECTIN PATHWAY 3020All SZGR 2.0 genes in this pathway
PID P38 ALPHA BETA PATHWAY 3125All SZGR 2.0 genes in this pathway
PID CDC42 PATHWAY 7051All SZGR 2.0 genes in this pathway
PID RET PATHWAY 3929All SZGR 2.0 genes in this pathway
PID ANGIOPOIETIN RECEPTOR PATHWAY 5041All SZGR 2.0 genes in this pathway
PID TXA2PATHWAY 5743All SZGR 2.0 genes in this pathway
PID S1P S1P1 PATHWAY 2118All SZGR 2.0 genes in this pathway
PID NETRIN PATHWAY 3227All SZGR 2.0 genes in this pathway
PID INTEGRIN A9B1 PATHWAY 2518All SZGR 2.0 genes in this pathway
PID ARF6 DOWNSTREAM PATHWAY 1514All SZGR 2.0 genes in this pathway
PID MTOR 4PATHWAY 6955All SZGR 2.0 genes in this pathway
PID CXCR4 PATHWAY 10278All SZGR 2.0 genes in this pathway
PID PI3KCI PATHWAY 4940All SZGR 2.0 genes in this pathway
PID AJDISS 2PATHWAY 4838All SZGR 2.0 genes in this pathway
PID IL2 PI3K PATHWAY 3427All SZGR 2.0 genes in this pathway
PID P75 NTR PATHWAY 6951All SZGR 2.0 genes in this pathway
PID ECADHERIN NASCENT AJ PATHWAY 3933All SZGR 2.0 genes in this pathway
PID AVB3 INTEGRIN PATHWAY 7553All SZGR 2.0 genes in this pathway
PID LIS1 PATHWAY 2822All SZGR 2.0 genes in this pathway
PID ERBB1 DOWNSTREAM PATHWAY 10578All SZGR 2.0 genes in this pathway
PID SYNDECAN 4 PATHWAY 3225All SZGR 2.0 genes in this pathway
PID UPA UPAR PATHWAY 4230All SZGR 2.0 genes in this pathway
PID ERBB2 ERBB3 PATHWAY 4435All SZGR 2.0 genes in this pathway
PID IL6 7 PATHWAY 4740All SZGR 2.0 genes in this pathway
PID ECADHERIN KERATINOCYTE PATHWAY 2119All SZGR 2.0 genes in this pathway
PID PDGFRB PATHWAY 129103All SZGR 2.0 genes in this pathway
PID TRKR PATHWAY 6248All SZGR 2.0 genes in this pathway
PID NEPHRIN NEPH1 PATHWAY 3124All SZGR 2.0 genes in this pathway
PID AR NONGENOMIC PATHWAY 3127All SZGR 2.0 genes in this pathway
PID A6B1 A6B4 INTEGRIN PATHWAY 4635All SZGR 2.0 genes in this pathway
PID RAC1 REG PATHWAY 3825All SZGR 2.0 genes in this pathway
PID ARF 3PATHWAY 1913All SZGR 2.0 genes in this pathway
PID EPHRINB REV PATHWAY 3025All SZGR 2.0 genes in this pathway
PID NCADHERIN PATHWAY 3332All SZGR 2.0 genes in this pathway
PID S1P S1P2 PATHWAY 2419All SZGR 2.0 genes in this pathway
PID EPHA2 FWD PATHWAY 1916All SZGR 2.0 genes in this pathway
PID INTEGRIN A4B1 PATHWAY 3324All SZGR 2.0 genes in this pathway
PID RAC1 PATHWAY 5437All SZGR 2.0 genes in this pathway
PID FAK PATHWAY 5945All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY RHO GTPASES 11381All SZGR 2.0 genes in this pathway
REACTOME SIGNALLING BY NGF 217167All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY SCF KIT 7859All SZGR 2.0 genes in this pathway
REACTOME DEVELOPMENTAL BIOLOGY 396292All SZGR 2.0 genes in this pathway
REACTOME CELL CELL COMMUNICATION 12077All SZGR 2.0 genes in this pathway
REACTOME NRAGE SIGNALS DEATH THROUGH JNK 4333All SZGR 2.0 genes in this pathway
REACTOME CELL DEATH SIGNALLING VIA NRAGE NRIF AND NADE 6043All SZGR 2.0 genes in this pathway
REACTOME P75 NTR RECEPTOR MEDIATED SIGNALLING 8161All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY GPCR 920449All SZGR 2.0 genes in this pathway
REACTOME GPVI MEDIATED ACTIVATION CASCADE 3125All SZGR 2.0 genes in this pathway
REACTOME AXON GUIDANCE 251188All SZGR 2.0 genes in this pathway
REACTOME G ALPHA1213 SIGNALLING EVENTS 7456All SZGR 2.0 genes in this pathway
REACTOME CD28 CO STIMULATION 3226All SZGR 2.0 genes in this pathway
REACTOME GPCR DOWNSTREAM SIGNALING 805368All SZGR 2.0 genes in this pathway
REACTOME ACTIVATION OF RAC 1411All SZGR 2.0 genes in this pathway
REACTOME SEMA3A PAK DEPENDENT AXON REPULSION 1514All SZGR 2.0 genes in this pathway
REACTOME CD28 DEPENDENT VAV1 PATHWAY 1110All SZGR 2.0 genes in this pathway
REACTOME SEMA4D IN SEMAPHORIN SIGNALING 3222All SZGR 2.0 genes in this pathway
REACTOME SEMAPHORIN INTERACTIONS 6853All SZGR 2.0 genes in this pathway
REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE 2721All SZGR 2.0 genes in this pathway
REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION 139All SZGR 2.0 genes in this pathway
REACTOME COSTIMULATION BY THE CD28 FAMILY 6348All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY ROBO RECEPTOR 3026All SZGR 2.0 genes in this pathway
REACTOME L1CAM INTERACTIONS 8662All SZGR 2.0 genes in this pathway
REACTOME NETRIN1 SIGNALING 4130All SZGR 2.0 genes in this pathway
REACTOME SIGNAL TRANSDUCTION BY L1 3425All SZGR 2.0 genes in this pathway
REACTOME DCC MEDIATED ATTRACTIVE SIGNALING 1311All SZGR 2.0 genes in this pathway
REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION 132101All SZGR 2.0 genes in this pathway
REACTOME DSCAM INTERACTIONS 1110All SZGR 2.0 genes in this pathway
REACTOME HEMOSTASIS 466331All SZGR 2.0 genes in this pathway
REACTOME HIV INFECTION 207122All SZGR 2.0 genes in this pathway
REACTOME HOST INTERACTIONS OF HIV FACTORS 13281All SZGR 2.0 genes in this pathway
REACTOME THE ROLE OF NEF IN HIV1 REPLICATION AND DISEASE PATHOGENESIS 2819All SZGR 2.0 genes in this pathway
REACTOME IMMUNE SYSTEM 933616All SZGR 2.0 genes in this pathway
REACTOME ADAPTIVE IMMUNE SYSTEM 539350All SZGR 2.0 genes in this pathway
REACTOME PLATELET ACTIVATION SIGNALING AND AGGREGATION 208138All SZGR 2.0 genes in this pathway
TURASHVILI BREAST DUCTAL CARCINOMA VS LOBULAR NORMAL UP 7350All SZGR 2.0 genes in this pathway
DIAZ CHRONIC MEYLOGENOUS LEUKEMIA UP 1382904All SZGR 2.0 genes in this pathway
TIMOFEEVA GROWTH STRESS VIA STAT1 DN 1612All SZGR 2.0 genes in this pathway
BORCZUK MALIGNANT MESOTHELIOMA UP 305185All SZGR 2.0 genes in this pathway
SENESE HDAC1 TARGETS DN 260143All SZGR 2.0 genes in this pathway
KINSEY TARGETS OF EWSR1 FLII FUSION UP 1278748All SZGR 2.0 genes in this pathway
ENK UV RESPONSE KERATINOCYTE UP 530342All SZGR 2.0 genes in this pathway
WANG ESOPHAGUS CANCER VS NORMAL DN 10166All SZGR 2.0 genes in this pathway
LI LUNG CANCER 4130All SZGR 2.0 genes in this pathway
DAIRKEE TERT TARGETS UP 380213All SZGR 2.0 genes in this pathway
CALVET IRINOTECAN SENSITIVE VS REVERTED UP 55All SZGR 2.0 genes in this pathway
NUYTTEN EZH2 TARGETS DN 1024594All SZGR 2.0 genes in this pathway
FRIDMAN SENESCENCE UP 7760All SZGR 2.0 genes in this pathway
FLECHNER BIOPSY KIDNEY TRANSPLANT OK VS DONOR UP 555346All SZGR 2.0 genes in this pathway
REN ALVEOLAR RHABDOMYOSARCOMA DN 408274All SZGR 2.0 genes in this pathway
ZAMORA NOS2 TARGETS UP 6941All SZGR 2.0 genes in this pathway
WHITESIDE CISPLATIN RESISTANCE UP 117All SZGR 2.0 genes in this pathway
MURAKAMI UV RESPONSE 6HR UP 3731All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE UP 16911088All SZGR 2.0 genes in this pathway
MACLACHLAN BRCA1 TARGETS UP 2116All SZGR 2.0 genes in this pathway
VERRECCHIA DELAYED RESPONSE TO TGFB1 3926All SZGR 2.0 genes in this pathway
LEE CALORIE RESTRICTION NEOCORTEX DN 8858All SZGR 2.0 genes in this pathway
VERRECCHIA RESPONSE TO TGFB1 C4 1310All SZGR 2.0 genes in this pathway
YOSHIMURA MAPK8 TARGETS DN 366257All SZGR 2.0 genes in this pathway
HINATA NFKB TARGETS KERATINOCYTE UP 9163All SZGR 2.0 genes in this pathway
HINATA NFKB TARGETS FIBROBLAST UP 8460All SZGR 2.0 genes in this pathway
HSIAO HOUSEKEEPING GENES 389245All SZGR 2.0 genes in this pathway
BYSTRYKH HEMATOPOIESIS STEM CELL IL3RA 96All SZGR 2.0 genes in this pathway
JOHNSTONE PARVB TARGETS 3 DN 918550All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-1015375441A,m8hsa-miR-101UACAGUACUGUGAUAACUGAAG
miR-1379879931Ahsa-miR-137UAUUGCUUAAGAAUACGCGUAG
miR-142-3p7477541A,m8hsa-miR-142-3pUGUAGUGUUUCCUACUUUAUGGA
miR-1445385441Ahsa-miR-144UACAGUAUAGAUGAUGUACUAG
miR-1823083151A,m8hsa-miR-182UUUGGCAAUGGUAGAACUCACA
miR-1941271331Ahsa-miR-194UGUAACAGCAACUCCAUGUGGA
miR-200bc/429715721m8hsa-miR-200bUAAUACUGCCUGGUAAUGAUGAC
hsa-miR-200cUAAUACUGCCGGGUAAUGAUGG
hsa-miR-429UAAUACUGUCUGGUAAAACCGU
miR-361101810251A,m8hsa-miR-361brainUUAUCAGAAUCUCCAGGGGUAC
miR-485-3p14931499m8hsa-miR-485-3pGUCAUACACGGCUCUCCUCUCU
miR-485-5p466472m8hsa-miR-485-5pAGAGGCUGGCCGUGAUGAAUUC
miR-4951251311Ahsa-miR-495brainAAACAAACAUGGUGCACUUCUUU
miR-963093151Ahsa-miR-96brainUUUGGCACUAGCACAUUUUUGC
miR-99/1007777831Ahsa-miR-99abrainAACCCGUAGAUCCGAUCUUGUG
hsa-miR-100brainAACCCGUAGAUCCGAACUUGUG
hsa-miR-99bbrainCACCCGUAGAACCGACCUUGCG