Gene Page: RELA
Summary ?
| GeneID | 5970 |
| Symbol | RELA |
| Synonyms | NFKB3|p65 |
| Description | v-rel avian reticuloendotheliosis viral oncogene homolog A |
| Reference | MIM:164014|HGNC:HGNC:9955|Ensembl:ENSG00000173039|HPRD:01241|Vega:OTTHUMG00000166566 |
| Gene type | protein-coding |
| Map location | 11q13 |
| Pascal p-value | 0.006 |
| Sherlock p-value | 0.71 |
| Fetal beta | -0.23 |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| DNM:Ambalavanan_2016 | Whole Exome Sequencing | This dataset includes 20 de novo mutations detected in 17 COS probands. | |
| PMID:cooccur | High-throughput literature-search | Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included. | |
| Literature | High-throughput literature-search | Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias | Click to show details |
| Network | Shortest path distance of core genes in the Human protein-protein interaction network | Contribution to shortest path in PPI network: 0.0873 |
Section I. Genetics and epigenetics annotation
DNM table
| Gene | Chromosome | Position | Ref | Alt | Transcript | AA change | Mutation type | Sift | CG46 | Trait | Study |
|---|---|---|---|---|---|---|---|---|---|---|---|
| RELA | chr11 | 65429164 | A | G | NM_021975 | p.(Ile110Thr) | nonsynonymous SNV | 0.878 | Childhood-onset schizophrenia | DNM:Ambalavanan_2016 |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| MEN1 | 0.90 | 0.91 |
| EDC4 | 0.89 | 0.92 |
| SETD1A | 0.89 | 0.90 |
| BAT2 | 0.89 | 0.91 |
| RAI1 | 0.89 | 0.90 |
| ZNF777 | 0.89 | 0.91 |
| STRN4 | 0.89 | 0.90 |
| CNOT3 | 0.88 | 0.89 |
| PHRF1 | 0.88 | 0.90 |
| AKAP8 | 0.88 | 0.89 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| AF347015.31 | -0.79 | -0.83 |
| MT-CO2 | -0.79 | -0.83 |
| AF347015.27 | -0.77 | -0.82 |
| AF347015.33 | -0.77 | -0.80 |
| MT-CYB | -0.76 | -0.81 |
| AF347015.8 | -0.76 | -0.82 |
| AF347015.21 | -0.75 | -0.87 |
| S100B | -0.74 | -0.80 |
| AF347015.15 | -0.73 | -0.79 |
| COPZ2 | -0.71 | -0.76 |
Section III. Gene Ontology annotation
| Molecular function | GO term | Evidence | Neuro keywords | PubMed ID |
|---|---|---|---|---|
| GO:0003700 | transcription factor activity | IEA | - | |
| GO:0003705 | RNA polymerase II transcription factor activity, enhancer binding | IDA | 3091258 | |
| GO:0042301 | phosphate binding | IDA | 10521409 | |
| GO:0051059 | NF-kappaB binding | IPI | 8441377 | |
| GO:0042802 | identical protein binding | IDA | 9437432 | |
| GO:0019901 | protein kinase binding | IPI | 10521409 |15465828 | |
| GO:0047485 | protein N-terminus binding | IPI | 7739562 | |
| Biological process | GO term | Evidence | Neuro keywords | PubMed ID |
| GO:0006355 | regulation of transcription, DNA-dependent | IEA | - | |
| GO:0010033 | response to organic substance | IDA | 10747850 | |
| GO:0006968 | cellular defense response | NAS | 8717528 | |
| GO:0010224 | response to UV-B | IDA | 15616591 | |
| GO:0006954 | inflammatory response | IDA | 12924514 | |
| GO:0006916 | anti-apoptosis | IDA | 10747850 | |
| GO:0051092 | positive regulation of NF-kappaB transcription factor activity | IDA | 15790681 | |
| GO:0051607 | defense response to virus | NAS | 8717528 | |
| GO:0019221 | cytokine-mediated signaling pathway | IDA | 15876188 | |
| GO:0043123 | positive regulation of I-kappaB kinase/NF-kappaB cascade | IEP | 12761501 | |
| Cellular component | GO term | Evidence | Neuro keywords | PubMed ID |
| GO:0005829 | cytosol | EXP | 10723127 | |
| GO:0005634 | nucleus | IDA | 3140380 | |
| GO:0005634 | nucleus | IEA | - | |
| GO:0005654 | nucleoplasm | EXP | 10723127 | |
| GO:0005667 | transcription factor complex | IDA | 12048232 | |
| GO:0005737 | cytoplasm | IDA | 3140380 |
Section IV. Protein-protein interaction annotation
| Interactors | Aliases B | Official full name B | Experimental | Source | PubMed ID |
|---|---|---|---|---|---|
| AES | AES-1 | AES-2 | ESP1 | GRG | GRG5 | TLE5 | amino-terminal enhancer of split | AES interacts with p65. | BIND | 10660609 |
| AES | AES-1 | AES-2 | ESP1 | GRG | GRG5 | TLE5 | amino-terminal enhancer of split | - | HPRD,BioGRID | 10660609 |
| AHR | - | aryl hydrocarbon receptor | - | HPRD,BioGRID | 11114727 |12181450 |
| AIFM1 | AIF | MGC111425 | PDCD8 | apoptosis-inducing factor, mitochondrion-associated, 1 | - | HPRD | 14743216 |
| AKAP8L | DKFZp434L0650 | HA95 | HAP95 | NAKAP | NAKAP95 | A kinase (PRKA) anchor protein 8-like | - | HPRD,BioGRID | 14743216 |
| APBA2 | D15S1518E | HsT16821 | LIN-10 | MGC99508 | MGC:14091 | MINT2 | X11L | amyloid beta (A4) precursor protein-binding, family A, member 2 | - | HPRD,BioGRID | 10777610 |
| AR | AIS | DHTR | HUMARA | KD | NR3C4 | SBMA | SMAX1 | TFM | androgen receptor | - | HPRD | 8798655 |
| ASCC1 | ASC1p50 | CGI-18 | RP11-150D20.4 | activating signal cointegrator 1 complex subunit 1 | Reconstituted Complex Two-hybrid | BioGRID | 12077347 |
| ASCC2 | ASC1p100 | activating signal cointegrator 1 complex subunit 2 | Reconstituted Complex Two-hybrid | BioGRID | 12077347 |
| ASCC3 | ASC1p200 | DJ467N11.1 | HELIC1 | MGC26074 | RNAH | dJ121G13.4 | activating signal cointegrator 1 complex subunit 3 | Reconstituted Complex Two-hybrid | BioGRID | 12077347 |
| ATP5A1 | ATP5A | ATP5AL2 | ATPM | MOM2 | OMR | ORM | hATP1 | ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle | - | HPRD | 14743216 |
| BARD1 | - | BRCA1 associated RING domain 1 | Affinity Capture-Western | BioGRID | 12700228 |
| BIRC3 | AIP1 | API2 | CIAP2 | HAIP1 | HIAP1 | MALT2 | MIHC | RNF49 | baculoviral IAP repeat-containing 3 | The cIAP-2 promoter interacts with p65. | BIND | 15494311 |
| BRCA1 | BRCAI | BRCC1 | IRIS | PSCP | RNF53 | breast cancer 1, early onset | - | HPRD,BioGRID | 12700228 |
| BTRC | BETA-TRCP | FBW1A | FBXW1 | FBXW1A | FWD1 | MGC4643 | bTrCP | bTrCP1 | betaTrCP | beta-transducin repeat containing | - | HPRD,BioGRID | 9990853 |
| CARM1 | PRMT4 | coactivator-associated arginine methyltransferase 1 | CARM1 interacts with p65. | BIND | 15616592 |
| CCND1 | BCL1 | D11S287E | PRAD1 | U21B31 | cyclin D1 | RELA (NF-kappaB p65 subunit) interacts with the CCND1 (Cyclin D1) promoter. | BIND | 15652748 |
| CCT8 | C21orf112 | Cctq | D21S246 | KIAA0002 | PRED71 | chaperonin containing TCP1, subunit 8 (theta) | - | HPRD | 14743216 |
| CDK9 | C-2k | CDC2L4 | CTK1 | PITALRE | TAK | cyclin-dependent kinase 9 | - | HPRD,BioGRID | 12173051 |
| CEBPB | C/EBP-beta | CRP2 | IL6DBP | LAP | MGC32080 | NF-IL6 | TCF5 | CCAAT/enhancer binding protein (C/EBP), beta | - | HPRD,BioGRID | 9570146 |12707271 |
| CEBPD | C/EBP-delta | CELF | CRP3 | NF-IL6-beta | CCAAT/enhancer binding protein (C/EBP), delta | - | HPRD,BioGRID | 9570146 |
| CHEK1 | CHK1 | CHK1 checkpoint homolog (S. pombe) | RELA interacts with CHEK1. This interaction was modeled on a demonstrated interaction between human RELA, and CHEK1 from an unspecified species. | BIND | 15775976 |
| CHUK | IKBKA | IKK-alpha | IKK1 | IKKA | NFKBIKA | TCF16 | conserved helix-loop-helix ubiquitous kinase | RELA (p65) interacts with CHUK (I-kappa-B-alpha). | BIND | 15845455 |
| CHUK | IKBKA | IKK-alpha | IKK1 | IKKA | NFKBIKA | TCF16 | conserved helix-loop-helix ubiquitous kinase | I-kappa-B-alpha interacts with RelA. | BIND | 15994554 |
| CREBBP | CBP | KAT3A | RSTS | CREB binding protein | - | HPRD,BioGRID | 9548485 |
| CREBBP | CBP | KAT3A | RSTS | CREB binding protein | CBP interacts with p65. | BIND | 9096323 |
| CREBBP | CBP | KAT3A | RSTS | CREB binding protein | RELA (NF-kappaB p65) interacts with CREBBP (CBP). | BIND | 16007092 |
| CSNK2A1 | CK2A1 | CKII | casein kinase 2, alpha 1 polypeptide | - | HPRD,BioGRID | 10938077 |
| CSNK2A2 | CK2A2 | CSNK2A1 | FLJ43934 | casein kinase 2, alpha prime polypeptide | Affinity Capture-Western Biochemical Activity | BioGRID | 10938077 |
| CXCL10 | C7 | IFI10 | INP10 | IP-10 | SCYB10 | crg-2 | gIP-10 | mob-1 | chemokine (C-X-C motif) ligand 10 | p65 interacts with promoter IP-10. | BIND | 15315758 |
| DHX9 | DDX9 | LKP | NDHII | RHA | DEAH (Asp-Glu-Ala-His) box polypeptide 9 | Affinity Capture-Western Reconstituted Complex Two-hybrid | BioGRID | 15355351 |
| DHX9 | DDX9 | LKP | NDHII | RHA | DEAH (Asp-Glu-Ala-His) box polypeptide 9 | - | HPRD | 14743216 |
| EGR1 | AT225 | G0S30 | KROX-24 | NGFI-A | TIS8 | ZIF-268 | ZNF225 | early growth response 1 | - | HPRD,BioGRID | 10671503 |
| EGR1 | AT225 | G0S30 | KROX-24 | NGFI-A | TIS8 | ZIF-268 | ZNF225 | early growth response 1 | RelA interacts with Egr-1 promoter. | BIND | 15616591 |
| EP300 | KAT3B | p300 | E1A binding protein p300 | p300 interacts with p65. | BIND | 9096323 |
| EP300 | KAT3B | p300 | E1A binding protein p300 | p300 interacts with p65. | BIND | 15616592 |
| EP300 | KAT3B | p300 | E1A binding protein p300 | - | HPRD,BioGRID | 9096323 |
| ETHE1 | HSCO | YF13H12 | ethylmalonic encephalopathy 1 | - | HPRD,BioGRID | 12398897 |
| FOS | AP-1 | C-FOS | v-fos FBJ murine osteosarcoma viral oncogene homolog | NF-kappa-B interacts with c-Fos. | BIND | 10488148 |
| FOS | AP-1 | C-FOS | v-fos FBJ murine osteosarcoma viral oncogene homolog | Phenotypic Enhancement Two-hybrid | BioGRID | 10488148 |
| FUS | CHOP | FUS-CHOP | FUS1 | TLS | TLS/CHOP | hnRNP-P2 | fusion (involved in t(12;16) in malignant liposarcoma) | - | HPRD,BioGRID | 11278855 |
| GCN1L1 | GCN1 | GCN1L | KIAA0219 | GCN1 general control of amino-acid synthesis 1-like 1 (yeast) | - | HPRD | 14743216 |
| GTF2B | TF2B | TFIIB | general transcription factor IIB | Reconstituted Complex | BioGRID | 7706261 |
| HAX1 | FLJ17042 | FLJ18492 | FLJ93803 | HCLSBP1 | HS1BP1 | SCN3 | HCLS1 associated protein X-1 | - | HPRD | 14743216 |
| HDAC1 | DKFZp686H12203 | GON-10 | HD1 | RPD3 | RPD3L1 | histone deacetylase 1 | - | HPRD,BioGRID | 11564889 |
| HDAC2 | RPD3 | YAF1 | histone deacetylase 2 | - | HPRD,BioGRID | 12138131 |12419806 |
| HDAC3 | HD3 | RPD3 | RPD3-2 | histone deacetylase 3 | Affinity Capture-Western | BioGRID | 11533489 |
| HEXIM1 | CLP1 | EDG1 | FLJ13562 | HIS1 | MAQ1 | hexamethylene bis-acetamide inducible 1 | - | HPRD,BioGRID | 12581153 |
| HMGA2 | BABL | HMGI-C | HMGIC | LIPO | STQTL9 | high mobility group AT-hook 2 | Reconstituted Complex | BioGRID | 12693954 |
| HMGB1 | DKFZp686A04236 | HMG1 | HMG3 | SBP-1 | high-mobility group box 1 | - | HPRD,BioGRID | 12665595 |
| HSPA8 | HSC54 | HSC70 | HSC71 | HSP71 | HSP73 | HSPA10 | LAP1 | MGC131511 | MGC29929 | NIP71 | heat shock 70kDa protein 8 | - | HPRD | 14743216 |
| IL8 | CXCL8 | GCP-1 | GCP1 | LECT | LUCT | LYNAP | MDNCF | MONAP | NAF | NAP-1 | NAP1 | interleukin 8 | The IL-8 promoter interacts with p65. | BIND | 15494311 |
| ING4 | MGC12557 | my036 | p29ING4 | inhibitor of growth family, member 4 | - | HPRD,BioGRID | 15029197 |
| ING4 | MGC12557 | my036 | p29ING4 | inhibitor of growth family, member 4 | ING4 interacts with p65. | BIND | 15029197 |
| IQGAP2 | - | IQ motif containing GTPase activating protein 2 | Affinity Capture-MS | BioGRID | 14743216 |
| IRAK1BP1 | AIP70 | MGC138458 | MGC138460 | SIMPL | interleukin-1 receptor-associated kinase 1 binding protein 1 | - | HPRD | 15485901 |
| IRF2 | DKFZp686F0244 | IRF-2 | interferon regulatory factor 2 | - | HPRD,BioGRID | 8550813 |
| ITGB3BP | CENP-R | CENPR | HSU37139 | NRIF3 | TAP20 | integrin beta 3 binding protein (beta3-endonexin) | - | HPRD,BioGRID | 12244126 |
| JUN | AP-1 | AP1 | c-Jun | jun oncogene | NF-kappa-B interacts with c-Jun. | BIND | 10488148 |
| JUN | AP-1 | AP1 | c-Jun | jun oncogene | - | HPRD,BioGRID | 9468519 |10488148 |
| KPNA2 | IPOA1 | QIP2 | RCH1 | SRP1alpha | karyopherin alpha 2 (RAG cohort 1, importin alpha 1) | - | HPRD,BioGRID | 12504098 |
| MAP3K8 | COT | EST | ESTF | FLJ10486 | TPL2 | Tpl-2 | c-COT | mitogen-activated protein kinase kinase kinase 8 | Affinity Capture-MS | BioGRID | 14743216 |
| MEN1 | MEAI | SCG2 | multiple endocrine neoplasia I | - | HPRD,BioGRID | 11526476 |
| MTPN | FLJ31098 | FLJ99857 | GCDP | V-1 | myotrophin | Affinity Capture-Western Reconstituted Complex | BioGRID | 11971907 |
| MYC | bHLHe39 | c-Myc | v-myc myelocytomatosis viral oncogene homolog (avian) | - | HPRD,BioGRID | 12027803 |
| NCF1 | FLJ79451 | NCF1A | NOXO2 | SH3PXD1A | p47phox | neutrophil cytosolic factor 1 | Affinity Capture-Western Reconstituted Complex | BioGRID | 12618429 |
| NCOA3 | ACTR | AIB-1 | AIB1 | CAGH16 | CTG26 | KAT13B | MGC141848 | RAC3 | SRC3 | TNRC14 | TNRC16 | TRAM-1 | pCIP | nuclear receptor coactivator 3 | SRC-3 interacts with NF-kappa-B. | BIND | 15383283 |
| NCOA6 | AIB3 | ANTP | ASC2 | HOX1.1 | HOXA7 | KIAA0181 | NRC | PRIP | RAP250 | TRBP | nuclear receptor coactivator 6 | Reconstituted Complex | BioGRID | 10847592 |
| NCOR2 | CTG26 | SMRT | SMRTE | SMRTE-tau | TNRC14 | TRAC-1 | TRAC1 | nuclear receptor co-repressor 2 | - | HPRD,BioGRID | 12589049 |
| NFKB1 | DKFZp686C01211 | EBP-1 | KBF1 | MGC54151 | NF-kappa-B | NFKB-p105 | NFKB-p50 | p105 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 | Affinity Capture-MS Reconstituted Complex | BioGRID | 8798655 |14743216 |
| NFKB1 | DKFZp686C01211 | EBP-1 | KBF1 | MGC54151 | NF-kappa-B | NFKB-p105 | NFKB-p50 | p105 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 | NFKB1 (p50) interacts with RELA (p65). | BIND | 15735750 |
| NFKB1 | DKFZp686C01211 | EBP-1 | KBF1 | MGC54151 | NF-kappa-B | NFKB-p105 | NFKB-p50 | p105 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 | p50 interacts with p65. This interaction was modeled on a demonstrated interaction between mouse p50 and mouse p65. | BIND | 9738011 |
| NFKB1 | DKFZp686C01211 | EBP-1 | KBF1 | MGC54151 | NF-kappa-B | NFKB-p105 | NFKB-p50 | p105 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 | - | HPRD | 8649779 |
| NFKB2 | LYT-10 | LYT10 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) | - | HPRD,BioGRID | 8413211 |
| NFKBIA | IKBA | MAD-3 | NFKBI | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | Affinity Capture-Western Reconstituted Complex | BioGRID | 8139561 |9738011 |9751059 |9990853 |11313474 |11533489 |12419806 |
| NFKBIA | IKBA | MAD-3 | NFKBI | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | I-kappa-B-alpha interacts with NF-kappa-B-p65. | BIND | 15125834 |
| NFKBIA | IKBA | MAD-3 | NFKBI | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | RelA, the p65 subunit of the NF-kappaB complex, interacts with I-kappaB-alpha | BIND | 14685242 |
| NFKBIB | IKBB | TRIP9 | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta | - | HPRD,BioGRID | 8816457 |12672800 |
| NFKBIB | IKBB | TRIP9 | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta | RelA, the p65 subunit of the NF-kappaB complex, interacts with I-kappaB-beta | BIND | 14685242 |
| NFKBIB | IKBB | TRIP9 | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta | I-kappa-B-beta interacts with p65. This interaction was modeled on a demonstrated interaction between mouse I-kappa-B-beta and mouse p65. | BIND | 8816457 |
| NFKBIE | IKBE | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon | Affinity Capture-Western Reconstituted Complex Two-hybrid | BioGRID | 9315679 |
| NKRF | ITBA4 | NRF | NFKB repressing factor | Reconstituted Complex | BioGRID | 10562553 |
| NKX2-1 | BCH | BHC | NK-2 | NKX2.1 | NKX2A | TEBP | TITF1 | TTF-1 | TTF1 | NK2 homeobox 1 | Affinity Capture-Western | BioGRID | 12040027 |
| NOTCH1 | TAN1 | hN1 | Notch homolog 1, translocation-associated (Drosophila) | - | HPRD,BioGRID | 8642313 |
| NPM1 | B23 | MGC104254 | NPM | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | - | HPRD | 14743216 |
| NR3C1 | GCCR | GCR | GR | GRL | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | Affinity Capture-Western in vitro in vivo | BioGRID | 7659084 |8290595 |10995388 |
| NR3C1 | GCCR | GCR | GR | GRL | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | - | HPRD | 7659084 |10995388 |
| PAPOLA | MGC5378 | PAP | poly(A) polymerase alpha | - | HPRD | 14743216 |
| PARP1 | ADPRT | ADPRT1 | PARP | PARP-1 | PPOL | pADPRT-1 | poly (ADP-ribose) polymerase 1 | - | HPRD,BioGRID | 11590148 |
| PGR | NR3C3 | PR | progesterone receptor | - | HPRD,BioGRID | 8626413 |
| PHB2 | BAP | BCAP37 | Bap37 | MGC117268 | PNAS-141 | REA | p22 | prohibitin 2 | - | HPRD | 14743216 |
| PIAS1 | DDXBP1 | GBP | GU/RH-II | MGC141878 | MGC141879 | ZMIZ3 | protein inhibitor of activated STAT, 1 | - | HPRD | 15657437 |
| PIAS3 | FLJ14651 | ZMIZ5 | protein inhibitor of activated STAT, 3 | Affinity Capture-Western Reconstituted Complex Two-hybrid | BioGRID | 15140884 |
| PML | MYL | PP8675 | RNF71 | TRIM19 | promyelocytic leukemia | - | HPRD,BioGRID | 12540841 |
| POU2F1 | OCT1 | OTF1 | POU class 2 homeobox 1 | - | HPRD,BioGRID | 12019209 |
| PPARA | MGC2237 | MGC2452 | NR1C1 | PPAR | hPPAR | peroxisome proliferator-activated receptor alpha | - | HPRD,BioGRID | 10542237 |
| PPP1R13L | IASPP | NKIP1 | RAI | protein phosphatase 1, regulatory (inhibitor) subunit 13 like | - | HPRD,BioGRID | 10336463 |
| PPP2CA | PP2Ac | PP2CA | RP-C | protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform | Reconstituted Complex | BioGRID | 11591705 |
| PPP2CB | PP2CB | protein phosphatase 2 (formerly 2A), catalytic subunit, beta isoform | Reconstituted Complex | BioGRID | 11591705 |
| PPP4C | PP4 | PPH3 | PPX | protein phosphatase 4 (formerly X), catalytic subunit | - | HPRD,BioGRID | 9837938 |
| PRKCZ | PKC-ZETA | PKC2 | protein kinase C, zeta | - | HPRD,BioGRID | 11684013 |
| REL | C-Rel | v-rel reticuloendotheliosis viral oncogene homolog (avian) | - | HPRD | 7886940 |11967310 |
| REL | C-Rel | v-rel reticuloendotheliosis viral oncogene homolog (avian) | Affinity Capture-MS Affinity Capture-Western Reconstituted Complex Two-hybrid | BioGRID | 8139561 |11967310 |14743216 |
| RELA | MGC131774 | NFKB3 | p65 | v-rel reticuloendotheliosis viral oncogene homolog A (avian) | Two-hybrid | BioGRID | 10336463 |
| RELB | I-REL | IREL | v-rel reticuloendotheliosis viral oncogene homolog B | Affinity Capture-MS | BioGRID | 14743216 |
| RFC1 | A1 | MGC51786 | MHCBFB | PO-GA | RECC1 | RFC | RFC140 | replication factor C (activator 1) 1, 145kDa | - | HPRD,BioGRID | 12509469 |
| RNF25 | AO7 | FLJ13906 | ring finger protein 25 | - | HPRD,BioGRID | 12748188 |
| RPL18 | - | ribosomal protein L18 | - | HPRD | 14743216 |
| RPS3 | FLJ26283 | FLJ27450 | MGC87870 | ribosomal protein S3 | - | HPRD | 14743216 |
| RUVBL2 | CGI-46 | ECP51 | INO80J | REPTIN | RVB2 | TIH2 | TIP48 | TIP49B | RuvB-like 2 (E. coli) | - | HPRD | 14743216 |
| RXRA | FLJ00280 | FLJ00318 | FLJ16020 | FLJ16733 | MGC102720 | NR2B1 | retinoid X receptor, alpha | Reconstituted Complex | BioGRID | 10075655 |
| SLC1A2 | EAAT2 | GLT-1 | solute carrier family 1 (glial high affinity glutamate transporter), member 2 | p65 interacts with the EAAT2 promoter. | BIND | 15660126 |
| SP1 | - | Sp1 transcription factor | - | HPRD | 7933095|12055073 |
| SP1 | - | Sp1 transcription factor | Affinity Capture-Western Reconstituted Complex | BioGRID | 7933095 |12055073 |
| SRF | MCM1 | serum response factor (c-fos serum response element-binding transcription factor) | Reconstituted Complex | BioGRID | 8670842 |
| STAT3 | APRF | FLJ20882 | HIES | MGC16063 | signal transducer and activator of transcription 3 (acute-phase response factor) | - | HPRD,BioGRID | 12057007 |
| TAF1 | BA2R | CCG1 | CCGS | DYT3 | KAT4 | N-TAF1 | NSCL2 | OF | P250 | TAF2A | TAFII250 | TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa | - | HPRD,BioGRID | 9584164 |
| TAF11 | MGC:15243 | PRO2134 | TAF2I | TAFII28 | TAF11 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 28kDa | - | HPRD,BioGRID | 9584164 |
| TAF4B | TAF2C2 | TAFII105 | TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa | Reconstituted Complex | BioGRID | 9724652 |
| TAF6 | DKFZp781E21155 | MGC:8964 | TAF2E | TAFII70 | TAFII80 | TAFII85 | TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa | - | HPRD,BioGRID | 9584164 |
| TBK1 | FLJ11330 | NAK | T2K | TANK-binding kinase 1 | Affinity Capture-MS | BioGRID | 14743216 |
| TBP | GTF2D | GTF2D1 | MGC117320 | MGC126054 | MGC126055 | SCA17 | TFIID | TATA box binding protein | - | HPRD,BioGRID | 7706261 |9584164 |
| TERT | EST2 | TCS1 | TP2 | TRT | hEST2 | telomerase reverse transcriptase | An unspecified isoform of TERT (hTERT) interacts with RELA (p65). | BIND | 12917431 |
| TERT | EST2 | TCS1 | TP2 | TRT | hEST2 | telomerase reverse transcriptase | - | HPRD,BioGRID | 12517770 |
| TLE1 | ESG | ESG1 | GRG1 | transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila) | TLE1 interacts with p65. | BIND | 10660609 |
| TLE1 | ESG | ESG1 | GRG1 | transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila) | Affinity Capture-Western | BioGRID | 10660609 |
| TNIP2 | ABIN-2 | ABIN2 | FLIP1 | KLIP | MGC4289 | TNFAIP3 interacting protein 2 | - | HPRD,BioGRID | 14743216 |
| TP53BP2 | 53BP2 | ASPP2 | BBP | PPP1R13A | p53BP2 | tumor protein p53 binding protein, 2 | - | HPRD | 10498867 |
| TRIB3 | C20orf97 | NIPK | SINK | SKIP3 | TRB3 | tribbles homolog 3 (Drosophila) | Affinity Capture-Western | BioGRID | 12736262 |
| TRIP4 | HsT17391 | thyroid hormone receptor interactor 4 | - | HPRD | 12077347 |
| TSC22D3 | DIP | DKFZp313A1123 | DSIPI | GILZ | TSC-22R | hDIP | TSC22 domain family, member 3 | - | HPRD | 12393603 |
| TUBA3C | TUBA2 | bA408E5.3 | tubulin, alpha 3c | - | HPRD | 14743216 |
| TUBB2B | DKFZp566F223 | FLJ98847 | MGC8685 | TUBB-PARALOG | bA506K6.1 | tubulin, beta 2B | - | HPRD | 14743216 |
| TWIST1 | ACS3 | BPES2 | BPES3 | SCS | TWIST | bHLHa38 | twist homolog 1 (Drosophila) | - | HPRD,BioGRID | 12553906 |
| UNC5CL | MGC34763 | ZUD | unc-5 homolog C (C. elegans)-like | - | HPRD,BioGRID | 14769797 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| KEGG MAPK SIGNALING PATHWAY | 267 | 205 | All SZGR 2.0 genes in this pathway |
| KEGG CHEMOKINE SIGNALING PATHWAY | 190 | 128 | All SZGR 2.0 genes in this pathway |
| KEGG APOPTOSIS | 88 | 62 | All SZGR 2.0 genes in this pathway |
| KEGG TOLL LIKE RECEPTOR SIGNALING PATHWAY | 102 | 88 | All SZGR 2.0 genes in this pathway |
| KEGG NOD LIKE RECEPTOR SIGNALING PATHWAY | 62 | 47 | All SZGR 2.0 genes in this pathway |
| KEGG RIG I LIKE RECEPTOR SIGNALING PATHWAY | 71 | 51 | All SZGR 2.0 genes in this pathway |
| KEGG CYTOSOLIC DNA SENSING PATHWAY | 56 | 44 | All SZGR 2.0 genes in this pathway |
| KEGG T CELL RECEPTOR SIGNALING PATHWAY | 108 | 89 | All SZGR 2.0 genes in this pathway |
| KEGG B CELL RECEPTOR SIGNALING PATHWAY | 75 | 56 | All SZGR 2.0 genes in this pathway |
| KEGG NEUROTROPHIN SIGNALING PATHWAY | 126 | 103 | All SZGR 2.0 genes in this pathway |
| KEGG ADIPOCYTOKINE SIGNALING PATHWAY | 67 | 57 | All SZGR 2.0 genes in this pathway |
| KEGG EPITHELIAL CELL SIGNALING IN HELICOBACTER PYLORI INFECTION | 68 | 44 | All SZGR 2.0 genes in this pathway |
| KEGG LEISHMANIA INFECTION | 72 | 56 | All SZGR 2.0 genes in this pathway |
| KEGG PATHWAYS IN CANCER | 328 | 259 | All SZGR 2.0 genes in this pathway |
| KEGG PANCREATIC CANCER | 70 | 56 | All SZGR 2.0 genes in this pathway |
| KEGG PROSTATE CANCER | 89 | 75 | All SZGR 2.0 genes in this pathway |
| KEGG CHRONIC MYELOID LEUKEMIA | 73 | 59 | All SZGR 2.0 genes in this pathway |
| KEGG ACUTE MYELOID LEUKEMIA | 60 | 47 | All SZGR 2.0 genes in this pathway |
| KEGG SMALL CELL LUNG CANCER | 84 | 67 | All SZGR 2.0 genes in this pathway |
| BIOCARTA RELA PATHWAY | 16 | 12 | All SZGR 2.0 genes in this pathway |
| BIOCARTA AKT PATHWAY | 22 | 16 | All SZGR 2.0 genes in this pathway |
| BIOCARTA ATM PATHWAY | 20 | 16 | All SZGR 2.0 genes in this pathway |
| BIOCARTA RANKL PATHWAY | 14 | 13 | All SZGR 2.0 genes in this pathway |
| BIOCARTA CDMAC PATHWAY | 16 | 15 | All SZGR 2.0 genes in this pathway |
| BIOCARTA CD40 PATHWAY | 15 | 13 | All SZGR 2.0 genes in this pathway |
| BIOCARTA CERAMIDE PATHWAY | 22 | 16 | All SZGR 2.0 genes in this pathway |
| BIOCARTA TID PATHWAY | 19 | 15 | All SZGR 2.0 genes in this pathway |
| BIOCARTA GCR PATHWAY | 22 | 17 | All SZGR 2.0 genes in this pathway |
| BIOCARTA CXCR4 PATHWAY | 24 | 22 | All SZGR 2.0 genes in this pathway |
| BIOCARTA RNA PATHWAY | 10 | 9 | All SZGR 2.0 genes in this pathway |
| BIOCARTA EPONFKB PATHWAY | 11 | 11 | All SZGR 2.0 genes in this pathway |
| BIOCARTA FMLP PATHWAY | 39 | 29 | All SZGR 2.0 genes in this pathway |
| BIOCARTA FREE PATHWAY | 10 | 7 | All SZGR 2.0 genes in this pathway |
| BIOCARTA HIVNEF PATHWAY | 58 | 43 | All SZGR 2.0 genes in this pathway |
| BIOCARTA HCMV PATHWAY | 17 | 16 | All SZGR 2.0 genes in this pathway |
| BIOCARTA GSK3 PATHWAY | 27 | 26 | All SZGR 2.0 genes in this pathway |
| BIOCARTA DEATH PATHWAY | 33 | 24 | All SZGR 2.0 genes in this pathway |
| BIOCARTA RACCYCD PATHWAY | 26 | 23 | All SZGR 2.0 genes in this pathway |
| BIOCARTA KERATINOCYTE PATHWAY | 46 | 38 | All SZGR 2.0 genes in this pathway |
| BIOCARTA MAPK PATHWAY | 87 | 68 | All SZGR 2.0 genes in this pathway |
| BIOCARTA PPARA PATHWAY | 58 | 43 | All SZGR 2.0 genes in this pathway |
| BIOCARTA VIP PATHWAY | 29 | 26 | All SZGR 2.0 genes in this pathway |
| BIOCARTA NTHI PATHWAY | 24 | 20 | All SZGR 2.0 genes in this pathway |
| BIOCARTA NFKB PATHWAY | 23 | 19 | All SZGR 2.0 genes in this pathway |
| BIOCARTA RAS PATHWAY | 23 | 20 | All SZGR 2.0 genes in this pathway |
| BIOCARTA CARDIACEGF PATHWAY | 18 | 16 | All SZGR 2.0 genes in this pathway |
| BIOCARTA IL1R PATHWAY | 33 | 29 | All SZGR 2.0 genes in this pathway |
| BIOCARTA TCR PATHWAY | 49 | 37 | All SZGR 2.0 genes in this pathway |
| BIOCARTA TALL1 PATHWAY | 15 | 15 | All SZGR 2.0 genes in this pathway |
| BIOCARTA 41BB PATHWAY | 17 | 15 | All SZGR 2.0 genes in this pathway |
| BIOCARTA STRESS PATHWAY | 25 | 18 | All SZGR 2.0 genes in this pathway |
| BIOCARTA TNFR2 PATHWAY | 18 | 15 | All SZGR 2.0 genes in this pathway |
| BIOCARTA TOLL PATHWAY | 37 | 31 | All SZGR 2.0 genes in this pathway |
| PID FCER1 PATHWAY | 62 | 43 | All SZGR 2.0 genes in this pathway |
| PID BCR 5PATHWAY | 65 | 50 | All SZGR 2.0 genes in this pathway |
| PID LYSOPHOSPHOLIPID PATHWAY | 66 | 53 | All SZGR 2.0 genes in this pathway |
| PID P73PATHWAY | 79 | 59 | All SZGR 2.0 genes in this pathway |
| PID NFKAPPAB ATYPICAL PATHWAY | 17 | 15 | All SZGR 2.0 genes in this pathway |
| PID NFKAPPAB CANONICAL PATHWAY | 23 | 20 | All SZGR 2.0 genes in this pathway |
| PID CD40 PATHWAY | 31 | 26 | All SZGR 2.0 genes in this pathway |
| PID IL12 2PATHWAY | 63 | 54 | All SZGR 2.0 genes in this pathway |
| PID AVB3 OPN PATHWAY | 31 | 29 | All SZGR 2.0 genes in this pathway |
| PID ANGIOPOIETIN RECEPTOR PATHWAY | 50 | 41 | All SZGR 2.0 genes in this pathway |
| PID HDAC CLASSI PATHWAY | 66 | 50 | All SZGR 2.0 genes in this pathway |
| PID IL1 PATHWAY | 34 | 28 | All SZGR 2.0 genes in this pathway |
| PID REG GR PATHWAY | 82 | 60 | All SZGR 2.0 genes in this pathway |
| PID TNF PATHWAY | 46 | 33 | All SZGR 2.0 genes in this pathway |
| PID IL2 PI3K PATHWAY | 34 | 27 | All SZGR 2.0 genes in this pathway |
| PID CERAMIDE PATHWAY | 48 | 37 | All SZGR 2.0 genes in this pathway |
| PID IL23 PATHWAY | 37 | 30 | All SZGR 2.0 genes in this pathway |
| PID HIV NEF PATHWAY | 35 | 26 | All SZGR 2.0 genes in this pathway |
| REACTOME SIGNALLING BY NGF | 217 | 167 | All SZGR 2.0 genes in this pathway |
| REACTOME DEVELOPMENTAL BIOLOGY | 396 | 292 | All SZGR 2.0 genes in this pathway |
| REACTOME TRIF MEDIATED TLR3 SIGNALING | 74 | 54 | All SZGR 2.0 genes in this pathway |
| REACTOME RIP MEDIATED NFKB ACTIVATION VIA DAI | 18 | 15 | All SZGR 2.0 genes in this pathway |
| REACTOME DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR BCR | 97 | 66 | All SZGR 2.0 genes in this pathway |
| REACTOME ACTIVATION OF NF KAPPAB IN B CELLS | 64 | 43 | All SZGR 2.0 genes in this pathway |
| REACTOME SIGNALING BY THE B CELL RECEPTOR BCR | 126 | 90 | All SZGR 2.0 genes in this pathway |
| REACTOME TCR SIGNALING | 54 | 46 | All SZGR 2.0 genes in this pathway |
| REACTOME DOWNSTREAM TCR SIGNALING | 37 | 32 | All SZGR 2.0 genes in this pathway |
| REACTOME REGULATED PROTEOLYSIS OF P75NTR | 10 | 9 | All SZGR 2.0 genes in this pathway |
| REACTOME P75NTR SIGNALS VIA NFKB | 14 | 10 | All SZGR 2.0 genes in this pathway |
| REACTOME NFKB IS ACTIVATED AND SIGNALS SURVIVAL | 11 | 8 | All SZGR 2.0 genes in this pathway |
| REACTOME P75 NTR RECEPTOR MEDIATED SIGNALLING | 81 | 61 | All SZGR 2.0 genes in this pathway |
| REACTOME TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX | 23 | 17 | All SZGR 2.0 genes in this pathway |
| REACTOME SIGNALING BY ILS | 107 | 86 | All SZGR 2.0 genes in this pathway |
| REACTOME TRAF6 MEDIATED NFKB ACTIVATION | 21 | 17 | All SZGR 2.0 genes in this pathway |
| REACTOME TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION | 77 | 57 | All SZGR 2.0 genes in this pathway |
| REACTOME NFKB AND MAP KINASES ACTIVATION MEDIATED BY TLR4 SIGNALING REPERTOIRE | 72 | 53 | All SZGR 2.0 genes in this pathway |
| REACTOME RIG I MDA5 MEDIATED INDUCTION OF IFN ALPHA BETA PATHWAYS | 73 | 57 | All SZGR 2.0 genes in this pathway |
| REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION | 72 | 53 | All SZGR 2.0 genes in this pathway |
| REACTOME MYD88 MAL CASCADE INITIATED ON PLASMA MEMBRANE | 83 | 63 | All SZGR 2.0 genes in this pathway |
| REACTOME INNATE IMMUNE SYSTEM | 279 | 178 | All SZGR 2.0 genes in this pathway |
| REACTOME ACTIVATED TLR4 SIGNALLING | 93 | 69 | All SZGR 2.0 genes in this pathway |
| REACTOME IMMUNE SYSTEM | 933 | 616 | All SZGR 2.0 genes in this pathway |
| REACTOME TOLL RECEPTOR CASCADES | 118 | 84 | All SZGR 2.0 genes in this pathway |
| REACTOME ADAPTIVE IMMUNE SYSTEM | 539 | 350 | All SZGR 2.0 genes in this pathway |
| REACTOME CYTOKINE SIGNALING IN IMMUNE SYSTEM | 270 | 204 | All SZGR 2.0 genes in this pathway |
| ODONNELL TFRC TARGETS UP | 456 | 228 | All SZGR 2.0 genes in this pathway |
| ZHOU INFLAMMATORY RESPONSE FIMA UP | 544 | 308 | All SZGR 2.0 genes in this pathway |
| ZHOU INFLAMMATORY RESPONSE LPS UP | 431 | 237 | All SZGR 2.0 genes in this pathway |
| MARKS ACETYLATED NON HISTONE PROTEINS | 15 | 9 | All SZGR 2.0 genes in this pathway |
| GILMORE CORE NFKB PATHWAY | 14 | 10 | All SZGR 2.0 genes in this pathway |
| SCHEIDEREIT IKK TARGETS | 18 | 15 | All SZGR 2.0 genes in this pathway |
| RASHI RESPONSE TO IONIZING RADIATION 2 | 127 | 92 | All SZGR 2.0 genes in this pathway |
| SCHLOSSER SERUM RESPONSE UP | 134 | 93 | All SZGR 2.0 genes in this pathway |
| SCHEIDEREIT IKK INTERACTING PROTEINS | 58 | 45 | All SZGR 2.0 genes in this pathway |
| DACOSTA UV RESPONSE VIA ERCC3 UP | 309 | 199 | All SZGR 2.0 genes in this pathway |
| TSAI RESPONSE TO IONIZING RADIATION | 149 | 101 | All SZGR 2.0 genes in this pathway |
| SPIELMAN LYMPHOBLAST EUROPEAN VS ASIAN DN | 584 | 395 | All SZGR 2.0 genes in this pathway |
| PUJANA BREAST CANCER LIT INT NETWORK | 101 | 73 | All SZGR 2.0 genes in this pathway |
| SCIAN INVERSED TARGETS OF TP53 AND TP73 DN | 31 | 23 | All SZGR 2.0 genes in this pathway |
| AMIT EGF RESPONSE 480 HELA | 164 | 118 | All SZGR 2.0 genes in this pathway |
| FERRANDO T ALL WITH MLL ENL FUSION UP | 87 | 67 | All SZGR 2.0 genes in this pathway |
| ABRAHAM ALPC VS MULTIPLE MYELOMA DN | 19 | 14 | All SZGR 2.0 genes in this pathway |
| BROWNE HCMV INFECTION 20HR UP | 240 | 152 | All SZGR 2.0 genes in this pathway |
| KAYO AGING MUSCLE UP | 244 | 165 | All SZGR 2.0 genes in this pathway |
| ZHANG PROLIFERATING VS QUIESCENT | 51 | 41 | All SZGR 2.0 genes in this pathway |
| SESTO RESPONSE TO UV C0 | 107 | 72 | All SZGR 2.0 genes in this pathway |
| JACKSON DNMT1 TARGETS UP | 77 | 57 | All SZGR 2.0 genes in this pathway |
| LEE CALORIE RESTRICTION NEOCORTEX DN | 88 | 58 | All SZGR 2.0 genes in this pathway |
| WELCSH BRCA1 TARGETS DN | 141 | 92 | All SZGR 2.0 genes in this pathway |
| KYNG RESPONSE TO H2O2 | 71 | 42 | All SZGR 2.0 genes in this pathway |
| DACOSTA UV RESPONSE VIA ERCC3 COMMON UP | 77 | 47 | All SZGR 2.0 genes in this pathway |
| LABBE TARGETS OF TGFB1 AND WNT3A DN | 108 | 68 | All SZGR 2.0 genes in this pathway |
| BLUM RESPONSE TO SALIRASIB UP | 245 | 159 | All SZGR 2.0 genes in this pathway |
| WINTER HYPOXIA METAGENE | 242 | 168 | All SZGR 2.0 genes in this pathway |
| HINATA NFKB TARGETS KERATINOCYTE UP | 91 | 63 | All SZGR 2.0 genes in this pathway |
| HINATA NFKB TARGETS FIBROBLAST UP | 84 | 60 | All SZGR 2.0 genes in this pathway |
| JOHNSTONE PARVB TARGETS 3 UP | 430 | 288 | All SZGR 2.0 genes in this pathway |
| BRUINS UVC RESPONSE VIA TP53 GROUP B | 549 | 316 | All SZGR 2.0 genes in this pathway |
| PURBEY TARGETS OF CTBP1 AND SATB1 DN | 180 | 116 | All SZGR 2.0 genes in this pathway |