Gene Page: REN

Summary ?
GeneID5972
SymbolREN
SynonymsHNFJ2
Descriptionrenin
ReferenceMIM:179820|HGNC:HGNC:9958|Ensembl:ENSG00000143839|HPRD:01564|Vega:OTTHUMG00000036059
Gene typeprotein-coding
Map location1q32
Fetal beta0.146
eGeneMeta

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
PMID:cooccurHigh-throughput literature-searchSystematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: schizophrenia,schizophrenic,schizophrenics,schizophreniasClick to show details
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 1 

Section I. Genetics and epigenetics annotation


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
PTPN30.950.37
GRID2IP0.950.27
FAM19A40.940.34
SUSD20.940.25
CHRNA30.940.45
TTC39A0.920.50
FAM180B0.920.14
NPL0.910.45
GNG130.910.37
PAPPA0.900.46
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
MEIS3P2-0.230.16
WDR86-0.22-0.21
CACNB3-0.210.13
SSBP4-0.210.12
BAIAP2-0.200.09
AP002414.1-0.200.08
CHRNE-0.200.12
PPM1M-0.200.09
PLEKHO1-0.20-0.01
SLC26A4-0.20-0.25

Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005102receptor bindingIPINeurotransmitter (GO term level: 4)12045255 
GO:0004190aspartic-type endopeptidase activityIEA-
GO:0008233peptidase activityIDA12045255 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0002003angiotensin maturationIDA12045255 
GO:0001822kidney developmentIMP16116425 
GO:0006508proteolysisIDA12045255 
GO:0008217regulation of blood pressureTAS7584914 
GO:0043408regulation of MAPKKK cascadeIDA12045255 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005576extracellular regionIEA-
GO:0005615extracellular spaceIDA12045255 
GO:0005737cytoplasmIDA18029348 
GO:0016020membraneIEA-
GO:0043231intracellular membrane-bounded organelleIDA18029348 

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG RENIN ANGIOTENSIN SYSTEM 1710All SZGR 2.0 genes in this pathway
BIOCARTA ACE2 PATHWAY 137All SZGR 2.0 genes in this pathway
TAKEDA TARGETS OF NUP98 HOXA9 FUSION 3D UP 182110All SZGR 2.0 genes in this pathway
TAKEDA TARGETS OF NUP98 HOXA9 FUSION 8D UP 15791All SZGR 2.0 genes in this pathway
TAKEDA TARGETS OF NUP98 HOXA9 FUSION 10D UP 194122All SZGR 2.0 genes in this pathway
TAKEDA TARGETS OF NUP98 HOXA9 FUSION 16D UP 175108All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY DOXORUBICIN UP 1142669All SZGR 2.0 genes in this pathway
GRAESSMANN RESPONSE TO MC AND DOXORUBICIN UP 612367All SZGR 2.0 genes in this pathway
CEBALLOS TARGETS OF TP53 AND MYC DN 3831All SZGR 2.0 genes in this pathway
TCGA GLIOBLASTOMA COPY NUMBER UP 7536All SZGR 2.0 genes in this pathway
DORSEY GAB2 TARGETS 3117All SZGR 2.0 genes in this pathway
YOSHIMURA MAPK8 TARGETS UP 1305895All SZGR 2.0 genes in this pathway
MIKKELSEN MCV6 ICP WITH H3K27ME3 7446All SZGR 2.0 genes in this pathway
MIKKELSEN MEF ICP WITH H3K27ME3 206108All SZGR 2.0 genes in this pathway
DANG REGULATED BY MYC DN 253192All SZGR 2.0 genes in this pathway
KIM BIPOLAR DISORDER OLIGODENDROCYTE DENSITY CORR DN 8859All SZGR 2.0 genes in this pathway
RAO BOUND BY SALL4 ISOFORM B 517302All SZGR 2.0 genes in this pathway