Gene Page: RFC2

Summary ?
GeneID5982
SymbolRFC2
SynonymsRFC40
Descriptionreplication factor C subunit 2
ReferenceMIM:600404|HGNC:HGNC:9970|Ensembl:ENSG00000049541|HPRD:02675|Vega:OTTHUMG00000023239
Gene typeprotein-coding
Map location7q11.23
Pascal p-value0.559
Fetal beta0.873
DMG1 (# studies)

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CNV:YESCopy number variation studiesManual curation
CV:PGCnpGenome-wide Association StudyGWAS
DMG:Jaffe_2016Genome-wide DNA methylation analysisThis dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05. 1

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

ProbeChromosomePositionNearest geneP (dis)Beta (dis)FDR (dis)Study
cg00955230773669205RFC25.76E-9-0.0113.13E-6DMG:Jaffe_2016


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
PIP5KL10.770.68
AC078802.10.770.82
MARCH110.760.75
C15orf270.750.76
LRFN50.740.73
GAP430.730.57
CNTN60.730.72
RP11-277L2.10.720.69
YBX20.710.65
PTPLA0.710.53
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
CASKIN2-0.39-0.44
AF347015.2-0.39-0.26
AF347015.26-0.37-0.25
AF347015.8-0.36-0.21
IMPA2-0.36-0.46
AF347015.15-0.36-0.20
AF347015.33-0.36-0.20
PHYHD1-0.35-0.38
MT-CO2-0.35-0.19
SORBS3-0.35-0.40

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG DNA REPLICATION 3621All SZGR 2.0 genes in this pathway
KEGG NUCLEOTIDE EXCISION REPAIR 4425All SZGR 2.0 genes in this pathway
KEGG MISMATCH REPAIR 2314All SZGR 2.0 genes in this pathway
PID FANCONI PATHWAY 4728All SZGR 2.0 genes in this pathway
PID ATR PATHWAY 3925All SZGR 2.0 genes in this pathway
REACTOME CELL CYCLE 421253All SZGR 2.0 genes in this pathway
REACTOME CELL CYCLE MITOTIC 325185All SZGR 2.0 genes in this pathway
REACTOME CELL CYCLE CHECKPOINTS 12470All SZGR 2.0 genes in this pathway
REACTOME TRANSCRIPTION COUPLED NER TC NER 4524All SZGR 2.0 genes in this pathway
REACTOME POL SWITCHING 139All SZGR 2.0 genes in this pathway
REACTOME NUCLEOTIDE EXCISION REPAIR 5127All SZGR 2.0 genes in this pathway
REACTOME REPAIR SYNTHESIS FOR GAP FILLING BY DNA POL IN TC NER 1411All SZGR 2.0 genes in this pathway
REACTOME SYNTHESIS OF DNA 9253All SZGR 2.0 genes in this pathway
REACTOME DNA REPAIR 11259All SZGR 2.0 genes in this pathway
REACTOME CHROMOSOME MAINTENANCE 12280All SZGR 2.0 genes in this pathway
REACTOME GLOBAL GENOMIC NER GG NER 3520All SZGR 2.0 genes in this pathway
REACTOME LAGGING STRAND SYNTHESIS 1912All SZGR 2.0 genes in this pathway
REACTOME DNA REPLICATION 192110All SZGR 2.0 genes in this pathway
REACTOME ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS 3818All SZGR 2.0 genes in this pathway
REACTOME TELOMERE MAINTENANCE 7557All SZGR 2.0 genes in this pathway
REACTOME EXTENSION OF TELOMERES 2717All SZGR 2.0 genes in this pathway
REACTOME G2 M CHECKPOINTS 4523All SZGR 2.0 genes in this pathway
REACTOME S PHASE 10966All SZGR 2.0 genes in this pathway
REACTOME DNA STRAND ELONGATION 3018All SZGR 2.0 genes in this pathway
GARY CD5 TARGETS DN 431263All SZGR 2.0 genes in this pathway
BORCZUK MALIGNANT MESOTHELIOMA UP 305185All SZGR 2.0 genes in this pathway
BASAKI YBX1 TARGETS UP 290177All SZGR 2.0 genes in this pathway
TIEN INTESTINE PROBIOTICS 24HR UP 557331All SZGR 2.0 genes in this pathway
KINSEY TARGETS OF EWSR1 FLII FUSION UP 1278748All SZGR 2.0 genes in this pathway
KIM WT1 TARGETS DN 459276All SZGR 2.0 genes in this pathway
RODRIGUES THYROID CARCINOMA POORLY DIFFERENTIATED UP 633376All SZGR 2.0 genes in this pathway
ENK UV RESPONSE KERATINOCYTE UP 530342All SZGR 2.0 genes in this pathway
DACOSTA UV RESPONSE VIA ERCC3 UP 309199All SZGR 2.0 genes in this pathway
CALVET IRINOTECAN SENSITIVE VS RESISTANT UP 55All SZGR 2.0 genes in this pathway
PUJANA BREAST CANCER LIT INT NETWORK 10173All SZGR 2.0 genes in this pathway
PUJANA BRCA1 PCC NETWORK 16521023All SZGR 2.0 genes in this pathway
KAUFFMANN MELANOMA RELAPSE UP 6125All SZGR 2.0 genes in this pathway
BENPORATH CYCLING GENES 648385All SZGR 2.0 genes in this pathway
KAUFFMANN DNA REPAIR GENES 230137All SZGR 2.0 genes in this pathway
KAUFFMANN DNA REPLICATION GENES 14787All SZGR 2.0 genes in this pathway
RADAEVA RESPONSE TO IFNA1 UP 5240All SZGR 2.0 genes in this pathway
MANALO HYPOXIA DN 289166All SZGR 2.0 genes in this pathway
REN BOUND BY E2F 6140All SZGR 2.0 genes in this pathway
MURAKAMI UV RESPONSE 6HR DN 2113All SZGR 2.0 genes in this pathway
SONG TARGETS OF IE86 CMV PROTEIN 6042All SZGR 2.0 genes in this pathway
MURAKAMI UV RESPONSE 24HR 2013All SZGR 2.0 genes in this pathway
SARRIO EPITHELIAL MESENCHYMAL TRANSITION UP 180114All SZGR 2.0 genes in this pathway
TOYOTA TARGETS OF MIR34B AND MIR34C 463262All SZGR 2.0 genes in this pathway
GRADE COLON AND RECTAL CANCER UP 285167All SZGR 2.0 genes in this pathway
TAYLOR METHYLATED IN ACUTE LYMPHOBLASTIC LEUKEMIA 7752All SZGR 2.0 genes in this pathway
BLUM RESPONSE TO SALIRASIB DN 342220All SZGR 2.0 genes in this pathway
MUELLER PLURINET 299189All SZGR 2.0 genes in this pathway
FRASOR RESPONSE TO SERM OR FULVESTRANT DN 5029All SZGR 2.0 genes in this pathway
CHANG CYCLING GENES 14883All SZGR 2.0 genes in this pathway
SHEDDEN LUNG CANCER POOR SURVIVAL A6 456285All SZGR 2.0 genes in this pathway
HOSHIDA LIVER CANCER SURVIVAL DN 11376All SZGR 2.0 genes in this pathway
KOBAYASHI EGFR SIGNALING 24HR DN 251151All SZGR 2.0 genes in this pathway
CAIRO HEPATOBLASTOMA CLASSES UP 605377All SZGR 2.0 genes in this pathway
DANG MYC TARGETS UP 143100All SZGR 2.0 genes in this pathway
DANG BOUND BY MYC 1103714All SZGR 2.0 genes in this pathway
WHITFIELD CELL CYCLE S 16286All SZGR 2.0 genes in this pathway
CHICAS RB1 TARGETS SENESCENT 572352All SZGR 2.0 genes in this pathway
WANG RESPONSE TO GSK3 INHIBITOR SB216763 DN 374217All SZGR 2.0 genes in this pathway
DUTERTRE ESTRADIOL RESPONSE 24HR UP 324193All SZGR 2.0 genes in this pathway
LI DCP2 BOUND MRNA 8957All SZGR 2.0 genes in this pathway
JOHNSTONE PARVB TARGETS 3 DN 918550All SZGR 2.0 genes in this pathway
FEVR CTNNB1 TARGETS DN 553343All SZGR 2.0 genes in this pathway
KOINUMA TARGETS OF SMAD2 OR SMAD3 824528All SZGR 2.0 genes in this pathway
GOBERT OLIGODENDROCYTE DIFFERENTIATION UP 570339All SZGR 2.0 genes in this pathway