Gene Page: RING1

Summary
GeneID  6015
Symbol  RING1
Synonyms  RING1A|RNF1
Description  ring finger protein 1
See related  HGNC:10018|MIM:602045|Ensembl:ENSG00000204227|HPRD:03624|
Locus tag  DADB-100D22.6
Gene type  protein-coding
Map location  6p21.3
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GSMA_Igenome scan meta-analysisPsr: 0.033 
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenias, schizophrenia]Click to show detail
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
PRDM40.930.93
DDX19A0.920.92
EIF2AK40.920.91
FAM120B0.920.92
NOLC10.910.91
ABCF20.910.90
VPS390.910.93
ZFYVE10.910.91
RABGEF10.910.90
RNF2160.910.90
Top 10 negatively co-expressed genes
AF347015.21-0.80-0.84
MT-CO2-0.79-0.79
AF347015.31-0.79-0.79
AF347015.8-0.77-0.79
FXYD1-0.77-0.78
AF347015.33-0.75-0.75
AF347015.27-0.75-0.77
MT-CYB-0.75-0.75
HIGD1B-0.75-0.76
IFI27-0.73-0.74
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0003682chromatin bindingIEA-
GO:0005515protein bindingIEA-
GO:0004842ubiquitin-protein ligase activityIEA-
GO:0016874ligase activityIEA-
GO:0008270zinc ion bindingNAS-
GO:0016564transcription repressor activityIDA9199346 
GO:0046872metal ion bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006355regulation of transcription, DNA-dependentIEA-
GO:0006350transcriptionIEA-
GO:0006511ubiquitin-dependent protein catabolic processIEA-
GO:0009952anterior/posterior pattern formationIEA-
GO:0016568chromatin modificationNAS-
GO:0016574histone ubiquitinationIEA-
GO:0048593camera-type eye morphogenesisIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0000151ubiquitin ligase complexIEA-
GO:0001739sex chromatinIEA-
GO:0005634nucleusIDA9199346 
GO:0005730nucleolusIDA18029348 
GO:0005737cytoplasmIDA18029348 
GO:0016607nuclear speckIEA-
GO:0031519PcG protein complexIEA-
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
BMI1MGC12685 | PCGF4 | RNF51BMI1 polycomb ring finger oncogeneRING1 interacts with BMI1.BIND9858531 
-HPRD,BioGRID9199346 |9858531 
CBX2CDCA6 | M33 | MGC10561chromobox homolog 2 (Pc class homolog, Drosophila)Reconstituted ComplexBioGRID10369680 
CBX4NBP16 | PC2 | hPC2chromobox homolog 4 (Pc class homolog, Drosophila)RING1 interacts with HPC2.BIND9858531 
-HPRD,BioGRID9199346 |9858531 
CBX7-chromobox homolog 7-HPRD,BioGRID14647293 
CBX8HPC3 | PC3 | RC1chromobox homolog 8 (Pc class homolog, Drosophila)-HPRD,BioGRID10825164 
E2F1E2F-1 | RBAP1 | RBBP3 | RBP3E2F transcription factor 1Affinity Capture-WesternBioGRID11583618 
E2F6E2F-6 | MGC111545E2F transcription factor 6-HPRD,BioGRID11171983 
ELAC2ELC2 | FLJ10530 | FLJ36693 | FLJ42848 | HPC2elaC homolog 2 (E. coli)-HPRD9199346 
FHL1FHL1B | FLH1A | KYO-T | MGC111107 | SLIM1 | XMPMA | bA535K18.1four and a half LIM domains 1KyoT interacts with RING1. This interaction was modeled on a demonstrated interaction between KyoT from unspecified species and human RING1.BIND15710417 
PHC1EDR1 | HPH1 | RAE28polyhomeotic homolog 1 (Drosophila)Affinity Capture-WesternBioGRID9199346 
RB1OSRC | RB | p105-Rb | pRb | pp110retinoblastoma 1-HPRD,BioGRID11583618 
RING1RING1A | RNF1ring finger protein 1-HPRD9199346 
Reconstituted Complex
Two-hybrid		BioGRID9858531 
RING1 forms a homodimer.BIND9858531 
RYBPAAP1 | DEDAF | YEAF1RING1 and YY1 binding protein-HPRD,BioGRID10369680 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
DEURIG_T_CELL_PROLYMPHOCYTIC_LEUKEMIA_UP 368234All SZGR genes in this pathway
OSMAN_BLADDER_CANCER_UP 404246All SZGR genes in this pathway
DIRMEIER_LMP1_RESPONSE_LATE_DN 3222All SZGR genes in this pathway
LOPEZ_MBD_TARGETS 957597All SZGR genes in this pathway
STEGMEIER_PRE-MITOTIC_CELL_CYCLE_REGULATORS 118All SZGR genes in this pathway
NGUYEN_NOTCH1_TARGETS_DN 8667All SZGR genes in this pathway
MUNSHI_MULTIPLE_MYELOMA_UP 8152All SZGR genes in this pathway
CHIBA_RESPONSE_TO_TSA_UP 5233All SZGR genes in this pathway
DAVIES_MULTIPLE_MYELOMA_VS_MGUS_UP 1310All SZGR genes in this pathway
KOINUMA_TARGETS_OF_SMAD2_OR_SMAD3 824528All SZGR genes in this pathway
ZWANG_EGF_INTERVAL_DN 214124All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-1332632m8hsa-miR-133aUUGGUCCCCUUCAACCAGCUGU
hsa-miR-133bUUGGUCCCCUUCAACCAGCUA
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


Copyright © Bioinformatics and Systems Medicine Laboratory All Rights Reserved since 2009.