Gene Page: PROK2

Summary ?
GeneID60675
SymbolPROK2
SynonymsBV8|HH4|KAL4|MIT1|PK2
Descriptionprokineticin 2
ReferenceMIM:607002|HGNC:HGNC:18455|Ensembl:ENSG00000163421|HPRD:08446|Vega:OTTHUMG00000158809
Gene typeprotein-coding
Map location3p13
Pascal p-value0.03

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
GSMA_IIAGenome scan meta-analysis (All samples)Psr: 0.04047 
GSMA_IIEGenome scan meta-analysis (European-ancestry samples)Psr: 0.04359 
ExpressionMeta-analysis of gene expressionP value: 1.597 
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 1 

Section I. Genetics and epigenetics annotation


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0001664G-protein-coupled receptor bindingTAS12728244 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007218neuropeptide signaling pathwayIEANeurotransmitter (GO term level: 8)-
GO:0000187activation of MAPK activityTAS12728244 
GO:0001525angiogenesisIDA12604792 
GO:0007204elevation of cytosolic calcium ion concentrationTAS12728244 
GO:0007283spermatogenesisIMP10580115 
GO:0008283cell proliferationIDA12604792 
GO:0006954inflammatory responseNAS11259612 
GO:0006935chemotaxisIDA12604792 
GO:0006916anti-apoptosisIDA12604792 
GO:0019233sensory perception of painTAS12728244 
GO:0045987positive regulation of smooth muscle contractionIDA11259612 
GO:0048511rhythmic processIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005576extracellular regionTAS12466223 

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
BENPORATH SUZ12 TARGETS 1038678All SZGR 2.0 genes in this pathway
BENPORATH EED TARGETS 1062725All SZGR 2.0 genes in this pathway
BENPORATH ES WITH H3K27ME3 1118744All SZGR 2.0 genes in this pathway
BENPORATH PRC2 TARGETS 652441All SZGR 2.0 genes in this pathway
MARZEC IL2 SIGNALING DN 3624All SZGR 2.0 genes in this pathway
VART KSHV INFECTION ANGIOGENIC MARKERS DN 13892All SZGR 2.0 genes in this pathway
MEISSNER BRAIN HCP WITH H3K4ME3 AND H3K27ME3 1069729All SZGR 2.0 genes in this pathway
MEISSNER NPC HCP WITH H3K4ME2 AND H3K27ME3 349234All SZGR 2.0 genes in this pathway
MIKKELSEN NPC HCP WITH H3K27ME3 341243All SZGR 2.0 genes in this pathway
KUMAR PATHOGEN LOAD BY MACROPHAGES 275155All SZGR 2.0 genes in this pathway
KUMAR AUTOPHAGY NETWORK 7146All SZGR 2.0 genes in this pathway
ZWANG TRANSIENTLY UP BY 2ND EGF PULSE ONLY 1725838All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-369-3p104810541Ahsa-miR-369-3pAAUAAUACAUGGUUGAUCUUU
miR-37410481054m8hsa-miR-374UUAUAAUACAACCUGAUAAGUG