Gene Page: RPA1

Summary ?
GeneID6117
SymbolRPA1
SynonymsHSSB|MST075|REPA1|RF-A|RP-A|RPA70
Descriptionreplication protein A1
ReferenceMIM:179835|HGNC:HGNC:10289|Ensembl:ENSG00000132383|HPRD:01565|Vega:OTTHUMG00000090579
Gene typeprotein-coding
Map location17p13.3
Pascal p-value0.127
Sherlock p-value0.761
DMG1 (# studies)
eGeneMeta
SupportAscano FMRP targets

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
DMG:Wockner_2014Genome-wide DNA methylation analysisThis dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 2

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

ProbeChromosomePositionNearest geneP (dis)Beta (dis)FDR (dis)Study
cg02316852171737342RPA11.356E-40.2590.031DMG:Wockner_2014
cg22295628171733433RPA1;SMYD41.932E-4-0.3570.035DMG:Wockner_2014


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section IV. Protein-protein interaction annotation

InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
AKTIPFT1 | FTSAKT interacting proteinTwo-hybridBioGRID16169070 
ASCC2ASC1p100activating signal cointegrator 1 complex subunit 2Two-hybridBioGRID16169070 
ATRFRP1 | MEC1 | SCKL | SCKL1ataxia telangiectasia and Rad3 relatedProtein-peptideBioGRID10608806 
ATRIPDKFZp762J2115 | FLJ12343 | MGC20625 | MGC21482 | MGC26740ATR interacting proteinCo-localizationBioGRID12791985 
BLMBS | MGC126616 | MGC131618 | MGC131620 | RECQ2 | RECQL2 | RECQL3Bloom syndromeBiochemical Activity
Co-localization
Reconstituted Complex		BioGRID10825162 |11950880 
|12181313 
BRCA2BRCC2 | FACD | FAD | FAD1 | FANCB | FANCD | FANCD1breast cancer 2, early onsetAffinity Capture-Western
Reconstituted Complex		BioGRID12527904 
C8orf30AFLJ40907chromosome 8 open reading frame 30ATwo-hybridBioGRID16169070 
CPE-carboxypeptidase ETwo-hybridBioGRID16169070 
FANCAFA | FA-H | FA1 | FAA | FACA | FAH | FANCH | MGC75158Fanconi anemia, complementation group AAffinity Capture-MSBioGRID12973351 
HELB-helicase (DNA) B-HPRD12181327 
KINBTCD | KIN17KIN, antigenic determinant of recA protein homolog (mouse)Co-fractionationBioGRID12754299 
MCM2BM28 | CCNL1 | CDCL1 | D3S3194 | KIAA0030 | MGC10606 | MITOTIN | cdc19minichromosome maintenance complex component 2-HPRD,BioGRID12614612 
MCM4CDC21 | CDC54 | MGC33310 | P1-CDC21 | hCdc21minichromosome maintenance complex component 4Two-hybridBioGRID12614612 
MCM6MCG40308 | Mis5 | P105MCMminichromosome maintenance complex component 6Two-hybridBioGRID12614612 
MCM7CDABP0042 | CDC47 | MCM2 | P1.1-MCM3 | P1CDC47 | P85MCM | PNAS-146minichromosome maintenance complex component 7-HPRD,BioGRID12614612 
MSH4-mutS homolog 4 (E. coli)Co-localizationBioGRID11950880 
MUTYHMGC4416 | MYHmutY homolog (E. coli)hMYH is associated in vivo with replication protein A (RPA)BIND11092888 
MUTYHMGC4416 | MYHmutY homolog (E. coli)-HPRD,BioGRID11092888 
ORC2LORC2origin recognition complex, subunit 2-like (yeast)-HPRD,BioGRID12614612 
ORC6LORC6origin recognition complex, subunit 6 like (yeast)Two-hybridBioGRID12614612 
PCNAMGC8367proliferating cell nuclear antigen-HPRD,BioGRID12171929 
PRKDCDNA-PKcs | DNAPK | DNPK1 | HYRC | HYRC1 | XRCC7 | p350protein kinase, DNA-activated, catalytic polypeptide-HPRD,BioGRID10064605 
RAD51BRCC5 | HRAD51 | HsRad51 | HsT16930 | RAD51A | RECARAD51 homolog (RecA homolog, E. coli) (S. cerevisiae)Reconstituted ComplexBioGRID12077133 
RAD52-RAD52 homolog (S. cerevisiae)Reconstituted ComplexBioGRID12077133 
RAD9ARAD9RAD9 homolog A (S. pombe)Rad9 interacts with RPA70.BIND15897895 
RBM23CAPERbeta | FLJ10482 | MGC4458 | PP239 | RNPC4RNA binding motif protein 23Two-hybridBioGRID16169070 
RPA1HSSB | REPA1 | RF-A | RP-A | RPA70replication protein A1, 70kDa-HPRD,BioGRID11927569 
RPA2REPA2 | RPA32replication protein A2, 32kDa-HPRD9461578 |12754299 
RPA2REPA2 | RPA32replication protein A2, 32kDaAffinity Capture-Western
Co-crystal Structure		BioGRID10064605 |11927569 
RPA3REPA3replication protein A3, 14kDa-HPRD,BioGRID9461578 
RPA4HSU24186 | MGC120333 | MGC120334replication protein A4, 34kDa-HPRD,BioGRID7760808 
SELENBP1FLJ13813 | LPSB | SP56 | hSBP | hSP56selenium binding protein 1Two-hybridBioGRID16169070 
TCEA2TFIIStranscription elongation factor A (SII), 2Two-hybridBioGRID16169070 
TIPINFLJ20516TIMELESS interacting proteinAffinity Capture-Western
Co-localization		BioGRID17296725 
TP53FLJ92943 | LFS1 | TRP53 | p53tumor protein p53Affinity Capture-Western
Reconstituted Complex		BioGRID11751427 |15489903 
TP53BP153BP1 | FLJ41424 | MGC138366 | p202tumor protein p53 binding protein 1Affinity Capture-MS
Affinity Capture-Western		BioGRID15856006 
TREX1AGS1 | AGS5 | CRV | DKFZp434J0310 | DRN3 | HERNSthree prime repair exonuclease 1-HPRD12791985 
XPAXP1 | XPACxeroderma pigmentosum, complementation group A-HPRD,BioGRID7565690 


Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG DNA REPLICATION 3621All SZGR 2.0 genes in this pathway
KEGG NUCLEOTIDE EXCISION REPAIR 4425All SZGR 2.0 genes in this pathway
KEGG MISMATCH REPAIR 2314All SZGR 2.0 genes in this pathway
KEGG HOMOLOGOUS RECOMBINATION 2817All SZGR 2.0 genes in this pathway
BIOCARTA P53HYPOXIA PATHWAY 2321All SZGR 2.0 genes in this pathway
PID FANCONI PATHWAY 4728All SZGR 2.0 genes in this pathway
PID ATR PATHWAY 3925All SZGR 2.0 genes in this pathway
REACTOME ACTIVATION OF THE PRE REPLICATIVE COMPLEX 3116All SZGR 2.0 genes in this pathway
REACTOME MEIOSIS 11681All SZGR 2.0 genes in this pathway
REACTOME CELL CYCLE 421253All SZGR 2.0 genes in this pathway
REACTOME PROCESSIVE SYNTHESIS ON THE LAGGING STRAND 1510All SZGR 2.0 genes in this pathway
REACTOME CELL CYCLE MITOTIC 325185All SZGR 2.0 genes in this pathway
REACTOME CELL CYCLE CHECKPOINTS 12470All SZGR 2.0 genes in this pathway
REACTOME HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION INDEPENDENT DOUBLE STRAND BREAKS 1711All SZGR 2.0 genes in this pathway
REACTOME TRANSCRIPTION COUPLED NER TC NER 4524All SZGR 2.0 genes in this pathway
REACTOME M G1 TRANSITION 8145All SZGR 2.0 genes in this pathway
REACTOME G1 S TRANSITION 11263All SZGR 2.0 genes in this pathway
REACTOME NUCLEOTIDE EXCISION REPAIR 5127All SZGR 2.0 genes in this pathway
REACTOME REPAIR SYNTHESIS FOR GAP FILLING BY DNA POL IN TC NER 1411All SZGR 2.0 genes in this pathway
REACTOME SYNTHESIS OF DNA 9253All SZGR 2.0 genes in this pathway
REACTOME DOUBLE STRAND BREAK REPAIR 2414All SZGR 2.0 genes in this pathway
REACTOME MITOTIC G1 G1 S PHASES 13779All SZGR 2.0 genes in this pathway
REACTOME MITOTIC M M G1 PHASES 17298All SZGR 2.0 genes in this pathway
REACTOME DNA REPAIR 11259All SZGR 2.0 genes in this pathway
REACTOME CHROMOSOME MAINTENANCE 12280All SZGR 2.0 genes in this pathway
REACTOME GLOBAL GENOMIC NER GG NER 3520All SZGR 2.0 genes in this pathway
REACTOME FORMATION OF INCISION COMPLEX IN GG NER 2311All SZGR 2.0 genes in this pathway
REACTOME MEIOTIC RECOMBINATION 8662All SZGR 2.0 genes in this pathway
REACTOME LAGGING STRAND SYNTHESIS 1912All SZGR 2.0 genes in this pathway
REACTOME DNA REPLICATION 192110All SZGR 2.0 genes in this pathway
REACTOME ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS 3818All SZGR 2.0 genes in this pathway
REACTOME TELOMERE MAINTENANCE 7557All SZGR 2.0 genes in this pathway
REACTOME REMOVAL OF THE FLAP INTERMEDIATE FROM THE C STRAND 108All SZGR 2.0 genes in this pathway
REACTOME EXTENSION OF TELOMERES 2717All SZGR 2.0 genes in this pathway
REACTOME G2 M CHECKPOINTS 4523All SZGR 2.0 genes in this pathway
REACTOME S PHASE 10966All SZGR 2.0 genes in this pathway
REACTOME DNA STRAND ELONGATION 3018All SZGR 2.0 genes in this pathway
ZHOU INFLAMMATORY RESPONSE LIVE DN 384220All SZGR 2.0 genes in this pathway
CASORELLI ACUTE PROMYELOCYTIC LEUKEMIA DN 663425All SZGR 2.0 genes in this pathway
DIAZ CHRONIC MEYLOGENOUS LEUKEMIA UP 1382904All SZGR 2.0 genes in this pathway
BORCZUK MALIGNANT MESOTHELIOMA UP 305185All SZGR 2.0 genes in this pathway
OSMAN BLADDER CANCER DN 406230All SZGR 2.0 genes in this pathway
RHEIN ALL GLUCOCORTICOID THERAPY DN 362238All SZGR 2.0 genes in this pathway
TIEN INTESTINE PROBIOTICS 24HR UP 557331All SZGR 2.0 genes in this pathway
KINSEY TARGETS OF EWSR1 FLII FUSION UP 1278748All SZGR 2.0 genes in this pathway
BERENJENO TRANSFORMED BY RHOA UP 536340All SZGR 2.0 genes in this pathway
HEIDENBLAD AMPLICON 12P11 12 UP 3317All SZGR 2.0 genes in this pathway
OXFORD RALA TARGETS UP 97All SZGR 2.0 genes in this pathway
OXFORD RALB TARGETS DN 96All SZGR 2.0 genes in this pathway
OXFORD RALA AND RALB TARGETS UP 107All SZGR 2.0 genes in this pathway
MOHANKUMAR TLX1 TARGETS UP 414287All SZGR 2.0 genes in this pathway
PUJANA BREAST CANCER LIT INT NETWORK 10173All SZGR 2.0 genes in this pathway
PUJANA XPRSS INT NETWORK 168103All SZGR 2.0 genes in this pathway
PUJANA BRCA1 PCC NETWORK 16521023All SZGR 2.0 genes in this pathway
PUJANA BRCA2 PCC NETWORK 423265All SZGR 2.0 genes in this pathway
PUJANA ATM PCC NETWORK 1442892All SZGR 2.0 genes in this pathway
PUJANA CHEK2 PCC NETWORK 779480All SZGR 2.0 genes in this pathway
PUJANA BRCA CENTERED NETWORK 11772All SZGR 2.0 genes in this pathway
SHEN SMARCA2 TARGETS UP 424268All SZGR 2.0 genes in this pathway
MORI SMALL PRE BII LYMPHOCYTE DN 7652All SZGR 2.0 genes in this pathway
COLLIS PRKDC SUBSTRATES 2015All SZGR 2.0 genes in this pathway
KAUFFMANN DNA REPAIR GENES 230137All SZGR 2.0 genes in this pathway
KAUFFMANN DNA REPLICATION GENES 14787All SZGR 2.0 genes in this pathway
TARTE PLASMA CELL VS PLASMABLAST DN 309206All SZGR 2.0 genes in this pathway
SASAKI ADULT T CELL LEUKEMIA 176122All SZGR 2.0 genes in this pathway
ALCALAY AML BY NPM1 LOCALIZATION DN 184132All SZGR 2.0 genes in this pathway
WEIGEL OXIDATIVE STRESS BY TBH AND H2O2 3624All SZGR 2.0 genes in this pathway
KAAB FAILED HEART ATRIUM DN 14199All SZGR 2.0 genes in this pathway
MA PITUITARY FETAL VS ADULT UP 2921All SZGR 2.0 genes in this pathway
SONG TARGETS OF IE86 CMV PROTEIN 6042All SZGR 2.0 genes in this pathway
BILD E2F3 ONCOGENIC SIGNATURE 246153All SZGR 2.0 genes in this pathway
MARTINEZ RB1 TARGETS UP 673430All SZGR 2.0 genes in this pathway
MARTINEZ TP53 TARGETS UP 602364All SZGR 2.0 genes in this pathway
MARTINEZ RB1 AND TP53 TARGETS UP 601369All SZGR 2.0 genes in this pathway
ACEVEDO LIVER TUMOR VS NORMAL ADJACENT TISSUE UP 863514All SZGR 2.0 genes in this pathway
ZHANG BREAST CANCER PROGENITORS UP 425253All SZGR 2.0 genes in this pathway
BLUM RESPONSE TO SALIRASIB DN 342220All SZGR 2.0 genes in this pathway
MUELLER PLURINET 299189All SZGR 2.0 genes in this pathway
HOFFMANN LARGE TO SMALL PRE BII LYMPHOCYTE UP 163102All SZGR 2.0 genes in this pathway
HOFFMANN IMMATURE TO MATURE B LYMPHOCYTE UP 4334All SZGR 2.0 genes in this pathway
FERRANDO HOX11 NEIGHBORS 2313All SZGR 2.0 genes in this pathway
ZHAN EARLY DIFFERENTIATION GENES DN 4229All SZGR 2.0 genes in this pathway
ISHIDA E2F TARGETS 5327All SZGR 2.0 genes in this pathway
BOYAULT LIVER CANCER SUBCLASS G1 UP 11370All SZGR 2.0 genes in this pathway
PUJANA BREAST CANCER WITH BRCA1 MUTATED UP 5627All SZGR 2.0 genes in this pathway
CAIRO HEPATOBLASTOMA UP 207143All SZGR 2.0 genes in this pathway
CHICAS RB1 TARGETS SENESCENT 572352All SZGR 2.0 genes in this pathway
JOHNSTONE PARVB TARGETS 3 DN 918550All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE LATE 1137655All SZGR 2.0 genes in this pathway
LEE BMP2 TARGETS DN 882538All SZGR 2.0 genes in this pathway
FEVR CTNNB1 TARGETS DN 553343All SZGR 2.0 genes in this pathway
GOBERT OLIGODENDROCYTE DIFFERENTIATION UP 570339All SZGR 2.0 genes in this pathway