Gene Page: RPS6KA3

Summary
GeneID  6197
Symbol  RPS6KA3
Synonyms  CLS|HU-3|ISPK-1|MAPKAPK1B|MRX19|RSK|RSK2|S6K-alpha3|p90-RSK2|pp90RSK2
Description  ribosomal protein S6 kinase, 90kDa, polypeptide 3
See related  HGNC:10432|MIM:300075|Ensembl:ENSG00000177189|HPRD:02092|
Locus tag  RP11-393H10.3
Gene type  protein-coding
Map location  Xp22.2-p22.1
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
ExpressionExpressionP value: 1.889 
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 1 
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 1.2387 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
RPL380.960.93
RPL27A0.960.96
RPL300.960.95
RPL230.950.95
RPL35A0.950.93
RPL6P100.950.90
RPS200.950.93
RPL37A0.950.93
RPS80.940.93
RPL240.940.93
Top 10 negatively co-expressed genes
ATP10A-0.61-0.81
EDN3-0.58-0.73
PTPRB-0.57-0.74
BCL2L2-0.57-0.78
ABCB1-0.56-0.73
SYNM-0.56-0.77
MAP3K5-0.56-0.73
SLC6A12-0.56-0.76
EHD2-0.56-0.78
APOL1-0.56-0.73
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0000166nucleotide bindingIEA-
GO:0000287magnesium ion bindingIEA-
GO:0004867serine-type endopeptidase inhibitor activityIEA-
GO:0005524ATP bindingIEA-
GO:0004674protein serine/threonine kinase activityEXP9770464 
GO:0004674protein serine/threonine kinase activityTAS8141249 
GO:0016740transferase activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007417central nervous system developmentTASBrain (GO term level: 6)10319851 
GO:0001501skeletal system developmentTAS8955270 
GO:0006468protein amino acid phosphorylationIEA-
GO:0007243protein kinase cascadeIEA-
GO:0007165signal transductionTAS10436156 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005634nucleusIDA18029348 
GO:0005654nucleoplasmEXP9770464 |16626623 
GO:0005737cytoplasmIDA18029348 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
CREBBPCBP | KAT3A | RSTSCREB binding protein-HPRD,BioGRID11564891 
GRIN1NMDA1 | NMDAR1 | NR1glutamate receptor, ionotropic, N-methyl D-aspartate 1-HPRD10862698 
MAPK1ERK | ERK2 | ERT1 | MAPK2 | P42MAPK | PRKM1 | PRKM2 | p38 | p40 | p41 | p41mapkmitogen-activated protein kinase 1Affinity Capture-WesternBioGRID8939914 |9915826 
-HPRD12832467 
MAPK14CSBP1 | CSBP2 | CSPB1 | EXIP | Mxi2 | PRKM14 | PRKM15 | RK | SAPK2A | p38 | p38ALPHAmitogen-activated protein kinase 14Affinity Capture-WesternBioGRID11157753 
MAPK3ERK1 | HS44KDAP | HUMKER1A | MGC20180 | P44ERK1 | P44MAPK | PRKM3mitogen-activated protein kinase 3-HPRD12832467 
Affinity Capture-WesternBioGRID8939914 
METTL1C12orf1 | FLJ95748 | TRM8 | YDL201wmethyltransferase like 1Mettl1 interacts with and is phosphorylated by RSKBIND15861136 
PDPK1MGC20087 | MGC35290 | PDK1 | PRO04613-phosphoinositide dependent protein kinase-1-HPRD,BioGRID10856237 
PEA15HMAT1 | HUMMAT1H | MAT1 | MAT1H | PEA-15 | PEDphosphoprotein enriched in astrocytes 15-HPRD,BioGRID12796492 
PEA-15 interacts with RSK2.BIND12796492 
RPS6KA3CLS | HU-3 | ISPK-1 | MAPKAPK1B | MRX19 | RSK | RSK2 | S6K-alpha3 | p90-RSK2 | pp90RSK2ribosomal protein S6 kinase, 90kDa, polypeptide 3RSK2 interacts and phosphorylates RSK2. This interaction was modeled on a demonstrated interaction between human RSK2 and RSK2 from an unspecified species.BIND15919995 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_MAPK_SIGNALING_PATHWAY 267205All SZGR genes in this pathway
KEGG_OOCYTE_MEIOSIS 11479All SZGR genes in this pathway
KEGG_MTOR_SIGNALING_PATHWAY 5240All SZGR genes in this pathway
KEGG_LONG_TERM_POTENTIATION 7057All SZGR genes in this pathway
KEGG_NEUROTROPHIN_SIGNALING_PATHWAY 126103All SZGR genes in this pathway
KEGG_PROGESTERONE_MEDIATED_OOCYTE_MATURATION 8659All SZGR genes in this pathway
BIOCARTA_MAPK_PATHWAY 8768All SZGR genes in this pathway
BIOCARTA_GPCR_PATHWAY 3731All SZGR genes in this pathway
ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS 4535All SZGR genes in this pathway
SA_B_CELL_RECEPTOR_COMPLEXES 2420All SZGR genes in this pathway
ST_ERK1_ERK2_MAPK_PATHWAY 3225All SZGR genes in this pathway
SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES 6754All SZGR genes in this pathway
SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES 5141All SZGR genes in this pathway
SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES 3631All SZGR genes in this pathway
ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY 3729All SZGR genes in this pathway
PID_AR_PATHWAY 6146All SZGR genes in this pathway
PID_ERBB1_DOWNSTREAM_PATHWAY 10578All SZGR genes in this pathway
PID_PDGFRB_PATHWAY 129103All SZGR genes in this pathway
REACTOME_SIGNALLING_BY_NGF 217167All SZGR genes in this pathway
REACTOME_DEVELOPMENTAL_BIOLOGY 396292All SZGR genes in this pathway
REACTOME_TRIF_MEDIATED_TLR3_SIGNALING 7454All SZGR genes in this pathway
REACTOME_NGF_SIGNALLING_VIA_TRKA_FROM_THE_PLASMA_MEMBRANE 137105All SZGR genes in this pathway
REACTOME_GASTRIN_CREB_SIGNALLING_PATHWAY_VIA_PKC_AND_MAPK 205136All SZGR genes in this pathway
REACTOME_NUCLEAR_EVENTS_KINASE_AND_TRANSCRIPTION_FACTOR_ACTIVATION 2420All SZGR genes in this pathway
REACTOME_ERK_MAPK_TARGETS 2117All SZGR genes in this pathway
REACTOME_TRANSMISSION_ACROSS_CHEMICAL_SYNAPSES 186155All SZGR genes in this pathway
REACTOME_NEURONAL_SYSTEM 279221All SZGR genes in this pathway
REACTOME_SIGNALING_BY_GPCR 920449All SZGR genes in this pathway
REACTOME_NEUROTRANSMITTER_RECEPTOR_BINDING_AND_DOWNSTREAM_TRANSMISSION_IN_THE_POSTSYNAPTIC_CELL 137110All SZGR genes in this pathway
REACTOME_AXON_GUIDANCE 251188All SZGR genes in this pathway
REACTOME_ACTIVATION_OF_NMDA_RECEPTOR_UPON_GLUTAMATE_BINDING_AND_POSTSYNAPTIC_EVENTS 3732All SZGR genes in this pathway
REACTOME_CREB_PHOSPHORYLATION_THROUGH_THE_ACTIVATION_OF_RAS 2723All SZGR genes in this pathway
REACTOME_POST_NMDA_RECEPTOR_ACTIVATION_EVENTS 3328All SZGR genes in this pathway
REACTOME_MAP_KINASE_ACTIVATION_IN_TLR_CASCADE 5037All SZGR genes in this pathway
REACTOME_MAPK_TARGETS_NUCLEAR_EVENTS_MEDIATED_BY_MAP_KINASES 3024All SZGR genes in this pathway
REACTOME_L1CAM_INTERACTIONS 8662All SZGR genes in this pathway
REACTOME_SIGNAL_TRANSDUCTION_BY_L1 3425All SZGR genes in this pathway
REACTOME_RECYCLING_PATHWAY_OF_L1 2715All SZGR genes in this pathway
REACTOME_TRAF6_MEDIATED_INDUCTION_OF_NFKB_AND_MAP_KINASES_UPON_TLR7_8_OR_9_ACTIVATION 7757All SZGR genes in this pathway
REACTOME_NFKB_AND_MAP_KINASES_ACTIVATION_MEDIATED_BY_TLR4_SIGNALING_REPERTOIRE 7253All SZGR genes in this pathway
REACTOME_MYD88_MAL_CASCADE_INITIATED_ON_PLASMA_MEMBRANE 8363All SZGR genes in this pathway
REACTOME_INNATE_IMMUNE_SYSTEM 279178All SZGR genes in this pathway
REACTOME_ACTIVATED_TLR4_SIGNALLING 9369All SZGR genes in this pathway
REACTOME_IMMUNE_SYSTEM 933616All SZGR genes in this pathway
REACTOME_TOLL_RECEPTOR_CASCADES 11884All SZGR genes in this pathway
IGARASHI_ATF4_TARGETS_DN 9065All SZGR genes in this pathway
DIAZ_CHRONIC_MEYLOGENOUS_LEUKEMIA_UP 1382904All SZGR genes in this pathway
BORCZUK_MALIGNANT_MESOTHELIOMA_UP 305185All SZGR genes in this pathway
GRABARCZYK_BCL11B_TARGETS_UP 8140All SZGR genes in this pathway
DODD_NASOPHARYNGEAL_CARCINOMA_UP 1821933All SZGR genes in this pathway
ENK_UV_RESPONSE_EPIDERMIS_DN 508354All SZGR genes in this pathway
MCBRYAN_PUBERTAL_BREAST_4_5WK_DN 196131All SZGR genes in this pathway
MCBRYAN_PUBERTAL_TGFB1_TARGETS_UP 169127All SZGR genes in this pathway
DACOSTA_UV_RESPONSE_VIA_ERCC3_XPCS_DN 8871All SZGR genes in this pathway
DACOSTA_UV_RESPONSE_VIA_ERCC3_DN 855609All SZGR genes in this pathway
SPIELMAN_LYMPHOBLAST_EUROPEAN_VS_ASIAN_DN 584395All SZGR genes in this pathway
NUYTTEN_EZH2_TARGETS_UP 1037673All SZGR genes in this pathway
KOYAMA_SEMA3B_TARGETS_UP 292168All SZGR genes in this pathway
FLECHNER_BIOPSY_KIDNEY_TRANSPLANT_REJECTED_VS_OK_DN 546351All SZGR genes in this pathway
FLECHNER_BIOPSY_KIDNEY_TRANSPLANT_OK_VS_DONOR_UP 555346All SZGR genes in this pathway
LU_AGING_BRAIN_DN 153120All SZGR genes in this pathway
WELCSH_BRCA1_TARGETS_UP 198132All SZGR genes in this pathway
XU_GH1_AUTOCRINE_TARGETS_UP 268157All SZGR genes in this pathway
CREIGHTON_ENDOCRINE_THERAPY_RESISTANCE_4 307185All SZGR genes in this pathway
MARSON_BOUND_BY_FOXP3_UNSTIMULATED 1229713All SZGR genes in this pathway
KYNG_DNA_DAMAGE_BY_GAMMA_AND_UV_RADIATION 8865All SZGR genes in this pathway
KYNG_DNA_DAMAGE_UP 226164All SZGR genes in this pathway
LIN_NPAS4_TARGETS_UP 163100All SZGR genes in this pathway
MILI_PSEUDOPODIA_HAPTOTAXIS_UP 518299All SZGR genes in this pathway
YAGI_AML_WITH_11Q23_REARRANGED 351238All SZGR genes in this pathway
HOELZEL_NF1_TARGETS_UP 13993All SZGR genes in this pathway
GABRIELY_MIR21_TARGETS 289187All SZGR genes in this pathway
PILON_KLF1_TARGETS_UP 504321All SZGR genes in this pathway
LINSLEY_MIR16_TARGETS 206127All SZGR genes in this pathway
PASINI_SUZ12_TARGETS_DN 315215All SZGR genes in this pathway
ZWANG_CLASS_1_TRANSIENTLY_INDUCED_BY_EGF 516308All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
let-7/9844324438m8hsa-let-7abrainUGAGGUAGUAGGUUGUAUAGUU
hsa-let-7bbrainUGAGGUAGUAGGUUGUGUGGUU
hsa-let-7cbrainUGAGGUAGUAGGUUGUAUGGUU
hsa-let-7dbrainAGAGGUAGUAGGUUGCAUAGU
hsa-let-7ebrainUGAGGUAGGAGGUUGUAUAGU
hsa-let-7fbrainUGAGGUAGUAGAUUGUAUAGUU
hsa-miR-98brainUGAGGUAGUAAGUUGUAUUGUU
hsa-let-7gSZUGAGGUAGUAGUUUGUACAGU
hsa-let-7ibrainUGAGGUAGUAGUUUGUGCUGU
miR-142-5p513651421Ahsa-miR-142-5pCAUAAAGUAGAAAGCACUAC
miR-15/16/195/424/497120126m8hsa-miR-15abrainUAGCAGCACAUAAUGGUUUGUG
hsa-miR-16brainUAGCAGCACGUAAAUAUUGGCG
hsa-miR-15bbrainUAGCAGCACAUCAUGGUUUACA
hsa-miR-195SZUAGCAGCACAGAAAUAUUGGC
hsa-miR-424CAGCAGCAAUUCAUGUUUUGAA
hsa-miR-497CAGCAGCACACUGUGGUUUGU
miR-155312318m8hsa-miR-155UUAAUGCUAAUCGUGAUAGGGG
miR-17-5p/20/93.mr/106/519.d44444450m8hsa-miR-17-5pCAAAGUGCUUACAGUGCAGGUAGU
hsa-miR-20abrainUAAAGUGCUUAUAGUGCAGGUAG
hsa-miR-106aAAAAGUGCUUACAGUGCAGGUAGC
hsa-miR-106bSZUAAAGUGCUGACAGUGCAGAU
hsa-miR-20bSZCAAAGUGCUCAUAGUGCAGGUAG
hsa-miR-519dCAAAGUGCCUCCCUUUAGAGUGU
miR-1816366431A,m8hsa-miR-181abrainAACAUUCAACGCUGUCGGUGAGU
hsa-miR-181bSZAACAUUCAUUGCUGUCGGUGGG
hsa-miR-181cbrainAACAUUCAACCUGUCGGUGAGU
hsa-miR-181dbrainAACAUUCAUUGUUGUCGGUGGGUU
miR-183446244681Ahsa-miR-183UAUGGCACUGGUAGAAUUCACUG
hsa-miR-183UAUGGCACUGGUAGAAUUCACUG
miR-1864965021Ahsa-miR-186CAAAGAAUUCUCCUUUUGGGCUU
hsa-miR-186CAAAGAAUUCUCCUUUUGGGCUU
miR-190518451901Ahsa-miR-190UGAUAUGUUUGAUAUAUUAGGU
hsa-miR-190UGAUAUGUUUGAUAUAUUAGGU
miR-200bc/429588594m8hsa-miR-200bUAAUACUGCCUGGUAAUGAUGAC
hsa-miR-200cUAAUACUGCCGGGUAAUGAUGG
hsa-miR-429UAAUACUGUCUGGUAAAACCGU
miR-203.1310131071Ahsa-miR-203UGAAAUGUUUAGGACCACUAG
hsa-miR-203UGAAAUGUUUAGGACCACUAG
miR-204/211499850051A,m8hsa-miR-204brainUUCCCUUUGUCAUCCUAUGCCU
hsa-miR-211UUCCCUUUGUCAUCCUUCGCCU
miR-205408240891A,m8hsa-miR-205UCCUUCAUUCCACCGGAGUCUG
miR-2144864492m8hsa-miR-21brainUAGCUUAUCAGACUGAUGUUGA
hsa-miR-590GAGCUUAUUCAUAAAAGUGCAG
miR-216455145571Ahsa-miR-216UAAUCUCAGCUGGCAACUGUG
miR-21843491Ahsa-miR-218brainUUGUGCUUGAUCUAACCAUGU
hsa-miR-218brainUUGUGCUUGAUCUAACCAUGU
miR-224397239781Ahsa-miR-224CAAGUCACUAGUGGUUCCGUUUA
miR-32353525358m8hsa-miR-323brainGCACAUUACACGGUCGACCUCU
miR-32645144520m8hsa-miR-326CCUCUGGGCCCUUCCUCCAG
miR-3767998051Ahsa-miR-376aAUCAUAGAGGAAAAUCCACGU
hsa-miR-376bAUCAUAGAGGAAAAUCCAUGUU
miR-38154085414m8hsa-miR-381UAUACAAGGGCAAGCUCUCUGU
miR-3843253311Ahsa-miR-384AUUCCUAGAAAUUGUUCAUA
miR-410546054661Ahsa-miR-410AAUAUAACACAGAUGGCCUGU
miR-4946786841Ahsa-miR-494brainUGAAACAUACACGGGAAACCUCUU
miR-93.hd/291-3p/294/295/302/372/373/5203883951A,m8hsa-miR-93brainAAAGUGCUGUUCGUGCAGGUAG
hsa-miR-302aUAAGUGCUUCCAUGUUUUGGUGA
hsa-miR-302bUAAGUGCUUCCAUGUUUUAGUAG
hsa-miR-302cUAAGUGCUUCCAUGUUUCAGUGG
hsa-miR-302dUAAGUGCUUCCAUGUUUGAGUGU
hsa-miR-372AAAGUGCUGCGACAUUUGAGCGU
hsa-miR-373GAAGUGCUUCGAUUUUGGGGUGU
hsa-miR-520eAAAGUGCUUCCUUUUUGAGGG
hsa-miR-520aAAAGUGCUUCCCUUUGGACUGU
hsa-miR-520bAAAGUGCUUCCUUUUAGAGGG
hsa-miR-520cAAAGUGCUUCCUUUUAGAGGGUU
hsa-miR-520dAAAGUGCUUCUCUUUGGUGGGUU
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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