Gene Page: RPS10
Summary ?
| GeneID | 6204 |
| Symbol | RPS10 |
| Synonyms | DBA9|S10 |
| Description | ribosomal protein S10 |
| Reference | MIM:603632|HGNC:HGNC:10383|Ensembl:ENSG00000124614|HPRD:04697|Vega:OTTHUMG00000014546 |
| Gene type | protein-coding |
| Map location | 6p21.31 |
| Pascal p-value | 0.388 |
| Sherlock p-value | 0.064 |
| Fetal beta | 0.361 |
| DMG | 1 (# studies) |
| eGene | Anterior cingulate cortex BA24 |
| Support | G2Cdb.humanPSD G2Cdb.humanPSP |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| DMG:Wockner_2014 | Genome-wide DNA methylation analysis | This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). | 1 |
| GSMA_I | Genome scan meta-analysis | Psr: 0.033 | |
| GSMA_IIE | Genome scan meta-analysis (European-ancestry samples) | Psr: 0.04433 |
Section I. Genetics and epigenetics annotation
Differentially methylated gene
| Probe | Chromosome | Position | Nearest gene | P (dis) | Beta (dis) | FDR (dis) | Study |
|---|---|---|---|---|---|---|---|
| cg08961047 | 6 | 34395138 | RPS10 | 9.91E-6 | 0.391 | 0.013 | DMG:Wockner_2014 |
eQTL annotation
| SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
|---|---|---|---|---|---|---|---|---|
| rs6907486 | 6 | 34253877 | RPS10 | ENSG00000124614.9 | 2.615E-6 | 0 | 139926 | gtex_brain_ba24 |
| rs206942 | 6 | 34255476 | RPS10 | ENSG00000124614.9 | 2.717E-6 | 0 | 138327 | gtex_brain_ba24 |
| rs206941 | 6 | 34260177 | RPS10 | ENSG00000124614.9 | 2.615E-6 | 0 | 133626 | gtex_brain_ba24 |
| rs7765498 | 6 | 34263037 | RPS10 | ENSG00000124614.9 | 2.615E-6 | 0 | 130766 | gtex_brain_ba24 |
| rs6924982 | 6 | 34269856 | RPS10 | ENSG00000124614.9 | 2.615E-6 | 0 | 123947 | gtex_brain_ba24 |
| rs6930978 | 6 | 34270668 | RPS10 | ENSG00000124614.9 | 2.615E-6 | 0 | 123135 | gtex_brain_ba24 |
| rs410340 | 6 | 34271778 | RPS10 | ENSG00000124614.9 | 2.615E-6 | 0 | 122025 | gtex_brain_ba24 |
| rs206921 | 6 | 34283355 | RPS10 | ENSG00000124614.9 | 2.611E-6 | 0 | 110448 | gtex_brain_ba24 |
| rs3798556 | 6 | 34294006 | RPS10 | ENSG00000124614.9 | 2.615E-6 | 0 | 99797 | gtex_brain_ba24 |
| rs206936 | 6 | 34302869 | RPS10 | ENSG00000124614.9 | 2.615E-6 | 0 | 90934 | gtex_brain_ba24 |
| rs111671909 | 6 | 34313198 | RPS10 | ENSG00000124614.9 | 2.615E-6 | 0 | 80605 | gtex_brain_ba24 |
| rs464553 | 6 | 34315079 | RPS10 | ENSG00000124614.9 | 2.615E-6 | 0 | 78724 | gtex_brain_ba24 |
| rs458576 | 6 | 34315091 | RPS10 | ENSG00000124614.9 | 2.615E-6 | 0 | 78712 | gtex_brain_ba24 |
| rs206924 | 6 | 34339221 | RPS10 | ENSG00000124614.9 | 2.615E-6 | 0 | 54582 | gtex_brain_ba24 |
| rs3798560 | 6 | 34343566 | RPS10 | ENSG00000124614.9 | 2.615E-6 | 0 | 50237 | gtex_brain_ba24 |
| rs414739 | 6 | 34344653 | RPS10 | ENSG00000124614.9 | 2.615E-6 | 0 | 49150 | gtex_brain_ba24 |
| rs206919 | 6 | 34349541 | RPS10 | ENSG00000124614.9 | 2.615E-6 | 0 | 44262 | gtex_brain_ba24 |
| rs77016453 | 6 | 34355535 | RPS10 | ENSG00000124614.9 | 2.615E-6 | 0 | 38268 | gtex_brain_ba24 |
| rs6912971 | 6 | 34355658 | RPS10 | ENSG00000124614.9 | 2.615E-6 | 0 | 38145 | gtex_brain_ba24 |
| rs9368810 | 6 | 34374795 | RPS10 | ENSG00000124614.9 | 1.371E-7 | 0 | 19008 | gtex_brain_ba24 |
| rs9380433 | 6 | 34377626 | RPS10 | ENSG00000124614.9 | 2.884E-6 | 0 | 16177 | gtex_brain_ba24 |
| rs6924482 | 6 | 34387216 | RPS10 | ENSG00000124614.9 | 2.621E-6 | 0 | 6587 | gtex_brain_ba24 |
| rs2006833 | 6 | 34389143 | RPS10 | ENSG00000124614.9 | 2.615E-6 | 0 | 4660 | gtex_brain_ba24 |
| rs1811968 | 6 | 34389181 | RPS10 | ENSG00000124614.9 | 2.583E-6 | 0 | 4622 | gtex_brain_ba24 |
| rs9469779 | 6 | 34393845 | RPS10 | ENSG00000124614.9 | 1.454E-6 | 0 | -42 | gtex_brain_ba24 |
| rs7757586 | 6 | 34395536 | RPS10 | ENSG00000124614.9 | 1.337E-6 | 0 | -1733 | gtex_brain_ba24 |
| rs9394214 | 6 | 34397353 | RPS10 | ENSG00000124614.9 | 1.457E-6 | 0 | -3550 | gtex_brain_ba24 |
| rs3913009 | 6 | 34397848 | RPS10 | ENSG00000124614.9 | 1.457E-6 | 0 | -4045 | gtex_brain_ba24 |
| rs3913010 | 6 | 34397920 | RPS10 | ENSG00000124614.9 | 1.457E-6 | 0 | -4117 | gtex_brain_ba24 |
| rs7757900 | 6 | 34398879 | RPS10 | ENSG00000124614.9 | 1.457E-6 | 0 | -5076 | gtex_brain_ba24 |
| rs9368813 | 6 | 34399814 | RPS10 | ENSG00000124614.9 | 1.457E-6 | 0 | -6011 | gtex_brain_ba24 |
| rs7773447 | 6 | 34405046 | RPS10 | ENSG00000124614.9 | 9.164E-7 | 0 | -11243 | gtex_brain_ba24 |
| rs9366856 | 6 | 34405715 | RPS10 | ENSG00000124614.9 | 1.244E-6 | 0 | -11912 | gtex_brain_ba24 |
| rs9394218 | 6 | 34405721 | RPS10 | ENSG00000124614.9 | 1.244E-6 | 0 | -11918 | gtex_brain_ba24 |
| rs9469780 | 6 | 34406801 | RPS10 | ENSG00000124614.9 | 8.403E-7 | 0 | -12998 | gtex_brain_ba24 |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| MUSTN1 | 0.86 | 0.87 |
| FXYD1 | 0.84 | 0.87 |
| IFI27 | 0.84 | 0.88 |
| METRN | 0.81 | 0.87 |
| HSD17B14 | 0.80 | 0.86 |
| COX4I2 | 0.79 | 0.82 |
| GIMAP5 | 0.79 | 0.83 |
| VAMP5 | 0.79 | 0.86 |
| TINAGL1 | 0.79 | 0.82 |
| NDUFA4L2 | 0.79 | 0.79 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| RNASEN | -0.75 | -0.84 |
| ZNF23 | -0.74 | -0.83 |
| PARG | -0.73 | -0.77 |
| CNOT4 | -0.73 | -0.79 |
| RNF146 | -0.73 | -0.80 |
| HEATR5B | -0.73 | -0.80 |
| NFX1 | -0.72 | -0.79 |
| IKBKAP | -0.72 | -0.80 |
| MARK3 | -0.72 | -0.81 |
| SCAPER | -0.72 | -0.81 |
Section III. Gene Ontology annotation
| Molecular function | GO term | Evidence | Neuro keywords | PubMed ID |
|---|---|---|---|---|
| GO:0005515 | protein binding | IPI | 17353931 | |
| Biological process | GO term | Evidence | Neuro keywords | PubMed ID |
| GO:0006414 | translational elongation | EXP | 15189156 | |
| Cellular component | GO term | Evidence | Neuro keywords | PubMed ID |
| GO:0005829 | cytosol | EXP | 12588972 | |
| GO:0005840 | ribosome | IEA | - | |
| GO:0005840 | ribosome | NAS | 7772601 | |
| GO:0005737 | cytoplasm | IEA | - | |
| GO:0022627 | cytosolic small ribosomal subunit | IDA | 8706699 |15883184 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| KEGG RIBOSOME | 88 | 43 | All SZGR 2.0 genes in this pathway |
| REACTOME TRANSLATION | 222 | 75 | All SZGR 2.0 genes in this pathway |
| REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX | 74 | 24 | All SZGR 2.0 genes in this pathway |
| REACTOME SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE | 179 | 53 | All SZGR 2.0 genes in this pathway |
| REACTOME ACTIVATION OF THE MRNA UPON BINDING OF THE CAP BINDING COMPLEX AND EIFS AND SUBSEQUENT BINDING TO 43S | 84 | 30 | All SZGR 2.0 genes in this pathway |
| REACTOME PEPTIDE CHAIN ELONGATION | 153 | 41 | All SZGR 2.0 genes in this pathway |
| REACTOME METABOLISM OF PROTEINS | 518 | 242 | All SZGR 2.0 genes in this pathway |
| REACTOME 3 UTR MEDIATED TRANSLATIONAL REGULATION | 176 | 51 | All SZGR 2.0 genes in this pathway |
| REACTOME METABOLISM OF MRNA | 284 | 128 | All SZGR 2.0 genes in this pathway |
| REACTOME METABOLISM OF RNA | 330 | 155 | All SZGR 2.0 genes in this pathway |
| REACTOME INFLUENZA LIFE CYCLE | 203 | 72 | All SZGR 2.0 genes in this pathway |
| REACTOME INFLUENZA VIRAL RNA TRANSCRIPTION AND REPLICATION | 169 | 47 | All SZGR 2.0 genes in this pathway |
| REACTOME NONSENSE MEDIATED DECAY ENHANCED BY THE EXON JUNCTION COMPLEX | 176 | 57 | All SZGR 2.0 genes in this pathway |
| OSMAN BLADDER CANCER DN | 406 | 230 | All SZGR 2.0 genes in this pathway |
| ENK UV RESPONSE KERATINOCYTE UP | 530 | 342 | All SZGR 2.0 genes in this pathway |
| MCBRYAN PUBERTAL BREAST 3 4WK DN | 39 | 27 | All SZGR 2.0 genes in this pathway |
| MCBRYAN PUBERTAL BREAST 4 5WK UP | 271 | 175 | All SZGR 2.0 genes in this pathway |
| MCBRYAN PUBERTAL BREAST 6 7WK DN | 79 | 54 | All SZGR 2.0 genes in this pathway |
| LI AMPLIFIED IN LUNG CANCER | 178 | 108 | All SZGR 2.0 genes in this pathway |
| GRASEMANN RETINOBLASTOMA WITH 6P AMPLIFICATION | 14 | 14 | All SZGR 2.0 genes in this pathway |
| DIRMEIER LMP1 RESPONSE EARLY | 66 | 48 | All SZGR 2.0 genes in this pathway |
| DAIRKEE TERT TARGETS UP | 380 | 213 | All SZGR 2.0 genes in this pathway |
| GRUETZMANN PANCREATIC CANCER DN | 203 | 134 | All SZGR 2.0 genes in this pathway |
| NUYTTEN EZH2 TARGETS DN | 1024 | 594 | All SZGR 2.0 genes in this pathway |
| TONG INTERACT WITH PTTG1 | 57 | 32 | All SZGR 2.0 genes in this pathway |
| KOYAMA SEMA3B TARGETS UP | 292 | 168 | All SZGR 2.0 genes in this pathway |
| AMIT EGF RESPONSE 120 HELA | 69 | 47 | All SZGR 2.0 genes in this pathway |
| POMEROY MEDULLOBLASTOMA DESMOPLASIC VS CLASSIC DN | 59 | 35 | All SZGR 2.0 genes in this pathway |
| POMEROY MEDULLOBLASTOMA PROGNOSIS DN | 43 | 28 | All SZGR 2.0 genes in this pathway |
| BLALOCK ALZHEIMERS DISEASE INCIPIENT UP | 390 | 242 | All SZGR 2.0 genes in this pathway |
| BLALOCK ALZHEIMERS DISEASE UP | 1691 | 1088 | All SZGR 2.0 genes in this pathway |
| RODWELL AGING KIDNEY NO BLOOD UP | 222 | 139 | All SZGR 2.0 genes in this pathway |
| RODWELL AGING KIDNEY UP | 487 | 303 | All SZGR 2.0 genes in this pathway |
| SANSOM APC TARGETS REQUIRE MYC | 210 | 123 | All SZGR 2.0 genes in this pathway |
| ALONSO METASTASIS UP | 198 | 128 | All SZGR 2.0 genes in this pathway |
| HSIAO HOUSEKEEPING GENES | 389 | 245 | All SZGR 2.0 genes in this pathway |
| MILI PSEUDOPODIA CHEMOTAXIS DN | 457 | 302 | All SZGR 2.0 genes in this pathway |
| MILI PSEUDOPODIA HAPTOTAXIS DN | 668 | 419 | All SZGR 2.0 genes in this pathway |
| YAMASHITA LIVER CANCER WITH EPCAM UP | 53 | 25 | All SZGR 2.0 genes in this pathway |
| MARTENS TRETINOIN RESPONSE DN | 841 | 431 | All SZGR 2.0 genes in this pathway |
| KIM ALL DISORDERS OLIGODENDROCYTE NUMBER CORR UP | 756 | 494 | All SZGR 2.0 genes in this pathway |
| KIM BIPOLAR DISORDER OLIGODENDROCYTE DENSITY CORR UP | 682 | 440 | All SZGR 2.0 genes in this pathway |
| BILANGES SERUM AND RAPAMYCIN SENSITIVE GENES | 68 | 35 | All SZGR 2.0 genes in this pathway |
| PURBEY TARGETS OF CTBP1 AND SATB1 UP | 87 | 52 | All SZGR 2.0 genes in this pathway |
| BOUDOUKHA BOUND BY IGF2BP2 | 111 | 59 | All SZGR 2.0 genes in this pathway |
| PECE MAMMARY STEM CELL UP | 146 | 75 | All SZGR 2.0 genes in this pathway |