SZGR2

Summary ?

GeneID	6256
Symbol	RXRA
Synonyms	NR2B1
Description	retinoid X receptor alpha
Reference	MIM:180245\|HGNC:HGNC:10477\|HPRD:01577\|
Gene type	protein-coding
Map location	9q34.3
Pascal p-value	0.498
Sherlock p-value	0.57
Fetal beta	-1.106

Gene in Data Sources

Gene set name	Method of gene set	Description	Info
CV:GWAScat	Genome-wide Association Studies	This data set includes 560 SNPs associated with schizophrenia. A total of 486 genes were mapped to these SNPs within 50kb.
CV:PGCnp	Genome-wide Association Study	GWAS
PMID:cooccur	High-throughput literature-search	Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
Literature	High-throughput literature-search	Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias	Click to show details

Section I. Genetics and epigenetics annotation

Section II. Transcriptome annotation

General gene expression (GTEx)

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions

Section III. Gene Ontology annotation

Molecular function	GO term	Evidence	Neuro keywords	PubMed ID
GO:0004886	retinoid-X receptor activity	TAS		1310260
GO:0003674	molecular_function	ND		-
GO:0003700	transcription factor activity	IDA		12037571
GO:0003706	ligand-regulated transcription factor activity	IDA		7990953
GO:0003707	steroid hormone receptor activity	IEA		-
GO:0003713	transcription coactivator activity	TAS		1651173
GO:0005496	steroid binding	IEA		-
GO:0005515	protein binding	IPI		12040021
GO:0008270	zinc ion binding	IEA		-
GO:0046872	metal ion binding	IEA		-
GO:0043565	sequence-specific DNA binding	IEA		-
Biological process	GO term	Evidence	Neuro keywords	PubMed ID
GO:0055012	ventricular cardiac muscle cell differentiation	IEA		-
GO:0055010	ventricular cardiac muscle morphogenesis	IEA		-
GO:0006355	regulation of transcription, DNA-dependent	IEA		-
GO:0006350	transcription	IEA		-
GO:0008203	cholesterol metabolic process	TAS		18544046
GO:0008150	biological_process	ND		-
GO:0006766	vitamin metabolic process	TAS		1651173
GO:0048384	retinoic acid receptor signaling pathway	IMP		17538076
GO:0032526	response to retinoic acid	IMP		17538076
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	IDA		12037571
GO:0044419	interspecies interaction between organisms	IEA		-
GO:0060038	cardiac muscle cell proliferation	IEA		-
Cellular component	GO term	Evidence	Neuro keywords	PubMed ID
GO:0005575	cellular_component	ND		-
GO:0005634	nucleus	IDA		7990953

Section IV. Protein-protein interaction annotation

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
ARNTL	BMAL1 \| BMAL1c \| JAP3 \| MGC47515 \| MOP3 \| PASD3 \| TIC \| bHLHe5	aryl hydrocarbon receptor nuclear translocator-like	Reconstituted Complex	BioGRID	11439184
BCL3	BCL4 \| D19S37	B-cell CLL/lymphoma 3	-	HPRD,BioGRID	9812988
BRD8	SMAP \| SMAP2 \| p120	bromodomain containing 8	Reconstituted Complex Two-hybrid	BioGRID	10517671
CLOCK	KAT13D \| KIAA0334 \| bHLHe8	clock homolog (mouse)	Reconstituted Complex Two-hybrid	BioGRID	11439184
COPS2	ALIEN \| CSN2 \| SGN2 \| TRIP15	COP9 constitutive photomorphogenic homolog subunit 2 (Arabidopsis)	-	HPRD	7776974
CTNNB1	CTNNB \| DKFZp686D02253 \| FLJ25606 \| FLJ37923	catenin (cadherin-associated protein), beta 1, 88kDa	Affinity Capture-Western	BioGRID	12771132
CTSL1	CATL \| CTSL \| FLJ31037 \| MEP	cathepsin L1	-	HPRD,BioGRID	9837884 \|9918848
DNTTIP2	ERBP \| FCF2 \| HSU15552 \| LPTS-RP2 \| MGC163494 \| RP4-561L24.1 \| TdIF2	deoxynucleotidyltransferase, terminal, interacting protein 2	-	HPRD,BioGRID	15047147
EDF1	EDF-1 \| MBF1 \| MGC9058	endothelial differentiation-related factor 1	-	HPRD,BioGRID	12040021
FUS	CHOP \| FUS-CHOP \| FUS1 \| TLS \| TLS/CHOP \| hnRNP-P2	fusion (involved in t(12;16) in malignant liposarcoma)	-	HPRD,BioGRID	9440806
GADD45A	DDIT1 \| GADD45	growth arrest and DNA-damage-inducible, alpha	-	HPRD,BioGRID	10872826
GADD45G	CR6 \| DDIT2 \| GADD45gamma \| GRP17	growth arrest and DNA-damage-inducible, gamma	-	HPRD,BioGRID	10872826
HBXIP	MGC71071 \| XIP	hepatitis B virus x interacting protein	Affinity Capture-Western Reconstituted Complex	BioGRID	14578865
HDAC3	HD3 \| RPD3 \| RPD3-2	histone deacetylase 3	Reconstituted Complex	BioGRID	12943985
HDAC4	HA6116 \| HD4 \| HDAC-A \| HDACA \| KIAA0288	histone deacetylase 4	Reconstituted Complex	BioGRID	12943985
IGFBP3	BP-53 \| IBP3	insulin-like growth factor binding protein 3	-	HPRD,BioGRID	10874028
ITGB3BP	CENP-R \| CENPR \| HSU37139 \| NRIF3 \| TAP20	integrin beta 3 binding protein (beta3-endonexin)	-	HPRD,BioGRID	10490654
JMJD1C	DKFZp761F0118 \| FLJ14374 \| KIAA1380 \| RP11-10C13.2 \| TRIP8	jumonji domain containing 1C	-	HPRD	7776974
MECR	CGI-63 \| FASN2B \| NRBF1	mitochondrial trans-2-enoyl-CoA reductase	-	HPRD	9795230
MED1	CRSP1 \| CRSP200 \| DRIP205 \| DRIP230 \| MGC71488 \| PBP \| PPARBP \| PPARGBP \| RB18A \| TRAP220 \| TRIP2	mediator complex subunit 1	-	HPRD	9653119
MED24	ARC100 \| CRSP100 \| CRSP4 \| DRIP100 \| KIAA0130 \| MGC8748 \| THRAP4 \| TRAP100	mediator complex subunit 24	-	HPRD,BioGRID	9653119
MPG	AAG \| APNG \| CRA36.1 \| MDG \| Mid1 \| PIG11 \| PIG16 \| anpg	N-methylpurine-DNA glycosylase	MPG interacts with RXRA (RXR-alpha). This interaction was modeled on a demonstrated interaction between MPG from an unspecified species and RXRA from an unspecified species.	BIND	14761960
MYOD1	MYF3 \| MYOD \| PUM \| bHLHc1	myogenic differentiation 1	-	HPRD,BioGRID	9692544
NCOA1	F-SRC-1 \| KAT13A \| MGC129719 \| MGC129720 \| NCoA-1 \| RIP160 \| SRC-1 \| SRC1 \| bHLHe42	nuclear receptor coactivator 1	Two-hybrid	BioGRID	12612084
NCOA1	F-SRC-1 \| KAT13A \| MGC129719 \| MGC129720 \| NCoA-1 \| RIP160 \| SRC-1 \| SRC1 \| bHLHe42	nuclear receptor coactivator 1	-	HPRD	7481822
NCOA2	GRIP1 \| KAT13C \| MGC138808 \| NCoA-2 \| TIF2	nuclear receptor coactivator 2	GRIP1 interacts with RXR. This interaction was modeled on a demonstrated interaction between mouse GRIP1 and human RXR.	BIND	9920895
NCOA2	GRIP1 \| KAT13C \| MGC138808 \| NCoA-2 \| TIF2	nuclear receptor coactivator 2	Reconstituted Complex Two-hybrid	BioGRID	11851396 \|12612084
NCOA3	ACTR \| AIB-1 \| AIB1 \| CAGH16 \| CTG26 \| KAT13B \| MGC141848 \| RAC3 \| SRC3 \| TNRC14 \| TNRC16 \| TRAM-1 \| pCIP	nuclear receptor coactivator 3	ACTR interacts with RXR.	BIND	9267036
NCOA3	ACTR \| AIB-1 \| AIB1 \| CAGH16 \| CTG26 \| KAT13B \| MGC141848 \| RAC3 \| SRC3 \| TNRC14 \| TNRC16 \| TRAM-1 \| pCIP	nuclear receptor coactivator 3	-	HPRD,BioGRID	9267036
NCOA4	ARA70 \| DKFZp762E1112 \| ELE1 \| PTC3 \| RFG	nuclear receptor coactivator 4	-	HPRD	10347167
NCOA6	AIB3 \| ANTP \| ASC2 \| HOX1.1 \| HOXA7 \| KIAA0181 \| NRC \| PRIP \| RAP250 \| TRBP	nuclear receptor coactivator 6	Affinity Capture-Western Reconstituted Complex Two-hybrid	BioGRID	10567404 \|11158331 \|11773444 \|14578865
NFKB1	DKFZp686C01211 \| EBP-1 \| KBF1 \| MGC54151 \| NF-kappa-B \| NFKB-p105 \| NFKB-p50 \| p105	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1	-	HPRD,BioGRID	10075655
NFKBIB	IKBB \| TRIP9	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta	-	HPRD,BioGRID	7776974 \|9452433
NPAS2	FLJ23138 \| MGC71151 \| MOP4 \| PASD4 \| bHLHe9	neuronal PAS domain protein 2	Reconstituted Complex Two-hybrid	BioGRID	11439184
NR0B2	FLJ17090 \| SHP \| SHP1	nuclear receptor subfamily 0, group B, member 2	-	HPRD,BioGRID	10594021
NR1H2	LXR-b \| LXRB \| NER \| NER-I \| RIP15 \| UNR	nuclear receptor subfamily 1, group H, member 2	-	HPRD,BioGRID	7760852
NR1H3	LXR-a \| LXRA \| RLD-1	nuclear receptor subfamily 1, group H, member 3	Reconstituted Complex	BioGRID	8621574
NR1H4	BAR \| FXR \| HRR-1 \| HRR1 \| MGC163445 \| RIP14	nuclear receptor subfamily 1, group H, member 4	-	HPRD,BioGRID	7760852
NR1I2	BXR \| ONR1 \| PAR \| PAR1 \| PAR2 \| PARq \| PRR \| PXR \| SAR \| SXR	nuclear receptor subfamily 1, group I, member 2	-	HPRD	9727070
NR1I3	CAR \| CAR1 \| MB67 \| MGC150433 \| MGC97144 \| MGC97209	nuclear receptor subfamily 1, group I, member 3	-	HPRD,BioGRID	8114692
NR2E3	ESCS \| MGC49976 \| PNR \| RNR \| RP37 \| rd7	nuclear receptor subfamily 2, group E, member 3	Reconstituted Complex	BioGRID	10611353
NR2F1	COUP-TFI \| EAR-3 \| EAR3 \| ERBAL3 \| NR2F2 \| SVP44 \| TCFCOUP1 \| TFCOUP1	nuclear receptor subfamily 2, group F, member 1	-	HPRD	1311101
NR2F6	EAR-2 \| EAR2 \| ERBAL2	nuclear receptor subfamily 2, group F, member 6	Two-hybrid	BioGRID	10318855
NR4A1	GFRP1 \| HMR \| MGC9485 \| N10 \| NAK-1 \| NGFIB \| NP10 \| NUR77 \| TR3	nuclear receptor subfamily 4, group A, member 1	Reconstituted Complex Two-hybrid	BioGRID	14980220
NR4A2	HZF-3 \| NOT \| NURR1 \| RNR1 \| TINUR	nuclear receptor subfamily 4, group A, member 2	-	HPRD	7705655 \|7758108
NRBF2	COPR1 \| COPR2 \| DKFZp564C1664 \| FLJ30395 \| NRBF-2	nuclear receptor binding factor 2	-	HPRD,BioGRID	10786636
NRIP1	FLJ77253 \| RIP140	nuclear receptor interacting protein 1	-	HPRD,BioGRID	8887632
NSD1	ARA267 \| DKFZp666C163 \| FLJ10684 \| FLJ22263 \| FLJ44628 \| KMT3B \| SOTOS \| STO	nuclear receptor binding SET domain protein 1	-	HPRD	9628876
PARP1	ADPRT \| ADPRT1 \| PARP \| PARP-1 \| PPOL \| pADPRT-1	poly (ADP-ribose) polymerase 1	-	HPRD	10082530
PML	MYL \| PP8675 \| RNF71 \| TRIM19	promyelocytic leukemia	Reconstituted Complex	BioGRID	10610177
PNRC2	FLJ20312 \| MGC99541	proline-rich nuclear receptor coactivator 2	-	HPRD	11574675
POU2F1	OCT1 \| OTF1	POU class 2 homeobox 1	-	HPRD,BioGRID	10383413
POU2F2	OCT2 \| OTF2 \| Oct-2	POU class 2 homeobox 2	Reconstituted Complex	BioGRID	10383413
PPARA	MGC2237 \| MGC2452 \| NR1C1 \| PPAR \| hPPAR	peroxisome proliferator-activated receptor alpha	-	HPRD,BioGRID	10195690
PPARG	NR1C3 \| PPARG1 \| PPARG2 \| PPARgamma	peroxisome proliferator-activated receptor gamma	-	HPRD,BioGRID	7838715 \|10854698
PPARG	NR1C3 \| PPARG1 \| PPARG2 \| PPARgamma	peroxisome proliferator-activated receptor gamma	-	HPRD	7838715 \|10854698 \|10882139
PPARGC1A	LEM6 \| PGC-1(alpha) \| PGC-1v \| PGC1 \| PGC1A \| PPARGC1	peroxisome proliferator-activated receptor gamma, coactivator 1 alpha	-	HPRD,BioGRID	11714715
PRMT2	HRMT1L1 \| MGC111373	protein arginine methyltransferase 2	PRMT2 interacts with RXR-alpha.	BIND	12039952
PSMC3IP	GT198 \| HOP2 \| HUMGT198A \| TBPIP	PSMC3 interacting protein	-	HPRD	11739747
RARA	NR1B1 \| RAR	retinoic acid receptor, alpha	Co-purification Reconstituted Complex	BioGRID	1314167 \|12052862
RARG	NR1B3 \| RARC	retinoic acid receptor, gamma	-	HPRD	10835357
RELA	MGC131774 \| NFKB3 \| p65	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Reconstituted Complex	BioGRID	10075655
RNF8	FLJ12013 \| KIAA0646	ring finger protein 8	-	HPRD,BioGRID	14981089
SP1	-	Sp1 transcription factor	Reconstituted Complex	BioGRID	10361124
SRC	ASV \| SRC1 \| c-SRC \| p60-Src	v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)	Reconstituted Complex	BioGRID	10517671
SRF	MCM1	serum response factor (c-fos serum response element-binding transcription factor)	-	HPRD	11641790
TADA3L	ADA3 \| FLJ20221 \| FLJ21329 \| hADA3	transcriptional adaptor 3 (NGG1 homolog, yeast)-like	-	HPRD,BioGRID	12235159
TBP	GTF2D \| GTF2D1 \| MGC117320 \| MGC126054 \| MGC126055 \| SCA17 \| TFIID	TATA box binding protein	-	HPRD,BioGRID	7667283
TDG	-	thymine-DNA glycosylase	Reconstituted Complex	BioGRID	12874288
THRA	AR7 \| EAR7 \| ERB-T-1 \| ERBA \| ERBA1 \| MGC000261 \| MGC43240 \| NR1A1 \| THRA1 \| THRA2 \| c-ERBA-1	thyroid hormone receptor, alpha (erythroblastic leukemia viral (v-erb-a) oncogene homolog, avian)	Co-purification	BioGRID	1314167
THRA	AR7 \| EAR7 \| ERB-T-1 \| ERBA \| ERBA1 \| MGC000261 \| MGC43240 \| NR1A1 \| THRA1 \| THRA2 \| c-ERBA-1	thyroid hormone receptor, alpha (erythroblastic leukemia viral (v-erb-a) oncogene homolog, avian)	-	HPRD	1331778
THRB	ERBA-BETA \| ERBA2 \| GRTH \| MGC126109 \| MGC126110 \| NR1A2 \| PRTH \| THR1 \| THRB1 \| THRB2	thyroid hormone receptor, beta (erythroblastic leukemia viral (v-erb-a) oncogene homolog 2, avian)	Reconstituted Complex	BioGRID	9368056
TMPRSS3	DFNB10 \| DFNB8 \| ECHOS1 \| TADG12	transmembrane protease, serine 3	Two-hybrid	BioGRID	16169070
TRIM24	PTC6 \| RNF82 \| TF1A \| TIF1 \| TIF1A \| TIF1ALPHA \| hTIF1	tripartite motif-containing 24	-	HPRD	9115274 \|9632676 \|11851396
TRIM24	PTC6 \| RNF82 \| TF1A \| TIF1 \| TIF1A \| TIF1ALPHA \| hTIF1	tripartite motif-containing 24	Reconstituted Complex	BioGRID	9115274 \|11851396
TRIP10	CIP4 \| HSTP \| STOT \| STP	thyroid hormone receptor interactor 10	-	HPRD	7776974
TRIP4	HsT17391	thyroid hormone receptor interactor 4	-	HPRD	7776974
UBQLN4	A1U \| C1orf6 \| CIP75 \| UBIN	ubiquilin 4	Two-hybrid	BioGRID	16169070
VDR	NR1I1	vitamin D (1,25- dihydroxyvitamin D3) receptor	Reconstituted Complex Two-hybrid	BioGRID	9632709
VDR	NR1I1	vitamin D (1,25- dihydroxyvitamin D3) receptor	VDR interacts with RXRA (RXRalpha) to form a heterodimer.	BIND	15829977
ZBTB16	PLZF \| ZNF145	zinc finger and BTB domain containing 16	-	HPRD	8622986
ZNHIT3	TRIP3	zinc finger, HIT type 3	-	HPRD	7776974

Section V. Pathway annotation

Pathway name	Pathway size	# SZGR 2.0 genes in pathway	Info
KEGG PPAR SIGNALING PATHWAY	69	47	All SZGR 2.0 genes in this pathway
KEGG ADIPOCYTOKINE SIGNALING PATHWAY	67	57	All SZGR 2.0 genes in this pathway
KEGG PATHWAYS IN CANCER	328	259	All SZGR 2.0 genes in this pathway
KEGG THYROID CANCER	29	26	All SZGR 2.0 genes in this pathway
KEGG SMALL CELL LUNG CANCER	84	67	All SZGR 2.0 genes in this pathway
KEGG NON SMALL CELL LUNG CANCER	54	47	All SZGR 2.0 genes in this pathway
BIOCARTA VDR PATHWAY	12	7	All SZGR 2.0 genes in this pathway
BIOCARTA EGFR SMRTE PATHWAY	11	11	All SZGR 2.0 genes in this pathway
BIOCARTA PPARA PATHWAY	58	43	All SZGR 2.0 genes in this pathway
BIOCARTA RARRXR PATHWAY	15	9	All SZGR 2.0 genes in this pathway
BIOCARTA CARM1 PATHWAY	13	11	All SZGR 2.0 genes in this pathway
PID AR TF PATHWAY	53	38	All SZGR 2.0 genes in this pathway
PID RXR VDR PATHWAY	26	24	All SZGR 2.0 genes in this pathway
PID RETINOIC ACID PATHWAY	30	23	All SZGR 2.0 genes in this pathway
PID A6B1 A6B4 INTEGRIN PATHWAY	46	35	All SZGR 2.0 genes in this pathway
REACTOME DEVELOPMENTAL BIOLOGY	396	292	All SZGR 2.0 genes in this pathway
REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION	36	27	All SZGR 2.0 genes in this pathway
REACTOME PPARA ACTIVATES GENE EXPRESSION	104	72	All SZGR 2.0 genes in this pathway
REACTOME RORA ACTIVATES CIRCADIAN EXPRESSION	24	17	All SZGR 2.0 genes in this pathway
REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION	24	16	All SZGR 2.0 genes in this pathway
REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA	23	16	All SZGR 2.0 genes in this pathway
REACTOME GENERIC TRANSCRIPTION PATHWAY	352	181	All SZGR 2.0 genes in this pathway
REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY	49	36	All SZGR 2.0 genes in this pathway
REACTOME METABOLISM OF LIPIDS AND LIPOPROTEINS	478	302	All SZGR 2.0 genes in this pathway
REACTOME FATTY ACID TRIACYLGLYCEROL AND KETONE BODY METABOLISM	168	115	All SZGR 2.0 genes in this pathway
REACTOME CIRCADIAN CLOCK	53	40	All SZGR 2.0 genes in this pathway
REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION	72	53	All SZGR 2.0 genes in this pathway
NAKAMURA TUMOR ZONE PERIPHERAL VS CENTRAL DN	634	384	All SZGR 2.0 genes in this pathway
HUTTMANN B CLL POOR SURVIVAL UP	276	187	All SZGR 2.0 genes in this pathway
MULLIGHAN MLL SIGNATURE 1 UP	380	236	All SZGR 2.0 genes in this pathway
MULLIGHAN MLL SIGNATURE 2 UP	418	263	All SZGR 2.0 genes in this pathway
RODRIGUES THYROID CARCINOMA ANAPLASTIC DN	537	339	All SZGR 2.0 genes in this pathway
ENK UV RESPONSE KERATINOCYTE UP	530	342	All SZGR 2.0 genes in this pathway
LINDGREN BLADDER CANCER CLUSTER 1 UP	121	71	All SZGR 2.0 genes in this pathway
WANG ESOPHAGUS CANCER VS NORMAL DN	101	66	All SZGR 2.0 genes in this pathway
RIZ ERYTHROID DIFFERENTIATION	77	51	All SZGR 2.0 genes in this pathway
RIZ ERYTHROID DIFFERENTIATION CCNE1	40	26	All SZGR 2.0 genes in this pathway
LINDGREN BLADDER CANCER WITH LOH IN CHR9Q	116	71	All SZGR 2.0 genes in this pathway
EINAV INTERFERON SIGNATURE IN CANCER	27	16	All SZGR 2.0 genes in this pathway
SPIELMAN LYMPHOBLAST EUROPEAN VS ASIAN UP	479	299	All SZGR 2.0 genes in this pathway
GROSS HYPOXIA VIA ELK3 UP	209	139	All SZGR 2.0 genes in this pathway
GROSS HYPOXIA VIA ELK3 AND HIF1A DN	103	71	All SZGR 2.0 genes in this pathway
LOPEZ MBD TARGETS	957	597	All SZGR 2.0 genes in this pathway
SCHWAB TARGETS OF BMYB POLYMORPHIC VARIANTS UP	13	9	All SZGR 2.0 genes in this pathway
RICKMAN METASTASIS DN	261	155	All SZGR 2.0 genes in this pathway
SAKAI CHRONIC HEPATITIS VS LIVER CANCER DN	36	24	All SZGR 2.0 genes in this pathway
GOTTWEIN TARGETS OF KSHV MIR K12 11	63	45	All SZGR 2.0 genes in this pathway
BASSO CD40 SIGNALING UP	101	76	All SZGR 2.0 genes in this pathway
URS ADIPOCYTE DIFFERENTIATION UP	74	51	All SZGR 2.0 genes in this pathway
SU LIVER	55	32	All SZGR 2.0 genes in this pathway
WELCSH BRCA1 TARGETS DN	141	92	All SZGR 2.0 genes in this pathway
MARTINEZ RB1 TARGETS UP	673	430	All SZGR 2.0 genes in this pathway
MARTINEZ TP53 TARGETS UP	602	364	All SZGR 2.0 genes in this pathway
MARTINEZ RB1 AND TP53 TARGETS UP	601	369	All SZGR 2.0 genes in this pathway
MASSARWEH TAMOXIFEN RESISTANCE DN	258	160	All SZGR 2.0 genes in this pathway
MASSARWEH RESPONSE TO ESTRADIOL	61	47	All SZGR 2.0 genes in this pathway
CAMPS COLON CANCER COPY NUMBER UP	92	45	All SZGR 2.0 genes in this pathway
ACEVEDO NORMAL TISSUE ADJACENT TO LIVER TUMOR DN	354	216	All SZGR 2.0 genes in this pathway
ACEVEDO LIVER CANCER DN	540	340	All SZGR 2.0 genes in this pathway
ZHANG TLX TARGETS 36HR UP	221	150	All SZGR 2.0 genes in this pathway
GUTIERREZ CHRONIC LYMPHOCYTIC LEUKEMIA DN	56	39	All SZGR 2.0 genes in this pathway
RAMPON ENRICHED LEARNING ENVIRONMENT EARLY DN	10	10	All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 4HR DN	254	158	All SZGR 2.0 genes in this pathway
BHAT ESR1 TARGETS NOT VIA AKT1 DN	88	61	All SZGR 2.0 genes in this pathway
LEE BMP2 TARGETS DN	882	538	All SZGR 2.0 genes in this pathway
PHONG TNF RESPONSE VIA P38 PARTIAL	160	106	All SZGR 2.0 genes in this pathway
SMIRNOV RESPONSE TO IR 6HR UP	166	97	All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-124.1	3381	3387	m8	hsa-miR-124a	UUAAGGCACGCGGUGAAUGCCA
miR-124/506	2093	2099	m8	hsa-miR-506	UAAGGCACCCUUCUGAGUAGA
				hsa-miR-124^brain	UAAGGCACGCGGUGAAUGCC
				hsa-miR-506	UAAGGCACCCUUCUGAGUAGA
				hsa-miR-124^brain	UAAGGCACGCGGUGAAUGCC
miR-128	3804	3810	1A	hsa-miR-128a	UCACAGUGAACCGGUCUCUUUU
miR-128	3804	3810	1A	hsa-miR-128b	UCACAGUGAACCGGUCUCUUUC
miR-130/301	1431	1437	m8	hsa-miR-130a^brain	CAGUGCAAUGUUAAAAGGGCAU
				hsa-miR-301	CAGUGCAAUAGUAUUGUCAAAGC
				hsa-miR-130b^brain	CAGUGCAAUGAUGAAAGGGCAU
				hsa-miR-454-3p	UAGUGCAAUAUUGCUUAUAGGGUUU
miR-148/152	1432	1438	m8	hsa-miR-148a	UCAGUGCACUACAGAACUUUGU
				hsa-miR-152^brain	UCAGUGCAUGACAGAACUUGGG
				hsa-miR-148b	UCAGUGCAUCACAGAACUUUGU
miR-19	1430	1436	m8	hsa-miR-19a	UGUGCAAAUCUAUGCAAAACUGA
miR-19	1430	1436	m8	hsa-miR-19b	UGUGCAAAUCCAUGCAAAACUGA
miR-27	3804	3811	1A,m8	hsa-miR-27a^brain	UUCACAGUGGCUAAGUUCCGC
miR-27	3804	3811	1A,m8	hsa-miR-27b^brain	UUCACAGUGGCUAAGUUCUGC
miR-493-5p	3498	3504	1A	hsa-miR-493-5p	UUGUACAUGGUAGGCUUUCAUU
miR-9	623	629	1A	hsa-miR-9^SZ	UCUUUGGUUAUCUAGCUGUAUGA

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.

Gene Page: RXRA