Summary ?
GeneID6340
SymbolSCNN1G
SynonymsBESC3|ENaCg|ENaCgamma|PHA1|SCNEG
Descriptionsodium channel epithelial 1 gamma subunit
ReferenceMIM:600761|HGNC:HGNC:10602|Ensembl:ENSG00000166828|HPRD:02862|Vega:OTTHUMG00000131609
Gene typeprotein-coding
Map location16p12
Pascal p-value0.046
eGeneCerebellar Hemisphere
Cerebellum

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
GSMA_IIEGenome scan meta-analysis (European-ancestry samples)Psr: 0.01775 

Section I. Genetics and epigenetics annotation


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
FMNL10.920.89
RASGRF10.890.83
CTSB0.890.85
PTPRN0.890.85
GRIN10.880.82
TMEM38A0.880.93
CNNM10.880.76
ADAMTS80.880.89
PRRT30.880.89
TMEM132D0.870.81
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
TUBB2B-0.47-0.58
KIAA1949-0.47-0.47
TRAF4-0.46-0.60
RPL23A-0.46-0.63
RBMX2-0.46-0.66
FADS2-0.46-0.49
CARHSP1-0.46-0.63
BCL7C-0.45-0.60
DYNLT1-0.45-0.65
GPR125-0.45-0.46

Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005515protein bindingIPI11244092 
GO:0005216ion channel activityIEA-
GO:0015280amiloride-sensitive sodium channel activityTAS8640238 
GO:0031402sodium ion bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007588excretionTAS8640238 
GO:0006814sodium ion transportTAS8521520 
GO:0006811ion transportIEA-
GO:0050896response to stimulusIEA-
GO:0050909sensory perception of tasteIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005886plasma membraneIEA-
GO:0005887integral to plasma membraneTAS8640238 
GO:0016324apical plasma membraneIEA-

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG TASTE TRANSDUCTION 5228All SZGR 2.0 genes in this pathway
KEGG ALDOSTERONE REGULATED SODIUM REABSORPTION 4229All SZGR 2.0 genes in this pathway
GAL LEUKEMIC STEM CELL DN 244153All SZGR 2.0 genes in this pathway
KINSEY TARGETS OF EWSR1 FLII FUSION UP 1278748All SZGR 2.0 genes in this pathway
SABATES COLORECTAL ADENOMA DN 291176All SZGR 2.0 genes in this pathway
DODD NASOPHARYNGEAL CARCINOMA DN 1375806All SZGR 2.0 genes in this pathway
CHEBOTAEV GR TARGETS UP 7762All SZGR 2.0 genes in this pathway
BALLIF DEVELOPMENTAL DISABILITY P16 P12 DELETION 138All SZGR 2.0 genes in this pathway
BENPORATH SUZ12 TARGETS 1038678All SZGR 2.0 genes in this pathway
BENPORATH EED TARGETS 1062725All SZGR 2.0 genes in this pathway
BENPORATH ES WITH H3K27ME3 1118744All SZGR 2.0 genes in this pathway
BENPORATH PRC2 TARGETS 652441All SZGR 2.0 genes in this pathway
RIGGI EWING SARCOMA PROGENITOR UP 430288All SZGR 2.0 genes in this pathway
YOSHIMURA MAPK8 TARGETS UP 1305895All SZGR 2.0 genes in this pathway
MEISSNER NPC HCP WITH H3K27ME3 7959All SZGR 2.0 genes in this pathway
MEISSNER BRAIN HCP WITH H3K4ME3 AND H3K27ME3 1069729All SZGR 2.0 genes in this pathway
MIKKELSEN NPC HCP WITH H3K27ME3 341243All SZGR 2.0 genes in this pathway