Gene Page: CDH23

Summary ?
GeneID64072
SymbolCDH23
SynonymsCDHR23|USH1D
Descriptioncadherin-related 23
ReferenceMIM:605516|HGNC:HGNC:13733|Ensembl:ENSG00000107736|HPRD:05699|Vega:OTTHUMG00000019347
Gene typeprotein-coding
Map location10q22.1
Pascal p-value0.244
Sherlock p-value0.789
Fetal beta-1.583
DMG1 (# studies)
eGeneMyers' cis & trans
Meta
SupportCELL ADHESION AND TRANSSYNAPTIC SIGNALING

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
DMG:Jaffe_2016Genome-wide DNA methylation analysisThis dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05. 2
DMG:Wockner_2014Genome-wide DNA methylation analysisThis dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 2

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

ProbeChromosomePositionNearest geneP (dis)Beta (dis)FDR (dis)Study
cg125686331073533407CDH23;C10orf543.36E-5-0.3050.019DMG:Wockner_2014
cg098107501073533449CDH234.41E-8-0.0161.21E-5DMG:Jaffe_2016

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs16829545chr2151977407CDH23640723.913E-5trans
rs6741728chr2153268745CDH23640720.19trans
rs7584986chr2184111432CDH23640720.02trans
rs1396222chr4173279496CDH23640720.16trans
rs335993chr4173321789CDH23640720.18trans
rs10491487chr580323367CDH23640723.997E-4trans
rs17057688chr6130033232CDH23640720trans
rs6996695chr877540580CDH23640720.02trans
rs11139334chr984209393CDH23640723.532E-5trans
snp_a-42676730CDH23640720.01trans
rs3762058chr9116842332CDH23640720.17trans
rs946861chr1021281250CDH23640720.19trans
rs7111644chr1193300259CDH23640720.15trans
rs9989228chr1437809252CDH23640720.12trans
rs16955618chr1529937543CDH23640721.092E-5trans
rs2077735chr1558479024CDH23640720.04trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
BENPORATH SUZ12 TARGETS 1038678All SZGR 2.0 genes in this pathway
BENPORATH EED TARGETS 1062725All SZGR 2.0 genes in this pathway
BENPORATH ES WITH H3K27ME3 1118744All SZGR 2.0 genes in this pathway
BENPORATH PRC2 TARGETS 652441All SZGR 2.0 genes in this pathway
DOUGLAS BMI1 TARGETS UP 566371All SZGR 2.0 genes in this pathway
LEIN PONS MARKERS 8959All SZGR 2.0 genes in this pathway
MARTENS BOUND BY PML RARA FUSION 456287All SZGR 2.0 genes in this pathway
MARTENS TRETINOIN RESPONSE UP 857456All SZGR 2.0 genes in this pathway
ZWANG TRANSIENTLY UP BY 2ND EGF PULSE ONLY 1725838All SZGR 2.0 genes in this pathway