Gene Page: FN3K
Summary ?
| GeneID | 64122 |
| Symbol | FN3K |
| Synonyms | - |
| Description | fructosamine 3 kinase |
| Reference | MIM:608425|HGNC:HGNC:24822|Ensembl:ENSG00000167363|HPRD:16336|Vega:OTTHUMG00000177847 |
| Gene type | protein-coding |
| Map location | 17q25.3 |
| Pascal p-value | 0.446 |
| Sherlock p-value | 0.864 |
| Fetal beta | -0.332 |
| DMG | 1 (# studies) |
| eGene | Myers' cis & trans Meta |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| DMG:Jaffe_2016 | Genome-wide DNA methylation analysis | This dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05. | 1 |
Section I. Genetics and epigenetics annotation
Differentially methylated gene
| Probe | Chromosome | Position | Nearest gene | P (dis) | Beta (dis) | FDR (dis) | Study |
|---|---|---|---|---|---|---|---|
| cg27574244 | 17 | 80709357 | FN3K | 1.43E-9 | -0.025 | 1.39E-6 | DMG:Jaffe_2016 |
eQTL annotation
| SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
|---|---|---|---|---|---|---|---|---|
| rs11650019 | chr17 | 80750689 | FN3K | 64122 | 5.291E-8 | cis | ||
| rs610516 | chr17 | 80762838 | FN3K | 64122 | 3.059E-8 | cis | ||
| rs662669 | chr17 | 80776042 | FN3K | 64122 | 2.346E-12 | cis | ||
| rs603016 | chr17 | 80778780 | FN3K | 64122 | 1.843E-11 | cis | ||
| rs11078015 | chr17 | 80783008 | FN3K | 64122 | 4.369E-13 | cis | ||
| rs7225515 | chr17 | 80795782 | FN3K | 64122 | 1.273E-6 | cis | ||
| rs4986113 | chr17 | 80796235 | FN3K | 64122 | 1.549E-13 | cis | ||
| rs7216324 | chr17 | 80809464 | FN3K | 64122 | 5.871E-4 | cis | ||
| rs9913679 | chr17 | 80812897 | FN3K | 64122 | 0 | cis | ||
| rs7224427 | chr17 | 80825206 | FN3K | 64122 | 0.02 | cis | ||
| rs2292971 | chr17 | 80863856 | FN3K | 64122 | 0.03 | cis | ||
| rs10918646 | chr1 | 167126035 | FN3K | 64122 | 0.14 | trans | ||
| rs12091071 | chr1 | 167132050 | FN3K | 64122 | 0.17 | trans | ||
| rs4419089 | 0 | FN3K | 64122 | 5.084E-7 | trans | |||
| rs11650019 | chr17 | 80750689 | FN3K | 64122 | 1.2E-5 | trans | ||
| rs610516 | chr17 | 80762838 | FN3K | 64122 | 7.136E-6 | trans | ||
| rs662669 | chr17 | 80776042 | FN3K | 64122 | 5.783E-10 | trans | ||
| rs603016 | chr17 | 80778780 | FN3K | 64122 | 4.783E-9 | trans | ||
| rs11078015 | chr17 | 80783008 | FN3K | 64122 | 1.058E-10 | trans | ||
| rs7225515 | chr17 | 80795782 | FN3K | 64122 | 2.321E-4 | trans | ||
| rs4986113 | chr17 | 80796235 | FN3K | 64122 | 3.525E-11 | trans | ||
| rs7216324 | chr17 | 80809464 | FN3K | 64122 | 0.05 | trans | ||
| rs9913679 | chr17 | 80812897 | FN3K | 64122 | 0.12 | trans |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
No co-expressed genes in brain regions
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| STARK PREFRONTAL CORTEX 22Q11 DELETION DN | 517 | 309 | All SZGR 2.0 genes in this pathway |
| NIKOLSKY BREAST CANCER 17Q21 Q25 AMPLICON | 335 | 181 | All SZGR 2.0 genes in this pathway |
| AFFAR YY1 TARGETS DN | 234 | 137 | All SZGR 2.0 genes in this pathway |
| IVANOVA HEMATOPOIESIS MATURE CELL | 293 | 160 | All SZGR 2.0 genes in this pathway |
| CHEN METABOLIC SYNDROM NETWORK | 1210 | 725 | All SZGR 2.0 genes in this pathway |
| MIKKELSEN ES ICP WITH H3K4ME3 | 718 | 401 | All SZGR 2.0 genes in this pathway |
| CHYLA CBFA2T3 TARGETS DN | 242 | 146 | All SZGR 2.0 genes in this pathway |
| BRUINS UVC RESPONSE VIA TP53 GROUP A | 898 | 516 | All SZGR 2.0 genes in this pathway |