Gene Page: SFRP2
Summary ?
GeneID | 6423 |
Symbol | SFRP2 |
Synonyms | FRP-2|SARP1|SDF-5 |
Description | secreted frizzled-related protein 2 |
Reference | MIM:604157|HGNC:HGNC:10777|Ensembl:ENSG00000145423|HPRD:16041|Vega:OTTHUMG00000161559 |
Gene type | protein-coding |
Map location | 4q31.3 |
Pascal p-value | 0.006 |
eGene | Myers' cis & trans |
Gene in Data Sources
Gene set name | Method of gene set | Description | Info |
---|---|---|---|
CV:PGCnp | Genome-wide Association Study | GWAS |
Section I. Genetics and epigenetics annotation
eQTL annotation
SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
---|---|---|---|---|---|---|---|---|
rs954368 | chr4 | 154771775 | SFRP2 | 6423 | 0.07 | cis | ||
rs6820559 | chr4 | 154813698 | SFRP2 | 6423 | 0.03 | cis | ||
rs17131472 | chr1 | 91962966 | SFRP2 | 6423 | 3.305E-4 | trans | ||
rs546975 | chr1 | 91963738 | SFRP2 | 6423 | 0.13 | trans | ||
rs10218671 | chr1 | 158362552 | SFRP2 | 6423 | 0.18 | trans | ||
rs1835319 | chr2 | 16586056 | SFRP2 | 6423 | 0.05 | trans | ||
rs6710894 | chr2 | 66876700 | SFRP2 | 6423 | 0.16 | trans | ||
rs17821815 | chr2 | 119018522 | SFRP2 | 6423 | 0.01 | trans | ||
rs2115055 | chr2 | 119478688 | SFRP2 | 6423 | 0.14 | trans | ||
rs11679772 | chr2 | 158292302 | SFRP2 | 6423 | 0.19 | trans | ||
rs1691463 | chr3 | 84914366 | SFRP2 | 6423 | 0.07 | trans | ||
rs2922180 | chr3 | 125280472 | SFRP2 | 6423 | 5.172E-8 | trans | ||
rs2971271 | chr3 | 125450402 | SFRP2 | 6423 | 0.08 | trans | ||
rs2976809 | chr3 | 125451738 | SFRP2 | 6423 | 1.059E-5 | trans | ||
rs16889842 | chr4 | 9872012 | SFRP2 | 6423 | 0.05 | trans | ||
rs17776097 | chr4 | 90247162 | SFRP2 | 6423 | 0.19 | trans | ||
rs4033102 | chr4 | 111784204 | SFRP2 | 6423 | 0.03 | trans | ||
rs509952 | chr4 | 111788169 | SFRP2 | 6423 | 0.02 | trans | ||
rs313946 | chr4 | 113975904 | SFRP2 | 6423 | 0.01 | trans | ||
rs10050805 | chr5 | 30805352 | SFRP2 | 6423 | 0.01 | trans | ||
rs16894149 | chr5 | 61013724 | SFRP2 | 6423 | 0.15 | trans | ||
rs17143695 | chr5 | 117520843 | SFRP2 | 6423 | 0.14 | trans | ||
rs6874540 | chr5 | 149911669 | SFRP2 | 6423 | 0.15 | trans | ||
rs2273232 | chr5 | 149912526 | SFRP2 | 6423 | 0.15 | trans | ||
rs11954814 | chr5 | 155088338 | SFRP2 | 6423 | 0.12 | trans | ||
rs17056435 | chr5 | 158453782 | SFRP2 | 6423 | 2.686E-4 | trans | ||
rs12663807 | chr6 | 40571873 | SFRP2 | 6423 | 0.02 | trans | ||
rs6920042 | chr6 | 67907570 | SFRP2 | 6423 | 0.16 | trans | ||
rs6455226 | chr6 | 67930295 | SFRP2 | 6423 | 0 | trans | ||
rs16868852 | chr6 | 70980333 | SFRP2 | 6423 | 0.18 | trans | ||
rs283058 | chr6 | 118625224 | SFRP2 | 6423 | 0 | trans | ||
rs12216440 | chr6 | 118856821 | SFRP2 | 6423 | 0.11 | trans | ||
rs2056744 | chr6 | 144952933 | SFRP2 | 6423 | 0.12 | trans | ||
rs2430483 | chr7 | 104548631 | SFRP2 | 6423 | 0.01 | trans | ||
rs10273901 | chr7 | 131828566 | SFRP2 | 6423 | 0.13 | trans | ||
rs2199402 | chr8 | 9201002 | SFRP2 | 6423 | 0.06 | trans | ||
rs7841407 | chr8 | 9243427 | SFRP2 | 6423 | 0 | trans | ||
rs2739708 | chr8 | 17992280 | SFRP2 | 6423 | 0.03 | trans | ||
rs714131 | chr8 | 17992832 | SFRP2 | 6423 | 0.09 | trans | ||
rs2739726 | chr8 | 17998576 | SFRP2 | 6423 | 0.02 | trans | ||
rs2919377 | chr8 | 32573740 | SFRP2 | 6423 | 0.01 | trans | ||
rs680372 | chr8 | 36999626 | SFRP2 | 6423 | 0.19 | trans | ||
rs7850851 | chr9 | 37928770 | SFRP2 | 6423 | 0.12 | trans | ||
rs2253777 | chr9 | 93467893 | SFRP2 | 6423 | 0.04 | trans | ||
rs998410 | chr9 | 117622673 | SFRP2 | 6423 | 0.09 | trans | ||
rs9423711 | chr10 | 2574802 | SFRP2 | 6423 | 2.521E-6 | trans | ||
rs2388266 | chr10 | 2595037 | SFRP2 | 6423 | 0.1 | trans | ||
rs651134 | chr10 | 27549960 | SFRP2 | 6423 | 0.09 | trans | ||
rs748375 | chr10 | 33440178 | SFRP2 | 6423 | 0.08 | trans | ||
rs4514358 | chr10 | 43861923 | SFRP2 | 6423 | 0.02 | trans | ||
rs7081666 | chr10 | 47673800 | SFRP2 | 6423 | 0.01 | trans | ||
rs10488758 | chr11 | 103493095 | SFRP2 | 6423 | 0.09 | trans | ||
rs1905067 | chr11 | 103493989 | SFRP2 | 6423 | 0.15 | trans | ||
rs11225990 | chr11 | 103608380 | SFRP2 | 6423 | 0.1 | trans | ||
rs2305164 | chr12 | 365649 | SFRP2 | 6423 | 0.03 | trans | ||
rs10747972 | 0 | SFRP2 | 6423 | 0.18 | trans | |||
rs995817 | chr12 | 67557935 | SFRP2 | 6423 | 0.15 | trans | ||
rs10879027 | chr12 | 70237156 | SFRP2 | 6423 | 2.408E-4 | trans | ||
rs11112163 | chr12 | 105072508 | SFRP2 | 6423 | 0.16 | trans | ||
rs17080889 | chr13 | 20939135 | SFRP2 | 6423 | 0.17 | trans | ||
rs9551590 | chr13 | 29589464 | SFRP2 | 6423 | 0.04 | trans | ||
rs9532792 | chr13 | 41912654 | SFRP2 | 6423 | 0.15 | trans | ||
rs9590586 | chr13 | 41913130 | SFRP2 | 6423 | 0.17 | trans | ||
rs7358853 | chr13 | 41931685 | SFRP2 | 6423 | 0.19 | trans | ||
rs8002343 | chr13 | 41952090 | SFRP2 | 6423 | 0.17 | trans | ||
rs9315839 | chr13 | 41952872 | SFRP2 | 6423 | 0.19 | trans | ||
rs7982172 | chr13 | 41969697 | SFRP2 | 6423 | 0.16 | trans | ||
rs4942043 | chr13 | 41978218 | SFRP2 | 6423 | 0.03 | trans | ||
rs4402447 | chr13 | 41984741 | SFRP2 | 6423 | 0.16 | trans | ||
rs7982922 | chr13 | 43873335 | SFRP2 | 6423 | 0.18 | trans | ||
rs9529974 | chr13 | 72821935 | SFRP2 | 6423 | 3.814E-4 | trans | ||
rs17073665 | chr13 | 81541961 | SFRP2 | 6423 | 0 | trans | ||
rs11840833 | chr13 | 94378306 | SFRP2 | 6423 | 0.01 | trans | ||
rs16975617 | chr13 | 110867407 | SFRP2 | 6423 | 0.06 | trans | ||
rs10142086 | chr14 | 35135892 | SFRP2 | 6423 | 0.15 | trans | ||
rs1956517 | chr14 | 37738426 | SFRP2 | 6423 | 0.12 | trans | ||
rs1457420 | chr14 | 66958675 | SFRP2 | 6423 | 0.12 | trans | ||
rs2093759 | chr14 | 97171024 | SFRP2 | 6423 | 0 | trans | ||
rs17244419 | chr14 | 97171074 | SFRP2 | 6423 | 4.182E-5 | trans | ||
rs7177212 | chr15 | 34425413 | SFRP2 | 6423 | 0.19 | trans | ||
rs16976022 | chr15 | 55454260 | SFRP2 | 6423 | 0.07 | trans | ||
rs16976029 | chr15 | 55455268 | SFRP2 | 6423 | 0.03 | trans | ||
rs16976036 | chr15 | 55456921 | SFRP2 | 6423 | 0.04 | trans | ||
rs8034402 | chr15 | 55480932 | SFRP2 | 6423 | 0.1 | trans | ||
rs11073814 | chr15 | 89378883 | SFRP2 | 6423 | 0.18 | trans | ||
rs7165622 | chr15 | 93979910 | SFRP2 | 6423 | 0.1 | trans | ||
rs13380712 | chr16 | 25601181 | SFRP2 | 6423 | 0.04 | trans | ||
rs17841422 | chr17 | 20969134 | SFRP2 | 6423 | 0 | trans | ||
rs16977927 | chr17 | 72154232 | SFRP2 | 6423 | 0.05 | trans | ||
rs16940550 | chr18 | 13442256 | SFRP2 | 6423 | 0.19 | trans | ||
rs7236104 | chr18 | 14032818 | SFRP2 | 6423 | 0.14 | trans | ||
rs9949772 | chr18 | 31042632 | SFRP2 | 6423 | 0.1 | trans | ||
rs7236407 | chr18 | 47827597 | SFRP2 | 6423 | 0.1 | trans | ||
rs4987765 | chr18 | 60905021 | SFRP2 | 6423 | 0.06 | trans | ||
rs11873703 | chr18 | 61448702 | SFRP2 | 6423 | 6.602E-6 | trans | ||
rs6095741 | chr20 | 48666589 | SFRP2 | 6423 | 1.186E-10 | trans | ||
rs6004906 | chr22 | 26434554 | SFRP2 | 6423 | 0.04 | trans | ||
rs6000401 | chr22 | 37149335 | SFRP2 | 6423 | 0.13 | trans | ||
rs5991662 | chrX | 43335796 | SFRP2 | 6423 | 5.443E-5 | trans |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
No co-expressed genes in brain regions
Section V. Pathway annotation
Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
---|---|---|---|
KEGG WNT SIGNALING PATHWAY | 151 | 112 | All SZGR 2.0 genes in this pathway |
SENGUPTA NASOPHARYNGEAL CARCINOMA WITH LMP1 UP | 408 | 247 | All SZGR 2.0 genes in this pathway |
TURASHVILI BREAST DUCTAL CARCINOMA VS DUCTAL NORMAL UP | 44 | 25 | All SZGR 2.0 genes in this pathway |
TURASHVILI BREAST LOBULAR CARCINOMA VS DUCTAL NORMAL UP | 69 | 38 | All SZGR 2.0 genes in this pathway |
TURASHVILI BREAST LOBULAR CARCINOMA VS LOBULAR NORMAL DN | 74 | 42 | All SZGR 2.0 genes in this pathway |
NOJIMA SFRP2 TARGETS UP | 31 | 23 | All SZGR 2.0 genes in this pathway |
VECCHI GASTRIC CANCER ADVANCED VS EARLY UP | 175 | 120 | All SZGR 2.0 genes in this pathway |
KINSEY TARGETS OF EWSR1 FLII FUSION UP | 1278 | 748 | All SZGR 2.0 genes in this pathway |
MARKEY RB1 CHRONIC LOF UP | 115 | 78 | All SZGR 2.0 genes in this pathway |
GAUSSMANN MLL AF4 FUSION TARGETS E UP | 97 | 60 | All SZGR 2.0 genes in this pathway |
BERENJENO TRANSFORMED BY RHOA DN | 394 | 258 | All SZGR 2.0 genes in this pathway |
HATADA METHYLATED IN LUNG CANCER UP | 390 | 236 | All SZGR 2.0 genes in this pathway |
LIEN BREAST CARCINOMA METAPLASTIC | 35 | 25 | All SZGR 2.0 genes in this pathway |
SCHLESINGER METHYLATED IN COLON CANCER | 10 | 7 | All SZGR 2.0 genes in this pathway |
OHM METHYLATED IN ADULT CANCERS | 27 | 23 | All SZGR 2.0 genes in this pathway |
OHM EMBRYONIC CARCINOMA UP | 6 | 5 | All SZGR 2.0 genes in this pathway |
INGRAM SHH TARGETS DN | 64 | 41 | All SZGR 2.0 genes in this pathway |
SCHAEFFER PROSTATE DEVELOPMENT 12HR UP | 116 | 79 | All SZGR 2.0 genes in this pathway |
SCHAEFFER PROSTATE DEVELOPMENT 48HR UP | 487 | 286 | All SZGR 2.0 genes in this pathway |
BENPORATH ES 1 | 379 | 235 | All SZGR 2.0 genes in this pathway |
BENPORATH NANOG TARGETS | 988 | 594 | All SZGR 2.0 genes in this pathway |
BENPORATH OCT4 TARGETS | 290 | 172 | All SZGR 2.0 genes in this pathway |
BENPORATH SOX2 TARGETS | 734 | 436 | All SZGR 2.0 genes in this pathway |
BENPORATH NOS TARGETS | 179 | 105 | All SZGR 2.0 genes in this pathway |
UEDA CENTRAL CLOCK | 88 | 62 | All SZGR 2.0 genes in this pathway |
BHATTACHARYA EMBRYONIC STEM CELL | 89 | 60 | All SZGR 2.0 genes in this pathway |
GUO HEX TARGETS UP | 81 | 54 | All SZGR 2.0 genes in this pathway |
MATSUDA NATURAL KILLER DIFFERENTIATION | 475 | 313 | All SZGR 2.0 genes in this pathway |
ZHAN MULTIPLE MYELOMA MF UP | 47 | 27 | All SZGR 2.0 genes in this pathway |
WANG SMARCE1 TARGETS DN | 371 | 218 | All SZGR 2.0 genes in this pathway |
PAL PRMT5 TARGETS UP | 203 | 135 | All SZGR 2.0 genes in this pathway |
TSENG IRS1 TARGETS DN | 135 | 88 | All SZGR 2.0 genes in this pathway |
KEEN RESPONSE TO ROSIGLITAZONE DN | 106 | 68 | All SZGR 2.0 genes in this pathway |
BURTON ADIPOGENESIS PEAK AT 0HR | 63 | 48 | All SZGR 2.0 genes in this pathway |
TSENG ADIPOGENIC POTENTIAL DN | 46 | 28 | All SZGR 2.0 genes in this pathway |
BURTON ADIPOGENESIS 9 | 92 | 59 | All SZGR 2.0 genes in this pathway |
MARTINEZ RB1 TARGETS DN | 543 | 317 | All SZGR 2.0 genes in this pathway |
MARTINEZ TP53 TARGETS DN | 593 | 372 | All SZGR 2.0 genes in this pathway |
MARTINEZ RB1 AND TP53 TARGETS DN | 591 | 366 | All SZGR 2.0 genes in this pathway |
IZADPANAH STEM CELL ADIPOSE VS BONE DN | 108 | 68 | All SZGR 2.0 genes in this pathway |
MISHRA CARCINOMA ASSOCIATED FIBROBLAST DN | 24 | 13 | All SZGR 2.0 genes in this pathway |
VART KSHV INFECTION ANGIOGENIC MARKERS UP | 165 | 118 | All SZGR 2.0 genes in this pathway |
MCMURRAY TP53 HRAS COOPERATION RESPONSE DN | 67 | 46 | All SZGR 2.0 genes in this pathway |
MEISSNER BRAIN HCP WITH H3K4ME3 AND H3K27ME3 | 1069 | 729 | All SZGR 2.0 genes in this pathway |
KARLSSON TGFB1 TARGETS DN | 207 | 139 | All SZGR 2.0 genes in this pathway |
PURBEY TARGETS OF CTBP1 NOT SATB1 UP | 344 | 215 | All SZGR 2.0 genes in this pathway |
KATSANOU ELAVL1 TARGETS DN | 148 | 88 | All SZGR 2.0 genes in this pathway |
WANG MLL TARGETS | 289 | 188 | All SZGR 2.0 genes in this pathway |
DURAND STROMA S UP | 297 | 194 | All SZGR 2.0 genes in this pathway |
NABA SECRETED FACTORS | 344 | 197 | All SZGR 2.0 genes in this pathway |
NABA MATRISOME ASSOCIATED | 753 | 411 | All SZGR 2.0 genes in this pathway |
NABA MATRISOME | 1028 | 559 | All SZGR 2.0 genes in this pathway |