SZGR2

Summary ?

GeneID	6426
Symbol	SRSF1
Synonyms	ASF\|SF2\|SF2p33\|SFRS1\|SRp30a
Description	serine/arginine-rich splicing factor 1
Reference	MIM:600812\|HGNC:HGNC:10780\|HPRD:02887\|
Gene type	protein-coding
Map location	17q22
Pascal p-value	0.568
Sherlock p-value	0.187
Fetal beta	1.007
DMG	1 (# studies)

Gene in Data Sources

Gene set name	Method of gene set	Description	Info
CV:PGCnp	Genome-wide Association Study	GWAS
DMG:Jaffe_2016	Genome-wide DNA methylation analysis	This dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05.	1
PMID:cooccur	High-throughput literature-search	Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
Literature	High-throughput literature-search	Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias	Click to show details

Section I. Genetics and epigenetics annotation

Differentially methylated gene

Probe	Chromosome	Position	Nearest gene	P (dis)	Beta (dis)	FDR (dis)	Study
cg24063238	17	56085336	SRSF1	1.79E-8	-0.021	6.42E-6	DMG:Jaffe_2016

Section II. Transcriptome annotation

General gene expression (GTEx)

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
TMEM54	0.66	0.71
C5orf32	0.66	0.66
LRRC29	0.65	0.65
GCAT	0.64	0.64
CIB1	0.64	0.67
CISD3	0.64	0.64
ST6GALNAC6	0.62	0.62
RAMP1	0.62	0.65
ISOC2	0.62	0.59
C17orf89	0.61	0.61

Top 10 negatively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
MAP4K4	-0.51	-0.56
THOC2	-0.50	-0.55
CTTNBP2NL	-0.50	-0.53
ZCCHC6	-0.49	-0.54
ZNF197	-0.49	-0.51
PHF16	-0.49	-0.54
ZNF776	-0.49	-0.51
PHF20	-0.49	-0.52
LRIG2	-0.49	-0.52
BAZ1B	-0.49	-0.53

Section IV. Protein-protein interaction annotation

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
C1QBP	GC1QBP \| HABP1 \| SF2p32 \| gC1Q-R \| gC1qR \| p32	complement component 1, q subcomponent binding protein	-	HPRD,BioGRID	10022843
CLK1	CLK \| CLK/STY \| STY	CDC-like kinase 1	Biochemical Activity	BioGRID	8798720 \|12565863
CLK1	CLK \| CLK/STY \| STY	CDC-like kinase 1	-	HPRD	8617202
CRKRS	CRK7 \| CRKR \| KIAA0904	Cdc2-related kinase, arginine/serine-rich	-	HPRD	11683387
CROP	LUC7A \| OA48-18	cisplatin resistance-associated overexpressed protein	-	HPRD,BioGRID	12565863
DIDO1	BYE1 \| C20orf158 \| DATF1 \| DIDO2 \| DIDO3 \| DIO-1 \| DIO1 \| DKFZp434P1115 \| FLJ11265 \| KIAA0333 \| MGC16140 \| dJ885L7.8	death inducer-obliterator 1	Two-hybrid	BioGRID	16189514
DYRK1A	DYRK \| DYRK1 \| HP86 \| MNB \| MNBH	dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A	Biochemical Activity	BioGRID	14623875
LNX1	LNX \| MPDZ \| PDZRN2	ligand of numb-protein X 1	Two-hybrid	BioGRID	16189514
PRPF4	HPRP4 \| HPRP4P \| PRP4 \| Prp4p	PRP4 pre-mRNA processing factor 4 homolog (yeast)	-	HPRD,BioGRID	11418604
PRPF4B	KIAA0536 \| PR4H \| PRP4 \| PRP4H \| PRP4K \| dJ1013A10.1	PRP4 pre-mRNA processing factor 4 homolog B (yeast)	-	HPRD	11418604
PSIP1	DFS70 \| LEDGF \| MGC74712 \| PAIP \| PSIP2 \| p52 \| p75	PC4 and SFRS1 interacting protein 1	-	HPRD,BioGRID	9885563
RNPS1	E5.1 \| MGC117332	RNA binding protein S1, serine-rich domain	Affinity Capture-MS	BioGRID	17353931
SF3A2	PRP11 \| PRPF11 \| SAP62 \| SF3a66	splicing factor 3a, subunit 2, 66kDa	Affinity Capture-MS	BioGRID	12234937
SFRS1	ASF \| MGC5228 \| SF2 \| SF2p33 \| SRp30a	splicing factor, arginine/serine-rich 1	Reconstituted Complex Two-hybrid	BioGRID	8816452 \|9799243
SFRS11	DKFZp686M13204 \| dJ677H15.2 \| p54	splicing factor, arginine/serine-rich 11	-	HPRD,BioGRID	8816452
SFRS12	DKFZp564B176 \| MGC133045 \| SRrp508 \| SRrp86	splicing factor, arginine/serine-rich 12	-	HPRD	10757789 \|14559993
SFRS2	PR264 \| SC-35 \| SC35 \| SFRS2A \| SRp30b	splicing factor, arginine/serine-rich 2	Two-hybrid	BioGRID	8816452
SFRS2IP	CASP11 \| SIP1 \| SRRP129	splicing factor, arginine/serine-rich 2, interacting protein	-	HPRD,BioGRID	9447963
SFRS5	HRS \| SRP40	splicing factor, arginine/serine-rich 5	Reconstituted Complex	BioGRID	9799243
SIP1	GEMIN2 \| SIP1-delta	survival of motor neuron protein interacting protein 1	-	HPRD	9447963
SNRNP70	RNPU1Z \| RPU1 \| SNRP70 \| U170K \| U1AP \| U1RNP	small nuclear ribonucleoprotein 70kDa (U1)	-	HPRD,BioGRID	9799243
SRPK1	SFRSK1	SFRS protein kinase 1	-	HPRD	8208298 \|8798720 \|9472028 \|10390541
SRPK1	SFRSK1	SFRS protein kinase 1	Affinity Capture-Western Biochemical Activity Far Western Reconstituted Complex	BioGRID	9472028 \|10196197 \|12565863 \|17517895
SRPK2	FLJ36101 \| SFRSK2	SFRS protein kinase 2	-	HPRD,BioGRID	9472028 \|10196197
TCERG1	CA150 \| MGC133200 \| TAF2S	transcription elongation regulator 1	-	HPRD,BioGRID	15456888
TNPO3	IPO12 \| MTR10A \| TRN-SR \| TRN-SR2 \| TRNSR	transportin 3	-	HPRD	10366588 \|10713112
TOP1	TOPI	topoisomerase (DNA) I	-	HPRD	9611241\|12270705
TOP1	TOPI	topoisomerase (DNA) I	Far Western Reconstituted Complex	BioGRID	9611241 \|12270705
U2AF1	DKFZp313J1712 \| FP793 \| RN \| RNU2AF1 \| U2AF35 \| U2AFBP	U2 small nuclear RNA auxiliary factor 1	-	HPRD	8261509 \|9799243
U2AF1	DKFZp313J1712 \| FP793 \| RN \| RNU2AF1 \| U2AF35 \| U2AFBP	U2 small nuclear RNA auxiliary factor 1	Reconstituted Complex Two-hybrid	BioGRID	8816452 \|9799243
U2AF2	U2AF65	U2 small nuclear RNA auxiliary factor 2	Two-hybrid	BioGRID	16189514
YTHDC1	KIAA1966 \| YT521 \| YT521-B	YTH domain containing 1	-	HPRD	9473574
YWHAQ	14-3-3 \| 1C5 \| HS1	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide	Affinity Capture-MS	BioGRID	17353931
ZRSR2	MGC142014 \| MGC142040 \| U2AF1-RS2 \| U2AF1L2 \| U2AF1RS2 \| URP	zinc finger (CCCH type), RNA-binding motif and serine/arginine rich 2	-	HPRD	9237760

Section V. Pathway annotation

Pathway name	Pathway size	# SZGR 2.0 genes in pathway	Info
KEGG SPLICEOSOME	128	72	All SZGR 2.0 genes in this pathway
REACTOME PROCESSING OF CAPPED INTRON CONTAINING PRE MRNA	140	77	All SZGR 2.0 genes in this pathway
REACTOME TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM	54	34	All SZGR 2.0 genes in this pathway
REACTOME RNA POL II TRANSCRIPTION	105	54	All SZGR 2.0 genes in this pathway
REACTOME MRNA PROCESSING	161	86	All SZGR 2.0 genes in this pathway
REACTOME MRNA SPLICING	111	58	All SZGR 2.0 genes in this pathway
REACTOME MRNA SPLICING MINOR PATHWAY	45	19	All SZGR 2.0 genes in this pathway
REACTOME TRANSCRIPTION	210	127	All SZGR 2.0 genes in this pathway
REACTOME MRNA 3 END PROCESSING	35	18	All SZGR 2.0 genes in this pathway
REACTOME CLEAVAGE OF GROWING TRANSCRIPT IN THE TERMINATION REGION	44	22	All SZGR 2.0 genes in this pathway
LIU SOX4 TARGETS DN	309	191	All SZGR 2.0 genes in this pathway
GAZDA DIAMOND BLACKFAN ANEMIA MYELOID UP	30	19	All SZGR 2.0 genes in this pathway
GARY CD5 TARGETS DN	431	263	All SZGR 2.0 genes in this pathway
DIAZ CHRONIC MEYLOGENOUS LEUKEMIA UP	1382	904	All SZGR 2.0 genes in this pathway
BORCZUK MALIGNANT MESOTHELIOMA UP	305	185	All SZGR 2.0 genes in this pathway
TIEN INTESTINE PROBIOTICS 24HR UP	557	331	All SZGR 2.0 genes in this pathway
KINSEY TARGETS OF EWSR1 FLII FUSION UP	1278	748	All SZGR 2.0 genes in this pathway
ELVIDGE HYPOXIA DN	146	94	All SZGR 2.0 genes in this pathway
ELVIDGE HYPOXIA BY DMOG DN	59	40	All SZGR 2.0 genes in this pathway
BIDUS METASTASIS UP	214	134	All SZGR 2.0 genes in this pathway
DODD NASOPHARYNGEAL CARCINOMA DN	1375	806	All SZGR 2.0 genes in this pathway
ENK UV RESPONSE KERATINOCYTE DN	485	334	All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY DOXORUBICIN DN	1781	1082	All SZGR 2.0 genes in this pathway
GRAESSMANN RESPONSE TO MC AND DOXORUBICIN DN	770	415	All SZGR 2.0 genes in this pathway
BERENJENO TRANSFORMED BY RHOA UP	536	340	All SZGR 2.0 genes in this pathway
DARWICHE SKIN TUMOR PROMOTER UP	142	96	All SZGR 2.0 genes in this pathway
DARWICHE SKIN TUMOR PROMOTER DN	185	115	All SZGR 2.0 genes in this pathway
DARWICHE PAPILLOMA RISK LOW UP	162	104	All SZGR 2.0 genes in this pathway
DARWICHE PAPILLOMA RISK LOW DN	165	107	All SZGR 2.0 genes in this pathway
DARWICHE PAPILLOMA RISK HIGH UP	147	101	All SZGR 2.0 genes in this pathway
DARWICHE PAPILLOMA RISK HIGH DN	180	110	All SZGR 2.0 genes in this pathway
DARWICHE SQUAMOUS CELL CARCINOMA UP	146	104	All SZGR 2.0 genes in this pathway
DARWICHE SQUAMOUS CELL CARCINOMA DN	181	107	All SZGR 2.0 genes in this pathway
LASTOWSKA NEUROBLASTOMA COPY NUMBER UP	181	108	All SZGR 2.0 genes in this pathway
MATTIOLI MGUS VS PCL	116	62	All SZGR 2.0 genes in this pathway
SCHLOSSER MYC TARGETS REPRESSED BY SERUM	159	93	All SZGR 2.0 genes in this pathway
MARTORIATI MDM4 TARGETS FETAL LIVER DN	514	319	All SZGR 2.0 genes in this pathway
MOHANKUMAR TLX1 TARGETS UP	414	287	All SZGR 2.0 genes in this pathway
PUJANA BRCA1 PCC NETWORK	1652	1023	All SZGR 2.0 genes in this pathway
PUJANA ATM PCC NETWORK	1442	892	All SZGR 2.0 genes in this pathway
PUJANA CHEK2 PCC NETWORK	779	480	All SZGR 2.0 genes in this pathway
GROSS HYPOXIA VIA ELK3 UP	209	139	All SZGR 2.0 genes in this pathway
GROSS HYPOXIA VIA HIF1A UP	77	49	All SZGR 2.0 genes in this pathway
GROSS HYPOXIA VIA ELK3 AND HIF1A DN	103	71	All SZGR 2.0 genes in this pathway
RICKMAN TUMOR DIFFERENTIATED WELL VS POORLY UP	236	139	All SZGR 2.0 genes in this pathway
RICKMAN TUMOR DIFFERENTIATED MODERATELY VS POORLY DN	15	8	All SZGR 2.0 genes in this pathway
GOTZMANN EPITHELIAL TO MESENCHYMAL TRANSITION DN	206	136	All SZGR 2.0 genes in this pathway
PASQUALUCCI LYMPHOMA BY GC STAGE DN	165	104	All SZGR 2.0 genes in this pathway
BENPORATH ES 1	379	235	All SZGR 2.0 genes in this pathway
SAKAI TUMOR INFILTRATING MONOCYTES DN	81	51	All SZGR 2.0 genes in this pathway
BYSTROEM CORRELATED WITH IL5 DN	64	47	All SZGR 2.0 genes in this pathway
BASSO B LYMPHOCYTE NETWORK	143	96	All SZGR 2.0 genes in this pathway
PENG GLUCOSE DEPRIVATION DN	169	112	All SZGR 2.0 genes in this pathway
FLECHNER BIOPSY KIDNEY TRANSPLANT REJECTED VS OK DN	546	351	All SZGR 2.0 genes in this pathway
PENG GLUTAMINE DEPRIVATION DN	337	230	All SZGR 2.0 genes in this pathway
FLECHNER BIOPSY KIDNEY TRANSPLANT OK VS DONOR UP	555	346	All SZGR 2.0 genes in this pathway
THEILGAARD NEUTROPHIL AT SKIN WOUND DN	225	163	All SZGR 2.0 genes in this pathway
IVANOVA HEMATOPOIESIS LATE PROGENITOR	544	307	All SZGR 2.0 genes in this pathway
PAL PRMT5 TARGETS UP	203	135	All SZGR 2.0 genes in this pathway
BURTON ADIPOGENESIS PEAK AT 24HR	43	30	All SZGR 2.0 genes in this pathway
DAZARD RESPONSE TO UV SCC UP	123	75	All SZGR 2.0 genes in this pathway
BACOLOD RESISTANCE TO ALKYLATING AGENTS DN	60	45	All SZGR 2.0 genes in this pathway
MARSON BOUND BY FOXP3 STIMULATED	1022	619	All SZGR 2.0 genes in this pathway
MARSON BOUND BY FOXP3 UNSTIMULATED	1229	713	All SZGR 2.0 genes in this pathway
MARSON BOUND BY E2F4 UNSTIMULATED	728	415	All SZGR 2.0 genes in this pathway
STEARMAN LUNG CANCER EARLY VS LATE UP	125	89	All SZGR 2.0 genes in this pathway
AMUNDSON POOR SURVIVAL AFTER GAMMA RADIATION 2G	171	96	All SZGR 2.0 genes in this pathway
IWANAGA CARCINOGENESIS BY KRAS DN	120	81	All SZGR 2.0 genes in this pathway
GRADE COLON CANCER UP	871	505	All SZGR 2.0 genes in this pathway
GRADE COLON AND RECTAL CANCER UP	285	167	All SZGR 2.0 genes in this pathway
BLUM RESPONSE TO SALIRASIB DN	342	220	All SZGR 2.0 genes in this pathway
MUELLER PLURINET	299	189	All SZGR 2.0 genes in this pathway
ZHANG TLX TARGETS 36HR DN	185	116	All SZGR 2.0 genes in this pathway
ZHANG TLX TARGETS 60HR DN	277	166	All SZGR 2.0 genes in this pathway
ZHANG TLX TARGETS DN	89	50	All SZGR 2.0 genes in this pathway
MILI PSEUDOPODIA HAPTOTAXIS UP	518	299	All SZGR 2.0 genes in this pathway
SAKAI CHRONIC HEPATITIS VS LIVER CANCER UP	83	63	All SZGR 2.0 genes in this pathway
CAIRO HEPATOBLASTOMA CLASSES UP	605	377	All SZGR 2.0 genes in this pathway
KYNG WERNER SYNDROM AND NORMAL AGING DN	225	124	All SZGR 2.0 genes in this pathway
DANG REGULATED BY MYC UP	72	53	All SZGR 2.0 genes in this pathway
DANG MYC TARGETS UP	143	100	All SZGR 2.0 genes in this pathway
DANG BOUND BY MYC	1103	714	All SZGR 2.0 genes in this pathway
DORN ADENOVIRUS INFECTION 12HR UP	29	18	All SZGR 2.0 genes in this pathway
DORN ADENOVIRUS INFECTION 24HR DN	43	32	All SZGR 2.0 genes in this pathway
DORN ADENOVIRUS INFECTION 32HR DN	39	28	All SZGR 2.0 genes in this pathway
DORN ADENOVIRUS INFECTION 48HR DN	40	29	All SZGR 2.0 genes in this pathway
YAO TEMPORAL RESPONSE TO PROGESTERONE CLUSTER 8	49	36	All SZGR 2.0 genes in this pathway
YAO TEMPORAL RESPONSE TO PROGESTERONE CLUSTER 14	143	86	All SZGR 2.0 genes in this pathway
MARTENS TRETINOIN RESPONSE DN	841	431	All SZGR 2.0 genes in this pathway
JOHNSTONE PARVB TARGETS 2 DN	336	211	All SZGR 2.0 genes in this pathway
LEE BMP2 TARGETS DN	882	538	All SZGR 2.0 genes in this pathway
FEVR CTNNB1 TARGETS DN	553	343	All SZGR 2.0 genes in this pathway
PEDERSEN METASTASIS BY ERBB2 ISOFORM 7	403	240	All SZGR 2.0 genes in this pathway
FORTSCHEGGER PHF8 TARGETS DN	784	464	All SZGR 2.0 genes in this pathway
ABRAMSON INTERACT WITH AIRE	45	33	All SZGR 2.0 genes in this pathway

Gene Page: SRSF1