Gene Page: SH3BP2
Summary ?
| GeneID | 6452 |
| Symbol | SH3BP2 |
| Synonyms | 3BP-2|3BP2|CRBM|CRPM|RES4-23 |
| Description | SH3-domain binding protein 2 |
| Reference | MIM:602104|HGNC:HGNC:10825|Ensembl:ENSG00000087266|HPRD:03657|Vega:OTTHUMG00000160801 |
| Gene type | protein-coding |
| Map location | 4p16.3 |
| Pascal p-value | 0.641 |
| Fetal beta | 1.819 |
| DMG | 1 (# studies) |
| eGene | Nucleus accumbens basal ganglia |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| DMG:Wockner_2014 | Genome-wide DNA methylation analysis | This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). | 1 |
Section I. Genetics and epigenetics annotation
Differentially methylated gene
| Probe | Chromosome | Position | Nearest gene | P (dis) | Beta (dis) | FDR (dis) | Study |
|---|---|---|---|---|---|---|---|
| cg10869531 | 4 | 2808489 | SH3BP2 | 4.424E-4 | 0.457 | 0.045 | DMG:Wockner_2014 |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
No co-expressed genes in brain regions
Section IV. Protein-protein interaction annotation
| Interactors | Aliases B | Official full name B | Experimental | Source | PubMed ID |
|---|---|---|---|---|---|
| ABL1 | ABL | JTK7 | bcr/abl | c-ABL | p150 | v-abl | c-abl oncogene 1, receptor tyrosine kinase | - | HPRD | 8438166 |
| CBL | C-CBL | CBL2 | RNF55 | Cas-Br-M (murine) ecotropic retroviral transforming sequence | Reconstituted Complex | BioGRID | 9846481 |
| FGFR1 | BFGFR | CD331 | CEK | FGFBR | FLG | FLJ99988 | FLT2 | HBGFR | KAL2 | N-SAM | fibroblast growth factor receptor 1 | An unspecified isoform of FGFR1 interacts with SH3BP2. This interaction was modeled on a demonstrated interaction between FGFR1 from an unspecified species and human SH3BP2. | BIND | 15117958 |
| FYN | MGC45350 | SLK | SYN | FYN oncogene related to SRC, FGR, YES | Two-hybrid | BioGRID | 9846481 |
| GRB2 | ASH | EGFRBP-GRB2 | Grb3-3 | MST084 | MSTP084 | growth factor receptor-bound protein 2 | - | HPRD,BioGRID | 9846481 |
| LAT | LAT1 | pp36 | linker for activation of T cells | - | HPRD,BioGRID | 11390470 |
| PLCG1 | PLC-II | PLC1 | PLC148 | PLCgamma1 | phospholipase C, gamma 1 | - | HPRD,BioGRID | 11390470 |
| PLCG2 | - | phospholipase C, gamma 2 (phosphatidylinositol-specific) | - | HPRD | 11390470 |
| SYK | DKFZp313N1010 | FLJ25043 | FLJ37489 | spleen tyrosine kinase | - | HPRD,BioGRID | 9846481 |11390470 |
| VAV1 | VAV | vav 1 guanine nucleotide exchange factor | - | HPRD,BioGRID | 11390470 |
| VAV2 | - | vav 2 guanine nucleotide exchange factor | - | HPRD | 11390470 |
| ZAP70 | FLJ17670 | FLJ17679 | SRK | STD | TZK | ZAP-70 | zeta-chain (TCR) associated protein kinase 70kDa | - | HPRD | 11390470 |
| ZAP70 | FLJ17670 | FLJ17679 | SRK | STD | TZK | ZAP-70 | zeta-chain (TCR) associated protein kinase 70kDa | Affinity Capture-Western Reconstituted Complex | BioGRID | 9846481 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| KEGG NATURAL KILLER CELL MEDIATED CYTOTOXICITY | 137 | 92 | All SZGR 2.0 genes in this pathway |
| PID TCR PATHWAY | 66 | 51 | All SZGR 2.0 genes in this pathway |
| GINESTIER BREAST CANCER ZNF217 AMPLIFIED DN | 335 | 193 | All SZGR 2.0 genes in this pathway |
| MULLIGHAN NPM1 MUTATED SIGNATURE 1 UP | 276 | 165 | All SZGR 2.0 genes in this pathway |
| MULLIGHAN NPM1 SIGNATURE 3 UP | 341 | 197 | All SZGR 2.0 genes in this pathway |
| DODD NASOPHARYNGEAL CARCINOMA DN | 1375 | 806 | All SZGR 2.0 genes in this pathway |
| ENK UV RESPONSE EPIDERMIS UP | 293 | 179 | All SZGR 2.0 genes in this pathway |
| LASTOWSKA NEUROBLASTOMA COPY NUMBER DN | 800 | 473 | All SZGR 2.0 genes in this pathway |
| JAZAG TGFB1 SIGNALING VIA SMAD4 DN | 66 | 38 | All SZGR 2.0 genes in this pathway |
| MORI MATURE B LYMPHOCYTE UP | 90 | 62 | All SZGR 2.0 genes in this pathway |
| NING CHRONIC OBSTRUCTIVE PULMONARY DISEASE DN | 121 | 79 | All SZGR 2.0 genes in this pathway |
| BYSTRYKH HEMATOPOIESIS STEM CELL QTL TRANS | 882 | 572 | All SZGR 2.0 genes in this pathway |
| HALMOS CEBPA TARGETS DN | 46 | 26 | All SZGR 2.0 genes in this pathway |
| HOEGERKORP CD44 TARGETS DIRECT UP | 27 | 21 | All SZGR 2.0 genes in this pathway |
| BLALOCK ALZHEIMERS DISEASE UP | 1691 | 1088 | All SZGR 2.0 genes in this pathway |
| BROWNE HCMV INFECTION 48HR DN | 504 | 323 | All SZGR 2.0 genes in this pathway |
| KRIGE RESPONSE TO TOSEDOSTAT 6HR UP | 953 | 554 | All SZGR 2.0 genes in this pathway |
| KRIGE RESPONSE TO TOSEDOSTAT 24HR UP | 783 | 442 | All SZGR 2.0 genes in this pathway |
| BERNARD PPAPDC1B TARGETS DN | 58 | 39 | All SZGR 2.0 genes in this pathway |
| QI PLASMACYTOMA UP | 259 | 185 | All SZGR 2.0 genes in this pathway |
| MUELLER COMMON TARGETS OF AML FUSIONS DN | 31 | 21 | All SZGR 2.0 genes in this pathway |
| SHEDDEN LUNG CANCER GOOD SURVIVAL A12 | 317 | 177 | All SZGR 2.0 genes in this pathway |
| CHEN METABOLIC SYNDROM NETWORK | 1210 | 725 | All SZGR 2.0 genes in this pathway |
| COULOUARN TEMPORAL TGFB1 SIGNATURE DN | 138 | 99 | All SZGR 2.0 genes in this pathway |
| LI INDUCED T TO NATURAL KILLER UP | 307 | 182 | All SZGR 2.0 genes in this pathway |
| MARTENS BOUND BY PML RARA FUSION | 456 | 287 | All SZGR 2.0 genes in this pathway |
| JOHNSTONE PARVB TARGETS 3 DN | 918 | 550 | All SZGR 2.0 genes in this pathway |
| LIM MAMMARY STEM CELL DN | 428 | 246 | All SZGR 2.0 genes in this pathway |